Effects of a lifestyle intervention on psychosocial well-being of severe mentally ill residential patients: ELIPS, a cluster randomized controlled pragmatic trial
Large studies investigating the psychosocial effects of lifestyle interventions in patients with a severe mental illness (SMI) are scarce, especially in residential patients. This large, randomized controlled, multicentre pragmatic trial assessed the psychosocial effects of a combined diet-and-exercise lifestyle intervention targeting the obesogenic environment of SMI residential patients. Twenty-nine sheltered and clinical care teams were randomized into intervention (n=15) or control (n=14) arm. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 1, 2018 Category: Psychiatry Authors: Annemarie P.M. Stiekema, Anne Looijmans, Lisette van der Meer, Richard Bruggeman, Robert A. Schoevers, Eva Corpeleijn, Frederike J örg Source Type: research

Potentially fatal outcomes associated with clozapine
Clozapine has been shown to be the most efficacious therapy for treatment resistant schizophrenia, estimated at one third of all schizophrenia cases. There is significant morbidity and mortality associated with clozapine including risk of agranulocytosis, aspiration pneumonia, bowel ischemia, myocarditis, seizures, and weight gain. Here we present a case of a 62-year-old man with chronic paranoid schizophrenia refractory to numerous antipsychotics who was started on clozapine therapy during an acute inpatient psychiatric admission. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 1, 2018 Category: Psychiatry Authors: Kevin J. Li, Ronald J. Gurrera, Lynn E. Delisi Source Type: research

Emotional context restores cortical prediction error responses in schizophrenia
The mismatch negativity (MMN) deficit in schizophrenia is a consistently replicated finding and is considered a potential biomarker. From the cognitive neuroscience perspective, MMN represents a cortical correlate of the prediction error, a fundamental computational operator that may be at the core of various cognitive and clinical deficits observed in schizophrenia. The impact of emotion on cognitive processes in schizophrenia is insufficiently understood, and its impact on basic operators of cortical computation is largely unknown. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 28, 2018 Category: Psychiatry Authors: Bob O. Vogel, Joanna Stasch, Henrik Walter, Andres H. Neuhaus Source Type: research

Regulatory characterisation of the schizophrenia-associated CACNA1C proximal promoter and the potential role for the transcription factor EZH2 in schizophrenia aetiology
Genomic wide association studies identified the CACNA1C locus as genetically associated with both schizophrenia and bipolar affective disorder. CACNA1C encodes Cav1.2, one of four subunits of L-type voltage gated calcium channels. Variation resides in non-coding regions of CACNA1C which interact with the promoter and are validated expression quantitative trait loci. Using reporter gene constructs we demonstrate the CACNA1C promoter is a major mediator of inducible regulation of CACNA1C activity in the SH-SY5Y neuroblastoma cell line. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 28, 2018 Category: Psychiatry Authors: Kimberley J. Billingsley, Maurizio Manca, Olympia Gianfrancesco, David A. Collier, Helen Sharp, Vivien J. Bubb, John P. Quinn Source Type: research

Emotional context restores cortical prediction error responses in schizophrenia
The mismatch negativity (MMN) deficit in schizophrenia is a consistently replicated finding and is considered a potential biomarker. From the cognitive neuroscience perspective, MMN represents a cortical correlate of the prediction error, a fundamental computational operator that may be at the core of various cognitive and clinical deficits observed in schizophrenia. The impact of emotion on cognitive processes in schizophrenia is insufficiently understood, and its impact on basic operators of cortical computation is largely unknown. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 28, 2018 Category: Psychiatry Authors: Bob O. Vogel, Joanna Stasch, Henrik Walter, Andres H. Neuhaus Source Type: research

Regulatory characterisation of the schizophrenia-associated CACNA1C proximal promoter and the potential role for the transcription factor EZH2 in schizophrenia aetiology
Genomic wide association studies identified the CACNA1C locus as genetically associated with both schizophrenia and bipolar affective disorder. CACNA1C encodes Cav1.2, one of four subunits of L-type voltage gated calcium channels. Variation resides in non-coding regions of CACNA1C which interact with the promoter and are validated expression quantitative trait loci. Using reporter gene constructs we demonstrate the CACNA1C promoter is a major mediator of inducible regulation of CACNA1C activity in the SH-SY5Y neuroblastoma cell line. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 28, 2018 Category: Psychiatry Authors: Kimberley J. Billingsley, Maurizio Manca, Olympia Gianfrancesco, David A. Collier, Helen Sharp, Vivien J. Bubb, John P. Quinn Source Type: research

