Stroke Literature Synopses: Clinical Science [Stroke Literature Synopses: Clinical Science]
(Source: Stroke)
Source: Stroke - April 23, 2018 Category: Neurology Authors: Terence J. Quinn Tags: Cognitive Impairment Stroke Literature Synopses: Clinical Science Source Type: research

Advances in Stroke 2017 [Advances in Stroke]
(Source: Stroke)
Source: Stroke - April 23, 2018 Category: Neurology Authors: Julie Bernhardt, Richard D. Zorowitz, Kyra J. Becker, Emanuela Keller, Gustavo Saposnik, Daniel Strbian, Martin Dichgans, Daniel Woo, Mathew Reeves, Amanda Thrift, Chelsea S. Kidwell, Jean Marc Olivot, Mayank Goyal, Laurent Pierot, Derrick A. Bennett, Geo Tags: Genetics, Imaging, Rehabilitation, Treatment Advances in Stroke Source Type: research

Optical Coherence Tomography [Topical Review]
(Source: Stroke)
Source: Stroke - March 26, 2018 Category: Neurology Authors: Ching-Jen Chen, Jeyan S. Kumar, Stephanie H. Chen, Dale Ding, Thomas J. Buell, Samir Sur, Natasha Ironside, Evan Luther, Michael Ragosta III, Min S. Park, M. Yashar Kalani, Kenneth C. Liu, Robert M. Starke Tags: Optical Coherence Tomography (OCT) Topical Reviews Source Type: research

Clinical and Technological Approaches to the Prehospital Diagnosis of Large Vessel Occlusion [Topical Review]
(Source: Stroke)
Source: Stroke - March 26, 2018 Category: Neurology Authors: Stephen van Gaal, Andrew Demchuk Tags: Diagnostic Testing, Imaging, Prognosis, Intracranial Hemorrhage, Ischemic Stroke Topical Reviews Source Type: research

Cranial Cavernous Malformations [Topical Review]
(Source: Stroke)
Source: Stroke - March 26, 2018 Category: Neurology Authors: Christopher J. Stapleton, Fred G. Barker II Tags: Cerebrovascular Malformations, Intracranial Hemorrhage Topical Reviews Source Type: research

Ischemic Stroke Alters the Expression of the Transcribed Ultraconserved Regions of the Genome in Rat Brain [Brief Report]
Conclusions—This first report shows that ischemic stroke temporally alters the noncoding ultraconserved RNAs in spontaneously hypertensive rats, but their functional significance is yet to be evaluated. (Source: Stroke)
Source: Stroke - March 26, 2018 Category: Neurology Authors: Suresh L. Mehta, Raghu Vemuganti Tags: Basic Science Research, Gene Expression & Regulation, Ischemic Stroke Brief Reports Source Type: research

Geographic Modeling to Quantify the Impact of Primary and Comprehensive Stroke Center Destination Policies [Brief Report]
Conclusions—Within a large metropolitan area, the time cost of routing patients preferentially to PSCs and comprehensive stroke centers is low. (Source: Stroke)
Source: Stroke - March 26, 2018 Category: Neurology Authors: Michael T. Mullen, William Paȷerowski, Steven R. Messe, C. Crawford Mechem, Judy Jia, Michael Abboud, Guy David, Brendan G. Carr, Roger Band Tags: Ethics and Policy, Health Services, Ischemic Stroke Brief Reports Source Type: research

Transcranial Direct Current Stimulation Does Not Improve Language Outcome in Subacute Poststroke Aphasia [Brief Report]
Background and Purpose—The aim of the present study is to investigate the effect of transcranial direct current stimulation on word-finding treatment outcome in subacute poststroke aphasia.Methods—In this multi-center, double-blind, randomized controlled trial with 6-month follow-up, we included 58 patients with subacute aphasia ( (Source: Stroke)
Source: Stroke - March 26, 2018 Category: Neurology Authors: Kerstin Spielmann, W. Mieke E. van de Sandt-Koenderman, Majanka H. Heijenbrok-Kal, Gerard M. Ribbers Tags: Clinical Studies, Rehabilitation, Cerebrovascular Disease/Stroke, Neurostimulation Brief Reports Source Type: research

Eligibility for Endovascular Trial Enrollment in the 6- to 24-Hour Time Window [Brief Report]
Conclusions—Of all patients with acute ischemic stroke presenting to a single comprehensive stroke center, 1.7% of patients qualified for DAWN clinical trial enrollment with an additional 0.6% to 1% qualifying for the DEFUSE-3 trial. These data predict an increase in thrombectomy utilization with important implications for comprehensive stroke center resource optimization and stroke systems of care. (Source: Stroke)
Source: Stroke - March 26, 2018 Category: Neurology Authors: Ashutosh P. Jadhav, Shashvat M. Desai, Cynthia L. Kenmuir, Marcelo Rocha, Matthew T. Starr, Bradley J. Molyneaux, Bradley A. Gross, Brian T. Jankowitz, Tudor G. Jovin Tags: Cerebrovascular Disease/Stroke, Cerebrovascular Procedures, Ischemic Stroke Brief Reports Source Type: research

