Brief executive function training for individuals with severe mental illness: Effects on EEG synchronization and executive functioning
Executive Functioning (EF) is an important factor for community functioning for people with severe mental illness. Cognitive remediation programs often improve EF, but do so by using multiple therapeutic techniques. Little is known regarding how individual treatment elements promote cognitive improvement. Oscillatory brain activity is a potential neurophysiological mechanism that may change as a result of targeted training on computerized exercises. The current study aimed to examine the effects of a brief EF training program on EEG and neurocognitive measures. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 18, 2017 Category: Psychiatry Authors: Michael W. Best, Daniel Gale, Tanya Tran, Mashal K. Haque, Christopher R. Bowie Source Type: research

Impact of lifetime traumatic experiences on suicidality and likelihood of conversion in a cohort of individuals at clinical high-risk for psychosis
Recent research suggests that trauma history (TH) is a strong socio-environmental risk factor for the development of psychosis. While reported rates of childhood trauma are higher among individuals at clinical high-risk (CHR) for psychosis than in the general population, little research has explored the effects of trauma upon the severity of attenuated positive symptoms. We aimed to explore the specific relationships between TH and baseline symptom severity; likelihood of conversion to full-blown psychosis; suicidal ideation (SI); and suicidal behavior (SB) in a cohort of 200 help-seeking CHR individuals. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 18, 2017 Category: Psychiatry Authors: Margaux M. Grivel, Wei Leong, Michael D. Masucci, Rebecca A. Altschuler, Leigh Y. Arndt, Samantha L. Redman, Lawrence H. Yang, Gary Brucato, Ragy R. Girgis Source Type: research

Intimate partner violence and psychotic experiences in four U.S. cities
A large body of research has established a relationship between trauma exposure, particularly during childhood, and psychotic experiences. Yet, there remains a general lack of research on adult trauma exposure, including intimate partner violence (IPV), as a risk factor for psychotic experiences. The purpose of this study is to investigate the association between IPV and psychotic experiences in U.S. cities. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 18, 2017 Category: Psychiatry Authors: Roma Shah, Tara Von Mach, Lisa Fedina, Bruce Link, Jordan DeVylder Source Type: research

Deficient single item maintenance following intact updating in schizophrenia
Working memory is a core cognitive impairment in schizophrenia (Lee and Park, 2005; Silver et al., 2003), observed across modalities including visuospatial, auditory, and verbal working memory (Longenecker et al., 2010; Manglam et al., 2010; Park and Gooding, 2014). Baddeley proposed a working memory model in which a central executive controls how information is distributed and processed by lower level systems, the phonological loop and visuospatial sketchpad, which carry out auditory and visual information processing respectively (Baddeley, 1992; Baddeley, 2003). (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 18, 2017 Category: Psychiatry Authors: Tarra Combs, Jarett E. Roseberry, Leah H. Rubin, S. Kristian Hill Source Type: research

Fast and slow thinking in distressing delusions: A review of the literature and implications for targeted therapy
The recent literature on reasoning biases in psychosis and delusions is reviewed. The state-of-the-art knowledge from systematic reviews and meta-analyses on the evidence for jumping to conclusions is briefly summarised, before a fuller discussion of the more recent empirical literature on belief flexibility as applied to delusions. The methodology and evidence in relation to studies of belief flexibility and the Bias Against Disconfirmatory Evidence (BADE) across the delusional continuum will be critically appraised, and implications drawn for improving cognitive therapy. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 16, 2017 Category: Psychiatry Authors: Thomas Ward, Philippa A. Garety Source Type: research

Primary cilia formation is diminished in schizophrenia and bipolar disorder: A possible marker for these psychiatric diseases
Primary cilium (PC) is a microtubule-rich organelle that protrudes from the plasma membrane and acts as a cellular antenna sensing extracellular signals during brain development. DISC1 (Disrupted-in-Schizophrenia-1) is involved in PC formation and is considered a risk factor for neuropsychiatric disorders. We have previously described altered subcellular distribution of DISC1 and an aberrant microtubule organization in olfactory neuronal precursors (ONP) obtained from schizophrenia (SCZ) and bipolar disorder (BD) patients. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 16, 2017 Category: Psychiatry Authors: Jes ús Muñoz-Estrada, Alejandra Lora-Castellanos, Isaura Meza, Salvador Alarcón Elizalde, Gloria Benítez-King Source Type: research

