Integrated analysis supports ATXN1 as a schizophrenia risk gene
Protein-protein interaction (PPI) is informative in identifying hidden disease risk genes that tend to interact with known risk genes usually working together in the same disease module. With the use of an integrated approach combining PPI information with pathway and expression analysis as well as genome-wide association study (GWAS), we intended to find new risk genes for schizophrenia (SCZ). We showed that ATXN1 was the only direct PPI partner of the know SCZ risk gene ZNF804A, and it also had direct PPIs with other 18 known SCZ risk genes. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 18, 2017 Category: Psychiatry Authors: Jiewei Liu, Bing Su Source Type: research

The association between changes in depression/anxiety and trajectories of psychotic-like experiences over a year in adolescence
Recent cross-sectional studies suggest that psychotic-like experiences (PLEs) are associated with depression and anxiety in adolescents. While longitudinal studies have observed that adolescents suffer more severe symptoms of depression/anxiety when PLEs persist, it remains unclear whether depression/anxiety worsens or improves with PLE emergence or remission, respectively. In this prospective school-based study, we investigated the association between longitudinal changes in depression/anxiety and one-year PLE trajectories in adolescence. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 18, 2017 Category: Psychiatry Authors: Syudo Yamasaki, Satoshi Usami, Ryo Sasaki, Shinsuke Koike, Shuntaro Ando, Yuko Kitagawa, Misato Matamura, Masako Fukushima, Hiromi Yonehara, Jerome Clifford Foo, Atsushi Nishida, Tsukasa Sasaki Source Type: research

Integrated analysis supports ATXN1 as a schizophrenia risk gene
Protein-protein interaction (PPI) is informative in identifying hidden disease risk genes that tend to interact with known risk genes usually working together in the same disease module. With the use of an integrated approach combining PPI information with pathway and expression analysis as well as genome-wide association study (GWAS), we intended to find new risk genes for schizophrenia (SCZ). We showed that ATXN1 was the only direct PPI partner of the know SCZ risk gene ZNF804A, and it also had direct PPIs with other 18 known SCZ risk genes. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 18, 2017 Category: Psychiatry Authors: Jiewei Liu, Bing Su Source Type: research

The association between changes in depression/anxiety and trajectories of psychotic-like experiences over a year in adolescence
Recent cross-sectional studies suggest that psychotic-like experiences (PLEs) are associated with depression and anxiety in adolescents. While longitudinal studies have observed that adolescents suffer more severe symptoms of depression/anxiety when PLEs persist, it remains unclear whether depression/anxiety worsens or improves with PLE emergence or remission, respectively. In this prospective school-based study, we investigated the association between longitudinal changes in depression/anxiety and one-year PLE trajectories in adolescence. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 18, 2017 Category: Psychiatry Authors: Syudo Yamasaki, Satoshi Usami, Ryo Sasaki, Shinsuke Koike, Shuntaro Ando, Yuko Kitagawa, Misato Matamura, Masako Fukushima, Hiromi Yonehara, Jerome Clifford Foo, Atsushi Nishida, Tsukasa Sasaki Source Type: research

Prevalence of underweight in patients with schizophrenia: A meta-analysis
Although the relationship between body mass index and all-cause mortality is U-shaped, underweight has received comparatively less attention than obesity. There is only limited evidence to date regarding underweight among patients with schizophrenia. This is the first meta-analysis to address the prevalence of underweight in these patients. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 17, 2017 Category: Psychiatry Authors: Norio Sugawara, Kazushi Maruo, Takuro Sugai, Yutaro Suzuki, Yuji Ozeki, Kazutaka Shimoda, Toshiyuki Someya, Norio Yasui-Furukori Source Type: research

Genetic correlates of insight in schizophrenia
We examined genetic contributions to insight by investigating if polygenic risk scores (PRS) and candidate regions were associated with insight. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 17, 2017 Category: Psychiatry Authors: Rose Mary Xavier, Allison Vorderstrasse, Richard S.E. Keefe, Jennifer R. Dungan Source Type: research

