Increments in virulence of Candida albicans induced by androgenic anabolic steroids
Publication date: Available online 20 September 2019Source: SteroidsAuthor(s): Cristina Rauen Ribas, Alinne Ulbrich Mores Rymovicz, Rosimeire Takaki Rosa, Lorena Carolina Peña, Luiz Fernando Bianchini, Edvaldo Antonio Ribeiro Rosa (Source: Steroids)
Source: Steroids - September 22, 2019 Category: Drugs & Pharmacology Source Type: research
Estrogen signaling and estrogen receptors as prognostic indicators in laryngeal cancer
Publication date: Available online 17 September 2019Source: SteroidsAuthor(s): Anjali Verma, Nofrat Schwartz, D. Joshua Cohen, Barbara D. Boyan, Zvi SchwartzAbstractLaryngeal squamous cell carcinoma (LSCC) has been shown to respond to 17β-estradiol. However, the presence and characterization of estrogen receptors (ER) and other sex hormone receptors in LSCC are still being determined. Sex hormone receptors and the way sex hormones impact LSCC tumors are important for understanding which patients would benefit from hormone therapies, such as anti-estrogen therapies. This information also has prognostic value, as there may ...
Source: Steroids - September 18, 2019 Category: Drugs & Pharmacology Source Type: research
New cinnamic acid-pregenolone hybrids as potential antiproliferative agents: design, synthesis and biological evaluation
Publication date: Available online 16 September 2019Source: SteroidsAuthor(s): Yong-Xi Ge, Yan-Hong Wang, Juan Zhang, Zhi-Pu Yu, Xin Mu, Jia-Li Song, Yin-Yin Wang, Feifei Yang, Ning Meng, Cheng-Shi Jiang, Hua ZhangAbstractA series of new cinnamic acid-pregenolone hybrids (5a-5o) was designed, synthesized and evaluated for their in vitro antiproliferative activity. Some of them showed potential antiproliferative activity and selectivity towards a panel of cancer cell lines, including A549, H157, HepG2, MCF-7, and HL-60. Among these analogs, compound 5f showed the most promising activity with IC50 values ranging from 3.2 to ...
Source: Steroids - September 17, 2019 Category: Drugs & Pharmacology Source Type: research
Stereocontrolled Synthesis of the Four Possible 3-Methoxy and 3-Benzyloxy-16-Triazolyl-methyl-estra-17-ol Hybrids and their Antiproliferative Activities
Publication date: Available online 16 September 2019Source: SteroidsAuthor(s): Anita Kiss, János Wölfling, Erzsébet Mernyák, Éva Frank, Zsanett Benke, Seyyed Ashkan Senobar Tahaei, István Zupkó, Sándor Mahó, Gyula SchneiderAbstractThe four possible isomers of each of 3-methoxy- and 3-benzyloxyestra-1,3,5(10)-trien-17-ols (5–8 and 9–12) were converted through 16-p-tosyloxymethyl- or 16-bromomethyl derivatives into their 3-methoxy- and 3-benzyloxy-16-azidomethylestra(1,3,5(10)-triene derivatives (13–16 and 17–20). The regioselective Cu(I)-catalyzed 1,3-dipolar cycloaddition of these compounds with different ...
Source: Steroids - September 17, 2019 Category: Drugs & Pharmacology Source Type: research
New insights into progesterone actions on prolactin secretion and prolactinoma development
Publication date: Available online 12 September 2019Source: SteroidsAuthor(s): María A. Camilletti, Alejandra Abeledo-Machado, Erika Y. Faraoni, Peter Thomas, Graciela Díaz-TorgaAbstractProgesterone (P4) has controversial physiological effects on the regulation of the lactotroph population. While some studies have shown a negative role for P4 in prolactin secretion and lactotroph proliferation, antagonizing estradiol effects, others demonstrated a proliferative role of P4 at the pituitary level. Usually, progesterone actions in the pituitary gland were studied through their classical, genomic pathways triggered by nuclea...
