Impact of Smoking on Clinical Outcome and Recanalization After Intravenous Thrombolysis for Stroke [Clinical Sciences]
Conclusions—Our study suggests that good outcome in smokers is mainly related to differences in baseline characteristics and not to biological effects of smoking. The higher recanalization rates in smokers, however, call for further studies. (Source: Stroke)
Source: Stroke - April 23, 2018 Category: Neurology Authors: Rebekka Kurmann, Stefan T. Engelter, Patrik Michel, Andreas R. Luft, Susanne Wegener, Meret Branscheidt, Elissavet Eskioglou, Gaia Sirimarco, Philippe A. Lyrer, Henrik Gensicke, Thomas Horvath, Urs Fischer, Marcel Arnold, Hakan Sarikaya Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research
Predicting Intracerebral Hemorrhage Expansion With Noncontrast Computed Tomography [Clinical Sciences]
Background and Purpose—Although the computed tomographic angiography spot sign performs well as a biomarker for hematoma expansion (HE), computed tomographic angiography is not routinely performed in the emergency setting. We developed and validated a score to predict HE-based on noncontrast computed tomography (NCCT) findings in spontaneous acute intracerebral hemorrhage.Methods—After developing the score in a single-center cohort of patients with intracerebral hemorrhage (n=344), we validated it in a large clinical trial population (n=954) and in a multicenter intracerebral hemorrhage cohort (n=241). The following NC...
Source: Stroke - April 23, 2018 Category: Neurology Authors: Andrea Morotti, Dar Dowlatshahi, Gregoire Boulouis, Fahad Al-Ajlan, Andrew M. Demchuk, Richard I. Aviv, Liyang Yu, Kristin Schwab, Javier M. Romero, M. Edip Gurol, Anand Viswanathan, Christopher D. Anderson, Yuchiao Chang, Steven M. Greenberg, Adnan I. Qu Tags: Cerebrovascular Disease/Stroke, Intracranial Hemorrhage Original Contributions Source Type: research
Long-Term Risk of Hemorrhagic Stroke in Young Patients With Congenital Heart Disease [Clinical Sciences]
Conclusions—The relative risk of hemorrhagic stroke among children and young adults with CHD was almost 8× higher than that of matched controls from the general population, although the absolute risk was low. The highest risk of ICH and SAH occurred in patients with severe nonconotruncal defects and coarctation of the aorta. (Source: Stroke)
Source: Stroke - April 23, 2018 Category: Neurology Authors: Kok Wai Giang, Zacharias Mandalenakis, Mikael Dellborg, Georgios Lappas, Peter Eriksson, Per-Olof Hansson, Annika Rosengren Tags: Epidemiology, Cerebrovascular Disease/Stroke, Cerebrovascular Malformations, Intracranial Hemorrhage Original Contributions Source Type: research
Lipid-Lowering Agents and High HDL (High-Density Lipoprotein) Are Inversely Associated With Intracranial Aneurysm Rupture [Clinical Sciences]
Conclusions—Higher HDL values and the use of lipid-lowering agents are significantly inversely associated with ruptured intracranial aneurysms. (Source: Stroke)
Source: Stroke - April 23, 2018 Category: Neurology Authors: Anil Can, Victor M. Castro, Dmitriy Dligach, Sean Finan, Sheng Yu, Vivian Gainer, Nancy A. Shadick, Guergana Savova, Shawn Murphy, Tianxi Cai, Scott T. Weiss, Rose Du Tags: Risk Factors, Cerebral Aneurysm Original Contributions Source Type: research
Prevalence of Poststroke Neurocognitive Disorders Using National Institute of Neurological Disorders and Stroke-Canadian Stroke Network, VASCOG Criteria (Vascular Behavioral and Cognitive Disorders), and Optimized Criteria of Cognitive Deficit [Clinical Sciences]