Anhedonia reflects impairment in making relative value judgments between positive and neutral stimuli in schizophrenia
Anhedonia (i.e., diminished capacity to experience pleasure) has traditionally been viewed as a core symptom of schizophrenia (SZ). However, modern laboratory-based studies suggest that this definition may be incorrect, as hedonic capacity may be intact. Alternative conceptualizations have proposed that anhedonia may reflect an impairment in generating mental representations of affective value that are needed to guide decision-making and initiate motivated behavior. The current study evaluated this hypothesis in 42 outpatients with SZ and 19 healthy controls (CN) who completed two tasks: (a) an emotional experience task th...
Source: Schizophrenia Research - February 27, 2018 Category: Psychiatry Authors: Gregory P. Strauss, Katherine Frost Visser, William R. Keller, James M. Gold, Robert W. Buchanan Source Type: research

Damage to the left uncinate fasciculus is associated with heightened schizotypal traits: A multimodal lesion-mapping study
A growing body of evidence suggests that individuals with pronounced schizotypal traits also display particular neurophysiological and morphological features – notably with regard to left frontotemporal connectivity. However, the studies published to date have focused on subclinical subjects and psychiatric patients, rather than brain-damaged patients. Here, we used the French version of the Schizotypal Personality Questionnaire to assess schizotypal t raits in a sample of 97 patients having undergone surgical resection of a diffuse low-grade glioma. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 27, 2018 Category: Psychiatry Authors: Anne-Laure Lemaitre, Gilles Lafargue, Hugues Duffau, Guillaume Herbet Source Type: research

Temporal lobe thickness and verbal memory in first-degree relatives of individuals with schizophrenia
Cortical thinning in frontal and temporal regions has been reported in individuals diagnosed with schizophrenia and, less consistently, among their unaffected first-degree relatives. Likewise, first-degree relatives demonstrate attenuated differences in neurocognitive performance relative to healthy controls, indicating that neurocognitive performance may be an important endophenotype of the disorder. Less is known about how cortical thickness relates to neurocognitive performance in these individuals. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 27, 2018 Category: Psychiatry Authors: Vindia G. Fernandez, Robert Asarnow, Katherine L. Narr, Kenneth L. Subotnik, Heidi Kuppinger, David Fogelson, Keith H. Nuechterlein Source Type: research

Shorter telomere length in people with schizophrenia who live alone?
Human telomeres are repeated DNA-protein sequences (i.e., TTAGGG) that cap the ends of chromosomes and protect against chromosomal instability during cell replication (Blackburn and Epel, 2012). However, as a consequence of cell division, telomeres progressively get shorter with age, and a number of environmental factors, including psychosocial stress, may accelerate this shortening (Lin et al., 2012). Recent studies have found that shorter telomere length may be associated with schizophrenia (Rao et al., 2016), however, the specific contributing factors remain unknown. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 27, 2018 Category: Psychiatry Authors: Ryan P. Balzan, Varinderpal S. Dhillon, Dennis Liu, Lisa Hahn, Michael F. Fenech, Cherrie Galletly Tags: Letter to the editor Source Type: research

Schizophrenia-associated rs4702 G allele-specific downregulation of FURIN expression by miR-338-3p reduces BDNF production
Genome-wide association studies (GWAS) reveal numerous schizophrenia (SCZ)-associated single-nucleotide polymorphisms (SNPs); however, functional characterizations of the risk variants remain to be established. Using data from 108 SCZ GWAS loci, we performed systematic miRNA binding site screening of 128 SCZ-associated SNPs and found that 2 out of 3 SNPs located in the 3 ′UTR were predicted to alter 3 miRNAs' binding sites in 2 target genes. Of the identified SNPs, the most genome-wide significant SNP rs4702 (A/G) in the FURIN 3′UTR, previously identified as an SCZ-associated cis-expression quantitative trait l...
Source: Schizophrenia Research - February 27, 2018 Category: Psychiatry Authors: Yu Hou, Wenquan Liang, Jian Zhang, Qiyang Li, Haiyan Ou, Zhongju Wang, Shufen Li, Xingbing Huang, Cunyou Zhao Source Type: research

Validation of the importance of continua in representing delusional ideation in the general population
Previous studies have examined the distribution of psychotic like experiences (PLE) with the aim of informing the debate concerning the categorical versus continuous nature of psychosis. We extend this research by subjecting a number of competing models of delusional ideation to validation analysis to further examine previous findings. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 27, 2018 Category: Psychiatry Authors: Kim S. Betts, James Scott, Gail M. Williams, Jacob M. Najman, Rosa Alati Source Type: research