Source: Steroids - September 14, 2019 Category: Drugs & Pharmacology Source Type: research
Hypoxia induced cancer stem cell enrichment promotes resistance to androgen deprivation therapy in prostate cancer
Publication date: Available online 12 September 2019Source: SteroidsAuthor(s): Debbie O'Reilly, Patricia Johnson, Paul.J BuchananAbstractAndrogen deprivation therapy (ADT) is the main treatment to prolong survival in advance stage prostate cancer (PCa) but associated resistance leads to the development of terminal castrate resistant PCa (CRPC). Current research demonstrates a critical role of prostate cancer stem cells (PCSC) in the development of treatment resistance and subsequent disease progression. Despite uncertainty surrounding the origin of these cells, studies clearly show they are associated with poorer outcomes ...
Source: Steroids - September 14, 2019 Category: Drugs & Pharmacology Source Type: research
Soluble expression, purification and biochemical characterization of a C-7 cholesterol dehydrogenase from Drosophila melanogaster
Publication date: Available online 12 September 2019Source: SteroidsAuthor(s): Zhangliang Zhu, Chao Li, Xiaotao Cheng, Ying Chen, Menglu Zhu, Xin Liu, Shuhong Mao, Hui-Min Qin, Fuping LuAbstractThe C-7 cholesterol dehydrogenase (NVD), which converts cholesterol to 7-dehydrocholesterol (7-DHC) by 7,8-dehydrogenation, plays a pivotal role in the metabolism of cholesterol and steroid intermediates. The NVD protein was successfully expressed in insect Sf9 cells. To reduce the production cost for industrial application, the NVD gene was cloned into E. coli BL21(DE3). However, the His-tagged NVD protein showed poor binding to Ni...
Source: Steroids - September 14, 2019 Category: Drugs & Pharmacology Source Type: research
Nox1 Downregulators: A New Class of Therapeutics
Publication date: Available online 10 September 2019Source: SteroidsAuthor(s): Matthias Barton, Matthias R. Meyer, Eric R. ProssnitzAbstractChronic non-communicable diseases share the pathomechanism of increased reactive oxygen species (ROS) production by nicotinamide adenine dinucleotide phosphate (NADPH) oxidases, known as Nox. The recent discovery that expression of Nox1, a Nox isoform that has been implicated in the pathogenesis of cardiovascular and kidney disease, is regulated by the expression and activity of G protein-coupled estrogen receptor (GPER) led to the identification of orally active small-molecule GPER bl...
Source: Steroids - September 11, 2019 Category: Drugs & Pharmacology Source Type: research
ERα-targeted endocrine therapy, resistance and the role of GPER
Publication date: Available online 10 September 2019Source: SteroidsAuthor(s): Richard A. Pepermans, Eric R. ProssnitzAbstractEndocrine therapy is an effective option for the treatment of estrogen receptor alpha (ERα)-positive breast cancers. Unfortunately, a large fraction of women relapse with endocrine-resistant tumors. The presence of constitutively active ERα mutants, found in a subset of relapse tumors, is thought to be an important endocrine resistance mechanism and has prompted the search for more effective anti-hormone drugs that can effectively inhibit these mutant versions of the receptor. The G protein-couple...
Source: Steroids - September 11, 2019 Category: Drugs & Pharmacology Source Type: research
Nuclear action of FGF members in endocrine-related tissues and cancer: Interplay with steroid receptor pathways
Publication date: Available online 9 September 2019Source: SteroidsAuthor(s): Virginia Figueroa, María Sol Rodríguez, Claudia Lanari, Caroline Ana LambAbstractDysregulation of the fibroblast growth factors/fibroblast growth factor receptor (FGF/FGFR) pathway has been implicated in a wide range of human disorders and several members have been localized in the nuclear compartment. Hormone-activated steroid receptors or ligand independent activated receptors form nuclear complexes that activate gene transcription. This review aims to highlight the interplay between the steroid receptor and the FGF/FGFR pathways and focuses ...