The relation of vitamin D, metabolic risk and negative symptom severity in people with psychotic disorders
People with psychotic disorders have an increased metabolic risk and their mean life expectancy is reduced with circa 28years (Olfson et al., 2015).Predictors of this increased metabolic risk are genetic predisposition (Liu et al., 2013), lifestyle factors such as unhealthy diet, physical inactivity and smoking (Bobes et al., 2010), and the side effects of antipsychotic medication (Werner and Cove ñas, 2014;Chadda et al., 2013). Low vitamin D status might also contribute to an increased metabolic risk (Ginde et al., 2009;Kendrick et al., 2009;Kilkkinen et al., 2009;Ford et al., 2009) and all-cause mortality by promo...
Source: Schizophrenia Research - September 16, 2017 Category: Psychiatry Authors: J. Bruins, F. J örg, E.R. van den Heuvel, A.A. Bartels-Velthuis, E. Corpeleijn, F.A.J. Muskiet, G.H.M. Pijnenborg, R. Bruggeman Source Type: research

Impaired contextual fear-conditioning in MAM rodent model of schizophrenia
The methylazoxymethanol acetate (MAM) rodent neurodevelopmental model of schizophrenia exhibits aberrant dopamine system activation attributed to hippocampal dysfunction. Context discrimination is a component of numerous behavioral and cognitive functions and relies on intact hippocampal processing. The present study explored context processing behaviors, along with dopamine system activation, during fear learning in the MAM model.Male offspring of dams treated with MAM (20mg/kg, i.p.) or saline on gestational day 17 were used for electrophysiological and behavioral experiments. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 16, 2017 Category: Psychiatry Authors: Kathryn M. Gill, Sarah A. Miller, Anthony A. Grace Source Type: research

Fast and slow thinking in distressing delusions: A review of the literature and implications for targeted therapy
The recent literature on reasoning biases in psychosis and delusions is reviewed. The state-of-the-art knowledge from systematic reviews and meta-analyses on the evidence for jumping to conclusions is briefly summarised, before a fuller discussion of the more recent empirical literature on belief flexibility as applied to delusions. The methodology and evidence in relation to studies of belief flexibility and the Bias Against Disconfirmatory Evidence (BADE) across the delusional continuum will be critically appraised, and implications drawn for improving cognitive therapy. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 16, 2017 Category: Psychiatry Authors: Thomas Ward, Philippa A. Garety Source Type: research

Primary cilia formation is diminished in schizophrenia and bipolar disorder: A possible marker for these psychiatric diseases
Primary cilium (PC) is a microtubule-rich organelle that protrudes from the plasma membrane and acts as a cellular antenna sensing extracellular signals during brain development. DISC1 (Disrupted-in-Schizophrenia-1) is involved in PC formation and is considered a risk factor for neuropsychiatric disorders. We have previously described altered subcellular distribution of DISC1 and an aberrant microtubule organization in olfactory neuronal precursors (ONP) obtained from schizophrenia (SCZ) and bipolar disorder (BD) patients. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 16, 2017 Category: Psychiatry Authors: Jes ús Muñoz-Estrada, Alejandra Lora-Castellanos, Isaura Meza, Salvador Alarcón Elizalde, Gloria Benítez-King Source Type: research

The relation of vitamin D, metabolic risk and negative symptom severity in people with psychotic disorders
People with psychotic disorders have an increased metabolic risk and their mean life expectancy is reduced with circa 28years (Olfson et al., 2015).Predictors of this increased metabolic risk are genetic predisposition (Liu et al., 2013), lifestyle factors such as unhealthy diet, physical inactivity and smoking (Bobes et al., 2010), and the side effects of antipsychotic medication (Werner and Cove ñas, 2014;Chadda et al., 2013). Low vitamin D status might also contribute to an increased metabolic risk (Ginde et al., 2009;Kendrick et al., 2009;Kilkkinen et al., 2009;Ford et al., 2009) and all-cause mortality by promo...
Source: Schizophrenia Research - September 16, 2017 Category: Psychiatry Authors: J. Bruins, F. J örg, E.R. van den Heuvel, A.A. Bartels-Velthuis, E. Corpeleijn, F.A.J. Muskiet, G.H.M. Pijnenborg, R. Bruggeman Source Type: research