Proverb comprehension deficits in patients with schizophrenia —Neurocognitive and social cognitive correlates
Proverbs are used to communicate norms, to create intimacy, and to convey complex relations between people and their worldview (Gibbs 2001). Accordingly, the everyday communication of schizophrenic patients, for whom proverb comprehension has been described as deficient, suffers under their tendency to interpret proverbs literally. However, even though schizophrenic patients' proverb comprehension deficits are well known, much uncertainty still exists about the causes of those deficits and different theories have been proposed (Thoma and Daum 2006). (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 27, 2018 Category: Psychiatry Authors: Margaux Mohnke, Claudia Bach, Daniela Roesch-Ely Tags: Letter to the Editor Source Type: research

TNF- α and IL-6 are associated with the deficit syndrome and negative symptoms in patients with chronic schizophrenia
Increased inflammatory markers have been found in patients with chronic schizophrenia, and have been associated with negative symptoms. The deficit syndrome is a distinct subtype of schizophrenia, characterized by primary and enduring negative symptoms. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 27, 2018 Category: Psychiatry Authors: David R. Goldsmith, Ebrahim Haroon, Andrew H. Miller, Gregory P. Strauss, Peter F. Buckley, Brian J. Miller Source Type: research

Anhedonia reflects impairment in making relative value judgments between positive and neutral stimuli in schizophrenia
Anhedonia (i.e., diminished capacity to experience pleasure) has traditionally been viewed as a core symptom of schizophrenia (SZ). However, modern laboratory-based studies suggest that this definition may be incorrect, as hedonic capacity may be intact. Alternative conceptualizations have proposed that anhedonia may reflect an impairment in generating mental representations of affective value that are needed to guide decision-making and initiate motivated behavior. The current study evaluated this hypothesis in 42 outpatients with SZ and 19 healthy controls (CN) who completed two tasks: (a) an emotional experience task th...
Source: Schizophrenia Research - February 27, 2018 Category: Psychiatry Authors: Gregory P. Strauss, Katherine Frost Visser, William R. Keller, James M. Gold, Robert W. Buchanan Source Type: research

Damage to the left uncinate fasciculus is associated with heightened schizotypal traits: A multimodal lesion-mapping study
A growing body of evidence suggests that individuals with pronounced schizotypal traits also display particular neurophysiological and morphological features – notably with regard to left frontotemporal connectivity. However, the studies published to date have focused on subclinical subjects and psychiatric patients, rather than brain-damaged patients. Here, we used the French version of the Schizotypal Personality Questionnaire to assess schizotypal t raits in a sample of 97 patients having undergone surgical resection of a diffuse low-grade glioma. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 27, 2018 Category: Psychiatry Authors: Anne-Laure Lemaitre, Gilles Lafargue, Hugues Duffau, Guillaume Herbet Source Type: research

Temporal lobe thickness and verbal memory in first-degree relatives of individuals with schizophrenia
Cortical thinning in frontal and temporal regions has been reported in individuals diagnosed with schizophrenia and, less consistently, among their unaffected first-degree relatives. Likewise, first-degree relatives demonstrate attenuated differences in neurocognitive performance relative to healthy controls, indicating that neurocognitive performance may be an important endophenotype of the disorder. Less is known about how cortical thickness relates to neurocognitive performance in these individuals. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 27, 2018 Category: Psychiatry Authors: Vindia G. Fernandez, Robert Asarnow, Katherine L. Narr, Kenneth L. Subotnik, Heidi Kuppinger, David Fogelson, Keith H. Nuechterlein Source Type: research

Shorter telomere length in people with schizophrenia who live alone?
Human telomeres are repeated DNA-protein sequences (i.e., TTAGGG) that cap the ends of chromosomes and protect against chromosomal instability during cell replication (Blackburn and Epel, 2012). However, as a consequence of cell division, telomeres progressively get shorter with age, and a number of environmental factors, including psychosocial stress, may accelerate this shortening (Lin et al., 2012). Recent studies have found that shorter telomere length may be associated with schizophrenia (Rao et al., 2016), however, the specific contributing factors remain unknown. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 27, 2018 Category: Psychiatry Authors: Ryan P. Balzan, Varinderpal S. Dhillon, Dennis Liu, Lisa Hahn, Michael F. Fenech, Cherrie Galletly Tags: Letter to the editor Source Type: research

