Negative symptoms and the formation of social affiliative bonds in schizophrenia
Negative symptoms in schizophrenia are characterized by deficits in normative experiences and expression of emotion, and they are associated with poor social functioning. Negative symptoms relating to deficits in motivation and pleasure may hinder the development of affiliative bonds. The current study used a novel procedure to examine the relation between negative symptoms and the development of social affiliation within a laboratory setting. Fifty-five men (35 controls; 20 with a schizophrenia spectrum disorder) completed three Social Affiliation Enhancement Tasks with an experimenter partner. (Source: Schizophrenia Research)
Source: Schizophrenia Research - August 2, 2017 Category: Psychiatry Authors: Julie M. McCarthy, Kristen R. Bradshaw, Lauren T. Catalano, Cristina P. Garcia, Asia Malik, Melanie E. Bennett, Jack J. Blanchard Source Type: research

Thought, language, and communication deficits and association with everyday functional outcomes among community-dwelling middle-aged and older adults with schizophrenia
Older adults with schizophrenia experience poorer community integration and social functioning compared to same-age peers with no mental health disorders; these individuals are at elevated risk for functional decline and early institutionalization in long-term care facilities. Deficits in thought, language, and communication (TLC; that is, thought disorder and alogia) are core features of schizophrenia and may worsen with age; however, little research focuses on the functional sequelae of these impairments among older adults with schizophrenia. (Source: Schizophrenia Research)
Source: Schizophrenia Research - August 1, 2017 Category: Psychiatry Authors: Anjana Muralidharan, Anastasia Finch, Christopher R. Bowie, Philip D. Harvey Source Type: research

Comorbidity of chronic somatic diseases in patients with psychotic disorders and their influence on 4-year outcomes of integrated care treatment (ACCESS II study)
People with psychotic disorders fulfilling criteria of a severe and persistent mental illness (SPMI) display a high risk of somatic comorbidity (SC). (Source: Schizophrenia Research)
Source: Schizophrenia Research - August 1, 2017 Category: Psychiatry Authors: Martin Lambert, Friederike Ruppelt, Anna-Katharina Siem, Anja Christine Rohenkohl, Vivien Kraft, Daniel Luedecke, Mary Sengutta, Romy Schr öter, Anne Daubmann, Christoph U. Correll, Jürgen Gallinat, Anne Karow, Klaus Wiedemann, Daniel Schöttle Source Type: research

Translating cognitive behavioral interventions from bench to bedside: The feasibility and acceptability of cognitive remediation in research as compared to clinical settings
This study evaluated the fit between the program conditions and treatment model in research and clinical settings, with the goal of informing future research on the contextual challenges associated with the implementation of CR. Data was drawn from an initiative by New York State's Office of Mental Health (OMH), to implement CR programs for adults with Serious Mental Illness (SMI) in 16 state operated outpatient clinics. (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 30, 2017 Category: Psychiatry Authors: Alice Medalia, Matthew D. Erlich, Charlotte Soumet-Leman, Alice M. Saperstein Source Type: research

Pre-onset risk characteristics for mania among young people at clinical high risk for psychosis
Psychosis and mania share conceptual, genetic and clinical features, which suggest the possibility that they have common antecedents. Participants identified to be at-risk for psychosis might also be at-risk for mania. We aimed to identify the rate and predictors of transition to mania in a cohort of youth with clinical or familial risk for psychosis. (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 30, 2017 Category: Psychiatry Authors: Aswin Ratheesh, Susan M. Cotton, Christopher G. Davey, Ashleigh Lin, Stephen Wood, Hok Pan Yuen, Andreas Bechdolf, Patrick D. McGorry, Alison Yung, Michael Berk, Barnaby Nelson Source Type: research

Mismatch negativity in preclinical models of schizophrenia
Schizophrenia is a mental disorder associated with profoundly disruptive positive and negative symptomology that result in difficulties building close relationships with others, performing daily tasks and sustaining independent living, resulting in poor social, vocational and occupational attainment (functional outcome). Mismatch Negativity (MMN) is a change in the sensory event-related potential that occurs in response to deviation from an established pattern of stimulation. Patients with schizophrenia show a reduction in MMN that is positively associated with impaired cognition and poor functional outcome. (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 30, 2017 Category: Psychiatry Authors: Robert E. Featherstone, Olya Melnychenko, Steven J. Siegel Source Type: research