Mismatch negativity impairment is associated with deficits in identifying real-world environmental sounds in schizophrenia
Patients with schizophrenia (SZ) have impairments in processing auditory information that have been linked to deficits in cognitive and psychosocial functioning. Dysfunction in auditory sensory processing in SZ has been indexed by mismatch negativity (MMN), an event-related potential evoked by a rare, deviant stimulus embedded within a sequence of identical standard stimuli. Although MMN deficits in SZ have been studied extensively, relatively little is known about how these deficits relate to accurately identifying real-world, ecologically-salient sounds. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 16, 2017 Category: Psychiatry Authors: Yash B. Joshi, Barbara Breitenstein, Melissa Tarasenko, Michael L. Thomas, Wei-Li Chang, Joyce Sprock, Richard F. Sharp, Gregory A. Light Source Type: research

Impaired contextual fear-conditioning in MAM rodent model of schizophrenia
The methylazoxymethanol acetate (MAM) rodent neurodevelopmental model of schizophrenia exhibits aberrant dopamine system activation attributed to hippocampal dysfunction. Context discrimination is a component of numerous behavioral and cognitive functions and relies on intact hippocampal processing. The present study explored context processing behaviors, along with dopamine system activation, during fear learning in the MAM model.Male offspring of dams treated with MAM (20mg/kg, i.p.) or saline on gestational day 17 were used for electrophysiological and behavioral experiments. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 16, 2017 Category: Psychiatry Authors: Kathryn M. Gill, Sarah A. Miller, Anthony A. Grace Source Type: research

The nuts and bolts of Cognitive Remediation: Exploring how different training components relate to cognitive and functional gains
This study begins to fill this gap by exploring the relationship between CR ingredients, including alliance with a therapist, and therapy outcomes. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 14, 2017 Category: Psychiatry Authors: Matteo Cella, Til Wykes Source Type: research

Dissecting the catatonia phenotype in psychotic and mood disorders on the basis of familial-genetic factors
This study examines the familial aggregation (familiality) of different phenotypic definitions of catatonia in a sample of multiplex families with psychotic and mood disorders. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 14, 2017 Category: Psychiatry Authors: Victor Peralta, Lourdes Fa ñanás, Migdyrai Martín-Reyes, Manuel J. Cuesta Source Type: research

Pregabalin for anxiety in patients with schizophrenia — A randomized, double-blind placebo-controlled study
Anxiety is frequent in patients with schizophrenia and poses a major impact on patients perceived quality of life, daily functioning and risk of suicide. Pregabalin has shown effective in the treatment of generalized anxiety disorder and has been suggested for the treatment of anxiety in patients with schizophrenia. As evidence is sparse regarding treatment of anxiety in this patient group, we aimed to investigate the use of pregabalin for anxiety in patients with schizophrenia. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 14, 2017 Category: Psychiatry Authors: Ole Schjerning, Per Damkier, Signe Engelhardt Lykkegaard, Klaus Damgaard Jakobsen, Jimmi Nielsen Source Type: research

The nuts and bolts of Cognitive Remediation: Exploring how different training components relate to cognitive and functional gains
This study begins to fill this gap by exploring the relationship between CR ingredients, including alliance with a therapist, and therapy outcomes. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 14, 2017 Category: Psychiatry Authors: Matteo Cella, Til Wykes Source Type: research

Dissecting the catatonia phenotype in psychotic and mood disorders on the basis of familial-genetic factors
This study examines the familial aggregation (familiality) of different phenotypic definitions of catatonia in a sample of multiplex families with psychotic and mood disorders. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 14, 2017 Category: Psychiatry Authors: Victor Peralta, Lourdes Fa ñanás, Migdyrai Martín-Reyes, Manuel J. Cuesta Source Type: research

Pregabalin for anxiety in patients with schizophrenia — A randomized, double-blind placebo-controlled study
Anxiety is frequent in patients with schizophrenia and poses a major impact on patients perceived quality of life, daily functioning and risk of suicide. Pregabalin has shown effective in the treatment of generalized anxiety disorder and has been suggested for the treatment of anxiety in patients with schizophrenia. As evidence is sparse regarding treatment of anxiety in this patient group, we aimed to investigate the use of pregabalin for anxiety in patients with schizophrenia. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 14, 2017 Category: Psychiatry Authors: Ole Schjerning, Per Damkier, Signe Engelhardt Lykkegaard, Klaus Damgaard Jakobsen, Jimmi Nielsen Source Type: research

