Establishment of functional epithelial organoids from human lacrimal glands
Tear deficiency due to lacrimal gland (LG) dysfunction is one of the major causes of dry eye disease (DED). Therefore, LG stem cell-based therapies have been extensively reported to regenerate injured lacrimal... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 21, 2021 Category: Stem Cells Authors: Sang Yun Jeong, Woo Hee Choi, Seong Gyeong Jeon, Sookon Lee, Jong-Moon Park, Mira Park, Hookeun Lee, Helen Lew and Jongman Yoo Tags: Research Source Type: research
Efficient differentiation of human embryonic stem cells to retinal pigment epithelium under defined conditions
Age-related macular degeneration (AMD) is a highly prevalent form of blindness caused by loss death of cells of the retinal pigment epithelium (RPE). Transplantation of pluripotent stem cell (PSC)-derived RPE ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 21, 2021 Category: Stem Cells Authors: Ioannis J. Limnios, Yu-Qian Chau, Stuart J. Skabo, Denver C. Surrao and Helen C. O ’Neill Tags: Research Source Type: research
Efficacy and safety of mesenchymal stem cells co-infusion in allogeneic hematopoietic stem cell transplantation: a systematic review and meta-analysis
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is life-saving for severe hematological conditions. However, its outcomes need further improvement, and co-infusion of mesenchymal stem cells (MSC... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 20, 2021 Category: Stem Cells Authors: Teng Li, Chengxin Luo, Jiasi Zhang, Ling Wei, Wei Sun, Qin Xie, Yan Liu, Yongli Zhao, Shuangnian Xu and Lihua Wang Tags: Research Source Type: research
A novel MSC-based immune induction strategy for ABO-incompatible liver transplantation: a phase I/II randomized, open-label, controlled trial
ABO-incompatible liver transplantation (ABO-i LT) has become a rescue therapeutic option for patients with severe hepatic failure. Although the use of rituximab greatly reduces the morbidity of antibody-mediat... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 16, 2021 Category: Stem Cells Authors: Yingcai Zhang, Jiebin Zhang, Huimin Yi, Jun Zheng, Jianye Cai, Wenjie Chen, Tongyu Lu, Liang Chen, Cong Du, Jianrong Liu, Jia Yao, Hui Zhao, Guoying Wang, Binsheng Fu, Tong Zhang, Jian Zhang & hellip; Tags: Research Source Type: research
Signaling pathways governing breast cancer stem cells behavior
Breast cancer is the second common cancer and the leading cause of malignancy among females overall. Breast cancer stem cells (BCSCs) are a small population of breast cancer cells that play a critical role in ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 16, 2021 Category: Stem Cells Authors: Kai Song and Maryam Farzaneh Tags: Review Source Type: research
A randomized, controlled clinical trial of autologous stromal vascular fraction cells transplantation to promote mechanical stretch-induced skin regeneration
The regeneration response of the skin to mechanical stretching in vivo has been explored in reconstructive surgery to repair large-scale deformities. The ability of the skin to regenerate limits the reconstruc... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 15, 2021 Category: Stem Cells Authors: Poh-Ching Tan, Pei-Chuan Chao, Chen Cheng, Chu-Hsin Chen, Ru-Lin Huang, Shuang-Bai Zhou, Yun Xie and Qing-Feng Li Tags: Research Source Type: research
Retraction Note: Exosomes from glioma cells induce a tumor-like phenotype in mesenchymal stem cells by activating glycolysis
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13287-019-1149-5. (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 14, 2021 Category: Stem Cells Authors: Zhanjun Ma, Xue Cui, Li Lu, Guohu Chen, Yang Yang, Yan Hu, Yubao Lu, Zhangqi Cao, Yan Wang and Xuexi Wang Tags: Retraction Note Source Type: research
The preconditioning of lithium promotes mesenchymal stem cell-based therapy for the degenerated intervertebral disc via upregulating cellular ROS
Adipose-derived stem cell (ADSC) is one of the most widely used candidate cell for intervertebral disc (IVD) degeneration-related disease. However, the poor survival and low differentiation efficacy in stresse... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 14, 2021 Category: Stem Cells Authors: Zemin Zhu, Hongyuan Xing, Ruofu Tang, Shengjun Qian, Shaoqi He, Qiang Hu and Ning Zhang Tags: Research Source Type: research