Completing the puzzle: The search for pieces in the understanding of psychosis risk in 22q11.2 deletion syndrome
In this issue of Schizophrenia Research, Kates and colleagues provide an exemplary study examining the longitudinal trajectories of cortical thickness as a potential biomarker for later developing psychosis for younger individuals with 22q11.2 Deletion Syndrome (22q11DS). Although parallel efforts in first episode schizophrenia have produced such connections, Kates et al. provide some of the first data showing a linkage between brain architecture and later psychotic presentation in this well-known genetic condition using a longitudinal design. (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 30, 2017 Category: Psychiatry Authors: Stephen R. Hooper, Vandana Shashi Source Type: research

Promoting long-term functional improvement after cognitive remediation in schizophrenia
Cognitive remediation interventions have emerged as effective approaches for treating core cognitive impairments in people with schizophrenia. The efficacy of these approaches has been demonstrated in early course (Fisher et al. 2015) and long-term (Hogarty et al. 2004) patients, with evidence of improved neurocognitive, social-cognitive, symptom, and functional outcomes (Kurtz and Mueser 2008; Wykes et al. 2011. Meta-analytic reviews have often observed that the impact of these interventions on functional outcome are markedly enhanced when cognitive remediation is integrated within broader rehabilitation or psychosocial s...
Source: Schizophrenia Research - July 30, 2017 Category: Psychiatry Authors: Shaun M. Eack Source Type: research

Translating cognitive behavioral interventions from bench to bedside: The feasibility and acceptability of cognitive remediation in research as compared to clinical settings
This study evaluated the fit between the program conditions and treatment model in research and clinical settings, with the goal of informing future research on the contextual challenges associated with the implementation of CR. Data was drawn from an initiative by New York State's Office of Mental Health (OMH), to implement CR programs for adults with Serious Mental Illness (SMI) in 16 state operated outpatient clinics. (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 30, 2017 Category: Psychiatry Authors: Alice Medalia, Matthew D. Erlich, Charlotte Soumet-Leman, Alice M. Saperstein Source Type: research

Hyperprolactinaemia in first episode psychosis - A longitudinal assessment
Little is known about hyperprolactinaemia (HPL) in first episode psychosis (FEP) patients. We investigated longitudinal changes in serum prolactin in FEP, and the relationship between HPL, and antipsychotic medication and stress.Serum prolactin was recorded in FEP patients at recruitment and again, 3 and 12months later. HPL was defined as a serum prolactin level>410mIU/L (~19.3ng/ml) for males, and a serum prolactin level>510mIU/L (~24.1ng/ml) for females.From a total of 174 people with serum prolactin measurements at study recruitment, 43% (n=74) had HPL, whilst 27% (n=21/78) and 27% (n=26/95) had HPL at 3 and 12mon...
Source: Schizophrenia Research - July 28, 2017 Category: Psychiatry Authors: John Lally, Olesya Ajnakina, Brendon Stubbs, Hugh R. Williams, Marco Colizzi, Elena Carra, Sara Fraietta, Poonam Gardner-Sood, Kathryn E. Greenwood, Zerrin Atakan, Valeria Mondelli, Khalida Ismail, Oliver Howes, David M. Taylor, Shubalade Smith, David Hop Source Type: research

Schizotypy is associated with reduced mnemonic precision in visual working memory
Working memory (WM) maintains a limited amount of information over a short period of time at the service of other ongoing mental activities. Deficits in this function are often observed in schizophrenia spectrum disorders. The present study examined whether self-report schizotypy was associated with the qualitative, quantitative, or both aspects of visual WM and whether these impairments could be accounted for by sensory memory deficits and/or depressed mood in a group of non-clinical, medication-na ïve participants. (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 28, 2017 Category: Psychiatry Authors: Weizhen Xie, Marcus Cappiello, Hyung-Bum Park, Patricia Deldin, Raymond C.K. Chan, Weiwei Zhang Source Type: research

