The Data Registry of the European Competence Network on Mastocytosis (ECNM): Set Up, Projects, and Perspectives
Publication date: Available online 8 November 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Peter Valent, Joanna N.G. Oude Elberink, Aleksandra Gorska, Magdalena Lange, Roberta Zanotti, Björn van Anrooij, Massimiliano Bonifacio, Patrizia Bonadonna, Karoline V. Gleixner, Emir Hadzijusufovic, Cecelia Perkins, Karin Hartmann, Anja Illerhaus, Serena Merante, Chiara Elena, Khalid Shoumariyeh, Nikolas von Bubnoff, Roberta Parente, Massimo Triggiani, Juliana SchwaabMastocytosis is a unique hematologic neoplasm with complex biology and pathology and a variable clinical course. The disease c...
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 9, 2018 Category: Allergy & Immunology Source Type: research

Efficacy of rituximab as a single-agent therapy for the treatment of Granulomatous and Lymphocytic Interstitial Lung Disease (GLILD) in patients with Common Variable Immunodeficiency (CVID)
Publication date: Available online 5 November 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Lorenzo Cereser, Riccardo De Carli, Rossano Girometti, Alessandro De Pellegrin, Federico Reccardini, Barbara Frossi, Marco De Carli (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 6, 2018 Category: Allergy & Immunology Source Type: research

Relationship between anaphylaxis and use of beta-blockers and angiotensin-converting enzyme inhibitors: a systematic review and meta-analysis of observational studies
ConclusionThe quality of evidence showing that use of BBs and ACEI increases the severity of anaphylaxis is low owing to differences in the control of confounders arising from the concomitant presence of cardiovascular diseases. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 6, 2018 Category: Allergy & Immunology Source Type: research

Hematopoietic stem cell transplantation as treatment for patients with DOCK8 deficiency
ConclusionHSCT is curative in most DOCK8 deficient patients, confirming this approach as the treatment of choice. HSCT using a reduced toxicity regimen may offer the best chance for survival. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 3, 2018 Category: Allergy & Immunology Source Type: research

Allogeneic Hematopoietic Stem Cell Transplantation in Adolescent Patients with Chronic Granulomatous Disease
Publication date: Available online 2 November 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Danielle E. Arnold, Alix E. Seif, Soma Jyonouchi, Kathleen E. Sullivan, Nancy J. Bunin, Jennifer R. Heimall (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 3, 2018 Category: Allergy & Immunology Source Type: research

Allergic Rhinitis and Asthma induced by Boxelder Bug Sensitization
Publication date: Available online 2 November 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Jamie Zussman, Gerald J. Gleich (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 3, 2018 Category: Allergy & Immunology Source Type: research

A one-day, 90-minute aspirin challenge and desensitization protocol in aspirin-exacerbated respiratory disease
ConclusionsPatients with AERD on a stable asthma regimen and with a baseline FEV1>70% can be safely desensitized to aspirin using a 90-minute dose escalation protocol, starting at a dose of 40.5mg, and defining desensitization as tolerance of the repeated provocation dose and at least one subsequent aspirin dose, bringing total cumulative daily dose to ≥325mg. This protocol can routinely be completed in one day.Updating the current aspirin challenge and desensitization guidelines to include these three key elements will allow for maintaining an exceptional safety profile while increasing efficiency of this procedure....
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 3, 2018 Category: Allergy & Immunology Source Type: research

Anxiety and non-eosinophilic asthma among adults in the United States
Publication date: Available online 3 November 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Yueh-Ying Han, Erick Forno, Juan C. Celedón (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 3, 2018 Category: Allergy & Immunology Source Type: research

Practice Patterns Among Allergists on the Early Introduction of Peanut
Publication date: Available online 3 November 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Kara B. McNamara, Brian C. Schroer, Jaclyn Bjelac (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 3, 2018 Category: Allergy & Immunology Source Type: research

A Systematic Review of Patient and Family-Level Inhaled Corticosteroid Adherence Interventions in Adult African-Americans
ConclusionFew studies assessing asthma adherence interventions focused on adult African-American populations. No RCTs demonstrated improved ICS adherence in participants. Future studies are needed that are informed by behavior change theory and stakeholder engagement. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 3, 2018 Category: Allergy & Immunology Source Type: research

