The association between psychotic experiences and health-related quality of life: a cross-national analysis based on World Mental Health Surveys
Psychotic experiences (PEs) are associated with a range of mental and physical disorders, and disability, but little is known about the association between PEs and aspects of health-related quality of life (HRQoL). We aimed to investigate the association between PEs and five HRQoL indicators with various adjustments. Using data from the WHO World Mental Health surveys (n = 33,370 adult respondents from 19 countries), we assessed for PEs and five HRQoL indicators (self-rated physical or mental health, perceived level of stigma (embarrassment and discrimination), and social network burden). (Source: Schizophrenia Research)
Source: Schizophrenia Research - May 17, 2018 Category: Psychiatry Authors: Jordi Alonso, Sukanta Saha, Carmen C.W. Lim, Sergio Aguilar-Gaxiola, Ali Al-Hamzawi, Corina Benjet, Evelyn J. Bromet, Louisa Degenhardt, Giovanni de Girolamo, Oluyomi Esan, Silvia Florescu, Oye Gureje, Josep M. Haro, Chiyi Hu, Elie G. Karam, Georges Karam Source Type: research
Cortisol awakening response is decreased in patients with first-episode psychosis and increased in healthy controls with a history of severe childhood abuse
Childhood abuse is highly prevalent in psychosis patients, but whether/how it affects hypothalamic-pituitary-adrenal (HPA) axis at the onset of psychosis remains unclear. We aimed to investigate the effects of severity of childhood abuse on HPA axis activity, in first-episode psychosis (FEP) and healthy controls. (Source: Schizophrenia Research)
Source: Schizophrenia Research - May 15, 2018 Category: Psychiatry Authors: Simone Ciufolini, Charlotte Gayer-Anderson, Helen L. Fisher, Tiago Reis Marques, Heather Taylor, Marta Di Forti, Patricia Zunszain, Craig Morgan, Robin M. Murray, Carmine M. Pariante, Paola Dazzan, Valeria Mondelli Source Type: research
Reality testing of the efficacy of tDCS on auditory hallucinations in schizophrenia
After receiving an email from Psychiatry Advisor with the subject line, “Hallucinations in Schizophrenia Alleviated by tDCS” we read with interest the manuscript by Lee, et al. entitled “The effect of transcranial direct current stimulation on auditory hallucination in patients with schizophrenia” published online in Schizophrenia Research (Lee et al., 2018). In this manuscript, the authors performed a meta-analysis of 3 sham-controlled and 3 uncontrolled open label studies and pooled data to assess the impact of transcranial direct current stimulation (tDCS) on auditory hallucinations in patients with schizophreni...
Source: Schizophrenia Research - May 12, 2018 Category: Psychiatry Authors: Robert J. Morgan, Balwinder Singh Tags: Letter to the Editor Source Type: research
Altered predictive capability of the brain network EEG model in schizophrenia during cognition
The study of the mechanisms involved in cognition is of paramount importance for the understanding of the neurobiological substrates in psychiatric disorders. Hence, this research is aimed at exploring the brain network dynamics during a cognitive task. Specifically, we analyze the predictive capability of the pre-stimulus theta activity to ascertain the functional brain dynamics during cognition in both healthy and schizophrenia subjects. Firstly, EEG recordings were acquired during a three-tone oddball task from fifty-one healthy subjects and thirty-five schizophrenia patients. (Source: Schizophrenia Research)
Source: Schizophrenia Research - May 12, 2018 Category: Psychiatry Authors: Javier Gomez-Pilar, Jes ús Poza, Carlos Gómez, Georg Northoff, Alba Lubeiro, Benjamín B. Cea-Cañas, Vicente Molina, Roberto Hornero Source Type: research
Development and validation of the client engagement and service use scale: A pilot study
Specialized treatment for first episode psychosis offers clients a menu of services coordinated within a specialized treatment team. To enhance the impact of these services, promoting engagement and preventing early treatment drop-out is critical. However, engagement is poorly tracked and typically quantified through proxy variables such as session attendance, medication adherence, or working alliance. The aim of this study is to introduce and pilot a new measure of engagement for first episode psychosis coordinated specialty care, the Client Engagement and Service Use Scale (CENSUS). (Source: Schizophrenia Research)
