Advancements in stem cell-derived hepatocyte-like cell models for hepatotoxicity testing
Drug-induced liver injury (DILI) is one of the leading causes of clinical trial failures and high drug attrition rates. Currently, the commonly used hepatocyte models include primary human hepatocytes (PHHs), ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 25, 2021 Category: Stem Cells Authors: Meixian Jin, Xiao Yi, Wei Liao, Qi Chen, Wanren Yang, Yang Li, Shao Li, Yi Gao, Qing Peng and Shuqin Zhou Tags: Review Source Type: research
Effects of miR-672 on the angiogenesis of adipose-derived mesenchymal stem cells during bone regeneration
Sufficient vascular network plays an important role in the repair of bone defects. Bone morphogenetic protein 2 (BMP2) being a key regulator of angiogenesis has attracted the attention of researchers. In addit... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 25, 2021 Category: Stem Cells Authors: Mingjiao Chen, Meng Zhou, Yao Fu, Jin Li and Zi Wang Tags: Research Source Type: research
Exosomes derived from miR-301a-3p-overexpressing adipose-derived mesenchymal stem cells reverse hypoxia-induced erectile dysfunction in rat models
Erectile dysfunction (ED) has often been observed in patients with obstructive sleep apnea (OSA). Research on adipose-derived mesenchymal stem cell (ADSC)-derived exosomes has shown that they have significant ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 25, 2021 Category: Stem Cells Authors: Li Liang, Dachao Zheng, Chao Lu, Qinghong Xi, Hua Bao, Wengfeng Li, Yufei Gu, Yuanshen Mao, Bin Xu and Xin Gu Tags: Research Source Type: research
Resolvin E1 accelerates pulp repair by regulating inflammation and stimulating dentin regeneration in dental pulp stem cells
Unresolved inflammation and tissue destruction are considered to underlie the failure of dental pulp repair. As key mediators of the injury response, dental pulp stem cells (DPSCs) play a critical role in pulp... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 22, 2021 Category: Stem Cells Authors: Jie Chen, Huaxing Xu, Kun Xia, Shuhua Cheng and Qi Zhang Tags: Research Source Type: research
Exosomes derived from stem cells from apical papilla promote craniofacial soft tissue regeneration by enhancing Cdc42-mediated vascularization
Reconstruction of complex critical-size defects (CSD) in the craniofacial region is a major challenge, and soft tissue regeneration is crucial in determining the therapeutic outcomes of craniofacial CSD. Stem ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 22, 2021 Category: Stem Cells Authors: Yao Liu, Xueying Zhuang, Si Yu, Ning Yang, Jianhong Zeng, Xuemei Liu and Xu Chen Tags: Research Source Type: research
The delivery of hsa-miR-11401 by extracellular vesicles can relieve doxorubicin-induced mesenchymal stem cell apoptosis
Chemotherapy is an effective anti-tumor treatment. Mesenchymal stem cells (MSCs), exerting therapy effect on injured tissues during chemotherapy, may be damaged in the process. The possibility of self-healing ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 22, 2021 Category: Stem Cells Authors: Huifang Li, Haoyan Huang, Xiaoniao Chen, Shang Chen, Lu Yu, Chen Wang, Yue Liu, Kaiyue Zhang, Lingling Wu, Zhong-Chao Han, Na Liu, Jie Wu and Zongjin Li Tags: Research Source Type: research
Adult tissue-resident stem cells —fact or fiction?
