Aberrant corticostriatal connectivity predict positive symptoms of antipsychotic-na ïve patients with adolescent-onset schizophrenia during brain maturation
Patients with childhood- and adolescent-onset schizophrenia are thought to have severe clinical symptoms and age-related deviance in attention, memory, and executive function (Frangou, 2010). Given that early dopaminergic dysregulation in the striatum and cortical regions may be associated with the emergence of psychotic symptoms (Murray et al., 2008; Simpson et al., 2010), investigations into the corticostriatal circuits in adolescent patients may provide an exceptional opportunity to explore the pathogenesis of schizophrenia during brain maturation (Simpson et al., 2010). (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 21, 2017 Category: Psychiatry Authors: Junjie Zheng, Yan Zhang, Meiling Li, Wei Liao, Xujun Duan, Jingping Zhao, Huafu Chen Tags: Letter to the Editor Source Type: research

Disparity of end-of-life care in cancer patients with and without schizophrenia: A nationwide population-based cohort study
Cancer patients with schizophrenia may face disparities in end-of life care, and it is unclear whether schizophrenia affects their medical care and treatment. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 21, 2017 Category: Psychiatry Authors: Huei-Kai Huang, Ying-Wei Wang, Jyh-Gang Hsieh, Chia-Jung Hsieh Source Type: research

Rates and predictors of relapse following discontinuation of antipsychotic medication after a first episode of psychosis
There is uncertainty about the required duration of long-term antipsychotic maintenance medication after a first episode of psychosis. Robust predictors of relapse after discontinuation are yet to be identified. The present study aimed to determine the proportion of young people who discontinue their antipsychotic medication after a first episode of psychosis, the proportion who experience relapse, and predictors of relapse. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 21, 2017 Category: Psychiatry Authors: Meghan Bowtell, Scott Eaton, Kristen Thien, Melissa Bardell-Williams, Linglee Downey, Aswin Ratheesh, Eoin Killackey, Patrick McGorry, Brian O'Donoghue Source Type: research

Prolactin monitoring in first-episode psychotic patients
Clinicians do not routinely monitor prolactin levels when prescribing antipsychotics. Experts differ on the advisability of this. The latest National Institute of Clinical Excellence guidelines from the UK (NICE, 2014) does not recommend routine prolactin monitoring, nor does the widely-read US author Dr. Stephan Stahl recommend it in the latest edition of his Prescribers Guide (Stahl, 2017). He considers it “of dubious clinical benefit,” even for risperidone (pg. 646). On the other hand, the latest Maudsley Guidelines (Taylor et al., 2015), that is utilized in residency training throughout the British Isles, r...
Source: Schizophrenia Research - October 21, 2017 Category: Psychiatry Authors: David N. Osser Source Type: research

Clinicians should better invest in de-escalation than in fish-oil to prevent violence
In their recently published paper, Quiao et al. suggest that omega-3 fatty acid might be effective in preventing violence in schizophrenia. However, the presented results do not allow this conclusion for several reasons. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 21, 2017 Category: Psychiatry Authors: Tilman Steinert Tags: Letter to the Editor Source Type: research

Aberrant corticostriatal connectivity predict positive symptoms of antipsychotic-na ïve patients with adolescent-onset schizophrenia during brain maturation
Patients with childhood- and adolescent-onset schizophrenia are thought to have severe clinical symptoms and age-related deviance in attention, memory, and executive function (Frangou, 2010). Given that early dopaminergic dysregulation in the striatum and cortical regions may be associated with the emergence of psychotic symptoms (Murray et al., 2008; Simpson et al., 2010), investigations into the corticostriatal circuits in adolescent patients may provide an exceptional opportunity to explore the pathogenesis of schizophrenia during brain maturation (Simpson et al., 2010). (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 21, 2017 Category: Psychiatry Authors: Junjie Zheng, Yan Zhang, Meiling Li, Wei Liao, Xujun Duan, Jingping Zhao, Huafu Chen Tags: Letter to the Editor Source Type: research

Disparity of end-of-life care in cancer patients with and without schizophrenia: A nationwide population-based cohort study
Cancer patients with schizophrenia may face disparities in end-of life care, and it is unclear whether schizophrenia affects their medical care and treatment. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 21, 2017 Category: Psychiatry Authors: Huei-Kai Huang, Ying-Wei Wang, Jyh-Gang Hsieh, Chia-Jung Hsieh Source Type: research

Rates and predictors of relapse following discontinuation of antipsychotic medication after a first episode of psychosis
There is uncertainty about the required duration of long-term antipsychotic maintenance medication after a first episode of psychosis. Robust predictors of relapse after discontinuation are yet to be identified. The present study aimed to determine the proportion of young people who discontinue their antipsychotic medication after a first episode of psychosis, the proportion who experience relapse, and predictors of relapse. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 21, 2017 Category: Psychiatry Authors: Meghan Bowtell, Scott Eaton, Kristen Thien, Melissa Bardell-Williams, Linglee Downey, Aswin Ratheesh, Eoin Killackey, Patrick McGorry, Brian O'Donoghue Source Type: research

