Bone marrow mesenchymal stem cell-derived exosomes promote rotator cuff tendon-bone healing by promoting angiogenesis and regulating M1 macrophages in rats
Rotator cuff tears (RCTs) often require reconstructive surgery. Tendon-bone healing is critical for the outcome of rotator cuff reconstruction, but the process of tendon-bone healing is complex and difficult. ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - November 25, 2020 Category: Stem Cells Authors: Yao Huang, Bing He, Lei Wang, Bin Yuan, Hao Shu, Fucheng Zhang and Luning Sun Tags: Research Source Type: research
Mesenchymal stem cells promote pancreatic β-cell regeneration through downregulation of FoxO1 pathway
Mesenchymal stem cells (MSC) are non-haematopoietic, fibroblast-like multipotent stromal cells. In the injured pancreas, these cells are assumed to secrete growth factors and immunomodulatory molecules, which ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - November 25, 2020 Category: Stem Cells Authors: Rahul Khatri, Sybille Mazurek, Sebastian Friedrich Petry and Thomas Linn Tags: Research Source Type: research
Human levator veli palatini muscle: a novel source of mesenchymal stromal cells for use in the rehabilitation of patients with congenital craniofacial malformations
Bone reconstruction in congenital craniofacial differences, which affect about 2 –3% of newborns, has long been the focus of intensive research in the field of bone tissue engineering. The possibility of using ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - November 25, 2020 Category: Stem Cells Authors: Daniela Franco Bueno, Gerson Shigueru Kabayashi, Carla Cristina Gomes Pinheiro, Daniela Y. S. Tanikawa, Cassio Eduardo Raposo-Amaral, Diogenes Laercio Rocha, Jos é Ricardo Muniz Ferreira, Yoichiro Shibuya, Akishige Hokugo, Reza Jarrahy, Patricia A. ZuK a Tags: Research Source Type: research
Exosomes derived from three-dimensional cultured human umbilical cord mesenchymal stem cells ameliorate pulmonary fibrosis in a mouse silicosis model
Silicosis is an occupational respiratory disease caused by long-term excessive silica inhalation, which is most commonly encountered in industrial settings. Unfortunately, there is no effective therapy to dela... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - November 25, 2020 Category: Stem Cells Authors: Chunjie Xu, Jing Zhao, Qiuyue Li, Lin Hou, Yan Wang, Siling Li, Fuyang Jiang, Zhonghui Zhu and Lin Tian Tags: Research Source Type: research
Definitive hematopoietic stem/progenitor cells from human embryonic stem cells through serum/feeder-free organoid-induced differentiation
Ex vivo production of hematopoietic stem/precursor cells (HSPCs) represents a promising versatile approach for blood disorders. (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - November 24, 2020 Category: Stem Cells Authors: Selami Demirci, Juan J. Haro-Mora, Alexis Leonard, Claire Drysdale, Daniela Malide, Keyvan Keyvanfar, Khaled Essawi, Raul Vizcardo, Naritaka Tamaoki, Nicholas P. Restifo, John F. Tisdale and Naoya Uchida Tags: Research Source Type: research
Application of adipose-derived stem cells in photoaging: basic science and literature review
Photoaging is mainly induced by continuous exposure to sun light, causing multiple unwanted skin characters and accelerating skin aging. Adipose-derived stem cells(ADSCs) are promising in supporting skin repai... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - November 23, 2020 Category: Stem Cells Authors: Shidie Chen, Zhigang He and Jinghong Xu Tags: Review Source Type: research
Mesenchymal stem cells: amazing remedies for bone and cartilage defects
Skeletal disorders are among the leading debilitating factors affecting millions of people worldwide. The use of stem cells for tissue repair has raised many promises in various medical fields, including skele... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - November 23, 2020 Category: Stem Cells Authors: Parisa Kangari, Tahereh Talaei-Khozani, Iman Razeghian-Jahromi and Mahboobeh Razmkhah Tags: Review Source Type: research
Human adipose-derived stem cells enriched with VEGF-modified mRNA promote angiogenesis and long-term graft survival in a fat graft transplantation model