Life-long tissue homeostasis of adult tissues is supposedly maintained by the resident stem cells. These stem cells are quiescent in nature and rarely divide to self-renew and give rise to tissue-specific “pro... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 21, 2021 Category: Stem Cells Authors: Deepa Bhartiya Tags: Commentary Source Type: research
Involvement of the long noncoding RNA H19 in osteogenic differentiation and bone regeneration
Osteogenic differentiation and bone regeneration are complex processes involving multiple genes and multiple steps. In this review, we summarize the effects of the long noncoding RNA (lncRNA) H19 on osteogenic di... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 21, 2021 Category: Stem Cells Authors: Zimo Zhou, Mohammad Showkat Hossain and Da Liu Tags: Review Source Type: research
Differences of embedding adipose-derived stromal cells in natural and synthetic scaffolds for dermal and subcutaneous delivery
In recent years, adipose-derived stromal cells (ASCs) have been heavily studied for soft tissue regeneration, augmentation, and dermal wound healing. (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 19, 2021 Category: Stem Cells Authors: Frederik Penzien Mamsen, Lea Munthe-Fog, Mikela Karen Mungal Kring, Dominik Duscher, Mikkel Taudorf, Adam J. Katz and Stig-Frederik Trojahn K ølle Tags: Review Source Type: research
Human mesenchymal stem cell therapy promotes retinal ganglion cell survival and target reconnection after optic nerve crush in adult rats
Optic-nerve injury results in impaired transmission of visual signals to central targets and leads to the death of retinal ganglion cells (RGCs) and irreversible vision loss. Therapies with mesenchymal stem ce... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 19, 2021 Category: Stem Cells Authors: Almir Jord ão da Silva-Junior, Louise Alessandra Mesentier-Louro, Gabriel Nascimento-dos-Santos, Leandro Coelho Teixeira-Pinheiro, Juliana F. Vasques, Luiza Chimeli-Ormonde, Victor Bodart-Santos, Luiza Rachel Pinheiro de Carvalho, Marcelo Felippe Santiag Tags: Research Source Type: research
Advances in mesenchymal stem cell exosomes: a review
Stem cells can be used for regenerative medicine and as treatments for disease. The application of tissue engineering-related transplantation, stem cells, and local changes in the microenvironment is expected ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 19, 2021 Category: Stem Cells Authors: Yaya Tang, Yan Zhou and Hong-Jun Li Tags: Review Source Type: research
MSC-NTF (NurOwn ®) exosomes: a novel therapeutic modality in the mouse LPS-induced ARDS model
One of the most severe complications of the current COVID-19 pandemic is acute respiratory distress syndrome (ARDS). ARDS is caused by increased amounts of pro-inflammatory cytokines, leading to lung damage an... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 19, 2021 Category: Stem Cells Authors: Haggai Kaspi, Jonathan Semo, Nathalie Abramov, Chen Dekel, Stacy Lindborg, Ralph Kern, Chaim Lebovits and Revital Aricha Tags: Research Source Type: research
Correction to: Optical mapping of human embryonic stem cell-derived cardiomyocyte graft electrical activity in injured hearts
An amendment to this paper has been published and can be accessed via the original article. (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 19, 2021 Category: Stem Cells Authors: Dominic Filice, Wahiba Dhahri, Joell L. Solan, Paul D. Lampe, Erin Steele, Nikita Milani, Benjamin Van Biber, Wei-Zhong Zhu, Tamilla Sadikov Valdman, Rocco Romagnuolo, Jos é David Otero-Cruz, Kip D. Hauch, Matthew W. Kay, Narine Sarvazyan and Michael A. Tags: Correction Source Type: research
The miR-204-5p/FOXC1/GDF7 axis regulates the osteogenic differentiation of human adipose-derived stem cells via the AKT and p38 signalling pathways
Human adipose-derived stem cells (hADSCs) are stem cells with the potential to differentiate in multiple directions. miR-204-5p is expressed at low levels during the osteogenic differentiation of hADSCs, and i... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 18, 2021 Category: Stem Cells Authors: You Zhou, Siyu Liu, Wei Wang, Qiang Sun, Mengzhu Lv, Shude Yang, Shuang Tong and Shu Guo Tags: Research Source Type: research
Inhibition of TGF β improves hematopoietic stem cell niche and ameliorates cancer-related anemia
Cancer cachexia is a wasting syndrome that is quite common in terminal-stage cancer patients. Cancer-related anemia is one of the main features of cancer cachexia and mostly results in a poor prognosis. The di... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 18, 2021 Category: Stem Cells Authors: Boyan Wang, Yi Wang, Hainan Chen, Senyu Yao, Xiaofan Lai, Yuan Qiu, Jianye Cai, Yinong Huang, Xiaoyue Wei, Yuanjun Guan, Tao Wang, Jiancheng Wang and Andy Peng Xiang Tags: Research Source Type: research