Prevalence of underweight in patients with schizophrenia: A meta-analysis
Although the relationship between body mass index and all-cause mortality is U-shaped, underweight has received comparatively less attention than obesity. There is only limited evidence to date regarding underweight among patients with schizophrenia. This is the first meta-analysis to address the prevalence of underweight in these patients. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 17, 2017 Category: Psychiatry Authors: Norio Sugawara, Kazushi Maruo, Takuro Sugai, Yutaro Suzuki, Yuji Ozeki, Kazutaka Shimoda, Toshiyuki Someya, Norio Yasui-Furukori Source Type: research

Genetic correlates of insight in schizophrenia
We examined genetic contributions to insight by investigating if polygenic risk scores (PRS) and candidate regions were associated with insight. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 17, 2017 Category: Psychiatry Authors: Rose Mary Xavier, Allison Vorderstrasse, Richard S.E. Keefe, Jennifer R. Dungan Source Type: research

Importance of considering the role of tetraethyl lead when examining the relationship between environmental pollution and psychotic disorders
We read with great interest the systematic review by Attademo et al. (2017) on the link between environmental pollution and psychotic disorders. We are concerned that the authors failed to include search terms specific to the most extensively studied airborne neurotoxin, lead, thereby missing many important sources relevant to the link between air pollution and schizophrenia. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 16, 2017 Category: Psychiatry Authors: Esme Fuller-Thomson, Amy P. Munro Tags: Letter to the Editor Source Type: research

Effects of a nicotinic agonist on the Brief Psychiatric Rating Scale five-factor subscale model in schizophrenia
The excitatory, ligand-gated α7 nicotinic acetylcholine receptor (nAChR) has been implicated in the pathophysiology of schizophrenia based on convergent genetic, post-mortem, and psychopharmacological studies (reviewed in Freedman, 2014). Preclinical animal studies (reviewed in Lewis et al., 2017), as well as early phase clini cal studies of patients with schizophrenia (Olincy et al., 2006), suggest α7 nAChR agonists may be useful for treatment of cognitive dysfunction in schizophrenia. However, results of larger randomized placebo-controlled clinical trials of α7 nAChR agonists with a primary cognitive o...
Source: Schizophrenia Research - October 16, 2017 Category: Psychiatry Authors: Alan S. Lewis, Ann Olincy, Robert W. Buchanan, William R. Kem, Marina R. Picciotto, Robert Freedman Tags: Letter to the Editor Source Type: research

Importance of considering the role of tetraethyl lead when examining the relationship between environmental pollution and psychotic disorders
We read with great interest the systematic review by Attademo et al. (2017) on the link between environmental pollution and psychotic disorders. We are concerned that the authors failed to include search terms specific to the most extensively studied airborne neurotoxin, lead, thereby missing many important sources relevant to the link between air pollution and schizophrenia. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 16, 2017 Category: Psychiatry Authors: Esme Fuller-Thomson, Amy P. Munro Tags: Letter to the Editor Source Type: research

Effects of a nicotinic agonist on the Brief Psychiatric Rating Scale five-factor subscale model in schizophrenia
The excitatory, ligand-gated α7 nicotinic acetylcholine receptor (nAChR) has been implicated in the pathophysiology of schizophrenia based on convergent genetic, post-mortem, and psychopharmacological studies (reviewed in Freedman, 2014). Preclinical animal studies (reviewed in Lewis et al., 2017), as well as early phase clini cal studies of patients with schizophrenia (Olincy et al., 2006), suggest α7 nAChR agonists may be useful for treatment of cognitive dysfunction in schizophrenia. However, results of larger randomized placebo-controlled clinical trials of α7 nAChR agonists with a primary cognitive o...
Source: Schizophrenia Research - October 16, 2017 Category: Psychiatry Authors: Alan S. Lewis, Ann Olincy, Robert W. Buchanan, William R. Kem, Marina R. Picciotto, Robert Freedman Tags: Letter to the Editor Source Type: research

Addiction and schizophrenia: A translational perspective
Schizophrenia, a complex neuropsychiatric syndrome that affects nearly 1% of the population and includes positive, negative, and cognitive symptoms (Andreasen, 2000), is associated with a variety of co-occurring substance use disorders (Buckley et al., 2009). The Epidemiologic Catchment Area survey showed that individuals with schizophrenia have a high rate of substance (e.g., alcohol, cannabis, and cocaine) use disorders – nearly 5 times the rate seen in the general population (Regier et al., 1990). (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 15, 2017 Category: Psychiatry Authors: Alan I. Green, Jibran Y. Khokhar Source Type: research

