Lyophilized powder of mesenchymal stem cell supernatant attenuates acute lung injury through the IL-6 –p-STAT3–p63–JAG2 pathway
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are syndromes of acute respiratory failure with extremely high mortality and few effective treatments. Mesenchymal stem cells (MSCs) may r... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 29, 2021 Category: Stem Cells Authors: Wenjun Peng, Meijia Chang, Yuanyuan Wu, Wensi Zhu, Lin Tong, Ge Zhang, Qin Wang, Jie Liu, Xiaoping Zhu, Tingting Cheng, Yijia Li, Xi Chen, Dong Weng, Sanhong Liu, Hongwei Zhang, Yao Su & hellip; Tags: Research Source Type: research
Any closer to successful therapy of multiple myeloma? CAR-T cell is a good reason for optimism
Despite many recent advances on cancer novel therapies, researchers have yet a long way to cure cancer. They have to deal with tough challenges before they can reach success. Nonetheless, it seems that recentl... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 29, 2021 Category: Stem Cells Authors: Faroogh Marofi, Safa Tahmasebi, Heshu Sulaiman Rahman, Denis Kaigorodov, Alexander Markov, Alexei Valerievich Yumashev, Navid Shomali, Max Stanley Chartrand, Yashwant Pathak, Rebar N. Mohammed, Mostafa Jarahian, Roza Motavalli and Farhad Motavalli Khiavi Tags: Review Source Type: research
Natural killer cell therapy for hematologic malignancies: successes, challenges, and the future
The adoptive transfer of natural killer (NK) cells is an emerging therapy in the field of immuno-oncology. In the last 3 decades, NK cells have been utilized to harness the anti-tumor immune response in a wide... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 25, 2021 Category: Stem Cells Authors: Margaret G. Lamb, Hemalatha G. Rangarajan, Brian P. Tullius and Dean A. Lee Tags: Review Source Type: research
Applications and therapeutic mechanisms of action of mesenchymal stem cells in radiation-induced lung injury
Radiation-induced lung injury (RILI) is one of the most common complications associated with radiotherapy, characterized by early-stage radiation pneumonia and subsequent radiation pulmonary fibrosis. However,... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 25, 2021 Category: Stem Cells Authors: Shiying Niu and Yueying Zhang Tags: Review Source Type: research
Role of glioblastoma stem cells in cancer therapeutic resistance: a perspective on antineoplastic agents from natural sources and chemical derivatives
Glioblastoma (GBM) is the highest-grade form of glioma, as well as one of the most aggressive types of cancer, exhibiting rapid cellular growth and highly invasive behavior. Despite significant advances in dia... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 24, 2021 Category: Stem Cells Authors: Ana Laura V. Alves, Izabela N. F. Gomes, Adriana C. Carloni, Marcela N. Rosa, Luciane S. da Silva, Adriane F. Evangelista, Rui Manuel Reis and Viviane Aline O. Silva Tags: Review Source Type: research
Transplantation of human amniotic epithelial cells promotes morphological and functional regeneration in a rat uterine scar model
Cesarean scar defect (CSD) is characterized by the presence of fibrotic tissue and decreased muscular density which is induced by cesarean section. Serious CSD may eventually result in infertility or obstetric... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 24, 2021 Category: Stem Cells Authors: Yihui Fan, Junyan Sun, Qiuwan Zhang and Dongmei Lai Tags: Research Source Type: research
Advances in intranasal application of stem cells in the treatment of central nervous system diseases
Stem cells are characterized by their self-renewal and multipotency and have great potential in the therapy of various disorders. However, the blood –brain barrier (BBB) limits the application of stem cells in ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 24, 2021 Category: Stem Cells Authors: Yu-Ting Zhang, Kai-Jie He, Jin-Bao Zhang, Quan-Hong Ma, Fen Wang and Chun-Feng Liu Tags: Review Source Type: research
Mesenchymal stem cells cultured in serum-free medium ameliorate experimental peritoneal fibrosis
In this study, we compared the ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 23, 2021 Category: Stem Cells Authors: Kohei Nagasaki, Ayumu Nakashima, Ryo Tamura, Naoki Ishiuchi, Kiyomasa Honda, Toshinori Ueno, Shigehiro Doi, Yukio Kato and Takao Masaki Tags: Research Source Type: research