Injured skin as risk factor for chlorhexidine anaphylaxis
Publication date: November–December 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 6Author(s): Gianfranco Calogiuri, Lene Heise Garvey, Elisabetta DiLeo, Eustachio Nettis, Angelo Vacca, Caterina Foti (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 2, 2018 Category: Allergy & Immunology Source Type: research

Cover 1
Publication date: November–December 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 6Author(s): (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 2, 2018 Category: Allergy & Immunology Source Type: research

Table of Contents
Publication date: November–December 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 6Author(s): (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 2, 2018 Category: Allergy & Immunology Source Type: research

Original Article Highlights From This Issue
Publication date: November–December 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 6Author(s): (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 2, 2018 Category: Allergy & Immunology Source Type: research

Editorial Board
Publication date: November–December 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 6Author(s): (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 2, 2018 Category: Allergy & Immunology Source Type: research

Information for Readers
Publication date: November–December 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 6Author(s): (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 2, 2018 Category: Allergy & Immunology Source Type: research

Practice Notes from the AAAI
Publication date: November–December 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 6Author(s): (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 2, 2018 Category: Allergy & Immunology Source Type: research

Continuing Medical Education Calendar
Publication date: November–December 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 6Author(s): (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 2, 2018 Category: Allergy & Immunology Source Type: research

CME Exam: Cross-Reactive Aeroallergens: Which Need to Cross Our Mind in Food Allergy Diagnosis?
Publication date: November–December 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 6Author(s): (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 2, 2018 Category: Allergy & Immunology Source Type: research

Environmental Food Exposure: What Is the Risk of Clinical Reactivity From Cross-Contact and What Is the Risk of Sensitization
Publication date: November–December 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 6Author(s): William J. Sheehan, Steve L. Taylor, Wanda Phipatanakul, Helen A. BroughFor food-allergic individuals, the typical exposure to food proteins happens during ingestion; however, individuals may be exposed to foods in other ways. In addition to ingestion reactions, allergic patients may have reactions from cutaneous or mucosal exposures to food proteins, with the classic example being a peanut-allergic child touching a counter with peanut butter and then rubbing their eyes. Similar to ...
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 2, 2018 Category: Allergy & Immunology Source Type: research

CME Exam: Environmental Food Exposure: What Is the Risk of Clinical Reactivity From Cross-Contact and What Is the Risk of Sensitization
Publication date: November–December 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 6Author(s): (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 2, 2018 Category: Allergy & Immunology Source Type: research

Aeroallergen Exposure and Spread in the Modern Era
The objective of this review was to present an overview of aeroallergens and the environmental factors influencing their current distribution. Using historical studies along with recent advancements, we will give an up-to-date description of the physical characteristics and aerodynamics of aeroallergens in addition to location, quantities, and timing of exposure. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 2, 2018 Category: Allergy & Immunology Source Type: research

CME Exam: Aeroallergen Exposure and Spread in the Modern Era
Publication date: November–December 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 6Author(s): (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 2, 2018 Category: Allergy & Immunology Source Type: research

Controversies in Allergy: Intradermal Aeroallergen Skin Testing
Publication date: November–December 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 6Author(s): Dennis K. Ledford, Richard F. Lockey (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 2, 2018 Category: Allergy & Immunology Source Type: research

Clinical Allergy at the Interface of Sticky Dust Particles and Crystal-Clear Proteins
Publication date: November–December 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 6Author(s): Brian Schroer, Rob C. Aalberse (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 2, 2018 Category: Allergy & Immunology Source Type: research

Latex Allergy Risks Live On
Publication date: November–December 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 6Author(s): Kim Liberatore, Kevin J. KellyReduction in the prevalence of IgE-mediated allergy to latex proteins from gloves in patients may lead to lax attention by health care personnel to avoid use of latex products in latex-allergic subjects. Recent evidence from the Pennsylvania Patient Safety Reporting System shows an alarming continuation of adverse events mostly from latex urinary catheters. We are strongly advocating that health care personnel must continue to pay close attention to avo...
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 2, 2018 Category: Allergy & Immunology Source Type: research