Functional network dysconnectivity as a biomarker of treatment resistance in schizophrenia
Schizophrenia may develop from disruptions in functional connectivity regulated by neurotransmitters such as dopamine and acetylcholine. The modulatory effects of these neurotransmitters might explain how antipsychotics attenuate symptoms of schizophrenia and account for the variable response to antipsychotics observed in clinical practice. Based on the putative mechanisms of antipsychotics and evidence of disrupted connectivity in schizophrenia, we hypothesised that functional network connectivity, as assessed using network-based statistics, would exhibit differences between treatment response subtypes of schizophrenia an...
Source: Schizophrenia Research - October 14, 2017 Category: Psychiatry Authors: Carolyn B. McNabb, Roger J. Tait, Meghan E. McIlwain, Valerie M. Anderson, John Suckling, Robert R. Kydd, Bruce R. Russell Source Type: research

Guided self-help cognitive-behaviour Intervention for VoicEs (GiVE): Results from a pilot randomised controlled trial in a transdiagnostic sample
Few patients have access to cognitive behaviour therapy for psychosis (CBTp) even though at least 16 sessions of CBTp is recommended in treatment guidelines. Briefer CBTp could improve access as the same number of therapists could see more patients. In addition, focusing on single psychotic symptoms, such as auditory hallucinations ( ‘voices’), rather than on psychosis more broadly, may yield greater benefits. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 13, 2017 Category: Psychiatry Authors: Cassie M. Hazell, Mark Hayward, Kate Cavanagh, Anna-Marie Jones, Clara Strauss Source Type: research

Combining actigraphy, ecological momentary assessment and neuroimaging to study apathy in patients with schizophrenia
Apathy can be defined as a reduction of goal-directed behavior and is a strong predictor for poor functional outcome in schizophrenia. However, no objective measure of apathy has been identified and assessment is limited to retrospective interview-based ratings. Here we aimed to identify more precise objective readouts of apathy for translational research and clinical practice. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 12, 2017 Category: Psychiatry Authors: Agne Kluge, Matthias Kirschner, Oliver M. Hager, Martin Bischof, Benedikt Habermeyer, Erich Seifritz, Sebastian Walther, Stefan Kaiser Source Type: research

DNA methylation age is not accelerated in brain or blood of subjects with schizophrenia
Individuals with schizophrenia (SZ) exhibit multiple premature age-related phenotypes and die ~20years prematurely. The accelerated aging hypothesis of SZ has been advanced to explain these observations, it posits that SZ-associated factors accelerate the progressive biological changes associated with normal aging. Testing the hypothesis has been limited by the absence of robust, meaningful, and multi-tissue measures of biological age. Recently, a method was described in which DNA methylation (DNAm) levels at 353 genomic sites are used to produce “DNAm age”, an estimate of biological age with advantages over ex...
Source: Schizophrenia Research - October 6, 2017 Category: Psychiatry Authors: Brandon C. McKinney, Huang Lin, Ying Ding, David A. Lewis, Robert A. Sweet Source Type: research

Using wearable technology to detect the autonomic signature of illness severity in schizophrenia
Research suggests that people with schizophrenia have autonomic dysfunctions. These have been linked to functioning problems, symptoms and considered a risk factor for illness chronicity. The aim of this study is to introduce a new Mobile Health (mHealth) method using wearable technology to assessing autonomic activity in people's everyday life. We aim to evaluate the new method acceptability and characterise the association between schizophrenia illness features and autonomic abnormalities. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 4, 2017 Category: Psychiatry Authors: Matteo Cella, Łukasz Okruszek, Megan Lawrence, Valerio Zarlenga, Zhimin He, Til Wykes Source Type: research

Schizophrenia in Wolfram Syndrome (DIDMOAD Syndrome): A case report in support of the mitochondrial dysfunction hypothesis
Schizophrenia is a chronic severe disabling psychiatric illness of neurodevelopmental origin with a lifetime prevalence of 1% (Saha et al., 2005). It is highly heritable and considered as a polygenic disorder whose origin or cause is still not clear (Cardno et al., 1999; Gottesman and Shields, 1967). Though it is considered to be a brain disorder, studies have shown that patient with schizophrenia may have various systemic abnormalities. Ultra-structural changes in the mitochondria have led to a proposal of Mitochondrial dysfunction as one of the promising pathways for the pathogenesis of schizophrenia (Park and Park, 2012...
Source: Schizophrenia Research - October 4, 2017 Category: Psychiatry Authors: Guru S. Gowda, Dev Rai, Ravi Kumar Nadella, Sarbesh Tiwari, Ravi Yadav, Suresh Bada Math Tags: Letter to the Editor Source Type: research