A 10-minute measure of global cognition: Validation of the Brief Cognitive Assessment Tool for Schizophrenia (B-CATS)
Schizophrenia is marked by a global cognitive impairment that contributes significantly to chronic disability and unemployment. As new treatments are developed for cognition in schizophrenia, clinicians require easily administered instruments to assess cognition. We previously developed a very brief cognitive battery (Bell et al., 2005). The Brief Cognitive Assessment Tool for Schizophrenia (B-CATS) was developed specifically to provide clinicians with a way to assess cognition in their patients with schizophrenia. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 13, 2017 Category: Psychiatry Authors: Irene M. Hurford, Joseph Ventura, Stephen R. Marder, Steven P. Reise, Robert M. Bilder Source Type: research

Genetic variation in cytokine genes and risk for transition to psychosis among individuals at ultra-high risk
Cytokines play important neurodevelopmental roles in the brain and the levels at which they are expressed are, in part, dependent on an individual's genetic background (Kronfol and Remick, 2000). A number of genetic studies have demonstrated associations between common variation in genes encoding inflammatory cytokines and schizophrenia in ethnically diverse populations (Butler et al., 2016). However, analogous genetic studies have not been conducted within an ultra-high risk (UHR) for psychosis population. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 12, 2017 Category: Psychiatry Authors: Chad A. Bousman, Tae Young Lee, Minah Kim, Junhee Lee, Md Shaki Mostaid, Minji Bang, Suk Kyoon An, Ian P. Everall, Christos Pantelis, Jun Soo Kwon Tags: Letter to the Editor Source Type: research

Changes in the level of Long Non-Coding RNA Gomafu gene expression in schizophrenia patients before and after antipsychotic medication
Schizophrenia (SCZ) is a serve and heritable mental disorder with a prevalence of approximately 1% worldwide population, characterized by delusions, hallucinations, cognitive impairment and abnormal social behavior. Despite major progress have made in recent decades, the underlying pathogenesis of SCZ are still unclear. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 11, 2017 Category: Psychiatry Authors: Yansong Liu, Shuquan Rao, Yong Xu, Fuquan Zhang, Zhiqiang Wang, Xudong Zhao Tags: Letter to the Editor Source Type: research

Risk factors of compliance with self-harm command hallucinations in individuals with affective and non-affective psychosis
Clinicians are often left with the difficult task of assessing and managing the risk of violent behaviors in individuals having command hallucinations, which may result in substantial rates of false positive or false negative. Moreover, findings on the association between command hallucinations and suicidal behaviors are limited. In an attempt to better understand compliance to this hallucinatory phenomenon, our objective was to identify the risk factors of compliance with self-harm command hallucinations. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 11, 2017 Category: Psychiatry Authors: Jules R. Dugr é, Jean-Pierre Guay, Alexandre Dumais Source Type: research

Changes in the level of Long Non-Coding RNA Gomafu gene expression in schizophrenia patients before and after antipsychotic medication
Schizophrenia (SCZ) is a serve and heritable mental disorder with a prevalence of approximately 1% worldwide population, characterized by delusions, hallucinations, cognitive impairment and abnormal social behavior. Despite major progress have made in recent decades, the underlying pathogenesis of SCZ are still unclear. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 11, 2017 Category: Psychiatry Authors: Yansong Liu, Shuquan Rao, Yong Xu, Fuquan Zhang, Zhiqiang Wang, Xudong Zhao Tags: Letter to the Editor Source Type: research

Risk factors of compliance with self-harm command hallucinations in individuals with affective and non-affective psychosis
Clinicians are often left with the difficult task of assessing and managing the risk of violent behaviors in individuals having command hallucinations, which may result in substantial rates of false positive or false negative. Moreover, findings on the association between command hallucinations and suicidal behaviors are limited. In an attempt to better understand compliance to this hallucinatory phenomenon, our objective was to identify the risk factors of compliance with self-harm command hallucinations. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 11, 2017 Category: Psychiatry Authors: Jules R. Dugr é, Jean-Pierre Guay, Alexandre Dumais Source Type: research

Brain TSPO imaging and gray matter volume in schizophrenia patients and in people at ultra high risk of psychosis: An [11C]PBR28 study
Patients with schizophrenia show whole brain and cortical gray matter (GM) volume reductions which are progressive early in their illness. Microglia, the resident immune cells in the CNS, phagocytose neurons and synapses. Some post mortem and in vivo studies in schizophrenia show evidence for elevated microglial activation compared to matched controls. However, it is currently unclear how these results relate to changes in cortical structure. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 9, 2017 Category: Psychiatry Authors: Sudhakar Selvaraj, Peter S. Bloomfield, Bo Cao, Mattia Veronese, Federico Turkheimer, Oliver D. Howes Source Type: research