Renaissance of armored immune effector cells, CAR-NK cells, brings the higher hope for successful cancer therapy
In recent decades, a new method of cellular immunotherapy was introduced based on engineering and empowering the immune effector cells. In this type of immunotherapy, the immune effector cells are equipped wit... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 22, 2021 Category: Stem Cells Authors: Faroogh Marofi, Heshu Sulaiman Rahman, Lakshmi Thangavelu, Aleksey Dorofeev, Favian Bayas-Morej ón, Naghmeh Shirafkan, Navid Shomali, Max Stanley Chartrand, Mostafa Jarahian, Ghasem Vahedi, Rebar N. Mohammed, Somayeh Shahrokh, Morteza Akbari and Farhad M Tags: Review Source Type: research
Human placenta mesenchymal stem cell-derived exosomes delay H2O2-induced aging in mouse cholangioids
Cholangiocyte senescence is an important pathological process in diseases such as primary sclerosing cholangitis (PSC) and primary biliary cirrhosis (PBC). Stem cell/induced pluripotent stem cell-derived exoso... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 22, 2021 Category: Stem Cells Authors: Wenyi Chen, Jiaqi Zhu, Feiyan Lin, Yanping Xu, Bing Feng, Xudong Feng, Xinyu Sheng, Xiaowei Shi, Qiaoling Pan, Jinfeng Yang, Jiong Yu, Lanjuan Li and Hongcui Cao Tags: Research Source Type: research
Improvement of ECM-based bioroot regeneration via N-acetylcysteine-induced antioxidative effects
The low survival rate or dysfunction of extracellular matrix (ECM)-based engineered organs caused by the adverse effects of unfavourable local microenvironments on seed cell viability and stemness, especially ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 22, 2021 Category: Stem Cells Authors: Jiayu Zhang, Tingting Lan, Xue Han, Yuchan Xu, Li Liao, Li Xie, Bo Yang, Weidong Tian and Weihua Guo Tags: Research Source Type: research
Propofol impairs specification of retinal cell types in zebrafish by inhibiting Zisp-mediated Noggin-1 palmitoylation and trafficking
Propofol can have adverse effects on developing neurons, leading to cognitive disorders, but the mechanism of such an effect remains elusive. Here, we aimed to investigate the effect of propofol on neuronal de... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 20, 2021 Category: Stem Cells Authors: Xiaoqing Fan, Haoran Yang, Lizhu Hu, Delong Wang, Ruiting Wang, Aijun Hao and Xueran Chen Tags: Research Source Type: research
Chitosan hydrogel-loaded MSC-derived extracellular vesicles promote skin rejuvenation by ameliorating the senescence of dermal fibroblasts
The senescence of dermal fibroblasts (DFLs) leads to an imbalance in the synthesis and degradation of extracellular matrix (ECM) proteins, presenting so-called senescence-associated secretory phenotype (SASP),... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 20, 2021 Category: Stem Cells Authors: Xiangnan Zhao, Yue Liu, Pingping Jia, Hui Cheng, Chen Wang, Shang Chen, Haoyan Huang, Zhibo Han, Zhong-Chao Han, Krzysztof Marycz, Xiaoniao Chen and Zongjin Li Tags: Research Source Type: research
Stem/progenitor cell in kidney: characteristics, homing, coordination, and maintenance
Renal failure has a high prevalence and is becoming a public health problem worldwide. However, the renal replacement therapies such as dialysis are not yet satisfactory for its multiple complications. While s... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 20, 2021 Category: Stem Cells Authors: Jiewu Huang, Yaozhong Kong, Chao Xie and Lili Zhou Tags: Review Source Type: research
Extracellular vesicles released from hiPSC-derived MSCs attenuate chronic prostatitis/chronic pelvic pain syndrome in rats by immunoregulation
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is an intractable nonbacterial inflammatory disease. Mesenchymal stem cells (MSCs) derived from human induced pluripotent stem cells (hiPSCs, iMSCs) h... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 20, 2021 Category: Stem Cells Authors: Xufeng Peng, Hailin Guo, Ji Yuan, Yu Chen, Yuguo Xia, Lin Wang, Ying Wang, Yichen Huang, Hua Xie, Yang Wang and Fang Chen Tags: Research Source Type: research
