The Journal of Steroid Biochemistry and Molecular Biology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.In silico identification of novel transcription factors associated with CYP27B1 transcriptional regulation in LPS-challenged mononuclear phagocytes
Publication date: Available online 27 January 2020Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Romina P. Martinelli, Julia M. Rodriguez, Lucas D. Daurelio, Luis EstebanAbstractRenal and extrarenal production of the active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)2D), is catalyzed by CYP27B1, an enzyme also called 1-α-hydroxylase. The overproduction of 1,25(OH)2D has been described in granulomatous diseases. High circulating concentrations of 1,25(OH)2D can lead to hypercalcemia. The aim of this work was to characterize the transcriptional regulation of CYP27B1 in human mononuclear...
Source: The Journal of Steroid Biochemistry and Molecular Biology - January 29, 2020 Category: Biochemistry Source Type: research
Vitamin D intake and the 10-year risk of urgency urinary incontinence in women
The objective was to assess whether greater vitamin D intake was associated with decreased risk of incident urgency and mixed UI over 10 years using 2 large prospective cohorts of middle-aged and older women. We analyzed 38,101 women from the Nurses’ Health Study I (NHS I) and 35,190 women from NHS II who were free of UI at baseline. We followed incident UI, defined as new UI occurring at least monthly, separately by subtype (urgency, mixed, stress UI), from 2002-2012. We categorized vitamin D intake from supplements and diet. We estimated relative risk for developing UI according to vitamin D intake using Cox-proportion...
Source: The Journal of Steroid Biochemistry and Molecular Biology - January 29, 2020 Category: Biochemistry Source Type: research
miR-326 down-regulate CYP19A1 expression and estradiol-17b production in buffalo granulosa cells through CREB and C/EBP-β
Publication date: Available online 26 January 2020Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Vaishali Chaurasiya, Suman Kumari, Suneel Kumar Onteru, Dheer SinghAbstractOvarian granulosa cells, known to be endocrine cells, have well active TLR4-/NFKB signalling mediated innate immune capabilities. We have previously shown that endotoxin not only transiently regulates proinflammatory cytokines but cells become tolerant on repeated exposure to endotoxin and impaired granulosa cells functions, which includes downregulation of CYP19A1 gene. To understand further endotoxin tolerance and impaired ...
Source: The Journal of Steroid Biochemistry and Molecular Biology - January 27, 2020 Category: Biochemistry Source Type: research
Bifidobacterium pseudolongum reduces triglycerides by modulating gut microbiota in mice fed high-fat food
Publication date: Available online 24 January 2020Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Tingbei Bo, Jing Wen, Yuanchun Zhao, Shuangjie Tian, Xueying Zhang, Dehua WangAbstractObesity has become a growing concern around the world. The purpose of this study was to investigate the potential benefit of Bifidobacterium pseudolongum (B. pseudolongum) on obesity, gut microbiota, and its physiological mechanism. The obese mice model was established with a high-fat diet (HFD), and the treatment were used the strain B. pseudolongum. We investigated the changes in fat content, plasma metabolites a...
Source: The Journal of Steroid Biochemistry and Molecular Biology - January 25, 2020 Category: Biochemistry Source Type: research
Systemic distribution of progesterone receptor subtypes in human tissues
In this study, we immunolocalized PR expression in various human tissues using PR (1294) specific antibody, which is capable of detecting both PRA and PRB, and PRB (250H11) specific antibody. Tissues from the uterus, ovary, breast, placenta, prostate, testis, cerebrum, cerebellum, pituitary, spinal cord, esophagus, stomach, small intestine, colon, pancreas, liver, kidney, urinary bladder, lung, heart, aorta, thymus, adrenal gland, thyroid, spleen, skin, and bone were examined in four different age groups (fetal, pediatric, young, and old) in male and female subjects. PR and PRB were detected in the nuclei of cells in the f...
