Association between sleep, childhood trauma and psychosis-like experiences
Psychosis-like experiences (PLEs), or attenuated positive symptoms of psychosis, present along a severity continuum and have been associated with distressing thoughts and impairments in functioning. Although knowledge of the clinical importance of PLEs is expanding, risk factors for their expression are still poorly understood. Sleep disturbances are one known factor that exacerbate PLEs expression and distress, and trauma exposure is associated with occurrence of PLEs, as well as increased risk of later sleep difficulties. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 8, 2018 Category: Psychiatry Authors: Nicole D. Andorko, Zachary B. Millman, Elizabeth Klingaman, Deborah Medoff, Emily Kline, Jordan DeVylder, Gloria Reeves, Jason Schiffman Source Type: research

Clozapine use in early psychosis
In this study, we aimed to determine; the proportion of young people with a first episode of psychosis (FEP) who would be considered eligible for clozapine treatment, the theoretical delay in commencing clozapine and to compare the outcomes of those treated with clozapine to those who were eligible but not treated with clozapine. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 8, 2018 Category: Psychiatry Authors: Kristen Thien, Meghan Bowtell, Scott Eaton, Melissa Bardell-Williams, Linglee Downey, Aswin Ratheesh, Patrick McGorry, Brian O'Donoghue Source Type: research

Early treatment resistance in a Latin-American cohort of patients with schizophrenia
Failure to respond to antipsychotic medication in schizophrenia is a common clinical scenario with significant morbidity. Recent studies have highlighted that many patients present treatment-resistance from disease onset. We here present an analysis of clozapine prescription patterns, used as a real-world proxy marker for treatment-resistance, in a cohort of 1195 patients with schizophrenia from a Latin-American cohort, to explore the timing of emergence of treatment resistance and possible subgroup differences. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 8, 2018 Category: Psychiatry Authors: Cristian Mena, Alfonso Gonzalez-Valderrama, Barbara Iruretagoyena, Juan Undurraga, Nicolas A. Crossley Source Type: research

Impaired reward responsiveness in schizophrenia
Anhedonia is a core negative symptom of schizophrenia. Schizophrenia patients report largely intact pleasure in consuming rewards, but have impairments in generating motivated behavior to pursue rewards, and show reduced fMRI activation of the reward pathway during presentation of rewarded stimuli. A computer based task measuring the development of a response bias in favor of rewarded stimuli permits assessment of reward-induced motivation. We hypothesized that subjects with schizophrenia would be impaired on this task. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 8, 2018 Category: Psychiatry Authors: Nicholas Taylor, Jeffrey P. Hollis, Sarah Corcoran, Robin Gross, Bruce Cuthbert, Lisette W. Swails, Erica Duncan Source Type: research

Changes in plasma levels of nitric oxide metabolites and negative symptoms after 16-week minocycline treatment in patients with schizophrenia
This study examined the effect of adjunctive minocycline on psychopathology and possibly relevant biomarkers in patients with schizophrenia. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 8, 2018 Category: Psychiatry Authors: Fang Liu, Bingkui Zhang, Liqin Xie, Ye Ruan, XiuFeng Xu, Yong Zeng, Louis Messina, Jingping Zhao, Xiaoduo Fan Source Type: research

Pupillary responses to a cognitive effort task in schizophrenia
Effort-based decision making paradigms are increasingly utilized to gain insight into the nature of motivation deficits. Although these tasks are being used to assess effort and motivation in schizophrenia, little work has been done to confirm that effort-based decision making tasks validly manipulate effort. In the current study, we adapted the effort component a cognitive effort-based decision making task (the Deck Choice Effort Task) for use with pupillometric assessment. We sought to confirm with psychophysiology that cognitive effort is manipulated. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 8, 2018 Category: Psychiatry Authors: L. Felice Reddy, Eric A. Reavis, Jonathan K. Wynn, Michael F. Green Source Type: research