What could be learned from a decade with standardized remission criteria in schizophrenia spectrum disorders: An exploratory follow-up study
A decade has passed since the standardized remission criteria of schizophrenia spectrum disorders —the Andreasen Criteria—were defined. Over 2000 studies have been published, but only a few describe symptomatic remission over time. In this prospective study we followed patients for 3 and 5years, respectively. The aim was to investigate how different symptoms affect the occurrence of remissio n and how the remission cut-off level affects remission sustainability.The participants were patients diagnosed with schizophrenia spectrum disorders (DSM-IV). (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 9, 2017 Category: Psychiatry Authors: Madeleine Johansson, Fredrik Hj ärthag, Lars Helldin Source Type: research

Brain TSPO imaging and gray matter volume in schizophrenia patients and in people at ultra high risk of psychosis: An [11C]PBR28 study
Patients with schizophrenia show whole brain and cortical gray matter (GM) volume reductions which are progressive early in their illness. Microglia, the resident immune cells in the CNS, phagocytose neurons and synapses. Some post mortem and in vivo studies in schizophrenia show evidence for elevated microglial activation compared to matched controls. However, it is currently unclear how these results relate to changes in cortical structure. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 9, 2017 Category: Psychiatry Authors: Sudhakar Selvaraj, Peter S. Bloomfield, Bo Cao, Mattia Veronese, Federico Turkheimer, Oliver D. Howes Source Type: research

What could be learned from a decade with standardized remission criteria in schizophrenia spectrum disorders: An exploratory follow-up study
A decade has passed since the standardized remission criteria of schizophrenia spectrum disorders —the Andreasen Criteria—were defined. Over 2000 studies have been published, but only a few describe symptomatic remission over time. In this prospective study we followed patients for 3 and 5years, respectively. The aim was to investigate how different symptoms affect the occurrence of remissio n and how the remission cut-off level affects remission sustainability.The participants were patients diagnosed with schizophrenia spectrum disorders (DSM-IV). (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 9, 2017 Category: Psychiatry Authors: Madeleine Johansson, Fredrik Hj ärthag, Lars Helldin Source Type: research

Motor abnormalities in first-episode psychosis patients and long-term psychosocial functioning
Motor abnormalities (MAs) are highly prevalent in patients with first-episode psychosis both before any exposure and after treatment with antipsychotic drugs. However, the extent to which these abnormalities have predictive value for long-term psychosocial functioning is unknown.One hundred antipsychotic-naive first-episode psychosis (FEP) patients underwent extensive motor evaluation including catatonic, parkinsonism, dyskinesia, akathisia and neurological soft signs. Patients were assessed at na ïve state and 6months later. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 7, 2017 Category: Psychiatry Authors: Manuel J. Cuesta, Elena Garc ía de Jalón, M. Sol Campos, Lucía Moreno-Izco, Ruth Lorente-Omeñaca, Ana M. Sánchez-Torres, Víctor Peralta Source Type: research

Prediction of self-stigma in early psychosis: 3-Year follow-up of the randomized-controlled trial on extended early intervention
Self-stigma represents a major barrier to recovery in people with psychotic disorders but is understudied in early illness stage. Longitudinal investigation of prediction for self-stigma is scarce and none is conducted in early psychosis. We aimed to prospectively examine baseline predictors of self-stigma in early psychosis patients in the context of a 3-year follow-up of a randomized-controlled trial (RCT) comparing 1-year extension of early intervention (EI) with step-down psychiatric care for first-episode psychosis (FEP). (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 7, 2017 Category: Psychiatry Authors: Ryan Wui Hang Ho, Wing Chung Chang, Vivian Wing Yan Kwong, Emily Sin Kei Lau, Gloria Hoi Kei Chan, Olivia Tsz Ting Jim, Christy Lai Ming Hui, Sherry Kit Wa Chan, Edwin Ho Ming Lee, Eric Yu Hai Chen Source Type: research