Schizophrenia-associated rs4702 G allele-specific downregulation of FURIN expression by miR-338-3p reduces BDNF production
Genome-wide association studies (GWAS) reveal numerous schizophrenia (SCZ)-associated single-nucleotide polymorphisms (SNPs); however, functional characterizations of the risk variants remain to be established. Using data from 108 SCZ GWAS loci, we performed systematic miRNA binding site screening of 128 SCZ-associated SNPs and found that 2 out of 3 SNPs located in the 3 ′UTR were predicted to alter 3 miRNAs' binding sites in 2 target genes. Of the identified SNPs, the most genome-wide significant SNP rs4702 (A/G) in the FURIN 3′UTR, previously identified as an SCZ-associated cis-expression quantitative trait l...
Source: Schizophrenia Research - February 27, 2018 Category: Psychiatry Authors: Yu Hou, Wenquan Liang, Jian Zhang, Qiyang Li, Haiyan Ou, Zhongju Wang, Shufen Li, Xingbing Huang, Cunyou Zhao Source Type: research

Validation of the importance of continua in representing delusional ideation in the general population
Previous studies have examined the distribution of psychotic like experiences (PLE) with the aim of informing the debate concerning the categorical versus continuous nature of psychosis. We extend this research by subjecting a number of competing models of delusional ideation to validation analysis to further examine previous findings. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 27, 2018 Category: Psychiatry Authors: Kim S. Betts, James Scott, Gail M. Williams, Jacob M. Najman, Rosa Alati Source Type: research

Proverb comprehension deficits in patients with schizophrenia —Neurocognitive and social cognitive correlates
Proverbs are used to communicate norms, to create intimacy, and to convey complex relations between people and their worldview (Gibbs 2001). Accordingly, the everyday communication of schizophrenic patients, for whom proverb comprehension has been described as deficient, suffers under their tendency to interpret proverbs literally. However, even though schizophrenic patients' proverb comprehension deficits are well known, much uncertainty still exists about the causes of those deficits and different theories have been proposed (Thoma and Daum 2006). (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 27, 2018 Category: Psychiatry Authors: Margaux Mohnke, Claudia Bach, Daniela Roesch-Ely Tags: Letter to the Editor Source Type: research

TNF- α and IL-6 are associated with the deficit syndrome and negative symptoms in patients with chronic schizophrenia
Increased inflammatory markers have been found in patients with chronic schizophrenia, and have been associated with negative symptoms. The deficit syndrome is a distinct subtype of schizophrenia, characterized by primary and enduring negative symptoms. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 27, 2018 Category: Psychiatry Authors: David R. Goldsmith, Ebrahim Haroon, Andrew H. Miller, Gregory P. Strauss, Peter F. Buckley, Brian J. Miller Source Type: research

Eosinopenia in women with schizophrenia: Drug-induced or a sign of gender specific difference in pathogenesis?
The amount of literature investigating the immunological and epigenetic aspects of schizophrenia is vastly growing. The involvement of immunological aspects presents itself e.g. in an altered distribution of leukocytes amongst patients with schizophrenia, compared to healthy controls (Voss et al., 2000). Sex has been proposed to be of significance to both etiology of schizophrenia (Chase et al., 2015) and to response to pharmacological treatment (Morag et al., 2013). The antipsychotic drug Clozapine is associated with several types of blood dyscrasia, including an increased risk of transient female eosinophilia (Rajagopal,...
Source: Schizophrenia Research - February 26, 2018 Category: Psychiatry Authors: M.I. Jakobsen, A. Fink-Jensen Tags: Letter to the Editor Source Type: research

Abnormal expression of ER quality control and ER associated degradation proteins in the dorsolateral prefrontal cortex in schizophrenia
Abnormalities in posttranslational protein modifications (PTMs) that regulate protein targeting, trafficking, synthesis, and function have been implicated in the pathophysiology of schizophrenia. The endoplasmic reticulum (ER) contains specialized machinery that facilitate protein synthesis, ER entry and exit, quality control, and post-translational processing, steps required for protein maturation. Dysregulation of these systems could represent potential mechanisms for abnormalities of neurotransmitter associated proteins in schizophrenia. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 26, 2018 Category: Psychiatry Authors: Pitna Kim, Madeline R. Scott, James H. Meador-Woodruff Source Type: research

Mothers with acute and chronic postpartum psychoses and impact on the mother-infant interaction
Maternal postpartum psychoses pose a serious risk to the mother-infant interaction. It is unclear how different subtypes of postpartum psychosis, including acute and chronic, might differentially affect the mother-infant interaction. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 26, 2018 Category: Psychiatry Authors: Brigitte Ramsauer, Sandra Achtergarde Source Type: research