Association between mismatch negativity and global functioning is specific to duration deviance in early stages of psychosis
Mismatch negativity (MMN) is a candidate biomarker for early stages of psychosis. Although an association among duration MMN (dMMN), cognitive deficits, and functional outcome in chronic schizophrenia has been shown by a large-scale study, the effects of deviant type and clinical stages have not been investigated. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 4, 2017 Category: Psychiatry Authors: Daisuke Koshiyama, Kenji Kirihara, Mariko Tada, Tatsuya Nagai, Mao Fujioka, Shinsuke Koike, Motomu Suga, Tsuyoshi Araki, Kiyoto Kasai Source Type: research

Using wearable technology to detect the autonomic signature of illness severity in schizophrenia
Research suggests that people with schizophrenia have autonomic dysfunctions. These have been linked to functioning problems, symptoms and considered a risk factor for illness chronicity. The aim of this study is to introduce a new Mobile Health (mHealth) method using wearable technology to assessing autonomic activity in people's everyday life. We aim to evaluate the new method acceptability and characterise the association between schizophrenia illness features and autonomic abnormalities. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 4, 2017 Category: Psychiatry Authors: Matteo Cella, Łukasz Okruszek, Megan Lawrence, Valerio Zarlenga, Zhimin He, Til Wykes Source Type: research

Schizophrenia in Wolfram Syndrome (DIDMOAD Syndrome): A case report in support of the mitochondrial dysfunction hypothesis
Schizophrenia is a chronic severe disabling psychiatric illness of neurodevelopmental origin with a lifetime prevalence of 1% (Saha et al., 2005). It is highly heritable and considered as a polygenic disorder whose origin or cause is still not clear (Cardno et al., 1999; Gottesman and Shields, 1967). Though it is considered to be a brain disorder, studies have shown that patient with schizophrenia may have various systemic abnormalities. Ultra-structural changes in the mitochondria have led to a proposal of Mitochondrial dysfunction as one of the promising pathways for the pathogenesis of schizophrenia (Park and Park, 2012...
Source: Schizophrenia Research - October 4, 2017 Category: Psychiatry Authors: Guru S. Gowda, Dev Rai, Ravi Kumar Nadella, Sarbesh Tiwari, Ravi Yadav, Suresh Bada Math Tags: Letter to the Editor Source Type: research

Association between mismatch negativity and global functioning is specific to duration deviance in early stages of psychosis
Mismatch negativity (MMN) is a candidate biomarker for early stages of psychosis. Although an association among duration MMN (dMMN), cognitive deficits, and functional outcome in chronic schizophrenia has been shown by a large-scale study, the effects of deviant type and clinical stages have not been investigated. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 4, 2017 Category: Psychiatry Authors: Daisuke Koshiyama, Kenji Kirihara, Mariko Tada, Tatsuya Nagai, Mao Fujioka, Shinsuke Koike, Motomu Suga, Tsuyoshi Araki, Kiyoto Kasai Source Type: research

The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) consortium: A collaborative cognitive and neuroimaging genetics project
This article describes the GENUS Consortium sample collection. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 2, 2017 Category: Psychiatry Authors: Gabri ëlla A.M. Blokland, Elisabetta C. del Re, Raquelle I. Mesholam-Gately, Jorge Jovicich, Joey W. Trampush, Matcheri S. Keshavan, Lynn E. DeLisi, James T.R. Walters, Jessica A. Turner, Anil K. Malhotra, Todd Lencz, Martha E. Shenton, Aristotle N. Voin Source Type: research