Dissociable auditory mismatch response and connectivity patterns in adolescents with schizophrenia and adolescents with bipolar disorder with psychosis: A magnetoencephalography study
There is overlap between schizophrenia and bipolar disorder regarding genetic risk as well as neuropsychological and structural brain deficits. Finding common and distinct event-response potential (ERP) responses and connectivity patterns may offer potential biomarkers to distinguish the disorders. (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 28, 2017 Category: Psychiatry Authors: Sven Braeutigam, Danai Dima, Sophia Frangou, Anthony James Source Type: research

Multiple retinal anomalies in schizophrenia
In addition to being a critical component of the visual system, the retina provides the opportunity for an accessible and noninvasive probe of brain pathology in neuropsychiatric disorders. Several studies have reported various retinal abnormalities in schizophrenia, some primary and others iatrogenic. There is now increasing evidence supporting the existence of retinal anomalies in schizophrenia across structural, neurochemical and physiological parameters. Here, we review the types of retinal pathology in schizophrenia and discuss how these findings may provide novel insights for future research into the neurodevelopment...
Source: Schizophrenia Research - July 26, 2017 Category: Psychiatry Authors: Selin A. Adams, Henry A. Nasrallah Source Type: research

A computational network analysis based on targets of antipsychotic agents
In this study we performed a computational network analysis based on targets of antipsychotic agents. We retrieved a total of 96 targets from 56 antipsychotic agents. By expression enrichment analysis, we identified that the expressions of antipsychotic target genes were significantly enriched in liver, brain, blood and corpus striatum. (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 26, 2017 Category: Psychiatry Authors: Lei Gao, Shuo Feng, Zhao-yuan Liu, Jiu-qiang Wang, Ke-ke Qi, Kai Wang Source Type: research

Catatonia in children and adolescents: New perspectives
Catatonia is a rare and severe psychomotor condition in children and adolescents. In the current report, we aimed to review the recent literature. (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 25, 2017 Category: Psychiatry Authors: Xavier Benarous, Marie Raffin, Vladimir Ferrafiat, Ang èle Consoli, David Cohen Source Type: research

Utilising symptom dimensions with diagnostic categories improves prediction of time to first remission in first-episode psychosis
There has been much recent debate concerning the relative clinical utility of symptom dimensions versus conventional diagnostic categories in patients with psychosis. We investigated whether symptom dimensions rated at presentation for first-episode psychosis (FEP) better predicted time to first remission than categorical diagnosis over a four-year follow-up. The sample comprised 193 FEP patients aged 18 –65years who presented to psychiatric services in South London, UK, between 2006 and 2010. Psychopathology was assessed at baseline with the Positive and Negative Syndrome Scale and five symptom dimensions were deriv...
Source: Schizophrenia Research - July 25, 2017 Category: Psychiatry Authors: Olesya Ajnakina, John Lally, Marta Di Forti, Simona A. Stilo, Anna Kolliakou, Poonam Gardner-Sood, Paola Dazzan, Carmine Pariante, Tiago Reis Marques, Valeria Mondelli, James MacCabe, Fiona Gaughran, Anthony S. David, Daniel Stamate, Robin M. Murray, Hele Source Type: research

Evidence for benefits in comorbid psychopathy and schizophrenia
We read the article recently published by Sedgwick et al. (2017) with great interest. The authors used a prepulse inhibition (PPI) paradigm to compare the sensorimotor gating characteristics of violent men with diagnoses of both psychosis and dissocial personality disorder, violent men with psychosis alone, dissocial personality disorder alone, and healthy non-violent male controls. Interestingly, the results showed evidence for a ‘double dose’ of deficit, with the comorbid group showing the greatest impairment compared with the psychosis alone and healthy control groups. (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 25, 2017 Category: Psychiatry Authors: Steven M. Gillespie, Ahmad M. Abu-Akel Tags: Letter to the Editor Source Type: research