Motor abnormalities in first-episode psychosis patients and long-term psychosocial functioning
Motor abnormalities (MAs) are highly prevalent in patients with first-episode psychosis both before any exposure and after treatment with antipsychotic drugs. However, the extent to which these abnormalities have predictive value for long-term psychosocial functioning is unknown.One hundred antipsychotic-naive first-episode psychosis (FEP) patients underwent extensive motor evaluation including catatonic, parkinsonism, dyskinesia, akathisia and neurological soft signs. Patients were assessed at na ïve state and 6months later. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 7, 2017 Category: Psychiatry Authors: Manuel J. Cuesta, Elena Garc ía de Jalón, M. Sol Campos, Lucía Moreno-Izco, Ruth Lorente-Omeñaca, Ana M. Sánchez-Torres, Víctor Peralta Source Type: research

Prediction of self-stigma in early psychosis: 3-Year follow-up of the randomized-controlled trial on extended early intervention
Self-stigma represents a major barrier to recovery in people with psychotic disorders but is understudied in early illness stage. Longitudinal investigation of prediction for self-stigma is scarce and none is conducted in early psychosis. We aimed to prospectively examine baseline predictors of self-stigma in early psychosis patients in the context of a 3-year follow-up of a randomized-controlled trial (RCT) comparing 1-year extension of early intervention (EI) with step-down psychiatric care for first-episode psychosis (FEP). (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 7, 2017 Category: Psychiatry Authors: Ryan Wui Hang Ho, Wing Chung Chang, Vivian Wing Yan Kwong, Emily Sin Kei Lau, Gloria Hoi Kei Chan, Olivia Tsz Ting Jim, Christy Lai Ming Hui, Sherry Kit Wa Chan, Edwin Ho Ming Lee, Eric Yu Hai Chen Source Type: research

Patients with psychosis struggle with scalar implicatures
Pragmatic language difficulties in people with psychosis have been demonstrated repeatedly but one of the most studied types of pragmatic language, i.e. scalar implicatures (SIs), has not yet been examined in this population. SIs are a special kind of pragmatic inferences, based on linguistic expressions like some, or, must. Such expressions are part of a scale of informativeness organized by informativity (e.g. some/many/all). Although semantically the less informative expressions imply the more informative ones, pragmatically people generally infer that the use of a less informative expression implies that the more infor...
Source: Schizophrenia Research - September 6, 2017 Category: Psychiatry Authors: Martien Wampers, Sofie Schrauwen, Marc De Hert, Leen Gielen, Walter Schaeken Source Type: research

An examination of components of recovery after five years of treatment in an early intervention program for psychosis
Recovery from psychotic disorders includes both symptomatic and functional components. Progress in understanding recovery requires careful replication and extension of findings using comparable measures. In the current paper, we present a study of five year recovery rates in an early intervention program in London, Canada with the same operational criteria as those used in a previous report from the OPUS cohort in Denmark. Our analysis extends the OPUS reports by including additional potential predictors of overall recovery, such as cognitive functioning, adherence to medication and early social support, and examining rate...
Source: Schizophrenia Research - September 6, 2017 Category: Psychiatry Authors: Ross M.G. Norman, Arlene MacDougall, Rahul Manchanda, Raj Harricharan Source Type: research

Bullying victimization and perpetration in a community sample of youth with psychotic like experiences
Prior studies indicate an association between psychotic-like experiences (PLEs) and bullying victimization; however, the most frequent types of bullying victimization and the association with bullying perpetration are unclear. A community sample of 1563 adolescents completed questionnaires examining PLEs and frequency of bullying victimization and perpetration. Compared to adolescents scoring below the psychosis-risk cut-off (n=1294), those with PLEs (who are putatively at-risk) (n=269) were more likely to report being the victims of overt, relational, and reputational bullying and to have perpetrated bullying against othe...
Source: Schizophrenia Research - September 6, 2017 Category: Psychiatry Authors: Gregory P. Strauss, Ian M. Raugh, Vijay A. Mittal, Brandon E. Gibb, Meredith E. Coles Source Type: research

Risk factors for increased duration of untreated psychosis. Results from the FACE-SZ dataset
This study investigated the prevalence, and associated risk factors, of long DUP in a large, non-selected sample of community-dwelling schizophrenia patients (SZ). (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 6, 2017 Category: Psychiatry Authors: G. Fond, L. Boyer, M. Andrianarisoa, O. Godin, L. Brunel, E. Bulzacka, N. Coulon, P.M. Llorca, F. Berna, B. Aouizerate, D. Capdevielle, T. D'Amato, C. Dubertret, J. Dubreucq, C. Faget, F. Gabayet, J. Mallet, D. Misdrahi, R. Rey, R. Richieri, P. Roux, C. P Source Type: research