Depression during first episode psychosis and subsequent suicide risk: A systematic review and meta-analysis of longitudinal studies
Evidence suggests first episode psychosis (FEP) is associated with suicide, and the influence of depression on suicidal behaviour in cross sectional studies is clear. However the influence of depression during FEP on longer-term mortality is not certain. Existing evidence was synthesised to understand the influence of depressive symptoms during FEP on subsequent suicidal behaviour. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 2, 2017 Category: Psychiatry Authors: Jessica McGinty, M. Sayeed Haque, Rachel Upthegrove Source Type: research

The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) consortium: A collaborative cognitive and neuroimaging genetics project
This article describes the GENUS Consortium sample collection. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 2, 2017 Category: Psychiatry Authors: Gabri ëlla A.M. Blokland, Elisabetta C. del Re, Raquelle I. Mesholam-Gately, Jorge Jovicich, Joey W. Trampush, Matcheri S. Keshavan, Lynn E. DeLisi, James T.R. Walters, Jessica A. Turner, Anil K. Malhotra, Todd Lencz, Martha E. Shenton, Aristotle N. Voin Source Type: research

Depression during first episode psychosis and subsequent suicide risk: A systematic review and meta-analysis of longitudinal studies
Evidence suggests first episode psychosis (FEP) is associated with suicide, and the influence of depression on suicidal behaviour in cross sectional studies is clear. However the influence of depression during FEP on longer-term mortality is not certain. Existing evidence was synthesised to understand the influence of depressive symptoms during FEP on subsequent suicidal behaviour. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 2, 2017 Category: Psychiatry Authors: Jessica McGinty, M. Sayeed Haque, Rachel Upthegrove Source Type: research

Editorial Board
(Source: Schizophrenia Research)
Source: Schizophrenia Research - October 1, 2017 Category: Psychiatry Source Type: research

In This Issue September 2017
As always, we attempt to bring together several different topics about schizophrenia etiology, pathophysiology and treatment within one issue so that they can “cross-fertilize” one another and thus contribute new insights about the illness. Thus, we have here brought together a much researched MRI measurement (cortical thickness) as a biological marker, inflammatory mechanisms, the cannabinoid system, treatment of facial affect recognition impairments , negative symptoms, and treatment resistant schizophrenia. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 1, 2017 Category: Psychiatry Authors: Lynn E. DeLisi Tags: Invited commentary Source Type: research

Structural anomalies of the peripheral olfactory system in psychosis high-risk subjects
Olfactory impairments are prominent in both schizophrenia and the preceding at-risk state. Their presence prior to illness predicts poor functional outcome. In schizophrenia, these impairments reflect peripheral olfactory structural abnormalities, which are hypothesized to arise during early embryonic development. If this is correct, then similar structural anomalies should be apparent among clinical high-risk subjects. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 30, 2017 Category: Psychiatry Authors: Bruce I. Turetsky, Paul J. Moberg, Megan Quarmley, Erich Dress, Monica E. Calkins, Kosha Ruparel, Karthik Prabhakaran, Raquel E. Gur, David R. Roalf Source Type: research

Influence of Venus and Mars in the cognitive sky of schizophrenia. Results from the first-step national FACE-SZ cohort
Sex differences can yield important clues regarding illness pathophysiology and its treatment. Schizophrenia (SZ) has a lower incidence rate, and a better prognosis, in women versus men. The present study investigated the cognitive profiles of both sexes in a large multi-centre sample of community-dwelling SZ patients. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 30, 2017 Category: Psychiatry Authors: G. Fond, L. Boyer, M. Leboyer, O. Godin, P.M. Llorca, M. Andrianarisoa, F. Berna, L. Brunel, B. Aouizerate, D. Capdevielle, I. Chereau, T. D'Amato, C. Dubertret, J. Dubreucq, C. Faget, F. Gabayet, J. Mallet, D. Misdrahi, R. Rey, C. Lancon, C. Passerieux, Source Type: research

Structural anomalies of the peripheral olfactory system in psychosis high-risk subjects
Olfactory impairments are prominent in both schizophrenia and the preceding at-risk state. Their presence prior to illness predicts poor functional outcome. In schizophrenia, these impairments reflect peripheral olfactory structural abnormalities, which are hypothesized to arise during early embryonic development. If this is correct, then similar structural anomalies should be apparent among clinical high-risk subjects. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 30, 2017 Category: Psychiatry Authors: Bruce I. Turetsky, Paul J. Moberg, Megan Quarmley, Erich Dress, Monica E. Calkins, Kosha Ruparel, Karthik Prabhakaran, Raquel E. Gur, David R. Roalf Source Type: research