Glucocorticoids and the risk of schizophrenia spectrum disorder in childhood and adolescence – A Danish nationwide study
Glucocorticoids can have psychosis as a potential side effect, but have also been suggested to yield protective effects due to anti-inflammatory properties. Nonetheless, knowledge is sparse on the association between glucocorticoid treatment and development of psychosis, which we aimed to study in this first large-scale longitudinal study.Among all individuals born in Denmark 1995 –2003 (n=597,257), we compared individuals who had redeemed ≥1 prescription for glucocorticoids to an active comparator group and a non-exposed group concerning subsequent development of schizophrenia spectrum disorders until 2013. (Sour...
Source: Schizophrenia Research - March 8, 2018 Category: Psychiatry Authors: Brian Villumsen Broberg, Iris E. Sommer, Michael Eriksen Benros, Birte Yding Glenth øj, Christiane Gasse, Ole Köhler-Forsberg Source Type: research

Schizophrenia and dissociation: Its relation with severity, self-esteem and awareness of illness
This article describes the conclusions of an investigation done with 120 Spanish patients: the finding of a new psychopathological profile within a subgroup of patients suffering from schizophrenia.The patients were evaluated through different questionnaires about sociodemographic data, traumatic events, the severity index (both clinical and psychopathological), self-esteem and consciousness of the illness. From the scores obtained on a scale of dissociative experiences, they were classified into two groups: high dissociative symptomatology or HD, and low dissociative symptomatology or LD. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 7, 2018 Category: Psychiatry Authors: Ania Justo, Alicia Risso, Andrew Moskowitz, Anabel Gonzalez Source Type: research

Sensorimotor gating deficits in schizophrenia: Advancing our understanding of the phenotype, its neural circuitry and genetic substrates
In her 1936 report of paired-pulse blink inhibition in 13 Yale undergraduate men, Helen Peak described “quantitative variation in amount of inhibition of the second response incident to changes in intensity of the first stimulus which precedes by different intervals of time” (Peak, 1936). These observations appeared to lay dormant for much of the next 30years, but there was a resurgence of intere st in startle modulation in the 1960's, based primarily on findings from Howard Hoffman's group (e.g. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 7, 2018 Category: Psychiatry Authors: Neal R. Swerdlow, Gregory A. Light Tags: Guest editorial Source Type: research

Considerations for the development and implementation of brief screening tools in the identification of early psychosis
The concept of prevention of mental health concerns has a long history. Preventive developmental psychopathology has identified biopsychosocial risk and protective factors, the elucidation of which has led to a variety of effective, disorder-specific, intervention strategies for mitigating symptoms and promoting wellness (e.g., child behavior issues, adolescent depression, anxiety and traumatic response). As the benefits of early intervention for those experiencing impairing attenuated psychosis symptoms (some of whom on an apparent trajectory towards psychosis-spectrum disorders) continues to mount (Okuzawa et al. (Source...
Source: Schizophrenia Research - March 7, 2018 Category: Psychiatry Authors: Jason Schiffman Source Type: research

Schizophrenia and dissociation: Its relation with severity, self-esteem and awareness of illness
This article describes the conclusions of an investigation done with 120 Spanish patients: the finding of a new psychopathological profile within a subgroup of patients suffering from schizophrenia.The patients were evaluated through different questionnaires about sociodemographic data, traumatic events, the severity index (both clinical and psychopathological), self-esteem and consciousness of the illness. From the scores obtained on a scale of dissociative experiences, they were classified into two groups: high dissociative symptomatology or HD, and low dissociative symptomatology or LD. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 7, 2018 Category: Psychiatry Authors: Ania Justo, Alicia Risso, Andrew Moskowitz, Anabel Gonzalez Source Type: research

Sensorimotor gating deficits in schizophrenia: Advancing our understanding of the phenotype, its neural circuitry and genetic substrates
In her 1936 report of paired-pulse blink inhibition in 13 Yale undergraduate men, Helen Peak described “quantitative variation in amount of inhibition of the second response incident to changes in intensity of the first stimulus which precedes by different intervals of time” (Peak, 1936). These observations appeared to lay dormant for much of the next 30years, but there was a resurgence of intere st in startle modulation in the 1960's, based primarily on findings from Howard Hoffman's group (e.g. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 7, 2018 Category: Psychiatry Authors: Neal R. Swerdlow, Gregory A. Light Tags: Guest editorial Source Type: research