Predicting response to rTMS for auditory hallucinations: Younger patients and females do better
The past 15years, many studies investigated the effectiveness of repetitive transcranial magnetic stimulation (rTMS) for auditory hallucinations (AH). Meta-analyses show effect sizes of 0.3 –0.8, with individual treatment effects ranging from zero to full recovery. In rTMS for depression, similar results prompted researchers to investigate predictors for response. Some of these predictors are younger age, treatment refractoriness (Fregni et al., 2006) and female gender (Kedzior et al ., 2014). We explored whether similar predictors exist in the field of AH. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 6, 2017 Category: Psychiatry Authors: Sanne Koops, Christina W. Slotema, Claire Kos, Leonie Bais, Andr é Aleman, Jan Dirk Blom, Iris E.C. Sommer Tags: Letter to the Editor Source Type: research

Increased platelet glycogen sysnthase kinase 3beta in first-episode psychosis
This study aimed to investigate GSK3B protein expression and phosphorylation in drug-na ïve first-episode psychosis patients (n=43) at baseline and following symptom remission, and in healthy controls (n=77). At baseline GSK3B total level was higher in patients (p (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 6, 2017 Category: Psychiatry Authors: Helena P.G. Joaquim, Marcus V. Zanetti, Mauricio H. Serpa, Martinus T. Van de Bilt, Paulo C. Sallet, Tiffany M. Chaim, Geraldo F. Busatto, Wagner F. Gattaz, Leda L. Talib Source Type: research

Patients with psychosis struggle with scalar implicatures
Pragmatic language difficulties in people with psychosis have been demonstrated repeatedly but one of the most studied types of pragmatic language, i.e. scalar implicatures (SIs), has not yet been examined in this population. SIs are a special kind of pragmatic inferences, based on linguistic expressions like some, or, must. Such expressions are part of a scale of informativeness organized by informativity (e.g. some/many/all). Although semantically the less informative expressions imply the more informative ones, pragmatically people generally infer that the use of a less informative expression implies that the more infor...
Source: Schizophrenia Research - September 6, 2017 Category: Psychiatry Authors: Martien Wampers, Sofie Schrauwen, Marc De Hert, Leen Gielen, Walter Schaeken Source Type: research

An examination of components of recovery after five years of treatment in an early intervention program for psychosis
Recovery from psychotic disorders includes both symptomatic and functional components. Progress in understanding recovery requires careful replication and extension of findings using comparable measures. In the current paper, we present a study of five year recovery rates in an early intervention program in London, Canada with the same operational criteria as those used in a previous report from the OPUS cohort in Denmark. Our analysis extends the OPUS reports by including additional potential predictors of overall recovery, such as cognitive functioning, adherence to medication and early social support, and examining rate...
Source: Schizophrenia Research - September 6, 2017 Category: Psychiatry Authors: Ross M.G. Norman, Arlene MacDougall, Rahul Manchanda, Raj Harricharan Source Type: research

Bullying victimization and perpetration in a community sample of youth with psychotic like experiences
Prior studies indicate an association between psychotic-like experiences (PLEs) and bullying victimization; however, the most frequent types of bullying victimization and the association with bullying perpetration are unclear. A community sample of 1563 adolescents completed questionnaires examining PLEs and frequency of bullying victimization and perpetration. Compared to adolescents scoring below the psychosis-risk cut-off (n=1294), those with PLEs (who are putatively at-risk) (n=269) were more likely to report being the victims of overt, relational, and reputational bullying and to have perpetrated bullying against othe...
Source: Schizophrenia Research - September 6, 2017 Category: Psychiatry Authors: Gregory P. Strauss, Ian M. Raugh, Vijay A. Mittal, Brandon E. Gibb, Meredith E. Coles Source Type: research

Risk factors for increased duration of untreated psychosis. Results from the FACE-SZ dataset
This study investigated the prevalence, and associated risk factors, of long DUP in a large, non-selected sample of community-dwelling schizophrenia patients (SZ). (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 6, 2017 Category: Psychiatry Authors: G. Fond, L. Boyer, M. Andrianarisoa, O. Godin, L. Brunel, E. Bulzacka, N. Coulon, P.M. Llorca, F. Berna, B. Aouizerate, D. Capdevielle, T. D'Amato, C. Dubertret, J. Dubreucq, C. Faget, F. Gabayet, J. Mallet, D. Misdrahi, R. Rey, R. Richieri, P. Roux, C. P Source Type: research

