Arterial Stiffness Is Associated With Basal Ganglia Enlarged Perivascular Spaces and Cerebral Small Vessel Disease Load [Brief Report]
Conclusions—We found that, in a cohort of hypertensive individuals, the arterial stiffness is associated with the total load of the cSVD, especially with lacunes and basal ganglia EPVS. (Source: Stroke)
Source: Stroke - April 23, 2018 Category: Neurology Authors: Iolanda Riba–Llena, Joan Jimenez–Balado, Xavier Castane, Anna Girona, Antonio Lopez–Rueda, Xavier Mundet, Carmen I. Jarca, Jose Alvarez–Sabin, Joan Montaner, Pilar Delgado Tags: Hypertension Brief Reports Source Type: research
Smoking and Risk of Ischemic Stroke in Young Men [Brief Report]
We examined the dose–response relationship between the quantity of cigarettes smoked and the odds of developing an ischemic stroke in men under age 50 years.Methods—The Stroke Prevention in Young Men Study is a population-based case–control study of risk factors for ischemic stroke in men ages 15 to 49 years. The χ2 test was used to test categorical comparisons. Logistic regression models were used to calculate the odds ratio for ischemic stroke occurrence comparing current and former smokers to never smokers. In the first model, we adjusted solely for age. In the second model, we adjusted for potential confounding ...
Source: Stroke - April 23, 2018 Category: Neurology Authors: Janina Markidan, John W. Cole, Carolyn A. Cronin, Jose G. Merino, Michael S. Phipps, Marcella A. Wozniak, Steven J. Kittner Tags: Epidemiology, Primary Prevention, Risk Factors, Secondary Prevention, Ischemic Stroke Brief Reports Source Type: research
Improving Microcirculatory Reperfusion Reduces Parenchymal Oxygen Radical Formation and Provides Neuroprotection [Basic Sciences]
Conclusions—Promoting microvascular reperfusion by protecting vasculature can secondarily reduce parenchymal ROS formation and provide neuroprotection. The model presented can be used to directly assess pharmacological end points postulated in brain parenchyma and vasculature in vivo. (Source: Stroke)
Source: Stroke - April 23, 2018 Category: Neurology Authors: Aslihan Taskiran-Sag, Muge Yemisci, Yasemin Gursoy-Ozdemir, Sefik Evren Erdener, Hulya Karatas, Deniz Yuce, Turgay Dalkara Tags: Ischemic Stroke, Neuroprotectants Original Contributions Source Type: research
Growth Hormone Improves Cognitive Function After Experimental Stroke [Basic Sciences]
Conclusions—These findings provide compelling preclinical evidence for the usage of GH as a potential therapeutic tool in the recovery phase of patients after stroke. (Source: Stroke)
Source: Stroke - April 23, 2018 Category: Neurology Authors: Lin Kooi Ong, Wei Zhen Chow, Clifford TeBay, Murielle Kluge, Giovanni Pietrogrande, Katarzyna Zalewska, Patricia Crock, N. David Aberg, Andrew Bivard, Sarah J. Johnson, Frederick R. Walker, Michael Nilsson, Jorgen Isgaard Tags: Angiogenesis, Basic Science Research, Growth Factors/Cytokines, Cognitive Impairment, Neurogenesis Original Contributions Source Type: research
Human Neural Stem Cell Extracellular Vesicles Improve Recovery in a Porcine Model of Ischemic Stroke [Basic Sciences]
Conclusions—This study demonstrated for the first time that in a large animal model novel NSC EVs significantly improved neural tissue preservation and functional levels post-MCAO, suggesting NSC EVs may be a paradigm changing stroke therapeutic. (Source: Stroke)
Source: Stroke - April 23, 2018 Category: Neurology Authors: Robin L. Webb, Erin E. Kaiser, Brian J. Jurgielewicz, Samantha Spellicy, Shelley L. Scoville, Tyler A. Thompson, Raymond L. Swetenburg, David C. Hess, Franklin D. West, Steven L. Stice Tags: Animal Models of Human Disease, Basic Science Research, Translational Studies, Treatment, Ischemic Stroke Original Contributions Source Type: research
Beneficial Role of Neutrophils Through Function of Lactoferrin After Intracerebral Hemorrhage [Basic Sciences]