Hypoxic preconditioning induces epigenetic changes and modifies swine mesenchymal stem cell angiogenesis and senescence in experimental atherosclerotic renal artery stenosis
Atherosclerotic renal artery stenosis (ARAS) is a risk factor for ischemic and hypertensive kidney disease (HKD) for which autologous mesenchymal stem cell (MSC) appears to be a promising therapy. However, MSC... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 14, 2021 Category: Stem Cells Authors: Busra Isik, Roman Thaler, Busra B. Goksu, Sabena M. Conley, Hayder Al-Khafaji, Arjunmohan Mohan, Mohsen Afarideh, Abdelrhman M. Abumoawad, Xiang Y. Zhu, James D. Krier, Ishran M. Saadiq, Hui Tang, Alfonso Eirin, LaTonya J. Hickson, Andre J. van Wijnen, St Tags: Research Source Type: research
Andrographolide promotes proliferative and osteogenic potentials of human placenta-derived mesenchymal stem cells through the activation of Wnt/ β-catenin signaling
The in vitro expansion and differentiation of mesenchymal stem cells derived from bone marrow (BM-hMSCs) are considered as potential therapeutic tools for clinical applications in bone tissue engineering and r... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 14, 2021 Category: Stem Cells Authors: Naruphong Phunikom, Nittaya Boonmuen, Pakpoom Kheolamai, Kanoknetr Suksen, Sirikul Manochantr, Chairat Tantrawatpan and Duangrat Tantikanlayaporn Tags: Research Source Type: research
Classical isoforms of protein kinase C (PKC) and Akt regulate the osteogenic differentiation of human dental follicle cells via both β-catenin and NF-κB
Human dental follicle cells (DFCs) are the precursor cells of the periodontium with a high potential for regenerative therapies of (alveolar) bone. However, the molecular mechanisms of osteogenic differentiati... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 14, 2021 Category: Stem Cells Authors: Oliver Pieles, Torsten E. Reichert and Christian Morsczeck Tags: Research Source Type: research
Evaluation of the Spanish population coverage of a prospective HLA haplobank of induced pluripotent stem cells
iPSC (induced pluripotent stem cells) banks of iPSC lines with homozygous HLA (human leukocyte antigen) haplotypes (haplobanks) are proposed as an affordable and off-the-shelf approach to allogeneic transplant... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 13, 2021 Category: Stem Cells Authors: Bel én Álvarez-Palomo, Iris García-Martinez, Jorge Gayoso, Angel Raya, Anna Veiga, María Luisa Abad, Adolfo Eiras, María Guzmán-Fulgencio, Mar Luis-Hidalgo, Cristina Eguizabal, Silvia Santos, Antonio Balas, Raquel Alenda, Francisco Sanchez-Gordo, La Tags: Research Source Type: research
Sinusoidal electromagnetic fields accelerate bone regeneration by boosting the multifunctionality of bone marrow mesenchymal stem cells
The repair of critical-sized bone defects is always a challenging problem. Electromagnetic fields (EMFs), used as a physiotherapy for bone defects, have been suspected to cause potential hazards to human healt... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 13, 2021 Category: Stem Cells Authors: Weigang Li, Wenbin Liu, Wei Wang, Jiachen Wang, Tian Ma, Jingyuan Chen, Hua Wu and Chaoxu Liu Tags: Research Source Type: research
Bone marrow mesenchymal stem cell exosomes suppress phosphate-induced aortic calcification via SIRT6 –HMGB1 deacetylation
Vascular calcification associated with chronic kidney disease (CKD) can increase the risk of mortality. Elevated serum levels of high mobility group box 1 (HMGB1) promotes vascular calcification in CKD via the... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 13, 2021 Category: Stem Cells Authors: Wenqian Wei, Xiaodong Guo, Lijie Gu, Jieshuang Jia, Man Yang, Weijie Yuan and Shu Rong Tags: Research Source Type: research
Identification of circulating CD31+CD45+ cell populations with the potential to differentiate into erythroid cells
Erythro-myeloid progenitors (EMP) are found in a population of cells expressing CD31 and CD45 markers (CD31+CD45+). A recent study indicated that EMPs persist until adulthood and can be a source of endothelial ce... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - April 13, 2021 Category: Stem Cells Authors: Maria Chiara G. Monaco, Dragan Maric, Ombretta Salvucci, Cristina Antonetti Lamorgese Passeri, Patrizia Accorsi, Eugene O. Major and Anna Concetta Berardi Tags: Letter Source Type: research