Eosinopenia in women with schizophrenia: Drug-induced or a sign of gender specific difference in pathogenesis?
The amount of literature investigating the immunological and epigenetic aspects of schizophrenia is vastly growing. The involvement of immunological aspects presents itself e.g. in an altered distribution of leukocytes amongst patients with schizophrenia, compared to healthy controls (Voss et al., 2000). Sex has been proposed to be of significance to both etiology of schizophrenia (Chase et al., 2015) and to response to pharmacological treatment (Morag et al., 2013). The antipsychotic drug Clozapine is associated with several types of blood dyscrasia, including an increased risk of transient female eosinophilia (Rajagopal,...
Source: Schizophrenia Research - February 26, 2018 Category: Psychiatry Authors: M.I. Jakobsen, A. Fink-Jensen Tags: Letter to the Editor Source Type: research

Abnormal expression of ER quality control and ER associated degradation proteins in the dorsolateral prefrontal cortex in schizophrenia
Abnormalities in posttranslational protein modifications (PTMs) that regulate protein targeting, trafficking, synthesis, and function have been implicated in the pathophysiology of schizophrenia. The endoplasmic reticulum (ER) contains specialized machinery that facilitate protein synthesis, ER entry and exit, quality control, and post-translational processing, steps required for protein maturation. Dysregulation of these systems could represent potential mechanisms for abnormalities of neurotransmitter associated proteins in schizophrenia. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 26, 2018 Category: Psychiatry Authors: Pitna Kim, Madeline R. Scott, James H. Meador-Woodruff Source Type: research

Mothers with acute and chronic postpartum psychoses and impact on the mother-infant interaction
Maternal postpartum psychoses pose a serious risk to the mother-infant interaction. It is unclear how different subtypes of postpartum psychosis, including acute and chronic, might differentially affect the mother-infant interaction. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 26, 2018 Category: Psychiatry Authors: Brigitte Ramsauer, Sandra Achtergarde Source Type: research

Effects of short-term, high-frequency repetitive transcranial magnetic stimulation to bilateral dorsolateral prefrontal cortex on smoking behavior and cognition in patients with schizophrenia and non-psychiatric controls
High rates of tobacco smoking and smoking cessation failure in schizophrenia may be related to prefrontal cortical dysfunction. Novel treatment options for tobacco use disorder are needed given the limited efficacy of current pharmacotherapies. Preliminary evidence suggests high-frequency repetitive transcranial magnetic stimulation (rTMS) to bilateral dorsolateral prefrontal cortex (DLPFC) may suppress tobacco craving in smokers with schizophrenia. The goal of this study was to determine effects of rTMS for tobacco craving and cognition using a short-term (3-day) human laboratory paradigm. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 24, 2018 Category: Psychiatry Authors: Karolina Kozak, Maryam Sharif-Razi, Marya Morozova, Erin V. Gaudette, Mera S. Barr, Zafiris J. Daskalakis, Daniel M. Blumberger, Tony P. George Source Type: research

What does the Managing Emotions branch of the MSCEIT add to the MATRICS consensus cognitive battery?
The Managing Emotions branch of the Mayer-Salovey-Caruso Emotional Intelligence Test (MSCEIT-ME) was included within the MATRICS Consensus Cognitive Battery (MCCB) as the measure of social cognition, although limited research has examined its associations with psychosocial functioning in people with schizophrenia or other severe mental illnesses. This secondary analysis with 107 participants examined what the MSCEIT-ME contributes to our understanding of functioning in this population, and whether it uniquely predicts psychosocial functioning after controlling for performance on the other MCCB tests and negative symptoms. ...
Source: Schizophrenia Research - February 24, 2018 Category: Psychiatry Authors: Nicole R. DeTore, Kim T. Mueser, Susan R. McGurk Source Type: research

Whole genome sequencing of 91 multiplex schizophrenia families reveals increased burden of rare, exonic copy number variation in schizophrenia probands and genetic heterogeneity
We report here the results from the CNV analysis of whole-genome sequences from 91 multiplex schizophrenia families. Employing four algorithms (CNVnator, Cn.mops, DELLY and LUMPY) to identify CNVs, we find 1231 rare deletions and 287 rare duplications in 300 individuals (77 with schizophrenia (SZ), 32 with schizoaffective disorder (SAD), 82 with another neuropsychiatric diagnosis and 109 unaffected). (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 24, 2018 Category: Psychiatry Authors: Fayeza F. Khan, Phillip E. Melton, Nina S. McCarthy, Bharti Morar, John Blangero, Eric K. Moses, Assen Jablensky Source Type: research