Source: Steroids - September 11, 2019 Category: Drugs & Pharmacology Source Type: research
Effects of transdermal administration of testosterone gel on the urinary steroid profile in hypogonadal men: implications in antidoping analysis
Publication date: Available online 6 September 2019Source: SteroidsAuthor(s): Michele Iannone, Amelia Palermo, Xavier de la Torre, Francesco Romanelli, Andrea Sansone, Massimiliano Sansone, Andrea Lenzi, Francesco BotrèAbstractTestosterone is one of the most abused pseudo-endogenous anabolic steroids in sport doping. The current method adopted to detect the abuse of testosterone and other pseudo-endogenous steroids (endogenous steroids when administered exogenously) is first based on the longitudinal monitoring of several urinary biomarkers, which constitute the so called “steroidal module” of the Athlete Biological P...
Source: Steroids - September 7, 2019 Category: Drugs & Pharmacology Source Type: research
New bufadienolides extracted from Rhinella marina inhibit Na,K-ATPase and induce apoptosis by activating caspases 3 and 9 in human breast and ovarian cancer cells
Publication date: Available online 6 September 2019Source: SteroidsAuthor(s): Israel José Pereira Garcia, Gisele Capanema de Oliveira, Jéssica Martins de Moura Valadares, Felipe Finger Banfi, Silmara Nunes Andrade, Túlio Resende Freitas, Evaldo dos Santos Monção Filho, Hérica de Lima Santos, Gerardo Magela Vieira Júnior, Mariana Helena Chaves, Domingos de Jesus Rodrigues, Bruno Antonio Marinho Sanchez, Fernando P. Varotti, Leandro Augusto BarbosaAbstractBufadienolide compounds have been used for growth inhibition and apoptosis induction in tumor cells. Those families of cardiotonic steroids can bind the Na,K-ATPase,...
Source: Steroids - September 7, 2019 Category: Drugs & Pharmacology Source Type: research
Role of Estrogen Receptors in Modulating Aldosterone Biosynthesis And Blood Pressure
Publication date: Available online 6 September 2019Source: SteroidsAuthor(s): Gian Paolo Rossi, Brasilina Caroccia, Teresa M. SecciaAbstractBlood pressure is lower in premenopausal women than in age-matched men; after menopause blood pressure values and the prevalence of hypertension show opposite trends indicating that estrogens contribute to maintaining normal blood pressure values in women. In experimental studies menopause increases aldosterone levels, an effect alleviated by estrogen treatment. We have recently discovered a role of estrogen receptors (ER) in controlling aldosterone biosynthesis in the human adrenocort...
Source: Steroids - September 7, 2019 Category: Drugs & Pharmacology Source Type: research
Identification of Two Additional Novel Mutations in The AR gene Associated with Severe Forms of Androgen Insensitivity Syndrome
In this study, genetic testing has confirmed the diagnosis of most CAIS patients and has revealed two novel mechanisms responsible for the pathogenesis of AIS, as well as seven other reported mutations. (Source: Steroids)
Source: Steroids - September 7, 2019 Category: Drugs & Pharmacology Source Type: research
Rapid signalling responses via the G protein-coupled estrogen receptor, GPER, in a hippocampal cell line
Publication date: Available online 6 September 2019Source: SteroidsAuthor(s): Peter D. EvansAbstractThe rapid non-genomic actions of 17β-estradiol in multiple tissues, including the nervous system, may involve the activation of the G-protein-coupled receptor, GPER. Different signalling pathways have been suggested to be activated by GPER in different cell lines and tissues. Controversially, GPER has also been suggested to be activated by the mineralocorticoid aldosterone, and by the non-steroidal diphenylacrylamide compound, STX, in some preparations. Evidence for the ability of the GPER agonist, G-1, and for aldosterone ...
Source: Steroids - September 7, 2019 Category: Drugs & Pharmacology Source Type: research