Considerations for the development and implementation of brief screening tools in the identification of early psychosis
The concept of prevention of mental health concerns has a long history. Preventive developmental psychopathology has identified biopsychosocial risk and protective factors, the elucidation of which has led to a variety of effective, disorder-specific, intervention strategies for mitigating symptoms and promoting wellness (e.g., child behavior issues, adolescent depression, anxiety and traumatic response). As the benefits of early intervention for those experiencing impairing attenuated psychosis symptoms (some of whom on an apparent trajectory towards psychosis-spectrum disorders) continues to mount (Okuzawa et al. (Source...
Source: Schizophrenia Research - March 7, 2018 Category: Psychiatry Authors: Jason Schiffman Source Type: research

Effects of cannabis use on body mass, fasting glucose and lipids during the first 12  months of treatment in schizophrenia spectrum disorders
In this study we investigated changes in body mass index (BMI), fasting blood glucose and lipids, and rates of metabolic syndrome risk factors in cannabis users vs. non-users in 109 minimally treated patients with first-episode schizophrenia, schizophreniform or schizo-affective disorder who were treated according to a standardized treatment regime with depot antipsychotic medication over 12  months. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 6, 2018 Category: Psychiatry Authors: F. Scheffler, S. Kilian, B. Chiliza, L. Asmal, L. Phahladira, S. du Plessis, M. Kidd, R.M. Murray, M. Di Forti, S. Seedat, R. Emsley Source Type: research

Challenges of managing delirium and catatonia in a medically ill patient
Untangling catatonia and delirium can be challenging. Furthermore, treatment of one syndrome can potentially worsen another. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 3, 2018 Category: Psychiatry Authors: Rachel Meyen, Elia E. Acevedo-Diaz, Sparsha S. Reddy Source Type: research

Altered proteomic profile in umbilical arterial serum from mothers with schizophrenia
Schizophrenia is known to be a multi-factorial disease caused by genetic and environmental factors. Accumulating evidence has demonstrated that intrauterine exposure to inflammation (maternal immune activation; MIA) subsequently leads to psychiatric diseases, including schizophrenia, owing to fetal programming (Estes and McAllister, 2016). Previous proteomic analysis of saliva revealed that proteins involved in innate immunity are increased in subjects with schizophrenia (Iavarone et al., 2014). (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 3, 2018 Category: Psychiatry Authors: Yoshinori Moriyama, Tomomi Kotani, Takafumi Ushida, Kenji Imai, Tomoko Nakano, Hiroyuki Tsuda, Fumitaka Kikkawa Tags: Letter to the Editor Source Type: research

Relationship between executive function, attachment style, and psychotic like experiences in typically developing youth
Psychotic like experiences (PLE's) are common in the general population, particularly during adolescence, which has generated interest in how PLE's emerge, and the extent to which they reflect either risk for, or resilience to, psychosis. The “attachment-developmental-cognitive” (ADC) model is one effort to model the effect of risk factors on PLEs. The ADC model proposes attachment insecurity as an early environmental insult that can contribute to altered neurodevelopment, increasing the likelihood of PLE's and psychosis. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 3, 2018 Category: Psychiatry Authors: Melanie A. Blair, George Nitzburg, Pamela DeRosse, Katherine H. Karlsgodt Source Type: research

Schizophrenia-like olfactory dysfunction induced by acute and postnatal phencyclidine exposure in rats
Deficits in olfactory abilities are frequently observed in schizophrenia patients. However, whether olfactory dysfunction is found in animal models is not known. Here, we examined whether two well-established schizophrenia rat models exhibit olfactory-relevant dysfunction that is similar to schizophrenia patients. Olfactory sensitivity was tested in rats that were acutely (3.3mg/kg) or postnatally (10mg/kg, at postnatal day 7, 9 and 11) treated with phencyclidine (PCP) as schizophrenia models. Electrophysiological recordings were conducted to measure the olfactory-relevant local field potential after acute PCP treatment. (...
Source: Schizophrenia Research - March 3, 2018 Category: Psychiatry Authors: Liang Shan, Tiane Liu, Zhijian Zhang, Qing Liu, Mengjiao Zhang, Xudong Zhao, Yan Zhang, Fuqiang Xu, Yuanye Ma Source Type: research