Clinical and cognitive correlates of unsheltered status in homeless persons with psychotic disorders
Homeless persons with psychosis are particularly susceptible to unsheltered homelessness, which includes living on the streets, in cars, and other places not meant for human habitation. Homeless persons with psychosis have distinct barriers to accessing care and comprise a high-need and hard-to-serve homeless subpopulation. Therefore, this study sought to understand unsheltered homelessness in persons with psychosis and its relationship to cognitive impairment, clinical symptoms, and community functioning, examined both categorically and dimensionally. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 24, 2018 Category: Psychiatry Authors: Katiah Llerena, Sonya Gabrielian, Michael F. Green Source Type: research

Virtual reality therapy for refractory auditory verbal hallucinations in schizophrenia: A pilot clinical trial
Schizophrenia is a chronic and severe mental illness that poses significant challenges. While many pharmacological and psychosocial interventions are available, many treatment-resistant schizophrenia patients continue to suffer from persistent psychotic symptoms, notably auditory verbal hallucinations (AVH), which are highly disabling. This unmet clinical need requires new innovative treatment options. Recently, a psychological therapy using computerized technology has shown large therapeutic effects on AVH severity by enabling patients to engage in a dialogue with a computerized representation of their voices. (Source: Sc...
Source: Schizophrenia Research - February 24, 2018 Category: Psychiatry Authors: Olivier Percie du Sert, St éphane Potvin, Olivier Lipp, Laura Dellazizzo, Mélanie Laurelli, Richard Breton, Pierre Lalonde, Kingsada Phraxayavong, Kieron O'Connor, Jean-François Pelletier, Tarik Boukhalfi, Patrice Renaud, Alexandre Dumais Source Type: research

Cardio-metabolic risk and its management in a cohort of clozapine-treated outpatients
To comprehensively assess cardio-metabolic risk factors and their management in a large sample of outpatients treated with clozapine. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 24, 2018 Category: Psychiatry Authors: Julia Margaret Lappin, Marlene Wijaya, Andrew Watkins, Rachel Morell, Scott Teasdale, Oscar Lederman, Simon Rosenbaum, Stephanie Dick, Philip Ward, Jackie Curtis Source Type: research

Effects of short-term, high-frequency repetitive transcranial magnetic stimulation to bilateral dorsolateral prefrontal cortex on smoking behavior and cognition in patients with schizophrenia and non-psychiatric controls
High rates of tobacco smoking and smoking cessation failure in schizophrenia may be related to prefrontal cortical dysfunction. Novel treatment options for tobacco use disorder are needed given the limited efficacy of current pharmacotherapies. Preliminary evidence suggests high-frequency repetitive transcranial magnetic stimulation (rTMS) to bilateral dorsolateral prefrontal cortex (DLPFC) may suppress tobacco craving in smokers with schizophrenia. The goal of this study was to determine effects of rTMS for tobacco craving and cognition using a short-term (3-day) human laboratory paradigm. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 24, 2018 Category: Psychiatry Authors: Karolina Kozak, Maryam Sharif-Razi, Marya Morozova, Erin V. Gaudette, Mera S. Barr, Zafiris J. Daskalakis, Daniel M. Blumberger, Tony P. George Source Type: research

What does the Managing Emotions branch of the MSCEIT add to the MATRICS consensus cognitive battery?
The Managing Emotions branch of the Mayer-Salovey-Caruso Emotional Intelligence Test (MSCEIT-ME) was included within the MATRICS Consensus Cognitive Battery (MCCB) as the measure of social cognition, although limited research has examined its associations with psychosocial functioning in people with schizophrenia or other severe mental illnesses. This secondary analysis with 107 participants examined what the MSCEIT-ME contributes to our understanding of functioning in this population, and whether it uniquely predicts psychosocial functioning after controlling for performance on the other MCCB tests and negative symptoms. ...
Source: Schizophrenia Research - February 24, 2018 Category: Psychiatry Authors: Nicole R. DeTore, Kim T. Mueser, Susan R. McGurk Source Type: research

Whole genome sequencing of 91 multiplex schizophrenia families reveals increased burden of rare, exonic copy number variation in schizophrenia probands and genetic heterogeneity
We report here the results from the CNV analysis of whole-genome sequences from 91 multiplex schizophrenia families. Employing four algorithms (CNVnator, Cn.mops, DELLY and LUMPY) to identify CNVs, we find 1231 rare deletions and 287 rare duplications in 300 individuals (77 with schizophrenia (SZ), 32 with schizoaffective disorder (SAD), 82 with another neuropsychiatric diagnosis and 109 unaffected). (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 24, 2018 Category: Psychiatry Authors: Fayeza F. Khan, Phillip E. Melton, Nina S. McCarthy, Bharti Morar, John Blangero, Eric K. Moses, Assen Jablensky Source Type: research