Character strengths of individuals with first episode psychosis in Individual Resiliency Training
Positive psychology interventions that integrate a person's strengths into treatment result in improvements in life satisfaction and well-being. Character strengths classified within six core virtues (wisdom/knowledge, courage, humanity, justice, temperance, and transcendence) have been the subject of substantial research. Though a number of studies have been conducted in the general population, little is known about the character strengths of individuals with first episode psychosis (FEP). Moreover, positive psychology principles, in particular a focus on personal strengths, have been increasingly integrated into FEP trea...
Source: Schizophrenia Research - October 21, 2017 Category: Psychiatry Authors: Julia Browne, Sue E. Estroff, Kelsey Ludwig, Carrington Merritt, Piper Meyer-Kalos, Kim T. Mueser, Jennifer D. Gottlieb, David L. Penn Source Type: research

The contribution of the contingent negative variation (CNV) to goal maintenance
The dot pattern expectancy (DPX) task has been strongly recommended as a measure of goal maintenance, which is impaired in schizophrenia patients. The current event-related potential (ERP) study was designed mainly to identify the ERP component that could represent the goal maintenance process of the DPX task as indexed by the error rate of the BX vs. AY (EBX-AY). We focused our analysis on the cue-phased contingent negative variation (CNV) and found a significant association between the EBX-AY and the amplitude of the difference wave of cue B vs. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 21, 2017 Category: Psychiatry Authors: Aihua Shen, Wan Zhao, Bingqian Han, Qiumei Zhang, Zhifang Zhang, Xiongying Chen, Jinguo Zhai, Min Chen, Boqi Du, Xiaoxiang Deng, Feng Ji, Chuanyue Wang, Yu-Tao Xiang, Hongjie Wu, Qi Dong, Chuansheng Chen, Jun Li Source Type: research

Developmental trajectory of mismatch negativity and visual event-related potentials in healthy controls: Implications for neurodevelopmental vs. neurodegenerative models of schizophrenia
Sensory processing deficits are core features of schizophrenia, reflected in impaired generation of event-related potential (ERP) measures such as auditory mismatch negativity (MMN) and visual P1. To understand the potential time course of development of deficits in schizophrenia, we obtained MMN to unattended duration, intensity and frequency deviants, and visual P1 to attended LSF stimuli, in 43 healthy individuals ages 6 to 25years (mean 17), and compared results to data from 30 adult schizophrenia patients (mean age 38). (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 21, 2017 Category: Psychiatry Authors: Cheryl M. Corcoran, Anastasia Stoops, Migyung Lee, Antigona Martinez, Pejman Sehatpour, Elisa C. Dias, Daniel C. Javitt Source Type: research

Sedentary behaviour, physical activity, cardiorespiratory fitness and cardiometabolic risk in psychosis: The PsychiActive project
This study aimed to explore the possible independent associations of sedentary behaviour (SB), physical activity (PA), and cardiorespiratory fitness (CRF) with clustered (CCRS) and individual cardiometabolic risk (waist circumference [waist], systolic/diastolic blood pressure, triglycerides, high-density lipoprotein-cholesterol, and fasting blood glucose) in patients with psychosis. In 43 outpatients with psychosis (mean age ±SD: 42.3±8.5years, 86% men), SB and light, moderate-to-vigorous, and total PA were measured with the SenseWear Pro3 Armband, and CRF with the 6-minute walking test. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 21, 2017 Category: Psychiatry Authors: Javier Bueno-Antequera, Miguel Ángel Oviedo-Caro, Diego Munguía-Izquierdo Source Type: research

Genetic analysis of deep phenotyping projects in common disorders
Several studies of complex psychotic disorders with large numbers of neurobiological phenotypes are currently under way, in living patients and controls, and on assemblies of brain specimens. Genetic analyses of such data typically present challenges, because of the choice of underlying hypotheses on genetic architecture of the studied disorders and phenotypes, large numbers of phenotypes, the appropriate multiple testing corrections, limited numbers of subjects, imputations required on missing phenotypes and genotypes, and the cross-disciplinary nature of the phenotype measures. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 20, 2017 Category: Psychiatry Authors: Elliot S. Gershon, Godfrey Pearlson, Matcheri S. Keshavan, Carol Tamminga, Brett Clementz, Peter F. Buckley, Ney Alliey-Rodriguez, Chunyu Liu, John A. Sweeney, Sarah Keedy, Shashwath A. Meda, Neeraj Tandon, Rebecca Shafee, Jeffrey R. Bishop, Elena I. Ivle Source Type: research