Influence of Venus and Mars in the cognitive sky of schizophrenia. Results from the first-step national FACE-SZ cohort
Sex differences can yield important clues regarding illness pathophysiology and its treatment. Schizophrenia (SZ) has a lower incidence rate, and a better prognosis, in women versus men. The present study investigated the cognitive profiles of both sexes in a large multi-centre sample of community-dwelling SZ patients. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 30, 2017 Category: Psychiatry Authors: G. Fond, L. Boyer, M. Leboyer, O. Godin, P.M. Llorca, M. Andrianarisoa, F. Berna, L. Brunel, B. Aouizerate, D. Capdevielle, I. Chereau, T. D'Amato, C. Dubertret, J. Dubreucq, C. Faget, F. Gabayet, J. Mallet, D. Misdrahi, R. Rey, C. Lancon, C. Passerieux, Source Type: research

Targeted neural network interventions for auditory hallucinations: Can TMS inform DBS?
The debilitating and refractory nature of auditory hallucinations (AH) in schizophrenia and other psychiatric disorders has stimulated investigations into neuromodulatory interventions that target the aberrant neural networks associated with them. Internal or invasive forms of brain stimulation such as deep brain stimulation (DBS) are currently being explored for treatment-refractory schizophrenia. The process of developing and implementing DBS is limited by symptom clustering within psychiatric constructs as well as a scarcity of causal tools with which to predict response, refine targeting or guide clinical decisions. (S...
Source: Schizophrenia Research - September 29, 2017 Category: Psychiatry Authors: Joseph J. Taylor, John H. Krystal, Deepak C. D'Souza, Jason Lee Gerrard, Philip R. Corlett Tags: Invited commentary Source Type: research

Drug-related predictors of readmission for schizophrenia among patients admitted to treatment for drug use disorders
This study aimed to assess drug-related predictors of readmission for schizophrenia among a national cohort of patients with a history of schizophrenia admitted to DUD treatment. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 29, 2017 Category: Psychiatry Authors: Kristine R ømer Thomsen, Birgitte Thylstrup, Michael Mulbjerg Pedersen, Mads Uffe Pedersen, Erik Simonsen, Morten Hesse Source Type: research

Neighbourhood ethnic density and psychosis — Is there a difference according to generation?
For different migrant groups living in an area with few people from the same ethnic background is associated with increased psychosis incidence (the ethnic density effect). We set out to answer the question: are there generational differences in this effect? (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 29, 2017 Category: Psychiatry Authors: Peter Schofield, Malene Thygesen, Jayati Das-Munshi, Laia Becares, Elizabeth Cantor-Graae, Esben Agerbo, Carsten Pedersen Source Type: research

Neuropsychological functioning and jumping to conclusions in recent onset psychosis patients
The reasoning bias of jumping to conclusions (JTC) consists of a tendency to make assumptions having little information. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 29, 2017 Category: Psychiatry Authors: Lucas Elio Gonz ález, Raquel López-Carrilero, Maria Luisa Barrigón, Eva Grasa, Ana Barajas, Esther Pousa, Fermín González-Higueras, Isabel Ruiz-Delgado, Jordi Cid, Esther Lorente-Rovira, Trinidad Pélaez, the Spanish Metacognition Study Group, Susana Source Type: research

Pregnancy exposure to quetiapine – Therapeutic drug monitoring in maternal blood, amniotic fluid and cord blood and obstetrical outcomes
This prospective study is the first to measure and correlate quetiapine concentrations in maternal blood, amniotic fluid and umbilical cord blood to account for the distribution of quetiapine. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 29, 2017 Category: Psychiatry Authors: Michael Paulzen, Tamme W. Goecke, Maxim Kuzin, Marc Augustin, Gerhard Gr ünder, Georgios Schoretsanitis Source Type: research