Similar psychotic and cognitive profile between ketamine dependence with persistent psychosis and schizophrenia
Ketamine has been used to probe the biology of psychosis and cognitive dysfunction in humans. High levels of ketamine abuse are associated with persisting psychosis (KPP) in a minority of users. However, relatively little is known about cognitive function among KPP patients and whether the cognitive impairments associated with KPP resemble those of schizophrenia (SZ). (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 3, 2018 Category: Psychiatry Authors: Wan-Ju Cheng, Chun-Hsin Chen, Chih-Ken Chen, Ming-Chyi Huang, Robert H. Pietrzak, John H. Krystal, Ke Xu Source Type: research

Is formal thought disorder in schizophrenia related to structural and functional aberrations in the language network? A systematic review of neuroimaging findings
This study aimed at 1) reviewing the literature on the neural correlates of FTD in schizophrenia, and 2) testing the hypothesis that FTD correlates with structural and functional aberrations in the language network.Medline, PsychInfo, and Embase were searched for neuroimaging studies, which applied a clinical measure to assess FTD in adults with schizophrenia and were published in English or German in peer-reviewed journals until December 2016. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 3, 2018 Category: Psychiatry Authors: Marialuisa Cavelti, Tilo Kircher, Arne Nagels, Werner Strik, Philipp Homan Source Type: research

Challenges of managing delirium and catatonia in a medically ill patient
Untangling catatonia and delirium can be challenging. Furthermore, treatment of one syndrome can potentially worsen another. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 3, 2018 Category: Psychiatry Authors: Rachel Meyen, Elia E. Acevedo-Diaz, Sparsha S. Reddy Source Type: research

Altered proteomic profile in umbilical arterial serum from mothers with schizophrenia
Schizophrenia is known to be a multi-factorial disease caused by genetic and environmental factors. Accumulating evidence has demonstrated that intrauterine exposure to inflammation (maternal immune activation; MIA) subsequently leads to psychiatric diseases, including schizophrenia, owing to fetal programming (Estes and McAllister, 2016). Previous proteomic analysis of saliva revealed that proteins involved in innate immunity are increased in subjects with schizophrenia (Iavarone et al., 2014). (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 3, 2018 Category: Psychiatry Authors: Yoshinori Moriyama, Tomomi Kotani, Takafumi Ushida, Kenji Imai, Tomoko Nakano, Hiroyuki Tsuda, Fumitaka Kikkawa Tags: Letter to the Editor Source Type: research

Relationship between executive function, attachment style, and psychotic like experiences in typically developing youth
Psychotic like experiences (PLE's) are common in the general population, particularly during adolescence, which has generated interest in how PLE's emerge, and the extent to which they reflect either risk for, or resilience to, psychosis. The “attachment-developmental-cognitive” (ADC) model is one effort to model the effect of risk factors on PLEs. The ADC model proposes attachment insecurity as an early environmental insult that can contribute to altered neurodevelopment, increasing the likelihood of PLE's and psychosis. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 3, 2018 Category: Psychiatry Authors: Melanie A. Blair, George Nitzburg, Pamela DeRosse, Katherine H. Karlsgodt Source Type: research

Schizophrenia-like olfactory dysfunction induced by acute and postnatal phencyclidine exposure in rats
Deficits in olfactory abilities are frequently observed in schizophrenia patients. However, whether olfactory dysfunction is found in animal models is not known. Here, we examined whether two well-established schizophrenia rat models exhibit olfactory-relevant dysfunction that is similar to schizophrenia patients. Olfactory sensitivity was tested in rats that were acutely (3.3mg/kg) or postnatally (10mg/kg, at postnatal day 7, 9 and 11) treated with phencyclidine (PCP) as schizophrenia models. Electrophysiological recordings were conducted to measure the olfactory-relevant local field potential after acute PCP treatment. (...
Source: Schizophrenia Research - March 3, 2018 Category: Psychiatry Authors: Liang Shan, Tiane Liu, Zhijian Zhang, Qing Liu, Mengjiao Zhang, Xudong Zhao, Yan Zhang, Fuqiang Xu, Yuanye Ma Source Type: research

