Inflammatory biomarkers in individuals at clinical high risk for psychosis (CHR-P): State or trait?
Studies linking neuro-inflammation to psychotic episodes has been rapidly expanding. Assessments of changes in inflammatory biomarkers in prodromal patients who subsequently convert to psychosis may help in predicting those likely to transition to psychosis. (Source: Schizophrenia Research)
Source: Schizophrenia Research - April 24, 2018 Category: Psychiatry Authors: Rita Khoury, Henry A. Nasrallah Source Type: research
Dysregulation of auditory neuroplasticity in schizophrenia
Schizophrenia is a complex brain syndrome characterized by an array of positive symptoms (delusions, hallucinations, disorganized speech), negative symptoms (alogia, apathy, avolition) and cognitive impairments (memory, executive functions). Although investigations of the cognitive deficits in schizophrenia have primarily concentrated on disturbances affecting higher-order cognitive processes, there is an increasing realization that schizophrenia also affects early sensory processing, which might, in fact, play a significant role in the development of higher-order cognitive impairments. (Source: Schizophrenia Research)
Source: Schizophrenia Research - April 24, 2018 Category: Psychiatry Authors: Patrice Voss, Maryse E. Thomas, Gerson D. Guercio, Etienne de Villers-Sidani Source Type: research
Association between increased serum d-serine and cognitive gains induced by intensive cognitive training in schizophrenia
Neuroscience-guided cognitive training induces significant improvement in cognition in schizophrenia subjects, but the biological mechanisms associated with these changes are unknown. In animals, intensive cognitive activity induces increased brain levels of the NMDA-receptor co-agonist d-serine, a molecular system that plays a role in learning-induced neuroplasticity and that may be hypoactive in schizophrenia. Here, we investigated whether training-induced gains in cognition were associated with increases in serum d-serine in outpatients with schizophrenia. (Source: Schizophrenia Research)
Source: Schizophrenia Research - April 23, 2018 Category: Psychiatry Authors: Rogerio Panizzutti, Melissa Fisher, Coleman Garrett, Wai Hong Man, Walter Sena, Caroline Madeira, Sophia Vinogradov Source Type: research
Corrigendum to “Neuroanatomical correlates of perceptual aberrations in psychosis” [Schizophr. Res. 179 (2017) 125–131]
The authors regret that the number of subjects reported under the Methods subheading of the Abstract is incorrect. The correct numbers are 56 individuals with a primary psychotic disorder and 42 healthy subjects. The authors would like to apologise for any inconvenience this caused. (Source: Schizophrenia Research)
Source: Schizophrenia Research - April 23, 2018 Category: Psychiatry Authors: E.A. Brosey, N.D. Woodward Tags: Corrigendum Source Type: research
Association between increased serum d-serine and cognitive gains induced by intensive cognitive training in schizophrenia
Neuroscience-guided cognitive training induces significant improvement in cognition in schizophrenia subjects, but the biological mechanisms associated with these changes are unknown. In animals, intensive cognitive activity induces increased brain levels of the NMDA-receptor co-agonist d-serine, a molecular system that plays a role in learning-induced neuroplasticity and that may be hypoactive in schizophrenia. Here, we investigated whether training-induced gains in cognition were associated with increases in serum d-serine in outpatients with schizophrenia. (Source: Schizophrenia Research)
Source: Schizophrenia Research - April 23, 2018 Category: Psychiatry Authors: Rogerio Panizzutti, Melissa Fisher, Coleman Garrett, Wai Hong Man, Walter Sena, Caroline Madeira, Sophia Vinogradov Source Type: research
