Adipose-derived stromal cells modulating composite allotransplant survival is correlated with B cell regulation in a rodent hind-limb allotransplantation model
In this study, ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - November 11, 2020 Category: Stem Cells Authors: Chien-Chang Chen, Rong-Fu Chen, Jheng-Syuan Shao, Yun-Ting Li, Yu-Chi Wang, Gerald Brandacher, Jiin-Haur Chuang and Yur-Ren Kuo Tags: Research Source Type: research
si-SNHG5-FOXF2 inhibits TGF- β1-induced fibrosis in human primary endometrial stromal cells by the Wnt/β-catenin signalling pathway
Intrauterine adhesions (IUAs) are manifestations of endometrial fibrosis characterized by inflammation and fibrinogen aggregation in the extracellular matrix (ECM). The available therapeutic interventions for ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - November 11, 2020 Category: Stem Cells Authors: Limin Liu, Guobin Chen, Taoliang Chen, Wenjuan Shi, Haiyan Hu, Kaijing Song, Ruichun Huang, Huihua Cai and Yuanli He Tags: Research Source Type: research
Bone marrow mesenchymal stem cell-derived exosomes promote plasminogen activator inhibitor 1 expression in vascular cells in the local microenvironment during rabbit osteonecrosis of the femoral head
Nontraumatic osteonecrosis of the femoral head (NONFH) is a highly disabling orthopedic disease in young individuals. Plasminogen activator inhibitor 1 (PAI-1) has been reported to be positively associated wit... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - November 11, 2020 Category: Stem Cells Authors: Lu Li, Yikai Wang, Xiaobing Yu, Yongming Bao, Lijia An, Xiaowei Wei, Weiting Yu, Baoyi Liu, Junlei Li, Jiahui Yang, Yan Xia, Ge Liu, Fang Cao, Xiuzhi Zhang and Dewei Zhao Tags: Research Source Type: research
Multilineage differentiation potential of hematoendothelial progenitors derived from human induced pluripotent stem cells
Human induced pluripotent stem cells (hiPSCs) offer a renewable source of cells for the generation of hematopoietic cells for cell-based therapy, disease modeling, and drug screening. However, current serum/fe... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - November 11, 2020 Category: Stem Cells Authors: Ratchapong Netsrithong, Siriwal Suwanpitak, Bootsakorn Boonkaew, Kongtana Trakarnsanga, Lung-Ji Chang, Chartsiam Tipgomut, Chinnavuth Vatanashevanopakorn, Kovit Pattanapanyasat and Methichit Wattanapanitch Tags: Research Source Type: research
Autologous adipose-derived stem cells for the treatment of complex cryptoglandular perianal fistula: a prospective case-control study
Complex cryptoglandular perianal fistula (CPAF) is a kind of anal fistula that may cause anal incontinence after surgery. Minimally invasive surgery of anal fistula is constantly emerging. Over the past 20 yea... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - November 10, 2020 Category: Stem Cells Authors: Yang Zhang, Min Ni, Chungen Zhou, Yehuang Wang, Yaxian Wang, Yang Shi, Jing Jin, Rui Zhang and Bin Jiang Tags: Research Source Type: research
Activation of mesenchymal stem cells promotes new bone formation within dentigerous cyst
Dentigerous cyst (DC) is a bone destructive disease and remains a challenge for clinicians. Marsupialization enables the bone to regenerate with capsule maintaining, making it a preferred therapeutic means for... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - November 10, 2020 Category: Stem Cells Authors: Yejia Yu, Mengyu Li, Yuqiong Zhou, Yueqi Shi, Wenjie Zhang, Geehun Son, Jing Ge, Jun Zhao, Zhiyuan Zhang, Dongxia Ye, Chi Yang and Shaoyi Wang Tags: Research Source Type: research
Combination of SB431542, Chir9901, and Bpv as a novel supplement in the culture of umbilical cord blood hematopoietic stem cells
Small molecule compounds have been well recognized for their promising power in the generation, expansion, and maintenance of embryonic or adult stem cells. The aim of this study was to identify a novel combin... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - November 9, 2020 Category: Stem Cells Authors: Morteza Zarrabi, Elaheh Afzal, Mohammad Hassan Asghari and Marzieh Ebrahimi Tags: Research Source Type: research
Skeletal muscle healing by M1-like macrophages produced by transient expression of exogenous GM-CSF