Source: The Journal of Steroid Biochemistry and Molecular Biology - January 25, 2020 Category: Biochemistry Source Type: research
Canadian Recommendations for Vitamin D Intake for Persons Affected by Multiple Sclerosis
Publication date: Available online 22 January 2020Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Stephanie A. Atkinson, James C. FleetAbstractIn 2016, the Multiple Sclerosis (MS) Society of Canada convened a panel of expert scientists, clinicians and patient advocate to review the evidence for an association between vitamin D status and MS prevention and/or disease modification. The goal was to develop clear and accurate recommendations on optimal vitamin D intake and status for people affected by MS for use in clinical practice and public health policy. The final consensus report was based on ...
Source: The Journal of Steroid Biochemistry and Molecular Biology - January 23, 2020 Category: Biochemistry Source Type: research
Impact of Dietary Vitamin D on Initiation and Progression of Oral Cancer
Publication date: Available online 22 January 2020Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Aparajita Verma, Vui King Vincent-Chong, Hendrik DeJong, Pamela A. Hershberger, Mukund SeshadriABSTRACTCalcitriol, the active metabolite of vitamin D, has been widely studied for its preventive and therapeutic activity against several cancers including oral squamous cell carcinoma (OSCC). However, the impact of dietary vitamin D supplementation on initiation and progression of OSCC is unclear. To address this gap in knowledge, we conducted preclinical trials using the 4-nitroquinoline-1-oxide (4NQO)...
Source: The Journal of Steroid Biochemistry and Molecular Biology - January 23, 2020 Category: Biochemistry Source Type: research
Molecular mechanisms of posaconazole- and itraconazole-induced pseudohyperaldosteronism and assessment of other systemically used azole antifungals
Publication date: Available online 23 January 2020Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Katharina R. Beck, Lucija Telisman, Chris J. van Koppen, George R. Thompson, Alex OdermattAbstractRecent reports described cases of severe hypertension and hypokalemia accompanied by low renin and aldosterone levels during antifungal therapy with posaconazole and itraconazole. These conditions represent characteristics of secondary endocrine hypertension caused by mineralocorticoid excess. Different mechanisms can cause mineralocorticoid excess, including inhibition of the adrenal steroidogenic enzy...
Source: The Journal of Steroid Biochemistry and Molecular Biology - January 23, 2020 Category: Biochemistry Source Type: research
Molecular docking, anti-proliferative activity and induction of apoptosis in human liver cancer cells treated with androstane derivatives: Implication of PI3K/AKT/mTOR pathway
Publication date: Available online 23 January 2020Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Shahad W. Kattan, Mohamed S. Nafie, Gamal A. Elmgeed, Walla Alelwani, Muhammad Badar, Mohamed A. TantawyAbstractWorldwide, cancer still an area with high unmet medical need. Lead optimization efforts toward structure-based drug design were employed to discover newly synthesized hetero-steroid derivatives with promising anticancer effects against hepatocellular carcinoma (HCC). The aim of our study is to evaluate the anti-proliferative activity, a dual PI3K/mTOR inhibitor, and mechanism of action of ...
Source: The Journal of Steroid Biochemistry and Molecular Biology - January 23, 2020 Category: Biochemistry Source Type: research
Development and application of a LC–MS/MS assay for simultaneous analysis of 25-hydroxyvitamin-D and 3-epi-25-hydroxyvitamin-D metabolites in canine serum
We describe a simplified workflow utilising supported liquid extraction (SLE) without derivatization that provides good linearity (mean r> 0.996) and accuracy across a broad dynamic range of 4–500 nmol/L for D3 metabolites and 7.8–500 nmol/L for D2 metabolites. Upon application of this assay to 117 canine serum samples, 25(OH)D3 was detectable in all samples with a median concentration of 82.1 nmol/L (inter-quartile range (IQR) 59.7–101.8 nmol/L). 3-epi-25(OH)D3 could be detected in 87.2 % of the study population, with a median concentration of 5.2 nmol/L (2.4–8.1 nmol/L). However, 3-epi-25(OH)D3 was qu...