In vivo gamma-aminobutyric acid and glutamate levels in people with first-episode schizophrenia: A proton magnetic resonance spectroscopy study
In this study, levels of GABA, Glx (summation of glutamate and glutamine), and other metabolites in the anterior cingulate cortex were measured and compared between first-episode schizophrenia subjects and healthy controls (HC). (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 24, 2017 Category: Psychiatry Authors: P.W. Chiu, Simon S.Y. Lui, Karen S.Y. Hung, Raymond C.K. Chan, Queenie Chan, P.C. Sham, Eric F.C. Cheung, Henry K.F. Mak Source Type: research

Associations of psychotic-like or manic-like experiences with later psychiatric disorders: An 11-year follow-up study of middle-aged adults
Psychotic-like experiences (PLEs) and manic-like experiences (MLEs) have been found to be associated with elevated risk for future psychotic disorders. However, most follow-up studies have been conducted on adolescent and young adult samples leaving the predictive value of PLEs and MLEs among middle-aged subjects largely unknown. Here we report findings of an 11-year follow-up study of middle-aged subjects with PLEs (n=86) or MLEs (n=45) at baseline and population controls (n=62). We found that PLEs or MLEs at baseline did not predict conversion to psychosis during an 11-year follow-up in this age group. (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 24, 2017 Category: Psychiatry Authors: Annamaria Wikstr öm, Annamari Tuulio-Henriksson, Jonna Perälä, Samuli Saarni, Jaana Suvisaari Tags: Letter to the Editor Source Type: research

Trajectories of schizotypy and their emotional and social functioning: An 18-month follow-up study
Schizotypy is a set of personality traits that convey liability to develop schizophrenia. Studying schizotypy in healthy individuals may facilitate the understanding of the psychopathological processes underlying schizophrenia. The present study aimed to examine the developmental trajectories of schizotypy over time using a longitudinal study design. The Chapman Scales for Psychosis Proneness were administered to 1541 college students at baseline, and subsequently at six-monthly intervals up to 18months. (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 24, 2017 Category: Psychiatry Authors: Yi Wang, Hai-song Shi, Wen-hua Liu, Dong-jie Xie, Fu-lei Geng, Chao Yan, Ya Wang, Ya-hui Xiao, Suzanne H.W. So, Chui-De Chiu, Patrick W.L. Leung, Eric F.C. Cheung, Diane C. Gooding, Raymond C.K. Chan Source Type: research

Editorial Board
(Source: Schizophrenia Research)
Source: Schizophrenia Research - July 22, 2017 Category: Psychiatry Source Type: research

Higher required dosage of antipsychotics to relieve the symptoms of first-onset Acute and Transient Psychotic Disorder (ATPD) predicted the subsequent diagnostic transition to schizophrenia: A longitudinal study
Previous studies have documented that the diagnosis of Acute and Transient Psychotic Disorder (ATPD) is not stable and may be subsequently revised to schizophrenia, affective disorders, or others (Queirazza et al., 2014; Pillmann and Marneros, 2005; Poon and Leung, 2017). And the factors, such as male patient, younger Age of Onset (AO), longer Days of the First Hospitalization (DFH), positive Family History of Mental Disorders (FHMD), and the Duration of Untreated Psychosis (DUP) are associated with the diagnosis transition from ATPD to schizophrenia, but these findings are inconsistent (Queirazza et al., 2014; Poon and Le...
Source: Schizophrenia Research - July 21, 2017 Category: Psychiatry Authors: Hui-yao Wang, Wan-jun Guo, Xiao-jing Li, Yu-jie Tao, Ya-jing Meng, Qiang Wang, Wei Deng, Tao Li Tags: Letter to the Editor Source Type: research

Dose equivalents for second generation long-acting injectable antipsychotics: The minimum effective dose method
The concept of dose equivalence of depot medication is important for many scientific and clinical purposes. (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 21, 2017 Category: Psychiatry Authors: Philipp H. Rothe, Stephan Heres, Stefan Leucht Source Type: research

Why transition risk to psychosis is not declining at the OASIS ultra high risk service: The hidden role of stable pretest risk enrichment
The reason for declining risk to psychosis across individuals assessed and meeting Ultra High Risk (UHR) criteria is still unclear. No studies have investigated the potential substantial role of the underlying risk enrichment across all the individuals undergoing an UHR assessment. (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 20, 2017 Category: Psychiatry Authors: P. Fusar-Poli, E. Palombini, C. Davies, D. Oliver, I. Bonoldi, V. Ramella-Cravaro, P. McGuire Source Type: research