Source: Schizophrenia Research - May 12, 2018 Category: Psychiatry Authors: Emily R. Kline, Nicole R. DeTore, Kristen Keefe, Larry J. Seidman, Vinod H. Srihari, Matcheri S. Keshavan, Margaret Guyer Source Type: research
Poor oral health in patients with schizophrenia: A systematic review and meta-analysis
Increased rates of comorbid physical illness have been commonly reported in patients with schizophrenia. However, there are fewer data on dental disease in these patients. We systematically evaluated existing data on the oral health survey of schizophrenia patients through meta-analysis. Using the available databases, we performed a systematic search to identify the studies examining the oral health in schizophrenia patients from January 1997 to June 2017, based on the inclusion and exclusion criteria. (Source: Schizophrenia Research)
Source: Schizophrenia Research - May 11, 2018 Category: Psychiatry Authors: Mi Yang, Peng Chen, Man-Xi He, Min Lu, Hong-Ming Wang, Jair C. Soares, Xiang-Yang Zhang Source Type: research
Dysbindin-1 contributes to prefrontal cortical dendritic arbor pathology in schizophrenia
This study sought to determine whether MARCKS, its regulatory protein dysbindin-1, and two proteins, identified using microarray data, CDC42BPA and ARHGEF6, were associated with dendritic arbor pathology in the DLPFC from schizophrenia and bipolar disorder subjects. Using western blotting, relative protein expression was assessed in the DLPFC (BA 46) grey matter from subjects with schizophrenia (n = 19), bipolar disorder (n = 17) and unaffected control subjects (n = 19). (Source: Schizophrenia Research)
Source: Schizophrenia Research - May 11, 2018 Category: Psychiatry Authors: Glenn T. Konopaske, Darrick T. Balu, Kendall T. Presti, Grace Chan, Francine M. Benes, Joseph T. Coyle Source Type: research
Sexual abuse and psychosis: The security of research findings
Sexual abuse is by its very nature likely to have pernicious effects: certainly its psychiatric consequences are extensive. They include a range of affective disorders, eating disorders, and alcohol and drug abuse (Jonas et al., 2011), but also psychotic disorders (Bebbington et al., 2004, 2011; Varese et al., 2012; de Vries et al., 2018) (Source: Schizophrenia Research)
Source: Schizophrenia Research - May 10, 2018 Category: Psychiatry Authors: Paul E. Bebbington Source Type: research
Age-related trajectories of social cognition in youth at clinical high risk for psychosis: An exploratory study
Clinical high risk (CHR) status is characterized by impairments in social cognition, but questions remain concerning their stability over development. In cross-sectional analysis of a large naturalistic sample, the current study examined whether those at CHR status show deviant trajectories for age-related change in social cognitive ability, and whether these trajectories are influenced by treatment history. (Source: Schizophrenia Research)
Source: Schizophrenia Research - May 8, 2018 Category: Psychiatry Authors: Charlie A. Davidson, Danijela Piskulic, Jean Addington, Kristen S. Cadenhead, Tyrone D. Cannon, Barbara A. Cornblatt, Thomas H. McGlashan, Diana O. Perkins, Larry J. Seidman, Ming T. Tsuang, Elaine F. Walker, Carrie E. Bearden, Daniel H. Mathalon, Scott W Source Type: research
The relationship between the level of exposure to stress factors and cannabis in recent onset psychosis
This study aims to determine the relationship between the level of exposure to stress factors and cannabis use with psychosis and to determine the combination effect among these factors in predicting a psychotic disorder. (Source: Schizophrenia Research)
Source: Schizophrenia Research - May 6, 2018 Category: Psychiatry Authors: Sara Arranz, Nuria Monferrer, M. Jose Algora, Angel Cabezas, Montse Sole, E. Vilella, J. Labad, Vanessa Sanchez-Gistau Source Type: research
Polygenic Risk Score and the (neuro)developmental ontogenesis of the schizophrenia spectrum vulnerability phenotypes
Mistry et al. (Mistry et al., 2017)'s recent overview on schizophrenia Polygenic Risk Score (s-PRS) and related phenotypic manifestations clearly indicates the potential of such an approach for understanding the liability for schizophrenia. Briefly, available empirical literature seems to converge on four major key-points: 1) pleiotropy between schizophrenia and other disorders (e.g. schizo-affective, bipolar, depressive and anxiety disorders); 2) less common-variant genetic overlap between schizophrenia and cognition than with other psychopathology; 3) small proportion of variance explained by currently available s-PRS fo...