Similar psychotic and cognitive profile between ketamine dependence with persistent psychosis and schizophrenia
Ketamine has been used to probe the biology of psychosis and cognitive dysfunction in humans. High levels of ketamine abuse are associated with persisting psychosis (KPP) in a minority of users. However, relatively little is known about cognitive function among KPP patients and whether the cognitive impairments associated with KPP resemble those of schizophrenia (SZ). (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 3, 2018 Category: Psychiatry Authors: Wan-Ju Cheng, Chun-Hsin Chen, Chih-Ken Chen, Ming-Chyi Huang, Robert H. Pietrzak, John H. Krystal, Ke Xu Source Type: research

Is formal thought disorder in schizophrenia related to structural and functional aberrations in the language network? A systematic review of neuroimaging findings
This study aimed at 1) reviewing the literature on the neural correlates of FTD in schizophrenia, and 2) testing the hypothesis that FTD correlates with structural and functional aberrations in the language network.Medline, PsychInfo, and Embase were searched for neuroimaging studies, which applied a clinical measure to assess FTD in adults with schizophrenia and were published in English or German in peer-reviewed journals until December 2016. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 3, 2018 Category: Psychiatry Authors: Marialuisa Cavelti, Tilo Kircher, Arne Nagels, Werner Strik, Philipp Homan Source Type: research

Triple advantages of injectable long acting second generation antipsychotics: Relapse prevention, neuroprotection, and lower mortality
The worst outcome for any medical disorder is death, followed closely by severe functional disability. Persons with schizophrenia suffer from high rates of both. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 2, 2018 Category: Psychiatry Authors: Henry A. Nasrallah Source Type: research

Creatine kinase (CK) and its association with aggressive behavior in patients with schizophrenia
To study the association between the serum creatine kinase (CK) level and aggressive behavior in patients with schizophrenia. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 2, 2018 Category: Psychiatry Authors: Xian-Dong Meng, Xi Cao, Tao Li, Ji-Ping Li Source Type: research

The association between schizophrenia and violence
In recent years Schizophrenia Research has published several important papers on the relationship between violence and psychosis. (Barkataki et al., 2005; Bulgari et al., 2017; Darrell-Berry et al., 2016; Imai et al., 2014; Large and Nielssen, 2011). Some of them are systematic reviews. A common weakness of many of the reviews in the field has been, however, that very broad terms have been used, particularly for violence and diagnostic categories. Violence is a broad concept, including everything from verbal threats and hostility to homicide. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 2, 2018 Category: Psychiatry Authors: Bj ørn Rishovd Rund Tags: Invited commentary Source Type: research

Triple advantages of injectable long acting second generation antipsychotics: Relapse prevention, neuroprotection, and lower mortality
The worst outcome for any medical disorder is death, followed closely by severe functional disability. Persons with schizophrenia suffer from high rates of both. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 2, 2018 Category: Psychiatry Authors: Henry A. Nasrallah Source Type: research

Creatine kinase (CK) and its association with aggressive behavior in patients with schizophrenia
To study the association between the serum creatine kinase (CK) level and aggressive behavior in patients with schizophrenia. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 2, 2018 Category: Psychiatry Authors: Xian-Dong Meng, Xi Cao, Tao Li, Ji-Ping Li Source Type: research

The association between schizophrenia and violence
In recent years Schizophrenia Research has published several important papers on the relationship between violence and psychosis. (Barkataki et al., 2005; Bulgari et al., 2017; Darrell-Berry et al., 2016; Imai et al., 2014; Large and Nielssen, 2011). Some of them are systematic reviews. A common weakness of many of the reviews in the field has been, however, that very broad terms have been used, particularly for violence and diagnostic categories. Violence is a broad concept, including everything from verbal threats and hostility to homicide. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 2, 2018 Category: Psychiatry Authors: Bj ørn Rishovd Rund Tags: Invited commentary Source Type: research