Development and psychometric properties of the Multidimensional Schizotypy Scale: A new measure for assessing positive, negative, and disorganized schizotypy
This article reports on the development of a new self-report questionnaire measure of schizotypy – the Multidimensional Schizotypy Scale (MSS). Schizotypy offers a useful and unifying construct for understanding schizophrenia-spectrum psychopathology. Questionnaire measures have been widely used to assess schizotypy and have greatly informed our understanding of the construct. However, availa ble measures suffer from a number of limitations, including lack of a clear conceptual framework, outdated wording, unclear factor structure, and psychometric shortcomings. (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 20, 2017 Category: Psychiatry Authors: Thomas R. Kwapil, Georgina M. Gross, Paul J. Silvia, Michael L. Raulin, Neus Barrantes-Vidal Source Type: research

Risk and resilience brain networks in treatment-resistant schizophrenia
This study sought to identify resting-state functional brain connectivity (rs-FC) representing putative risk or resilience endophenotypes in schizophrenia. (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 20, 2017 Category: Psychiatry Authors: Eleni P. Ganella, Caio Seguin, Cali F. Bartholomeusz, Sarah Whittle, Chad Bousman, Cassandra M.J. Wannan, Maria A. Di Biase, Christina Phassouliotis, Ian Everall, Christos Pantelis, Andrew Zalesky Source Type: research

Disrupted relationship between “resting state” connectivity and task-evoked activity during social perception in schizophrenia
Schizophrenia has been described as a self-disorder, whereas social deficits are key features of the illness. Changes in “resting state” activity of brain networks involved in self-related processing have been consistently reported in schizophrenia, but their meaning for social perception deficits remains poorly understood. Here, we applied a novel approach investigating the relationship between task-evoked neural activity during social perception and functional organization of self-related brain networks during a “resting state”. (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 20, 2017 Category: Psychiatry Authors: Sjoerd J.H. Ebisch, Vittorio Gallese, Anatolia Salone, Giovanni Martinotti, Giuseppe di Iorio, Dante Mantini, Mauro Gianni Perrucci, Gian Luca Romani, Massimo Di Giannantonio, Georg Northoff Source Type: research

Predicting relapse in schizophrenia: Is BDNF a plausible biological marker?
Understanding the biological processes that underlie why patients relapse is an issue of fundamental importance to the detection and prevention of relapse in schizophrenia. Brain Derived Neurotrophic Factor (BDNF), a facilitator of brain plasticity, is reduced in patients with schizophrenia. In the present study, we examined whether decreases in plasma BDNF levels could be used as a biological predictor of relapse in schizophrenia. A total of 221 patients were prospectively evaluated for relapse over 30months in the Preventing Relapse in Schizophrenia: Oral Antipsychotics Compared to Injectables: eValuating Efficacy (PROAC...
Source: Schizophrenia Research - July 19, 2017 Category: Psychiatry Authors: Anilkumar Pillai, Nina R. Schooler, Diya Peter, Stephen W. Looney, Donald C. Goff, Alexander Kopelowicz, John Lauriello, Theo Manschreck, Alan Mendelowitz, Del D. Miller, Joanne B. Severe, Daniel R. Wilson, Donna Ames, Juan Bustillo, John M. Kane, Peter F Source Type: research

The effect of antipsychotic medications on acoustic startle latency in schizophrenia
This study examined the effects of antipsychotic medication on startle latency. 108 CON and 132 SCZ subjects in three medication subgroups (94 on second-generation antipsychotics (SGA), 25 on first-generation antipsychotics (FGA), 13 unmedicated (NoMed)) were tested on a standard acoustic startle paradigm designed to measure startle magnitude, PPI, and latency. (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 18, 2017 Category: Psychiatry Authors: Molly Fargotstein, Wendy Hasenkamp, Robin Gross, Bruce Cuthbert, Amanda Green, Lisette Swails, Barbara Lewison, William Boshoven, Megan Keyes, Erica Duncan Source Type: research