Quantitative Arterial Tortuosity Suggests Arteriopathy in Children With Cryptogenic Stroke [Brief Report]
Conclusions—Pediatric cryptogenic stroke is frequently associated with cervicocerebral arteriopathies expressing altered QAT. QAT may be a diagnostic biomarker of arteriopathy in pediatric AIS. (Source: Stroke)
Source: Stroke - March 26, 2018 Category: Neurology Authors: Gabriel DeVela, J. Michael Taylor, Bin Zhang, Luke L. Linscott, Alan M. Chen, Kunal B. Karani, Andrew Furthmiller, James L. Leach, Sudhakar Vadivelu, Todd Abruzzo Tags: Vascular Biology, Pediatrics, Cerebrovascular Disease/Stroke Brief Reports Source Type: research

Endothelial Progenitor Cell Secretome and Oligovascular Repair in a Mouse Model of Prolonged Cerebral Hypoperfusion [Basic Sciences]
Conclusions—Factors secreted by EPCs may ameliorate white matter damage in the brain by boosting oligovascular remodeling. (Source: Stroke)
Source: Stroke - March 26, 2018 Category: Neurology Authors: Takakuni Maki, Anna Morancho, Pablo Martinez–San Segundo, Kazuhide Hayakawa, Haȷime Takase, Anna C. Liang, Marina Gabriel–Salazar, Esperanza Medina–Gutierrez, Kazuo Washida, Joan Montaner, Josephine Lok, Eng H. Lo, Ken Arai, Anna Tags: Angiogenesis, Animal Models of Human Disease, Basic Science Research, Cell Therapy, Growth Factors/Cytokines Original Contributions Source Type: research

Minocycline Effects on Intracerebral Hemorrhage-Induced Iron Overload in Aged Rats [Basic Sciences]
This study quantified brain iron levels after ICH with magnetic resonance imaging R2* mapping. The effect of minocycline on iron overload and ICH-induced brain injury in aged rats was also determined.Methods—Aged (18 months old) male Fischer 344 rats had an intracerebral injection of autologous blood or saline, and brain iron levels were measured by magnetic resonance imaging R2* mapping. Some ICH rats were treated with minocycline or vehicle. The rats were euthanized at days 7 and 28 after ICH, and brains were used for immunohistochemistry and Western blot analyses. Magnetic resonance imaging (T2-weighted, T2* gradient-...
Source: Stroke - March 26, 2018 Category: Neurology Authors: Shenglong Cao, Ya Hua, Richard F. Keep, Neeraj Chaudhary, Guohua Xi Tags: Basic Science Research, Intracranial Hemorrhage Original Contributions Source Type: research

Risk Factors for Poststroke Cognitive Decline [Clinical Sciences]
Background and Purpose—Poststroke cognitive decline causes disability. Risk factors for poststroke cognitive decline independent of survivors’ prestroke cognitive trajectories are uncertain.Methods—Among 22 875 participants aged ≥45 years without baseline cognitive impairment from the REGARDS cohort (Reasons for Geographic and Racial Differences in Stroke), enrolled from 2003 to 2007 and followed through September 2015, we measured the effect of incident stroke (n=694) on changes in cognitive functions and cognitive impairment (Six-Item Screener score (Source: Stroke)
Source: Stroke - March 26, 2018 Category: Neurology Authors: Deborah A. Levine, Virginia G. Wadley, Kenneth M. Langa, Frederick W. Unverzagt, Mohammed U. Kabeto, Bruno Giordani, George Howard, Virginia J. Howard, Mary Cushman, Suzanne E. Judd, Andrzej T. Galecki Tags: Quality and Outcomes, Cognitive Impairment, Ischemic Stroke Original Contributions Source Type: research

Atrial Cardiopathy and the Risk of Ischemic Stroke in the CHS (Cardiovascular Health Study) [Clinical Sciences]
Conclusions—In addition to clinically apparent AF, other evidence of abnormal atrial substrate is associated with subsequent ischemic stroke. This finding is consistent with the hypothesis that thromboembolism from the left atrium may occur in the setting of several different manifestations of atrial disease. (Source: Stroke)
Source: Stroke - March 26, 2018 Category: Neurology Authors: Hooman Kamel, Traci M. Bartz, Mitchell S.V. Elkind, Peter M. Okin, Evan L. Thacker, Kristen K. Patton, Phyllis K. Stein, Christopher R. deFilippi, Rebecca F. Gottesman, Susan R. Heckbert, Richard A. Kronmal, Elsayed Z. Soliman, W.T. Longstreth Jr Tags: Arrhythmias, Cardiomyopathy, Echocardiography, Electrocardiology (ECG), Ischemic Stroke Original Contributions Source Type: research

Improving Community Stroke Preparedness in the HHS (Hip-Hop Stroke) Randomized Clinical Trial [Clinical Sciences]
Background and Purpose—Deficiencies in stroke preparedness cause major delays to stroke thrombolysis, particularly among economically disadvantaged minorities. We evaluated the effectiveness of a stroke preparedness intervention delivered to preadolescent urban public school children on the stroke knowledge/preparedness of their parents.Methods—We recruited 3070 fourth through sixth graders and 1144 parents from 22 schools into a cluster randomized trial with schools randomized to the HHS (Hip-Hop Stroke) intervention or attentional control (nutrition classes). HHS is a 3-hour culturally tailored, theory-based, multime...
Source: Stroke - March 26, 2018 Category: Neurology Authors: Olajide Williams, Ellyn Leighton-Herrmann Quinn, Jeanne Teresi, Joseph P. Eimicke, Jian Kong, Gbenga Ogedegbe, James Noble Tags: Primary Prevention, Risk Factors, Cerebrovascular Disease/Stroke, Ischemic Stroke, Transient Ischemic Attack (TIA) Original Contributions Source Type: research