Second-to-fourth digit length ratio is associated with negative and affective symptoms in schizophrenia patients
Higher levels of circulating oestrogens in women and testosterone in men have been shown to have a protective effect against the clinical manifestations of schizophrenia, mostly with respect to negative symptomatology. Certain studies suggest that they also have a protective effect against the neuropsychological impairment observed in the disease. We investigated whether greater prenatal exposure to estrogens in women and to testosterone in men, reflected by the 2D:4D ratio, was similarly associated with decreased negative symptomatology and improved neuropsychological functioning in patients. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 1, 2018 Category: Psychiatry Authors: Nataly Paipa, Christian Stephan-Otto, Jorge Cuevas-Esteban, Araceli N úñez-Navarro, Judith Usall, Gildas Brébion Source Type: research

Associations between clinical and psychosocial factors and metabolic and cardiovascular risk factors in overweight patients with schizophrenia spectrum disorders – Baseline and two-years findings from the CHANGE trial
People with severe mental disorders die averagely 15years earlier than people in the Western background population, cardiovascular disease being the most frequent cause of death with unhealthy eating habits and lower levels of physical activity as major contributing risk factors. Understanding possible associations and predictors of the specific cardiovascular risk may permit more targeted and effective prevention. The aim of this study was to investigate the associations between clinical and psychosocial factors and several separate cardiovascular risk factors in a cohort of 428 persons with schizophrenia and abdominal ob...
Source: Schizophrenia Research - March 1, 2018 Category: Psychiatry Authors: Ane Storch Jakobsen, Helene Speyer, Hans Christian Brix N ørgaard, Carsten Hjorthøj, Jesper Krogh, Ole Mors, Merete Nordentoft Source Type: research

Effects of a lifestyle intervention on psychosocial well-being of severe mentally ill residential patients: ELIPS, a cluster randomized controlled pragmatic trial
Large studies investigating the psychosocial effects of lifestyle interventions in patients with a severe mental illness (SMI) are scarce, especially in residential patients. This large, randomized controlled, multicentre pragmatic trial assessed the psychosocial effects of a combined diet-and-exercise lifestyle intervention targeting the obesogenic environment of SMI residential patients. Twenty-nine sheltered and clinical care teams were randomized into intervention (n=15) or control (n=14) arm. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 1, 2018 Category: Psychiatry Authors: Annemarie P.M. Stiekema, Anne Looijmans, Lisette van der Meer, Richard Bruggeman, Robert A. Schoevers, Eva Corpeleijn, Frederike J örg Source Type: research

Potentially fatal outcomes associated with clozapine
Clozapine has been shown to be the most efficacious therapy for treatment resistant schizophrenia, estimated at one third of all schizophrenia cases. There is significant morbidity and mortality associated with clozapine including risk of agranulocytosis, aspiration pneumonia, bowel ischemia, myocarditis, seizures, and weight gain. Here we present a case of a 62-year-old man with chronic paranoid schizophrenia refractory to numerous antipsychotics who was started on clozapine therapy during an acute inpatient psychiatric admission. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 1, 2018 Category: Psychiatry Authors: Kevin J. Li, Ronald J. Gurrera, Lynn E. Delisi Source Type: research

Corrigendum to “Phenotype continuum between autism and schizophrenia: Evidence from the Movie for the Assessment of the social cognition (MASC)” [Schizophr. Res. 185 (2017) 161–166]
The authors regret. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 1, 2018 Category: Psychiatry Authors: Gilles Martinez, Charlotte Alexandre, C élia Mam-Lam-Fook, Narjes Bendjemaa, Raphaël Gaillard, Patricia Garel, Isabel Dziobek, Isabelle Amado, Marie-Odile Krebs Tags: Corrigendum Source Type: research

Editorial Board
(Source: Schizophrenia Research)
Source: Schizophrenia Research - March 1, 2018 Category: Psychiatry Source Type: research