Monocausal attribution and its relationship with reasoning biases in schizophrenia
Aberrant attributional styles are counted to a set of circumscribed cognitive biases that are implicated in the pathogenesis of (paranoid) psychosis. However, evidence for a specific profile (e.g., an exaggerated self-serving bias, other-blaming bias) has become equivocal over the years. More recently, one-sided (monocausal) attributions have been reported in patients with psychosis. (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 18, 2017 Category: Psychiatry Authors: Steffen Moritz, Richard P. Bentall, Katharina Kolbeck, Daniela Roesch-Ely Source Type: research

The effect of antipsychotic medications on acoustic startle latency in schizophrenia
This study examined the effects of antipsychotic medication on startle latency. 108 CON and 132 SCZ subjects in three medication subgroups (94 on second-generation antipsychotics (SGA), 25 on first-generation antipsychotics (FGA), 13 unmedicated (NoMed)) were tested on a standard acoustic startle paradigm designed to measure startle magnitude, PPI, and latency. (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 18, 2017 Category: Psychiatry Authors: Molly Fargotstein, Wendy Hasenkamp, Robin Gross, Bruce Cuthbert, Amanda Green, Lisette Swails, Barbara Lewison, William Boshoven, Megan Keyes, Erica Duncan Source Type: research

Increased gyrification in schizophrenia and non affective first episode of psychosis
Prefrontal cortex gyrification has been suggested to be altered in patients with schizophrenia and first episode psychosis. Therefore, it may represent a possible trait marker for these illnesses and an indirect evidence of a disrupted underlying connectivity. The aim of this study was to add further evidence to the existing literature on the role of prefrontal gyrification in psychosis by carrying out a study on a sizeable sample of chronic patients with schizophrenia and non-affective first-episode psychosis (FEP-NA) patients. (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 17, 2017 Category: Psychiatry Authors: Riccardo Zuliani, Giuseppe Delvecchio, Carolina Bonivento, Giulia Cattarinussi, Cinzia Perlini, Marcella Bellani, Veronica Marinelli, Maria Gloria Rossetti, Antonio Lasalvia, Andrew McIntosh, Stephen M. Lawrie, Matteo Balestrieri, Mirella Ruggeri, Paolo B Source Type: research

Application of plasma levels of olanzapine and N-desmethyl-olanzapine to monitor metabolic parameters in patients with schizophrenia
This study aimed to investigate the roles of OLZ or N-desmethyl-olanzapine (DMO) in metabolic outcomes among OLZ-treated patients with schizophrenia. The metabolic syndrome (MS) was diagnosed based on the modified the National Cholesterol Education Program Adult Treatment Panel III criteria for Asians. (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 15, 2017 Category: Psychiatry Authors: Mong-Liang Lu, Chun-Hsin Chen, Pei-Ting Kuo, Chia-Hui Lin, Tzu-Hua Wu Source Type: research

Emotional fMR auditory paradigm demonstrates normalization of limbic hyperactivity after cognitive behavior therapy for auditory hallucinations
This study explored the changes in brain activation associated with an emotional auditory paradigm when patients with schizophrenia and auditory hallucinations were treated with CBT. Functional magnetic resonance (fMR) imaging data were obtained from 55 subjects (17 patients with schizophrenia in the therapy group, 24 patients with schizophrenia in the control patient group, and 14 healthy control subjects). (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 15, 2017 Category: Psychiatry Authors: Eduardo J. Aguilar, Iluminada Corripio, Graci án García-Martí, Eva Grasa, Luis Martí-Bonmatí, Beatriz Gómez-Ansón, Julio Sanjuán, Fidel Núñez-Marín, Esther Lorente-Rovira, María J. Escartí, Alison Brabban, Douglas Turkington Source Type: research