Conclusions—LTF delivered to the ICH-affected brain by infiltrating PMNs may assist in hematoma detoxification and represent a powerful potential target for the treatment of ICH. (Source: Stroke)
Source: Stroke - April 23, 2018 Category: Neurology Authors: Xiurong Zhao, Shun–Ming Ting, Guanghua Sun, Meaghan Roy–O’Reilly, Alexis S. Mobley, Jesus Bautista Garrido, Xueping Zheng, Lidiya Obertas, Joo Eun Jung, Marian Kruzel, Jaroslaw Aronowski Tags: Translational Studies Original Contributions Source Type: research
Thalidomide Reduces Hemorrhage of Brain Arteriovenous Malformations in a Mouse Model [Basic Sciences]
Conclusions—Thalidomide and lenalidomide improve mural cell coverage of bAVM vessels and reduce bAVM hemorrhage, which is likely through upregulation of Pdgfb expression. (Source: Stroke)
Source: Stroke - April 23, 2018 Category: Neurology Authors: Wan Zhu, Wanqiu Chen, Dingquan Zou, Liang Wang, Chen Bao, Lei Zhan, Daniel Saw, Sen Wang, Ethan Winkler, Zhengxi Li, Meng Zhang, Fanxia Shen, Sonali Shaligram, Michael Lawton, Hua Su Tags: Angiogenesis, Animal Models of Human Disease, Cerebrovascular Malformations, Intracranial Hemorrhage Original Contributions Source Type: research
Critical Role of Flavin and Glutathione in Complex I-Mediated Bioenergetic Failure in Brain Ischemia/Reperfusion Inȷury [Basic Sciences]
Conclusions—Our results unveil a key role of mitochondrial complex I in the development of I/R brain injury and provide the mechanistic basis for the well-established mitochondrial dysfunction caused by I/R. Targeting the functional integrity of complex I in the early phase of reperfusion may provide a novel therapeutic strategy to prevent tissue injury after stroke. (Source: Stroke)
Source: Stroke - April 23, 2018 Category: Neurology Authors: Anja Kahl, Anna Stepanova, Csaba Konrad, Corey Anderson, Giovanni Manfredi, Ping Zhou, Costantino Iadecola, Alexander Galkin Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke, Neuroprotectants Original Contributions Source Type: research
Evolution of a US County System for Acute Comprehensive Stroke Care [Clinical Sciences]
We examined relationships between stroke details, reperfusion therapies, hospital transfers, and their change over time.Methods—All patients from January 1, 2013, to December 31, 2015, for whom 911 was called within 7 hours of onset in whom Emergency Medical Services personnel suspected acute stroke were evaluated.Results—Among 6132 patients, 3924 (64%) had confirmed diagnosis of stroke (74% ischemic/26% hemorrhagic), yielding diagnostic precision of 64% in the field. Of the 2892 patients with acute ischemic stroke, acute reperfusion therapy was given to 29.2% (21.7% intravenous tPA [tissue-type plasminogen activator] ...
Source: Stroke - April 23, 2018 Category: Neurology Authors: Radoslav I. Raychev, Dana Stradling, Nirav Patel, Joey R. Gee, David A. Lombardi, Johnson L. Moon, David M. Brown, Mayank Pathak, Wengui Yu, Samuel J. Stratton, Steven C. Cramer Tags: Cerebrovascular Disease/Stroke, Cerebrovascular Procedures, Ischemic Stroke Original Contributions Source Type: research
SCIL-STROKE (Subcutaneous Interleukin-1 Receptor Antagonist in Ischemic Stroke) [Clinical Sciences]
Background and Purpose—The proinflammatory cytokine IL-1 (interleukin-1) has a deleterious role in cerebral ischemia, which is attenuated by IL-1 receptor antagonist (IL-1Ra). IL-1 induces peripheral inflammatory mediators, such as interleukin-6, which are associated with worse prognosis after ischemic stroke. We investigated whether subcutaneous IL-1Ra reduces the peripheral inflammatory response in acute ischemic stroke.Methods—SCIL-STROKE (Subcutaneous Interleukin-1 Receptor Antagonist in Ischemic Stroke) was a single-center, double-blind, randomized, placebo-controlled phase 2 trial of subcutaneous IL-1Ra (100 mg a...