Targeted neural network interventions for auditory hallucinations: Can TMS inform DBS?
The debilitating and refractory nature of auditory hallucinations (AH) in schizophrenia and other psychiatric disorders has stimulated investigations into neuromodulatory interventions that target the aberrant neural networks associated with them. Internal or invasive forms of brain stimulation such as deep brain stimulation (DBS) are currently being explored for treatment-refractory schizophrenia. The process of developing and implementing DBS is limited by symptom clustering within psychiatric constructs as well as a scarcity of causal tools with which to predict response, refine targeting or guide clinical decisions. (S...
Source: Schizophrenia Research - September 29, 2017 Category: Psychiatry Authors: Joseph J. Taylor, John H. Krystal, Deepak C. D'Souza, Jason Lee Gerrard, Philip R. Corlett Tags: Invited commentary Source Type: research

Drug-related predictors of readmission for schizophrenia among patients admitted to treatment for drug use disorders
This study aimed to assess drug-related predictors of readmission for schizophrenia among a national cohort of patients with a history of schizophrenia admitted to DUD treatment. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 29, 2017 Category: Psychiatry Authors: Kristine R ømer Thomsen, Birgitte Thylstrup, Michael Mulbjerg Pedersen, Mads Uffe Pedersen, Erik Simonsen, Morten Hesse Source Type: research

Neighbourhood ethnic density and psychosis — Is there a difference according to generation?
For different migrant groups living in an area with few people from the same ethnic background is associated with increased psychosis incidence (the ethnic density effect). We set out to answer the question: are there generational differences in this effect? (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 29, 2017 Category: Psychiatry Authors: Peter Schofield, Malene Thygesen, Jayati Das-Munshi, Laia Becares, Elizabeth Cantor-Graae, Esben Agerbo, Carsten Pedersen Source Type: research

Neuropsychological functioning and jumping to conclusions in recent onset psychosis patients
The reasoning bias of jumping to conclusions (JTC) consists of a tendency to make assumptions having little information. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 29, 2017 Category: Psychiatry Authors: Lucas Elio Gonz ález, Raquel López-Carrilero, Maria Luisa Barrigón, Eva Grasa, Ana Barajas, Esther Pousa, Fermín González-Higueras, Isabel Ruiz-Delgado, Jordi Cid, Esther Lorente-Rovira, Trinidad Pélaez, the Spanish Metacognition Study Group, Susana Source Type: research

Pregnancy exposure to quetiapine – Therapeutic drug monitoring in maternal blood, amniotic fluid and cord blood and obstetrical outcomes
This prospective study is the first to measure and correlate quetiapine concentrations in maternal blood, amniotic fluid and umbilical cord blood to account for the distribution of quetiapine. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 29, 2017 Category: Psychiatry Authors: Michael Paulzen, Tamme W. Goecke, Maxim Kuzin, Marc Augustin, Gerhard Gr ünder, Georgios Schoretsanitis Source Type: research

White matter microstructure and cognitive remediation outcomes in schizophrenia
Cognitive remediation has emerged as an effective approach for the treatment of cognitive impairments in patients with schizophrenia that can aid in significantly improving functional recovery from the disorder (McGurk et al., 2007; Wykes et al., 2011). Most cognitive remediation protocols are predicated upon the assumption of neuroplasticity and that with repeated exercise, targeted cognitive training may be able to alter brain functions (Ramsay and MacDonald, 2015) or structure (Eack et al., 2010) in ways that meaningfully improve outcomes. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 28, 2017 Category: Psychiatry Authors: Sinead M. Kelly, Shaun M. Eack Source Type: research

Peripheral oxytocin and vasopressin are associated with clinical symptom severity and cognitive functioning in midlife women with chronic schizophrenia
Neuroendocrine factors may contribute to cognitive and clinical symptom severity in schizophrenia, particularly among midlife women who may be a particularly vulnerable subpopulation given menopausal-related hormonal changes. Numerous studies demonstrate influences of both sex steroid hormones and sexually dimorphic neurohormones including oxytocin (OT) and arginine vasopressin (AVP) on cognition and symptomatology in schizophrenia (Bergemann et al., 2007; Kulkarni et al., 2015; Rubin et al., 2014; Rubin et al., 2013; Rubin et al., 2010; Rubin et al., 2015). (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 28, 2017 Category: Psychiatry Authors: Leah H. Rubin, Heidi J. Wehring, Haley Demyanovich, C. Sue Carter, Hossein Pournajafi-Nazarloo, Stephanie M. Feldman, Amber K. Earl, Sharon August, James M. Gold, Deanna L. Kelly Tags: Letter to the Editor Source Type: research