A protein ‐centric view of in vitro biological model systems for schizophrenia
Schematic diagram of stem-cell derived two-dimensional schizophrenia (SCZ) culture models (left column) vs three-dimensional (3D) SCZ brain organoid models (middle column) to engineer neural networks for translational medicine. SCZ patient cells are reprogrammed toward human induced pluripotent stem cells (hiPSC). Derived 3D brain organoids from hiPSCs serve as a model for further investigations. The application of proteomics and posttranslational modification specific proteomics (PTMomics) on 3D organoids could contribute to a wealth of information regarding the underlying mechanisms of the diseases and cell responses to ...
Source: Stem Cells - August 30, 2021 Category: Stem Cells Authors: Abinaya Chandrasekaran,
Pia Jensen,
Fadumo A. Mohamed,
Madeline Lancaster,
Michael E. Benros,
Martin R. Larsen,
Kristine K. Freude Tags: Embryonic Stem Cells/Induced Pluripotent Stem Cells Source Type: research
Cell cycle ‐coupled changes in the level of reactive oxygen species support the proliferation of human pluripotent stem cells
The progression of the cell cycle in human pluripotent stem cells is coupled with the oscillation of the ROS level. The decrease in this level results in the disturbance of the regulation and progression of S-phase, which, in turn, cause the accumulation of DNA breaks and subsequent apoptosis. AbstractThe study of proliferation regulation in human pluripotent stem cells is crucial to gain insights into understanding the physiology of these cells. However, redox regulation of the pluripotent cell cycle remains largely unexplored. Here, using human embryonic stem cells (hESCs) as well as human induced pluripotent stem cells ...
Source: Stem Cells - August 30, 2021 Category: Stem Cells Authors: Ju. S. Ivanova,
N. A. Pugovkina,
I. E. Neganova,
I. V. Kozhukharova,
N. N. Nikolsky,
O. G. Lyublinskaya Tags: Embryonic Stem Cells/Induced Pluripotent Stem Cells Source Type: research
Human Induced Pluripotent Stem Cell ‐Derived Macrophages Ameliorate Liver Fibrosis
Human iPSCs are efficiently differentiated into both M1 and M2 macrophages. These cells were used to treat liver fibrosis in an immunodeficient mouse model. This treatment led to improvement in the fibrosis as measured by several complementary assays. ABSTRACTWith an increasing number of patients with degenerative hepatic diseases such as liver fibrosis, and a limited supply of donor organs, there is an unmet need for therapies that can repair or regenerate damaged liver tissue. Treatment with macrophages that are capable of phagocytosis and anti-inflammatory activities such as secretion of matrix metalloproteinases (MMPs)...
Source: Stem Cells - August 30, 2021 Category: Stem Cells Authors: Somayeh Pouyanfard,
Nairika Meshgin,
Luisjesus S Cruz,
Karin Diggle,
Hamidreza Hashemi,
Timothy V Pham,
Manuel Fierro,
Pablo Tamayo,
Andrea Fanjul,
Tatiana Kisseleva,
Dan S Kaufman Tags: Regenerative Medicine Source Type: research
Cell cycle ‐coupled changes in the level of reactive oxygen species support the proliferation of human pluripotent stem cells
The progression of the cell cycle in human pluripotent stem cells is coupled with the oscillation of the ROS level. The decrease in this level results in the disturbance of the regulation and progression of S-phase, which, in turn, cause the accumulation of DNA breaks and subsequent apoptosis. AbstractThe study of proliferation regulation in human pluripotent stem cells is crucial to gain insights into understanding the physiology of these cells. However, redox regulation of the pluripotent cell cycle remains largely unexplored. Here, using human embryonic stem cells (hESCs) as well as human induced pluripotent stem cells ...
Source: Stem Cells - August 30, 2021 Category: Stem Cells Authors: Ju. S. Ivanova,
N. A. Pugovkina,
I. E. Neganova,
I. V. Kozhukharova,
N. N. Nikolsky,
O. G. Lyublinskaya Tags: Embryonic Stem Cells/Induced Pluripotent Stem Cells Source Type: research
State ‐of‐play for cellular therapies in cardiac repair and regeneration
Cardiovascular disease is the primary cause of death around the world. For almost two decades, cell therapy has been proposed as a solution for heart disease. In this article, we report on the “state-of-play” of cellular therapies for cardiac repair and regeneration. AbstractCardiovascular disease is the primary cause of death around the world. For almost two decades, cell therapy has been proposed as a solution for heart disease. In this article, we report on the “state-of-play” of cellular therapies for cardiac repair and regeneration. We outline the progression of new ideas from the preclinical literature to ong...
Source: Stem Cells - August 28, 2021 Category: Stem Cells Authors: Ramana Vaka,
Darryl R. Davis Tags: CONCISE REVIEW Source Type: research
A preview of selected articles
(Source: Stem Cells)
Source: Stem Cells - August 26, 2021 Category: Stem Cells Authors: Stuart P. Atkinson Tags: PREVIEWS Source Type: research
Cover Image
The image depicts aggregates of mouse embryonic stem cells grown without leukemia inhibitory factor after 4 days in stirred suspension bioreactor.See Nath et al. beginning on page1166. (Source: Stem Cells)
Source: Stem Cells - August 26, 2021 Category: Stem Cells Tags: COVER IMAGE Source Type: research
Issue Information
(Source: Stem Cells)
Source: Stem Cells - August 26, 2021 Category: Stem Cells Tags: ISSUE INFORMATION Source Type: research
Cancer stem cell ‐targeted therapeutic approaches for overcoming trastuzumab resistance in HER2‐positive breast cancer
Several reported targeted therapies against breast cancer stem cells (BCSCs) to overcome trastuzumab resistance in HER2-positive breast cancer. AbstractApplication of the anti-HER2 drug trastuzumab has significantly improved the prognosis of patients with the HER2-positive subtype of breast cancer. However, 50% of patients withHER2 amplification relapse due to trastuzumab resistance. Accumulating evidence indicates that breast cancer is driven by a small subset of cancer-initiating cells or breast cancer stem cells (BCSCs), which have the capacity to self-renew and differentiate to regenerate the tumor cell hierarchy. Incr...
Source: Stem Cells - August 26, 2021 Category: Stem Cells Authors: Yan Qiu,
Libo Yang,
Honghong Liu,
Xiaobo Luo Tags: CONCISE REVIEW Source Type: research
Corrigendum
(Source: Stem Cells)
Source: Stem Cells - August 26, 2021 Category: Stem Cells Tags: CORRIGENDUM Source Type: research
A preview of selected articles
(Source: Stem Cells)
Source: Stem Cells - August 26, 2021 Category: Stem Cells Authors: Stuart P. Atkinson Tags: PREVIEWS Source Type: research
Cover Image
The image depicts aggregates of mouse embryonic stem cells grown without leukemia inhibitory factor after 4 days in stirred suspension bioreactor.See Nath et al. beginning on page1166. (Source: Stem Cells)
Source: Stem Cells - August 26, 2021 Category: Stem Cells Tags: COVER IMAGE Source Type: research
Issue Information
(Source: Stem Cells)
Source: Stem Cells - August 26, 2021 Category: Stem Cells Tags: ISSUE INFORMATION Source Type: research