A Multicenter Evaluation of Diagnosis and Management of Omega-5 Gliadin Allergy (Also Known as Wheat-Dependent Exercise-Induced Anaphylaxis) in 132 Adults
ConclusionOmega-5 gliadin allergy is a rare wheat allergy that presents with severe anaphylaxis. The diagnosis is frequently delayed, and therefore we recommend that all adult patients presenting with anaphylaxis of unclear cause should have omega-5 gliadin specific IgE tested. A gluten-free diet or avoidance of wheat-based meals in combination with exercise (if the cofactor is exercise) helps to significantly decrease the risk of future allergic reactions. However, antihistamines and an epinephrine autoinjector must always be prescribed because one-third of patients continue to have allergic reactions despite dietary advi...
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 2, 2018 Category: Allergy & Immunology Source Type: research

Epinephrine in Severe Allergic Reactions: The European Anaphylaxis Register
ConclusionsDespite clear recommendations, only a small proportion of anaphylaxis incidents are treated with epinephrine. We demonstrated a slight increase in treated patients when handled by professionals, but stagnation in lay- or self-treated anaphylaxis. The reaction circumstances, the respondent's professional background, and patient characteristics did not explain which reactions were treated. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 2, 2018 Category: Allergy & Immunology Source Type: research

Risk Factors for Return to the Emergency Department for Asthma: A Population-Based Study
ConclusionsNearly 1 in 8 individuals with a first ED visit for asthma returned to the ED within a year of the initial ED discharge. Targeting those at risk for ED return may help improve health care costs, productivity, and quality of life. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 2, 2018 Category: Allergy & Immunology Source Type: research

Emergency Department Recidivism and Asthma: Revisiting an Old Problem
Publication date: November–December 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 6Author(s): Joe K. Gerald, Kurt R. Denninghoff (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 2, 2018 Category: Allergy & Immunology Source Type: research

Explaining the Amount and Consistency of Medical Care and Self-Management Support in Asthma: A Survey of Primary Care Providers in France and the United Kingdom
Publication date: November–December 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 6Author(s): Marijn de Bruin, Alexandra L. Dima, Nathalie Texier, Eric van Ganse, ASTRO-LAB groupBackgroundThe quality of asthma primary care may vary between countries, health care practices, and health care professionals (HCPs). Identifying and explaining such differences is critical for health services improvement.ObjectivesTo examine the quality of asthma primary care in France and United Kingdom, and identify within-country and between-country predictors amenable to intervention.MethodsAn o...
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 2, 2018 Category: Allergy & Immunology Source Type: research

Improving Asthma Management: A Tale of Two Countries
Publication date: November–December 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 6Author(s): Kenneth R. Chapman (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 2, 2018 Category: Allergy & Immunology Source Type: research

Use of ICS/LABA Combinations or LAMA Is Associated with a Lower Risk of Acute Exacerbation in Patients with Coexistent COPD and Asthma
The objective of this study was to investigate medication effects on acute exacerbation in patients with coexistent COPD and asthma.MethodsUsing Taiwan's National Health Insurance Research Database, we conducted a nationwide population-based study to evaluate medication effects in patients with COPD and asthma. Patients diagnosed with both asthma and COPD between 1997 and 2012 were enrolled as the COPD + asthma cohort. The primary endpoint was acute exacerbation. The definitions of COPD and asthma were validated. The validation study confirmed the accuracy of definitions of COPD (86.2% sensitivity) and asthma (92.0% s...
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 2, 2018 Category: Allergy & Immunology Source Type: research

Association Between Obesity and Acute Severity Among Patients Hospitalized for Asthma Exacerbation
Publication date: November–December 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 6Author(s): Sarah Kyuragi Luthe, Atsushi Hirayama, Tadahiro Goto, Mohammad Kamal Faridi, Carlos A. Camargo, Kohei HasegawaBackgroundAlthough studies have demonstrated relations between obesity and incident asthma, little is known about the association of obesity with acute severity in adults hospitalized for asthma exacerbation.ObjectivesTo investigate the association of obesity with acute severity of asthma exacerbation.MethodsThis is a retrospective cohort study using population-based data of...
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 2, 2018 Category: Allergy & Immunology Source Type: research