Source: Schizophrenia Research - May 4, 2018 Category: Psychiatry Authors: Michele Poletti, Andrea Raballo Tags: Letter to the editor Source Type: research
Enhancing stress reactivity and wellbeing in early schizophrenia: A pilot study of individual coping awareness therapy (I-CAT)
Dear Editors: (Source: Schizophrenia Research)
Source: Schizophrenia Research - May 4, 2018 Category: Psychiatry Authors: Piper S. Meyer-Kalos, Kelsey A. Ludwig, Susan Gaylord, Diana O. Perkins, Karen Grewen, Olafur S. Palsson, Margaret Burchinal, David L. Penn Tags: Letter to the Editor Source Type: research
Association between catechol-O-methyltransferase genetic variation and functional connectivity in patients with first-episode schizophrenia
Dopamine in the prefrontal cortex (PFC) plays an important role in cognitive performance and regulates by catechol-O-methyltransferase (COMT) expression. To clarify the effect of COMT genotype on cognitive function in patients with schizophrenia, we performed DNA genotyping, cognitive evaluations, and functional magnetic resonance imaging (fMRI) in antipsychotic-na ïve patients with first-episode schizophrenia (FES) and matched healthy control subjects. We found that all cognitive domains were impaired in patients with FES compared with healthy subjects. (Source: Schizophrenia Research)
Source: Schizophrenia Research - May 3, 2018 Category: Psychiatry Authors: Hongyan Wang, Bin Zhang, Botao Zeng, Yingying Tang, Tianhong Zhang, Shanshan Zhao, Chunbo Li, Jijun Wang, Donald C. Goff Source Type: research
Identifying the genetic risk factors for treatment response to lurasidone by genome-wide association study: A meta-analysis of samples from three independent clinical trials
A genome-wide association study (GWAS) of response of schizophrenia patients to the atypical antipsychotic drug, lurasidone, based on two double-blind registration trials, identified SNPs from four classes of genes as predictors of efficacy, but none were genome wide significant (GWS). After inclusion of data from a third lurasidone trial, meta-analysis identified a GWS marker and other findings consistent with our first study. The primary end-point was change in Total Positive and Negative Syndrome Scale (PANSS) between baseline and last observation carried forward. (Source: Schizophrenia Research)
Source: Schizophrenia Research - May 2, 2018 Category: Psychiatry Authors: Jiang Li, Antony Loebel, Herbert Y. Meltzer Source Type: research
Improving cognitive training for schizophrenia using neuroplasticity enhancers: Lessons from decades of basic and clinical research
Mounting evidence indicates that schizophrenia is a disorder that stems from maladaptive plasticity within neural circuits and produces broad cognitive deficits leading to loss of autonomy. A large number of studies have identified abnormalities spanning many neurotransmitter systems in schizophrenia, and as a result, a variety of drugs have been developed to attempt to treat these abnormalities and enhance cognition. Unfortunately, positive results have been limited so far. This may be in part because the scope of abnormalities in the schizophrenic brain requires a treatment capable of engaging many different neurotransmi...
Source: Schizophrenia Research - May 2, 2018 Category: Psychiatry Authors: G.D. Guercio, M.E. Thomas, J.M. Cisneros-Franco, P. Voss, R. Panizzutti, E. de Villers-Sidani Source Type: research