Clinical and cognitive correlates of unsheltered status in homeless persons with psychotic disorders
Homeless persons with psychosis are particularly susceptible to unsheltered homelessness, which includes living on the streets, in cars, and other places not meant for human habitation. Homeless persons with psychosis have distinct barriers to accessing care and comprise a high-need and hard-to-serve homeless subpopulation. Therefore, this study sought to understand unsheltered homelessness in persons with psychosis and its relationship to cognitive impairment, clinical symptoms, and community functioning, examined both categorically and dimensionally. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 24, 2018 Category: Psychiatry Authors: Katiah Llerena, Sonya Gabrielian, Michael F. Green Source Type: research

Virtual reality therapy for refractory auditory verbal hallucinations in schizophrenia: A pilot clinical trial
Schizophrenia is a chronic and severe mental illness that poses significant challenges. While many pharmacological and psychosocial interventions are available, many treatment-resistant schizophrenia patients continue to suffer from persistent psychotic symptoms, notably auditory verbal hallucinations (AVH), which are highly disabling. This unmet clinical need requires new innovative treatment options. Recently, a psychological therapy using computerized technology has shown large therapeutic effects on AVH severity by enabling patients to engage in a dialogue with a computerized representation of their voices. (Source: Sc...
Source: Schizophrenia Research - February 24, 2018 Category: Psychiatry Authors: Olivier Percie du Sert, St éphane Potvin, Olivier Lipp, Laura Dellazizzo, Mélanie Laurelli, Richard Breton, Pierre Lalonde, Kingsada Phraxayavong, Kieron O'Connor, Jean-François Pelletier, Tarik Boukhalfi, Patrice Renaud, Alexandre Dumais Source Type: research

Cardio-metabolic risk and its management in a cohort of clozapine-treated outpatients
To comprehensively assess cardio-metabolic risk factors and their management in a large sample of outpatients treated with clozapine. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 24, 2018 Category: Psychiatry Authors: Julia Margaret Lappin, Marlene Wijaya, Andrew Watkins, Rachel Morell, Scott Teasdale, Oscar Lederman, Simon Rosenbaum, Stephanie Dick, Philip Ward, Jackie Curtis Source Type: research

Virus discovery analyses on post-mortem brain tissue and cerebrospinal fluid of schizophrenia patients
Dear Editors (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 22, 2018 Category: Psychiatry Authors: Jakub Tomasik, Saskia L. Smits, F. Markus Leweke, Pawe ł Eljasz, Suzan Pas, René S. Kahn, Albert D.M.E. Osterhaus, Sabine Bahn, Lot D. de Witte Tags: Letter to the Editor Source Type: research

Metabolic screening for patients with second-generation antipsychotic medication: A population-based study from 2004 to 2016
Patients with severe mental disorders have excess mortality due to preventable physical diseases, especially cardiovascular disease (Crump et al., 2013). One of the major risk factors for cardiovascular diseases is metabolic syndrome (Kaur, 2014), yet it has been reported that the prevalence for patients to develop metabolic syndrome doubles that of the general population (Riordan et al., 2011). A link between second-generation antipsychotic medications and the increased risk for both metabolic and cardiovascular abnormalities has been proposed (De Hert et al., 2012). (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 22, 2018 Category: Psychiatry Authors: Edwin H.M. Lee, Christy L.M. Hui, Eunice Y.L. Law, P.Y. Chan, W.C. Chang, Sherry K.W. Chan, Eric Y.H. Chen Tags: Letter to the Editor Source Type: research

Virus discovery analyses on post-mortem brain tissue and cerebrospinal fluid of schizophrenia patients
Dear Editors (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 22, 2018 Category: Psychiatry Authors: Jakub Tomasik, Saskia L. Smits, F. Markus Leweke, Pawe ł Eljasz, Suzan Pas, René S. Kahn, Albert D.M.E. Osterhaus, Sabine Bahn, Lot D. de Witte Tags: Letter to the Editor Source Type: research