Exacerbations in Adults with Asthma: A Systematic Review and External Validation of Prediction Models
ConclusionsThe preservation of 3 predictors in models derived from variable populations and the fairly consistent predictive properties of most models in 2 distinct validation populations suggest the feasibility of a generalizable model predicting severe exacerbations. Nevertheless, improvement of the models is warranted because predictive performances are below the desired level. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 2, 2018 Category: Allergy & Immunology Source Type: research

Anxiety, Depression, and Asthma Control: Changes After Standardized Treatment
Publication date: November–December 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 6Author(s): Joaquín Sastre, Astrid Crespo, Antonio Fernandez-Sanchez, Manuel Rial, Vicente Plaza, F. Callejas González, J. Jiménez López, M. Martínez Riaza, M. Moscardó Orenes, P. Prieto Montaño, M. Torrecillas Toro, C. Andreu Balaguer, M. Antón Girones, C. Baeza Martinez, I. Flores Martín, P. Gonzalez Delgado, M. Martos Calahorro, G. Mediero Carrasco, R. Rodríguez Pacheco, V. Vilella TomásBackgroundIt has been documen...
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 2, 2018 Category: Allergy & Immunology Source Type: research

Asthma Phenotypes Defined From Parameters Obtained During Recovery From a Hospital-Treated Exacerbation
ConclusionsThe clusters during recovery from an exacerbation of asthma were distinguished by airflow obstruction and a neutrophilic, eosinophilic, or mixed inflammation. Eosinophilic inflammation was found in smoking and nonsmoking patients with asthma during an exacerbation. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 2, 2018 Category: Allergy & Immunology Source Type: research

A Systematic Review of Associations of Physical Activity and Sedentary Time with Asthma Outcomes
ConclusionsPeople with asthma engage in lower levels of physical activity compared with controls. Higher levels of physical activity may positively impact on asthma clinical outcomes. Sedentary time should be more widely assessed. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 2, 2018 Category: Allergy & Immunology Source Type: research

Type 2 Biomarkers and Prediction of Future Exacerbations and Lung Function Decline in Adult Asthma
Publication date: November–December 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 6Author(s): Ruth Semprini, Mathew Williams, Alex Semprini, Alice McDouall, James Fingleton, Cecile Holweg, Mark Weatherall, Richard Beasley, Irene BraithwaiteBackgroundType 2 biomarkers that predict both likelihood of future severe exacerbations and response to mAb therapy in asthma would be useful clinically in identifying patients both at greater risk of hospitalization and most likely to benefit from mAb therapy.ObjectiveTo describe the association between type 2 biomarkers, blood eosinophil...
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 2, 2018 Category: Allergy & Immunology Source Type: research

Relationship of Inhaled Corticosteroid Adherence to Asthma Exacerbations in Patients with Moderate-to-Severe Asthma
ConclusionsApproximately 1 in 7 patients had elevated eosinophils. Adherence to ICS therapy was not associated with decreased exacerbations for these patients. Additional therapy should be considered for these patients, such as biologics, which have been previously shown to improve control in severe uncontrolled eosinophilic asthma. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 2, 2018 Category: Allergy & Immunology Source Type: research

Comparing Ran-Out Status of Inhaled Short-Acting Beta-Agonists in Emergency Department Patients with Acute Asthma: 1996-1998 versus 2015-2017
ConclusionsBetween 1996 and 2017, the proportion of ED patients with asthma who ran out of SABA inhalers significantly increased. The increase was explained, at least partially, by a lack of a written action plan. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 2, 2018 Category: Allergy & Immunology Source Type: research

Exposure and Sensitization to Pets Modify Endotoxin Association with Asthma and Wheeze
ConclusionsExposure to dog and cat allergens enhances the association of endotoxin with asthma and wheeze. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 2, 2018 Category: Allergy & Immunology Source Type: research