After traumatic skeletal muscle injury, muscle healing is often incomplete and produces extensive fibrosis. The sequence of M1 and M2 macrophage accumulation and the duration of each subtype in the injured are... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - November 6, 2020 Category: Stem Cells Authors: Leonardo Martins, Camila Congentino Gallo, T âmisa Seeko Bandeira Honda, Patrícia Terra Alves, Roberta Sessa Stilhano, Daniela Santoro Rosa, Timothy Jon Koh and Sang Won Han Tags: Research Source Type: research
Functionally enhanced placenta-derived mesenchymal stem cells inhibit adipogenesis in orbital fibroblasts with Graves ’ ophthalmopathy
Placenta-derived mesenchymal stem cells (PD-MSCs) have unique immunomodulatory properties. Phosphatase of regenerating liver-1 (PRL-1) regulates the self-renewal ability of stem cells and promotes proliferatio... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - November 5, 2020 Category: Stem Cells Authors: Jae Yeon Kim, Sohae Park, Hyun-Jung Lee, Helen Lew and Gi Jin Kim Tags: Research Source Type: research
Melphalan induces cardiotoxicity through oxidative stress in cardiomyocytes derived from human induced pluripotent stem cells
Treatment-induced cardiotoxicity is a leading noncancer-related cause of acute and late onset morbidity and mortality in cancer patients on antineoplastic drugs such as melphalan —increasing clinical case repor... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - November 5, 2020 Category: Stem Cells Authors: Rui Liu, Dong Li, Fangxu Sun, Antonio Rampoldi, Joshua T. Maxwell, Ronghu Wu, Peter Fischbach, Sharon M. Castellino, Yuhong Du, Haian Fu, Anant Mandawat and Chunhui Xu Tags: Research Source Type: research
Galectin-9 is required for endometrial regenerative cells to induce long-term cardiac allograft survival in mice
Endometrial regenerative cells (ERCs), a novel type of mesenchymal-like stem cells, were identified as an attractive candidate for immunoregulation and induction of cardiac allograft tolerance. However, the un... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - November 5, 2020 Category: Stem Cells Authors: Yiming Zhao, Xiang Li, Dingding Yu, Yonghao Hu, Wang Jin, Yafei Qin, Dejun Kong, Hongda Wang, Guangming Li, Alessandro Alessandrini and Hao Wang Tags: Research Source Type: research
Human placenta-derived mesenchymal stem cells stimulate ovarian function via miR-145 and bone morphogenetic protein signaling in aged rats
Aging has detrimental effects on the ovary, such as a progressive reduction in fertility and decreased hormone production, that greatly reduce the quality of life of women. Thus, the current study was undertak... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - November 5, 2020 Category: Stem Cells Authors: Kyeoung-Hwa Kim, Eun-Young Kim, Gi Jin Kim, Jung-Jae Ko, Kwang Yul Cha, Mi Kyung Koong and Kyung-Ah Lee Tags: Research Source Type: research
hPMSCs protects against d-galactose-induced oxidative damage of CD4+ T cells through activating Akt-mediated Nrf2 antioxidant signaling
Mesenchymal stem cells (MSCs) were considered a regenerative therapeutic approach in both acute and chronic diseases. However, whether MSCs regulate the antioxidant metabolism of CD4+ T cells and weaken immunosen... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - November 4, 2020 Category: Stem Cells Authors: Yanlian Xiong, Yueming Wang, Jiashen Zhang, Nannan Zhao, Hengchao Zhang, Aiping Zhang, Dongmei Zhao, Zhenhai Yu, Yancun Yin, Lele Song, Yanlei Xiong and Xiying Luan Tags: Research Source Type: research
Human umbilical cord mesenchymal stem cells restore the ovarian metabolome and rescue premature ovarian insufficiency in mice
Premature ovarian insufficiency (POI) is an ovarian dysfunction that seriously affects a woman ’s physiological health and reproduction. Mesenchymal stem cell (MSC) transplantation offers a promising treatment ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - November 4, 2020 Category: Stem Cells Authors: Yan Zhao, Jiao Ma, Peiye Yi, Jun Wu, Feiyan Zhao, Wan Tu, Wenjing Liu, Tianda Li, Yan Deng, Jie Hao, Hongmei Wang and Long Yan Tags: Research Source Type: research
Ca2+-activated mitochondrial biogenesis and functions improve stem cell fate in Rg3-treated human mesenchymal stem cells
Although mitochondrial functions are essential for cell survival, their critical roles in stem cell fate, including proliferation, differentiation, and senescence, remain elusive. Ginsenoside Rg3 exhibits vari... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - November 4, 2020 Category: Stem Cells Authors: Taeui Hong, Moon Young Kim, Dat Da Ly, Su Jung Park, Young Woo Eom, Kyu-Sang Park and Soon Koo Baik Tags: Short report Source Type: research