Fat grafting, as a standard treatment for numerous soft tissue defects, remains unpredictable and technique-dependent. Human adipose-derived stem cells (hADSCs) are promising candidates for cell-assisted thera... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - November 19, 2020 Category: Stem Cells Authors: Fei Yu, Nevin Witman, Dan Yan, Siyi Zhang, Meng Zhou, Yan Yan, Qinke Yao, Feixue Ding, Bingqian Yan, Huijing Wang, Wei Fu, Yang Lu and Yao Fu Tags: Research Source Type: research
Differences and similarities between cancer and somatic stem cells: therapeutic implications
Over the last decades, the cancer survival rate has increased due to personalized therapies, the discovery of targeted therapeutics and novel biological agents, and the application of palliative treatments. De... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - November 18, 2020 Category: Stem Cells Authors: Fiorella Rossi, Hunter Noren, Richard Jove, Vladimir Beljanski and Karl-Henrik Grinnemo Tags: Review Source Type: research
Process data of allogeneic ex vivo-expanded ABCB5+ mesenchymal stromal cells for human use: off-the-shelf GMP-manufactured donor-independent ATMP
Human dermal mesenchymal stromal cells (MSCs) expressing the ATP-binding cassette (ABC) efflux transporter ABCB5 represent an easily accessible MSC population that, based on preclinical and first-in-human data... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - November 16, 2020 Category: Stem Cells Authors: Seda Ballikaya, Samar Sadeghi, Elke Niebergall-Roth, Laura Nimtz, Jens Frindert, Alexandra Norrick, Nicole Stemler, Nicole Bauer, Yvonne Rosche, Vanessa Kratzenberg, Julia Pieper, Tina Ficek, Markus H. Frank, Christoph Ganss, Jasmina Esterlechner and Mark Tags: Research Source Type: research
Differentiation of human induced pluripotent stem cells into erythroid cells
During the last years, several strategies have been made to obtain mature erythrocytes or red blood cells (RBC) from the bone marrow or umbilical cord blood (UCB). However, UCB-derived hematopoietic stem cells... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - November 16, 2020 Category: Stem Cells Authors: Mohsen Ebrahimi, Mehdi Forouzesh, Setareh Raoufi, Mohammad Ramazii, Farhoodeh Ghaedrahmati and Maryam Farzaneh Tags: Review Source Type: research
Therapeutic efficacy of umbilical cord-derived stem cells for diabetes mellitus: a meta-analysis study
Stem cell therapy provides great hope for patients with diabetes mellitus (DM). DM is a seriously alarming metabolic disease characterized by hyperglycemia and β cell dysfunction. Efficient novel therapeutic m... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - November 16, 2020 Category: Stem Cells Authors: Dina H. Kassem and Mohamed M. Kamal Tags: Research Source Type: research
Momordica charantia polysaccharides modulate the differentiation of neural stem cells via SIRT1/ Β-catenin axis in cerebral ischemia/reperfusion
Stroke is the leading cause of long-term motor disability and cognitive impairment. Recently, neurogenesis has become an attractive strategy for the chronic recovery of stroke. It is important to understand th... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - November 16, 2020 Category: Stem Cells Authors: Zhaoli Hu, Fengying Li, Xiaoling Zhou, Feng Zhang, Linyan Huang, Bing Gu, Jiangang Shen and Suhua Qi Tags: Research Source Type: research
Enhanced differentiation of human pluripotent stem cells into pancreatic endocrine cells in 3D culture by inhibition of focal adhesion kinase
Generation of insulin-producing cells from human pluripotent stem cells (hPSCs) in vitro would be useful for drug discovery and cell therapy in diabetes. Three-dimensional (3D) culture is important for the acq... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - November 16, 2020 Category: Stem Cells Authors: Xiaofang Liu, Jinhua Qin, Mingyang Chang, Shuyong Wang, Yali Li, Xuetao Pei and Yunfang Wang Tags: Research Source Type: research
Human menstrual blood-derived stem cells mitigate bleomycin-induced pulmonary fibrosis through anti-apoptosis and anti-inflammatory effects
Idiopathic pulmonary fibrosis is a kind of diffuse interstitial lung disease, the pathogenesis of which is unclear, and there is currently a lack of good treatment to improve the survival rate. Human menstrual... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - November 11, 2020 Category: Stem Cells Authors: Xin Chen, Yi Wu, Yanling Wang, Lijun Chen, Wendi Zheng, Sining Zhou, Huikang Xu, Yifei Li, Li Yuan and Charlie Xiang Tags: Research Source Type: research