Conclusions—This study is the first to have optimized the operationalization of the criterion for poststroke cognitive impairment. It documented the prevalence of poststroke NCD in the GRECOG-VASC cohort and showed that mild cognitive impairment accounts for 80% of the affected patients. Finally, the method developed in the present study offers a means of harmonizing the diagnosis of NCD.Clinical Trial Registration—URL: https://www.clinicaltrials.gov. Unique identifier: NCT01339195. (Source: Stroke)
Source: Stroke - April 23, 2018 Category: Neurology Authors: Melanie Barbay, Herve Taillia, Claudine Nedelec–Ciceri, Flavie Bompaire, Camille Bonnin, Jerome Varvat, Francoise Grangette, Momar Diouf, Emmanuel Wiener, Jean–Louis Mas, Martine Roussel, Olivier Godefroy Tags: Cognitive Impairment Original Contributions Source Type: research
Intracranial Arterial Dolichoectasia and Stenosis [Clinical Sciences]
This study comprised 1237 participants (aged 57.2±9.4 years, 37.6% men) who underwent brain magnetic resonance imaging and magnetic resonance angiography. IADE was assessed based on basilar artery dolichoectasia (diameter, height of bifurcation, and laterality of basilar artery) and dilation of basilar artery and internal carotid artery (intracranial volume-adjusted diameter ≥2 SD). ICAS was defined as any degree of stenosis in at least 1 intracranial artery. The neuroimaging markers of cerebral small vessel disease, including lacunes, white matter hyperintensities, microbleeds, dilated perivascular spaces, and brain at...
Source: Stroke - April 23, 2018 Category: Neurology Authors: Fei-Fei Zhai, Shuang Yan, Ming-Li Li, Fei Han, Quan Wang, Li-Xin Zhou, Jun Ni, Ming Yao, Shu-Yang Zhang, Li-Ying Cui, Zheng-Yu Jin, Yi-Cheng Zhu Tags: Cerebrovascular Disease/Stroke, Atherosclerosis Original Contributions Source Type: research
Infections and Risk of Peripartum Stroke During Delivery Admissions [Clinical Sciences]
Conclusions—Infections present on admission increased stroke risk during delivery admissions in women with and without hypertensive disorders of pregnancy. The results were driven by genitourinary infections and sepsis. Infections may be an underrecognized precipitant of peripartum stroke. (Source: Stroke)
Source: Stroke - April 23, 2018 Category: Neurology Authors: Eliza C. Miller, Marisa Gallo, Erin R. Kulick, Alexander M. Friedman, Mitchell S.V. Elkind, Amelia K. Boehme Tags: Pregnancy, Risk Factors, Women, Cerebrovascular Disease/Stroke Original Contributions Source Type: research
Frequency of Patent Foramen Ovale and Migraine in Patients With Cryptogenic Stroke [Clinical Sciences]
Conclusions—In patients with cryptogenic stroke who have migraine, there is a high prevalence (79%) of PFO with right-to-left shunt. The timing of the stroke in migraineurs is usually not related to a migraine attack. These observations are consistent with the hypothesis that the mechanism of stroke in migraineurs is most likely because of a paradoxical embolus. Future cryptogenic stroke classification schemes should consider including PFO as a separate etiologic category. (Source: Stroke)
Source: Stroke - April 23, 2018 Category: Neurology Authors: Brian H. West, Nabil Noureddin, Yakov Mamzhi, Christopher G. Low, Alexandra C. Coluzzi, Evan J. Shih, Rubine Gevorgyan Fleming, Jeffrey L. Saver, David S. Liebeskind, Andrew Charles, Jonathan M. Tobis Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke, Embolism Original Contributions Source Type: research
Stroke Among Young West Africans [Clinical Sciences]