Source: The Journal of Steroid Biochemistry and Molecular Biology - January 23, 2020 Category: Biochemistry Source Type: research
Expression of estrogen receptor α variants and c-Fos in rat mammary gland and tumors
Publication date: Available online 20 January 2020Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Alicia Gutiérrez, Lorena Sambuco, Laura Álvarez, Mariel Núñez, Rosa Bergoc, Elsa Zotta, Gabriela Martín, Andrea RandiAbstractBreast cancer is currently the leading cause of cancer death among women worldwide. AP-1 (c-Fos/c-Jun) is associated with proliferation and survival, while cytoplasmic c-Fos activates phospholipid synthesis in cells induced to differentiate or grow. Estrogen receptor α 46 (ERα46) is a splice variant of full-length ERα66 and it is known that it has an inhibitory role in...
Source: The Journal of Steroid Biochemistry and Molecular Biology - January 21, 2020 Category: Biochemistry Source Type: research
Characteristics and sex dimorphism of 17β-hydroxysteroid dehydrogenase family genes in the olive flounder Paralichthys olivaceus
In this study, a total of ten Hsd17b family genes, including Hsd17b3, -4, -7, -8, -9, -10, -12a, -12b, -14 and -15, were identified in the flounder, which encoded critical enzymes acting on sex steroid synthesis and metabolism. Hsd17b genes were distributed on eight chromosomes. Hsd17b12a and -12b were located on chromosomes 19 and 7, respectively. It was speculated that these two genes were just highly similar rather than different transcripts derived from the same gene. According to the results of domain and motif analyses, they all belonged to the SDR superfamily and contained conserved Hsd17b motifs TGxxxGxG, PGxxxT, N...
Source: The Journal of Steroid Biochemistry and Molecular Biology - January 18, 2020 Category: Biochemistry Source Type: research
Daily and seasonal mitochondrial protection: unraveling common possible mechanisms involving vitamin d and melatonin
Publication date: Available online 16 January 2020Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Feres José Mocayar Marón, León Ferder, Russel J. Reiter, Walter ManuchaAbstractFrom an evolutionary point of view, vitamin D and melatonin appeared very early and share functions related to defense mechanisms. In the current clinical setting, vitamin D is exclusively associated with phosphocalcic metabolism. Meanwhile, melatonin has chronobiological effects and influences the sleep-wake cycle. Scientific evidence, however, has identified new actions of both molecules in different physiological an...
Source: The Journal of Steroid Biochemistry and Molecular Biology - January 17, 2020 Category: Biochemistry Source Type: research
Sex dimorphism in an animal model of multiple sclerosis: focus on pregnenolone synthesis
Publication date: Available online 17 January 2020Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): S. Giatti, R. Rigolio, S. Diviccaro, E. Falvo, D. Caruso, L.M. Garcia-Segura, G. Cavaletti, R.C. MelcangiABSTRACTNeuroactive steroids, molecules produced from cholesterol in steroidogenic cells (i.e., peripheral glands and nervous system) are physiological modulators and protective agents of nervous function. A possible role for neuroactive steroids in the sex-dimorphic clinical manifestation, onset and progression of Multiple Sclerosis (MS) has been recently suggested. To explore this possibility, ...
Source: The Journal of Steroid Biochemistry and Molecular Biology - January 17, 2020 Category: Biochemistry Source Type: research
VDR in Salivary Gland Homeostasis and Cancer
Publication date: Available online 17 January 2020Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Kara A. DeSantis, Samantha L. Robilotto, Mark Matson, Noor M. Kotb, Cathryn M. Lapierre, Zenab Minhas, Alana A. Leder, Khushbakht Abdul, Emily M. Facteau, JoEllen WelshAbstractThe vitamin D receptor (VDR) and its ligand 1,25(OH)2D3 (1,25D) impact differentiation and exert anti-tumor effects in many tissues, but its role in salivary gland has yet to be defined. Using immunohistochemistry (IHC), we have detected strong VDR expression in murine and human salivary gland ducts. Compared to normal gland, ...
Source: The Journal of Steroid Biochemistry and Molecular Biology - January 17, 2020 Category: Biochemistry Source Type: research
