[Editors' Choice] "Gli"-ful neighbors induce epithelial metaplasia
Gli1+ mesenchymal stromal cells induce epithelial metaplasia. (Source: Science Translational Medicine)
Source: Science Translational Medicine - November 25, 2020 Category: Biomedical Science Authors: Sengupta, S. Tags: Editors ' Choice Source Type: research
[Editors' Choice] The metabolic foibles of triple negative breast cancer
Metabolic profiling of triple-negative breast cancers may advance personalized therapies. (Source: Science Translational Medicine)
Source: Science Translational Medicine - November 25, 2020 Category: Biomedical Science Authors: Gallagher, E. J. Tags: Editors ' Choice Source Type: research
[Research Articles] Combination of metabolic intervention and T cell therapy enhances solid tumor immunotherapy
Treatment of solid tumors with T cell therapy has yielded limited therapeutic benefits to date. Although T cell therapy in combination with proinflammatory cytokines or immune checkpoints inhibitors has demonstrated preclinical and clinical successes in a subset of solid tumors, unsatisfactory results and severe toxicities necessitate the development of effective and safe combinatorial strategies. Here, the liposomal avasimibe (a metabolism-modulating drug) was clicked onto the T cell surface by lipid insertion without disturbing the physiological functions of the T cell. Avasimibe could be restrained on the T cell surface...
Source: Science Translational Medicine - November 25, 2020 Category: Biomedical Science Authors: Hao, M., Hou, S., Li, W., Li, K., Xue, L., Hu, Q., Zhu, L., Chen, Y., Sun, H., Ju, C., Zhang, C. Tags: Research Articles Source Type: research
[Research Articles] Systemic cancer therapy with engineered adenovirus that evades innate immunity
Oncolytic virus therapy is a cancer treatment modality that has the potential to improve outcomes for patients with currently incurable malignancies. Although intravascular delivery of therapeutic viruses provides access to disseminated tumors, this delivery route exposes the virus to opsonizing and inactivating factors in the blood, which limit the effective therapeutic virus dose and contribute to activation of systemic toxicities. When human species C adenovirus HAdv-C5 is delivered intravenously, natural immunoglobulin M (IgM) antibodies and coagulation factor X rapidly opsonize HAdv-C5, leading to virus sequestration ...
Source: Science Translational Medicine - November 25, 2020 Category: Biomedical Science Authors: Atasheva, S., Emerson, C. C., Yao, J., Young, C., Stewart, P. L., Shayakhmetov, D. M. Tags: Research Articles Source Type: research
[Research Articles] Tau and other proteins found in Alzheimers disease spinal fluid are linked to retromer-mediated endosomal traffic in mice and humans
Endosomal trafficking has emerged as a defective biological pathway in Alzheimer’s disease (AD), and the pathway is a source of cerebrospinal fluid (CSF) protein accumulation. Nevertheless, the identity of the CSF proteins that accumulate in the setting of defects in AD’s endosomal trafficking pathway remains unknown. Here, we performed a CSF proteomic screen in mice with a neuronal-selective knockout of the core of the retromer complex VPS35, a master conductor of endosomal traffic that has been implicated in AD. We then validated three of the most relevant proteomic findings: the amino terminus of the transme...
Source: Science Translational Medicine - November 25, 2020 Category: Biomedical Science Authors: Simoes, S., Neufeld, J. L., Triana-Baltzer, G., Moughadam, S., Chen, E. I., Kothiya, M., Qureshi, Y. H., Patel, V., Honig, L. S., Kolb, H., Small, S. A. Tags: Research Articles Source Type: research