In this Issue
Bonfiolo and colleagues (Bonfioli et al., 2018) conducted a randomized controlled trial of a physical activity intervention in 326 research participants with schizophrenia. Given the morbidity and mortality associated with sedentary behaviors for individuals with psychotic spectrum illnesses, their results of a nearly 25% improvement in at least one or more World Health Organization criteria for diet and exercise versus approximately 12% for the control group are encouraging. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 1, 2018 Category: Psychiatry Authors: John Torous Source Type: research

Corrigendum to “Therapeutic Effectiveness and Tolerability of Aripiprazole as Initial Choice of Treatment in First Episode Psychosis in an Early Intervention Service: A One-Year Outcome Study” [Schizophr. Res. 147, 120-125]
The authors ’ acknowledgment of funding was inadvertently excluded from the original publication. It should read as follows: (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 1, 2018 Category: Psychiatry Authors: Ashok Malla, Sally Mustafa, Aldanie Rho, Sherezad Abadi, Martin Lepage, Ridha Joober Tags: Corrigendum Source Type: research

Second-to-fourth digit length ratio is associated with negative and affective symptoms in schizophrenia patients
Higher levels of circulating oestrogens in women and testosterone in men have been shown to have a protective effect against the clinical manifestations of schizophrenia, mostly with respect to negative symptomatology. Certain studies suggest that they also have a protective effect against the neuropsychological impairment observed in the disease. We investigated whether greater prenatal exposure to estrogens in women and to testosterone in men, reflected by the 2D:4D ratio, was similarly associated with decreased negative symptomatology and improved neuropsychological functioning in patients. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 1, 2018 Category: Psychiatry Authors: Nataly Paipa, Christian Stephan-Otto, Jorge Cuevas-Esteban, Araceli N úñez-Navarro, Judith Usall, Gildas Brébion Source Type: research

Associations between clinical and psychosocial factors and metabolic and cardiovascular risk factors in overweight patients with schizophrenia spectrum disorders – Baseline and two-years findings from the CHANGE trial
People with severe mental disorders die averagely 15years earlier than people in the Western background population, cardiovascular disease being the most frequent cause of death with unhealthy eating habits and lower levels of physical activity as major contributing risk factors. Understanding possible associations and predictors of the specific cardiovascular risk may permit more targeted and effective prevention. The aim of this study was to investigate the associations between clinical and psychosocial factors and several separate cardiovascular risk factors in a cohort of 428 persons with schizophrenia and abdominal ob...
Source: Schizophrenia Research - March 1, 2018 Category: Psychiatry Authors: Ane Storch Jakobsen, Helene Speyer, Hans Christian Brix N ørgaard, Carsten Hjorthøj, Jesper Krogh, Ole Mors, Merete Nordentoft Source Type: research

Effects of a lifestyle intervention on psychosocial well-being of severe mentally ill residential patients: ELIPS, a cluster randomized controlled pragmatic trial
Large studies investigating the psychosocial effects of lifestyle interventions in patients with a severe mental illness (SMI) are scarce, especially in residential patients. This large, randomized controlled, multicentre pragmatic trial assessed the psychosocial effects of a combined diet-and-exercise lifestyle intervention targeting the obesogenic environment of SMI residential patients. Twenty-nine sheltered and clinical care teams were randomized into intervention (n=15) or control (n=14) arm. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 1, 2018 Category: Psychiatry Authors: Annemarie P.M. Stiekema, Anne Looijmans, Lisette van der Meer, Richard Bruggeman, Robert A. Schoevers, Eva Corpeleijn, Frederike J örg Source Type: research

Potentially fatal outcomes associated with clozapine
Clozapine has been shown to be the most efficacious therapy for treatment resistant schizophrenia, estimated at one third of all schizophrenia cases. There is significant morbidity and mortality associated with clozapine including risk of agranulocytosis, aspiration pneumonia, bowel ischemia, myocarditis, seizures, and weight gain. Here we present a case of a 62-year-old man with chronic paranoid schizophrenia refractory to numerous antipsychotics who was started on clozapine therapy during an acute inpatient psychiatric admission. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 1, 2018 Category: Psychiatry Authors: Kevin J. Li, Ronald J. Gurrera, Lynn E. Delisi Source Type: research