Predicting response to rTMS for auditory hallucinations: Younger patients and females do better
The past 15years, many studies investigated the effectiveness of repetitive transcranial magnetic stimulation (rTMS) for auditory hallucinations (AH). Meta-analyses show effect sizes of 0.3 –0.8, with individual treatment effects ranging from zero to full recovery. In rTMS for depression, similar results prompted researchers to investigate predictors for response. Some of these predictors are younger age, treatment refractoriness (Fregni et al., 2006) and female gender (Kedzior et al ., 2014). We explored whether similar predictors exist in the field of AH. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 6, 2017 Category: Psychiatry Authors: Sanne Koops, Christina W. Slotema, Claire Kos, Leonie Bais, Andr é Aleman, Jan Dirk Blom, Iris E.C. Sommer Tags: Letter to the Editor Source Type: research

Increased platelet glycogen sysnthase kinase 3beta in first-episode psychosis
This study aimed to investigate GSK3B protein expression and phosphorylation in drug-na ïve first-episode psychosis patients (n=43) at baseline and following symptom remission, and in healthy controls (n=77). At baseline GSK3B total level was higher in patients (p (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 6, 2017 Category: Psychiatry Authors: Helena P.G. Joaquim, Marcus V. Zanetti, Mauricio H. Serpa, Martinus T. Van de Bilt, Paulo C. Sallet, Tiffany M. Chaim, Geraldo F. Busatto, Wagner F. Gattaz, Leda L. Talib Source Type: research

Gliadin-related antibodies in schizophrenia
Gluten sensitivity (GS), a distinctly different immune response from celiac disease (CD), is believed to be associated with neurologic and psychiatric manifestations. Schizophrenia has been linked to enhanced immune reactivity to gluten (Jackson et al., 2012b). Recently, the production of AGA IgG antibodies has been proposed as a marker of GS. AGA IgG in schizophrenia have been associated with increased peripheral (Demyanovich et al., 2017) and central immune reactions (Rowland et al., 2017), and lower positive symptom scores as measured by the Brief Psychiatric Rating Scale (Jackson et al., 2014), suggesting that an AGA I...
Source: Schizophrenia Research - September 5, 2017 Category: Psychiatry Authors: Daniela Čiháková, William W. Eaton, Monica V. Talor, Uasim H. Harkus, Haley K. Demyanovich, Katrina Rodriguez, Stephanie Feldman, Deanna L. Kelly Tags: Letter to the Editor Source Type: research

Deficit of entropy modulation of the EEG in schizophrenia associated to cognitive performance and symptoms. A replication study
Spectral entropy (SE) is a measurement from information theory field that provides an estimation of EEG regularity and may be useful as a summary of its spectral properties. Previous studies using small samples reported a deficit of EEG entropy modulation in schizophrenia during cognitive activity. The present study is aimed at replicating this finding in a larger sample, to explore its cognitive and clinical correlates and to discard antipsychotic treatment as the main source of that deficit. We included 64 schizophrenia patients (21 first episodes, FE) and 65 healthy controls. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 5, 2017 Category: Psychiatry Authors: Vicente Molina, Alejandro Bachiller, Javier Gomez-Pilar, Alba Lubeiro, Roberto Hornero, Benjam ín Cea-Cañas, César Valcárcel, Mahmoun-Karim Haidar, Jesús Poza Source Type: research

Gliadin-related antibodies in schizophrenia
Gluten sensitivity (GS), a distinctly different immune response from celiac disease (CD), is believed to be associated with neurologic and psychiatric manifestations. Schizophrenia has been linked to enhanced immune reactivity to gluten (Jackson et al., 2012b). Recently, the production of AGA IgG antibodies has been proposed as a marker of GS. AGA IgG in schizophrenia have been associated with increased peripheral (Demyanovich et al., 2017) and central immune reactions (Rowland et al., 2017), and lower positive symptom scores as measured by the Brief Psychiatric Rating Scale (Jackson et al., 2014), suggesting that an AGA I...
Source: Schizophrenia Research - September 5, 2017 Category: Psychiatry Authors: Daniela Čiháková, William W. Eaton, Monica V. Talor, Uasim H. Harkus, Haley K. Demyanovich, Katrina Rodriguez, Stephanie Feldman, Deanna L. Kelly Tags: Letter to the Editor Source Type: research