Source: Stroke - April 23, 2018 Category: Neurology Authors: Craig J. Smith, Sharon Hulme, Andy Vail, Calvin Heal, Adrian R. Parry-Jones, Sylvia Scarth, Karen Hopkins, Margaret Hoadley, Stuart M. Allan, Nancy J. Rothwell, Stephen J. Hopkins, Pippa J. Tyrrell Tags: Inflammation, Treatment, Ischemic Stroke Original Contributions Source Type: research
Pseudo-Occlusion of the Internal Carotid Artery Predicts Poor Outcome After Reperfusion Therapy [Clinical Sciences]
This study aimed to evaluate the occurrence rate of the internal carotid artery pseudo-occlusion (ICA-PO) on 4-dimensional–computed tomography angiography and to investigate its relationship with clinical outcome after reperfusion therapy.Methods—In this case–control study, we retrospectively reviewed our prospectively collected database for consecutive acute ischemic stroke patients who received reperfusion therapy between June 2009 and February 2017. ICA-PO was defined when the arterial segment was not opacified on peak arterial phase yet was subsequently patent after artery peak phase on 4-dimensional–computed t...
Source: Stroke - April 23, 2018 Category: Neurology Authors: Zhicai Chen, Meixia Zhang, Feina Shi, Xiaoxian Gong, David Liebeskind, Xinfa Ding, Chang Liu, Ruiting Zhang, Min Lou Tags: Computerized Tomography (CT), Quality and Outcomes, Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research
Cerebrovascular Accidents During Mechanical Circulatory Support [Clinical Sciences]
Conclusions—Stroke is a major cause of morbidity and mortality in patients on LVAD support. Chronic obstructive pulmonary disease increases the risk of ischemic stroke, whereas dialysis may increase the risk of hemorrhagic stroke. Although any stroke increases mortality, post-LVAD hemorrhagic stroke was associated with higher mortality compared with ischemic stroke. (Source: Stroke)
Source: Stroke - April 23, 2018 Category: Neurology Authors: Saef Izzy, Daniel B. Rubin, Firas S. Ahmed, Feras Akbik, Simone Renault, Katelyn W. Sylvester, Henrikas Vaitkevicius, Jennifer A. Smallwood, Michael M. Givertz, Steven K. Feske Tags: Heart Failure, Complications, Quality and Outcomes, Intracranial Hemorrhage, Ischemic Stroke Original Contributions Source Type: research
Modified Thrombolysis in Cerebral Infarction 2C/Thrombolysis in Cerebral Infarction 3 Reperfusion Should Be the Aim of Mechanical Thrombectomy [Clinical Sciences]
Conclusions—Combining mTICI 2C and TICI 3 grades helps to determine a subgroup of patients achieving better functional outcomes than mTICI 2B patients. Achieving mTICI 2C/3 reperfusion should be the new aim of mechanical thrombectomy for anterior circulation LVO. (Source: Stroke)
Source: Stroke - April 23, 2018 Category: Neurology Authors: Cyril Dargazanli, Robert Fahed, Raphael Blanc, Benjamin Gory, Julien Labreuche, Alain Duhamel, Gaultier Marnat, Suzana Saleme, Vincent Costalat, Serge Bracard, Hubert Desal, Mikael Mazighi, Arturo Consoli, Michel Piotin, Bertrand Lapergue Tags: Cerebrovascular Disease/Stroke, Cerebrovascular Procedures, Ischemic Stroke Original Contributions Source Type: research
Long-Term Morphological Changes of Symptomatic Lacunar Infarcts and Surrounding White Matter on Structural Magnetic Resonance Imaging [Clinical Sciences]
Conclusions—Half of the sporadic symptomatic lacunar infarcts developed secondary changes in superior and inferior white matter. These white matter hyperintensity caps and tracks may reflect another aspect of cerebral small vessel-related disease progression. The clinical and prognostic values remain to be determined. (Source: Stroke)
Source: Stroke - April 23, 2018 Category: Neurology Authors: Caroline M.J. Loos, Stephen D.J. Makin, Julie Staals, Martin S. Dennis, Robert J. van Oostenbrugge, Joanna M. Wardlaw Tags: Magnetic Resonance Imaging (MRI), Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research
Alkaline Phosphatase and Outcomes in Patients With Preserved Renal Function [Clinical Sciences]
Conclusions—In patients with preserved kidney function, ALP may be an independent predictor of all-cause mortality, stroke recurrence, composite end point, and poor functional outcome after stroke. (Source: Stroke)
Source: Stroke - April 23, 2018 Category: Neurology Authors: Lixia Zong, Xianwei Wang, Zixiao Li, Xingquan Zhao, Liping Liu, Hao Li, Xia Meng, Yilong Wang, Yongjun Wang Tags: Clinical Studies, Risk Factors, Prognosis, Cerebrovascular Disease/Stroke Original Contributions Source Type: research