Metabolic screening for patients with second-generation antipsychotic medication: A population-based study from 2004 to 2016
Patients with severe mental disorders have excess mortality due to preventable physical diseases, especially cardiovascular disease (Crump et al., 2013). One of the major risk factors for cardiovascular diseases is metabolic syndrome (Kaur, 2014), yet it has been reported that the prevalence for patients to develop metabolic syndrome doubles that of the general population (Riordan et al., 2011). A link between second-generation antipsychotic medications and the increased risk for both metabolic and cardiovascular abnormalities has been proposed (De Hert et al., 2012). (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 22, 2018 Category: Psychiatry Authors: Edwin H.M. Lee, Christy L.M. Hui, Eunice Y.L. Law, P.Y. Chan, W.C. Chang, Sherry K.W. Chan, Eric Y.H. Chen Tags: Letter to the Editor Source Type: research

Psychotic experiences among police officers working in high-stress situations
Childhood trauma is a well-established risk factors for psychosis in adulthood (Kelleher et al., 2013). Recent work has suggested that this may be mediated by trauma exposure in adulthood, which frequently occurs among individuals exposed to childhood trauma and has likewise been linked to psychosis (Bhavsar et al., 2017). Nonetheless, trauma exposure in adulthood has been less studied in relation to psychosis, with some exceptions (e.g., crime victimization; Newbury et al., 2017; intimate partner violence: Shah et al., 2017). (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 21, 2018 Category: Psychiatry Authors: Jordan E. DeVylder Tags: Letter to the editor Source Type: research

Neuromelanin magnetic resonance imaging of the substantia nigra in first episode psychosis patients consumers of illicit substances
Neuromelanin (NM) is a by-product of the metabolism of noradrenalin and dopamine, neurotransmitters which are mainly distributed in the Substantia Nigra (SN) and Locus Coeruleus (Zucca et al., 2014). NM can be detected using a high-resolution Fast Spin Echo T1-weighted Magnetic Resonance Imaging (MRI) sequence at 3T (Sasaki et al., 2006). (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 21, 2018 Category: Psychiatry Authors: Marta Tavares, Sofia Reim ão, Inês Chendo, Miguel Carvalho, Pedro Levy, Rita G. Nunes Tags: Letter to the Editor Source Type: research

Psychotic experiences among police officers working in high-stress situations
Childhood trauma is a well-established risk factors for psychosis in adulthood (Kelleher et al., 2013). Recent work has suggested that this may be mediated by trauma exposure in adulthood, which frequently occurs among individuals exposed to childhood trauma and has likewise been linked to psychosis (Bhavsar et al., 2017). Nonetheless, trauma exposure in adulthood has been less studied in relation to psychosis, with some exceptions (e.g., crime victimization; Newbury et al., 2017; intimate partner violence: Shah et al., 2017). (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 21, 2018 Category: Psychiatry Authors: Jordan E. DeVylder Tags: Letter to the editor Source Type: research

Neuromelanin magnetic resonance imaging of the substantia nigra in first episode psychosis patients consumers of illicit substances
Neuromelanin (NM) is a by-product of the metabolism of noradrenalin and dopamine, neurotransmitters which are mainly distributed in the Substantia Nigra (SN) and Locus Coeruleus (Zucca et al., 2014). NM can be detected using a high-resolution Fast Spin Echo T1-weighted Magnetic Resonance Imaging (MRI) sequence at 3T (Sasaki et al., 2006). (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 21, 2018 Category: Psychiatry Authors: Marta Tavares, Sofia Reim ão, Inês Chendo, Miguel Carvalho, Pedro Levy, Rita G. Nunes Tags: Letter to the Editor Source Type: research

Preliminary evidence for neural responsiveness to infants in mothers with schizophrenia and the implications for healthy parenting
Schizophrenia is a severe mental illness that may significantly affect maternal sensitive behaviour. Neural correlates of maternal behaviour represent a potentially valuable means of differentiating objectively between healthy mothers expressing variations in maternal sensitivity. As mothers with schizophrenia (MWS) show deficits in behavioural responses to infants compared to healthy mothers, we explored whether maternal brain responses to infant stimuli would be significantly reduced in MWS. We also examined whether differences in maternal behaviour between healthy and ill mothers (during play interactions with own infan...
Source: Schizophrenia Research - February 19, 2018 Category: Psychiatry Authors: K.M. Abel, R.E. Elliott, D. Downey, H. Strachan, A. Elmadih, A. Wieck, S. Williams, J. Crowell, M.W. Wan Source Type: research

Associations of independent living and labor force participation with impairment indicators in schizophrenia and bipolar disorder at 20-year follow-up
We examined these relationships at the 20-year follow-up assessment of a first-admission sample. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 19, 2018 Category: Psychiatry Authors: M. Strassnig, R. Kotov, L. Fochtmann, M. Kalin, E.J. Bromet, P.D. Harvey Source Type: research