Emotional context restores cortical prediction error responses in schizophrenia
The mismatch negativity (MMN) deficit in schizophrenia is a consistently replicated finding and is considered a potential biomarker. From the cognitive neuroscience perspective, MMN represents a cortical correlate of the prediction error, a fundamental computational operator that may be at the core of various cognitive and clinical deficits observed in schizophrenia. The impact of emotion on cognitive processes in schizophrenia is insufficiently understood, and its impact on basic operators of cortical computation is largely unknown. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 28, 2018 Category: Psychiatry Authors: Bob O. Vogel, Joanna Stasch, Henrik Walter, Andres H. Neuhaus Source Type: research

Regulatory characterisation of the schizophrenia-associated CACNA1C proximal promoter and the potential role for the transcription factor EZH2 in schizophrenia aetiology
Genomic wide association studies identified the CACNA1C locus as genetically associated with both schizophrenia and bipolar affective disorder. CACNA1C encodes Cav1.2, one of four subunits of L-type voltage gated calcium channels. Variation resides in non-coding regions of CACNA1C which interact with the promoter and are validated expression quantitative trait loci. Using reporter gene constructs we demonstrate the CACNA1C promoter is a major mediator of inducible regulation of CACNA1C activity in the SH-SY5Y neuroblastoma cell line. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 28, 2018 Category: Psychiatry Authors: Kimberley J. Billingsley, Maurizio Manca, Olympia Gianfrancesco, David A. Collier, Helen Sharp, Vivien J. Bubb, John P. Quinn Source Type: research

Emotional context restores cortical prediction error responses in schizophrenia
The mismatch negativity (MMN) deficit in schizophrenia is a consistently replicated finding and is considered a potential biomarker. From the cognitive neuroscience perspective, MMN represents a cortical correlate of the prediction error, a fundamental computational operator that may be at the core of various cognitive and clinical deficits observed in schizophrenia. The impact of emotion on cognitive processes in schizophrenia is insufficiently understood, and its impact on basic operators of cortical computation is largely unknown. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 28, 2018 Category: Psychiatry Authors: Bob O. Vogel, Joanna Stasch, Henrik Walter, Andres H. Neuhaus Source Type: research

Regulatory characterisation of the schizophrenia-associated CACNA1C proximal promoter and the potential role for the transcription factor EZH2 in schizophrenia aetiology
Genomic wide association studies identified the CACNA1C locus as genetically associated with both schizophrenia and bipolar affective disorder. CACNA1C encodes Cav1.2, one of four subunits of L-type voltage gated calcium channels. Variation resides in non-coding regions of CACNA1C which interact with the promoter and are validated expression quantitative trait loci. Using reporter gene constructs we demonstrate the CACNA1C promoter is a major mediator of inducible regulation of CACNA1C activity in the SH-SY5Y neuroblastoma cell line. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 28, 2018 Category: Psychiatry Authors: Kimberley J. Billingsley, Maurizio Manca, Olympia Gianfrancesco, David A. Collier, Helen Sharp, Vivien J. Bubb, John P. Quinn Source Type: research

Anhedonia reflects impairment in making relative value judgments between positive and neutral stimuli in schizophrenia
Anhedonia (i.e., diminished capacity to experience pleasure) has traditionally been viewed as a core symptom of schizophrenia (SZ). However, modern laboratory-based studies suggest that this definition may be incorrect, as hedonic capacity may be intact. Alternative conceptualizations have proposed that anhedonia may reflect an impairment in generating mental representations of affective value that are needed to guide decision-making and initiate motivated behavior. The current study evaluated this hypothesis in 42 outpatients with SZ and 19 healthy controls (CN) who completed two tasks: (a) an emotional experience task th...
Source: Schizophrenia Research - February 27, 2018 Category: Psychiatry Authors: Gregory P. Strauss, Katherine Frost Visser, William R. Keller, James M. Gold, Robert W. Buchanan Source Type: research