Age and Sex Associations with Systemic Corticosteroid-Induced Morbidity in Asthma
Publication date: November–December 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 6Author(s): Luke E. Barry, Ciaran O'Neill, Chris Patterson, Joan Sweeney, David Price, Liam G. HeaneyBackgroundTreatment of severe asthma may include high-dose systemic corticosteroid therapy, which is associated with substantial comorbidity. There is evidence to suggest that this burden is not evenly distributed across age, sex, and corticosteroid exposure levels.ObjectiveTo examine the associations between age, sex, comorbidity, and patterns of health care cost across groups differentiated by...
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 2, 2018 Category: Allergy & Immunology Source Type: research

Long-Term Trajectories of Mild Asthma in Adulthood and Risk Factors of Progression
Publication date: November–December 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 6Author(s): Wenjia Chen, J. Mark FitzGerald, Larry D. Lynd, Don D. Sin, Mohsen SadatsafaviBackgroundMost patients with asthma have mild disease. However, the clinical course of mild asthma and risk factors for progression are not well studied.ObjectiveTo examine the long-term trajectories of mild asthma and the effects of early-stage risk factors on the subsequent disease course.MethodsFrom the administrative health data of British Columbia, Canada, we identified patients aged 14 to 45 years wi...
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 2, 2018 Category: Allergy & Immunology Source Type: research

The Use of Telemedicine for Penicillin Allergy Skin Testing
Publication date: November–December 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 6Author(s): Mary L. Staicu, Anne Marie Holly, Kelly M. Conn, Allison RamseyBackgroundPenicillin skin testing (PST) is increasingly used as a tool to evaluate penicillin allergy in patients with a reported history. The limited availability of allergists, however, may be an impeding factor.ObjectiveWe sought to assess the clinical utility of telemedicine to facilitate PST.MethodsPenicillin-allergic inpatients receiving systemic antibiotics were prospectively identified between April and August 20...
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 2, 2018 Category: Allergy & Immunology Source Type: research

Telemedicine Improves Allergy Care for Hospitalized Patients
Publication date: November–December 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 6Author(s): Jay M. Portnoy, Morgan Waller, Kathleen Farrell (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 2, 2018 Category: Allergy & Immunology Source Type: research

The Frequency and Clinical Features of Hypersensitivity Reactions to Antiepileptic Drugs in Children: A Prospective Study
Publication date: November–December 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 6Author(s): Hakan Guvenir, Emine Dibek Misirlioglu, Ersoy Civelek, Muge Toyran, Betul Buyuktiryaki, Tayfur Ginis, Murat Capanoglu, Esra Gurkas, Alev Guven, Can Naci KocabasBackgroundAntiepileptic drugs (AEDs) can cause hypersensitivity reactions during childhood. Studies report a wide clinical spectrum of reactions with AED use, ranging from a mild rash to severe cutaneous reactions.ObjectiveTo determine the prevalence and clinical features of AED hypersensitivity reactions during childhood.Met...
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 2, 2018 Category: Allergy & Immunology Source Type: research

Twenty Years' Experience with Anaphylaxis-Like Reactions to Local Anesthetics: Genuine Allergy is Rare
ConclusionsSkin testing and provocative LA challenge are useful to exclude LA allergy, and this testing procedure seems to be appropriate to identify the extremely rare cases with IgE-mediated LA allergy. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 2, 2018 Category: Allergy & Immunology Source Type: research

Iodinated Contrast Media Allergy in Patients Hospitalized for Investigation of Chest Pain
ConclusionsPCI did not induce substantial allergic reactions to ICM in patients with a previously diagnosed allergy. This study did not demonstrate an advantage for premedication. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 2, 2018 Category: Allergy & Immunology Source Type: research

The Kinetics of Antidrug Antibodies, Drug Levels, and Clinical Outcomes in Infliximab-Exposed Patients with Immune-Mediated Disorders
ConclusionThe present data suggest that most IFX-exposed patients develop ADAs within the first year of treatment irrespective of disease type. The clinical outcome to the treatment is preceded by ADA development, which in turn is associated with the reduction in drug serum levels. Both ADA evaluation and therapeutic drug monitoring may have a relevant impact on clinical practice, giving new insights to predict LOR and HRs. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 2, 2018 Category: Allergy & Immunology Source Type: research