Moral cognition and homicide amongst forensic patients with schizophrenia and schizoaffective disorder: A cross-sectional cohort study
Forensic patients with schizophrenia who had carried out a homicide scored higher on a measure of moral cognition (MFQ-30) than other violent patients. Neurocognitive impairment was associated with homicide by mediation via higher scores for in-group loyalty. (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 14, 2017 Category: Psychiatry Authors: Ken O'Reilly, Paul O'Connell, Aiden Corvin, Danny O'Sullivan, Ciaran Coyle, Ronan Mullaney, Padraic O'Flynn, Katie Grogan, Melanie Richter, Harry Kennedy Tags: Letter to the Editor Source Type: research

Treatment of social cognition in schizophrenia: Current status and future directions
This article critically evaluates the current evidence for social cognitive interventions, identifies limitations and open questions, and suggests priorities and directions for further research. (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 13, 2017 Category: Psychiatry Authors: William P. Horan, Michael F. Green Source Type: research

Interaction of reelin and stress on immobility in the forced swim test but not dopamine-mediated locomotor hyperactivity or prepulse inhibition disruption: Relevance to psychotic and mood disorders
Psychotic disorders, such as schizophrenia, as well as some mood disorders, such as bipolar disorder, have been suggested to share common biological risk factors. One such factor is reelin, a large extracellular matrix glycoprotein that regulates neuronal migration during development as well as numerous activity-dependent processes in the adult brain. The current study sought to evaluate whether a history of stress exposure interacts with endogenous reelin levels to modify behavioural endophenotypes of relevance to psychotic and mood disorders. (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 13, 2017 Category: Psychiatry Authors: Michael J. Notaras, Billie Vivian, Carey Wilson, Maarten van den Buuse Source Type: research

Clinical utility of the Calgary Depression Scale for Schizophrenia in individuals at ultra-high risk of psychosis
There is a pressing need for reliable and valid rating scales to assess and measure depression in individuals at ultra-high risk (UHR) of psychosis. The aim of this study was to examine the clinical utility of the Calgary Depression Scale for Schizophrenia (CDSS) in individuals at UHR of psychosis. 167 individuals at UHR of psychosis were included as participants in this study. The Structured Clinical Interview for DSM-IV Axis I Disorders, CDSS, Beck Anxiety Inventory and Global Assessment of Functioning were administered. (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 13, 2017 Category: Psychiatry Authors: Gurpreet Rekhi, Wai Yee Ng, Jimmy Lee Source Type: research

Cortical responses to tone and phoneme mismatch as a predictor of dyslexia? A systematic review
Evidence from event-related-potential (ERP) studies has repeatedly shown differences in the perception and processing of auditory stimuli in children with dyslexia compared to control children. The mismatch negativity (MMN) – an ERP component reflecting passive auditory change detection ability – has been found to be reduced, not only in children with a diagnosis of dyslexia, but also in infants and preschool children at risk of developing dyslexia. However, the results are controversial due to the different method s, age of the children and stimuli used. (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 13, 2017 Category: Psychiatry Authors: Susanne Volkmer, Gerd Schulte-K örne Source Type: research

Treatment of social cognition in schizophrenia: Current status and future directions
This article critically evaluates the current evidence for social cognitive interventions, identifies limitations and open questions, and suggests priorities and directions for further research. (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 13, 2017 Category: Psychiatry Authors: William P. Horan, Michael F. Green Source Type: research

Interaction of reelin and stress on immobility in the forced swim test but not dopamine-mediated locomotor hyperactivity or prepulse inhibition disruption: Relevance to psychotic and mood disorders
Psychotic disorders, such as schizophrenia, as well as some mood disorders, such as bipolar disorder, have been suggested to share common biological risk factors. One such factor is reelin, a large extracellular matrix glycoprotein that regulates neuronal migration during development as well as numerous activity-dependent processes in the adult brain. The current study sought to evaluate whether a history of stress exposure interacts with endogenous reelin levels to modify behavioural endophenotypes of relevance to psychotic and mood disorders. (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 13, 2017 Category: Psychiatry Authors: Michael J. Notaras, Billie Vivian, Carey Wilson, Maarten van den Buuse Source Type: research