Background and Purpose—Stroke in lower and middle-income countries affects a young and productive age group. Data on factors associated with stroke in the young are sorely lacking from lower and middle-income countries. Our objective is to characterize the nature of stroke and its risk factors among young West Africans aged (Source: Stroke)
Source: Stroke - April 23, 2018 Category: Neurology Authors: Fred Stephen Sarfo, Bruce Ovbiagele, Mulugeta Gebregziabher, Kolawole Wahab, Rufus Akinyemi, Albert Akpalu, Onoja Akpa, Reginald Obiako, Lukman Owolabi, Carolyn Jenkins, Mayowa Owolabi Tags: Epidemiology, Risk Factors, Intracranial Hemorrhage Original Contributions Source Type: research
Primary Results of the Multicenter ARISE II Study (Analysis of Revascularization in Ischemic Stroke With EmboTrap) [Major Clinical Trials]
Background and Purpose—EmboTrap is a novel stent retriever designed to achieve rapid and substantial flow restoration in acute ischemic stroke secondary to large-vessel occlusions. Here, we evaluated EmboTrap’s safety and efficacy compared with established stent retrievers.Methods—ARISE II (Analysis of Revascularization in Ischemic Stroke With EmboTrap) was a single-arm, prospective, multicenter study, comparing the EmboTrap device to a composite performance goal criterion derived using a Bayesian meta-analysis from the pivotal SWIFT (Solitaire device) and TREVO 2 (Trevo device) trials. Patients at 11 US and 8 Europe...
Source: Stroke - April 23, 2018 Category: Neurology Authors: Osama O. Zaidat, Hormozd Bozorgchami, Marc Ribo, Jeffrey L. Saver, Heinrich P. Mattle, Rene Chapot, Ana Paula Narata, Olivier Francois, Ashutosh P. Jadhav, Jonathan A. Grossberg, Christian H. Riedel, Aleȷandro Tomasello, Wayne M. Clark, Hannes Nord Tags: Ischemia, Revascularization, Cerebrovascular Disease/Stroke, Ischemic Stroke Major Clinical Trial Source Type: research
Future of Animal Modeling for Poststroke Tissue Repair [Focused Updates in Cerebrovascular Disease]
(Source: Stroke)
Source: Stroke - April 23, 2018 Category: Neurology Authors: Michel M. Modo, Jukka Jolkkonen, Marietta Zille, Johannes Boltze Tags: Animal Models of Human Disease, Basic Science Research, Cell Therapy, Stem Cells, Translational Studies Focused Updates in Cerebrovascular Disease Source Type: research
Customized Brain Cells for Stroke Patients Using Pluripotent Stem Cells [Focused Updates in Cerebrovascular Disease]
(Source: Stroke)
Source: Stroke - April 23, 2018 Category: Neurology Authors: Zaal Kokaia, Irene L. Llorente, S. Thomas Carmichael Tags: Basic Science Research, Cell Therapy, Ischemia, Stem Cells Focused Updates in Cerebrovascular Disease Source Type: research
Exosome Therapy for Stroke [Focused Updates in Cerebrovascular Disease]
(Source: Stroke)
Source: Stroke - April 23, 2018 Category: Neurology Authors: Jieli Chen, Michael Chopp Tags: Cell Therapy, Cerebrovascular Disease/Stroke, Neuroprotectants Focused Updates in Cerebrovascular Disease Source Type: research
Intra-Arterial Delivery of Cell Therapies for Stroke [Focused Updates in Cerebrovascular Disease]
(Source: Stroke)
Source: Stroke - April 23, 2018 Category: Neurology Authors: Raphael Guzman, Miroslaw Janowski, Piotr Walczak Tags: Cell Therapy, Transplantation, Ischemic Stroke Focused Updates in Cerebrovascular Disease Source Type: research
Cell Therapy for Chronic Stroke [Focused Updates in Cerebrovascular Disease]
(Source: Stroke)
Source: Stroke - April 23, 2018 Category: Neurology Authors: Lawrence R. Wechsler, Damien Bates, Paul Stroemer, Yaisa S. Andrews-Zwilling, Irina Aizman Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke Focused Updates in Cerebrovascular Disease Source Type: research