The role of self-disturbances and cognitive biases in the relationship between traumatic life events and psychosis proneness in a non-clinical sample
Traumatic life events have been established as an environmental risk factor for psychosis. However, the exact mechanisms by which traumatic life events increase risk for psychosis are unknown. In the present study we tested an integrative model of traumatic life events being related to psychosis proneness via self-disturbances and cognitive biases. (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 13, 2017 Category: Psychiatry Authors: Łukasz Gawęda, Katarzyna Prochwicz, Przemysław Adamczyk, Dorota Frydecka, Błażej Misiak, Kamila Kotowicz, Remigiusz Szczepanowski, Marcin Florkowski, Barnaby Nelson Source Type: research

Positive symptoms and social cognition impairment affect severity of suicidal ideation in schizophrenia
Recently, the Danish OPUS study (Madsen et al., 2016) demonstrated that suicidal ideation, when present at first episode of psychosis, persists during the first 10years after treatment initiation, thus fitting as a stable clinical feature and representing an early indicator of poor global outcome. We aimed to investigate the nature of suicidal ideation as a stable trait of schizophrenia through the study of its relations with other stable features of the disorder. (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 13, 2017 Category: Psychiatry Authors: Anna Comparelli, Valentina Corigliano, Dorian A. Lamis, Antonella De Carolis, Lorenzo Stampatore, Eleonora De Pisa, Paolo Girardi, Maurizio Pompili Tags: Letter to the Editor Source Type: research

Trial exclusion criteria and their impact on the estimation of antipsychotic drugs effect: A case study using the SOHO database
To explore the impact upon estimation of drug effect as a result of applying exclusion criteria in randomized-controlled trials (RCT) measuring the efficacy of antipsychotics (AP) in schizophrenia. (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 13, 2017 Category: Psychiatry Authors: Clementine Nordon, Thomas Bovagnet, Mark Belger, Javier Jimenez, Robert Olivares, Helene Chevrou-Severac, Helene Verdoux, Josep Maria Haro, Lucien Abenhaim, Helene Karcher, on behalf of the IMI GetReal WP2 group Source Type: research

Early trauma and clinical features of schizophrenia cases influenced by the BDNF Val66Met allele
Brain Derived Neurotrophic Factor (BDNF) gene has a functional variant resulting in a Valine (VAL) to Methionine (MET) substitution at codon 66 of the pro-BDNF. The low active MET variant is related to reduced BDNF release (Egan et al., 2003). BDNF's expression in adult life may be modulated by exposures during childhood development, with reduced expression observed in association with early traumas due from epigenetic modifications (Roth et al., 2009). The combination between these two BDNF expression reducers (Mondelli et al., 2011) might increase the occurrence and severity of stress related neurodegenerative disorders....
Source: Schizophrenia Research - July 12, 2017 Category: Psychiatry Authors: Andr é B. Veras, Clayton Peixoto, Julie Walsh Messinger, Mara Getz, Raymond Goetz, Peter Buckley, Moses V. Chao, Antonio E. Nardi, Dolores Malaspina, Thorsten Manfred Kranz Tags: Letter to the Editor Source Type: research

Physical health promotion in patients with functional psychoses receiving community psychiatric services: Results of the PHYSICO-DSM-VR study
The objective was to evaluate the efficacy of a package of health promotion strategies to improve diet and physical exercise in psychotic patients. (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 12, 2017 Category: Psychiatry Authors: Elena Bonfioli, Maria Angela Mazzi, Loretta Berti, Lorenzo Burti Source Type: research

Interactive effects of an N-methyl-d-aspartate receptor antagonist and a nicotinic acetylcholine receptor agonist on mismatch negativity: Implications for schizophrenia
We examined the interactive effects of ketamine, an NMDAR antagonist that produces transient schizophrenia-like neurophysiological effects, and nicotine, a nicotinic acetylcholine receptor (nAChR) agonist, in 30 healthy volunteers to determine whether nicotine prevents or attenuates MMN abnormalities. (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 12, 2017 Category: Psychiatry Authors: Holly K. Hamilton, Deepak C. D'Souza, Judith M. Ford, Brian J. Roach, Naomi S. Kort, Kyung-Heup Ahn, Savita Bhakta, Mohini Ranganathan, Daniel H. Mathalon Source Type: research