The Ultra-High-Risk for psychosis groups: Evidence to maintain the status quo
Individuals are considered Ultra-High-Risk (UHR) for psychosis if they meet a set of standardised criteria including presumed genetic vulnerability (Trait), or a recent history of Attenuated Psychotic Symptoms (APS) or Brief Limited Intermittent Psychotic Symptoms (BLIPS). Recent calls to revise these criteria have arisen from evidence that Trait, APS and BLIPS groups may transition to psychosis at different rates. Concurrently, it has become clear that the UHR status confers clinical risk beyond transition to psychosis. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 19, 2017 Category: Psychiatry Authors: M.J. McHugh, P.D. McGorry, H.P. Yuen, I.B. Hickie, A. Thompson, L. de Haan, N. Mossaheb, S. Smesny, A. Lin, C. Markulev, M. Schloegelhofer, S.J. Wood, D. Nieman, J.A. Hartmann, M. Nordentoft, M. Sch äfer, G.P. Amminger, A Yung, B. Nelson Source Type: research

Dimensional symptom severity and global cognitive function predict subjective quality of life in patients with schizophrenia and healthy adults
Over the last several decades Quality of Life (QoL) has become increasingly important as an indicator of treatment outcomes; particularly in schizophrenia spectrum disorders because of its close association with functional disability. Numerous studies seeking to elucidate the factors that contribute to QoL in this population have implicated both symptom severity and cognition in determining QoL but the findings have been mixed. The critical factors that appear to impede the lack of consensus in the extant literature examining determinants of QoL include the heterogeneity of the samples and measures examined as well as medi...
Source: Schizophrenia Research - October 19, 2017 Category: Psychiatry Authors: Pamela DeRosse, George C. Nitzburg, Melanie Blair, Anil K. Malhotra Source Type: research

Prevalence, risk factors and clinical characteristics of osteoporosis in Chinese inpatients with schizophrenia
We examined the prevalence of osteoporosis and its clinical correlates in Chinese patients with schizophrenia, which is not well-studied. A total of 199 inpatients (males/females=132/67; average age: 54.5 ±11.1years) and 107 healthy controls (males/females=22/85; average age: 41.7±11.9years) were recruited. Bone mineral density (BMD) was measured by ultrasonography of the calcaneus. The prevalence of osteoporosis and low BMD (osteoporosis and osteopenia) was 23.1% and 65.3% for the patient group, v ersus 7.5% and 39.3% for the control group (both p (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 19, 2017 Category: Psychiatry Authors: Jingyi Cui, Huaqing Liu, Jing Shao, Dong-Mei Xu, Yi Wang, Zheng Fei, Jiyu Wei, Wei Lu, Chun-Rong Wang, Rui He, Yangya Tan, Yi Fan, Yuping Ning, Ryan M. Cassidy, Jair C. Soares, Xingbing Huang, Xiang Yang Zhang Source Type: research

The Ultra-High-Risk for psychosis groups: Evidence to maintain the status quo
Individuals are considered Ultra-High-Risk (UHR) for psychosis if they meet a set of standardised criteria including presumed genetic vulnerability (Trait), or a recent history of Attenuated Psychotic Symptoms (APS) or Brief Limited Intermittent Psychotic Symptoms (BLIPS). Recent calls to revise these criteria have arisen from evidence that Trait, APS and BLIPS groups may transition to psychosis at different rates. Concurrently, it has become clear that the UHR status confers clinical risk beyond transition to psychosis. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 19, 2017 Category: Psychiatry Authors: M.J. McHugh, P.D. McGorry, H.P. Yuen, I.B. Hickie, A. Thompson, L. de Haan, N. Mossaheb, S. Smesny, A. Lin, C. Markulev, M. Schloegelhofer, S.J. Wood, D. Nieman, J.A. Hartmann, M. Nordentoft, M. Sch äfer, G.P. Amminger, A Yung, B. Nelson Source Type: research

Dimensional symptom severity and global cognitive function predict subjective quality of life in patients with schizophrenia and healthy adults
Over the last several decades Quality of Life (QoL) has become increasingly important as an indicator of treatment outcomes; particularly in schizophrenia spectrum disorders because of its close association with functional disability. Numerous studies seeking to elucidate the factors that contribute to QoL in this population have implicated both symptom severity and cognition in determining QoL but the findings have been mixed. The critical factors that appear to impede the lack of consensus in the extant literature examining determinants of QoL include the heterogeneity of the samples and measures examined as well as medi...
Source: Schizophrenia Research - October 19, 2017 Category: Psychiatry Authors: Pamela DeRosse, George C. Nitzburg, Melanie Blair, Anil K. Malhotra Source Type: research

Prevalence, risk factors and clinical characteristics of osteoporosis in Chinese inpatients with schizophrenia
We examined the prevalence of osteoporosis and its clinical correlates in Chinese patients with schizophrenia, which is not well-studied. A total of 199 inpatients (males/females=132/67; average age: 54.5 ±11.1years) and 107 healthy controls (males/females=22/85; average age: 41.7±11.9years) were recruited. Bone mineral density (BMD) was measured by ultrasonography of the calcaneus. The prevalence of osteoporosis and low BMD (osteoporosis and osteopenia) was 23.1% and 65.3% for the patient group, v ersus 7.5% and 39.3% for the control group (both p (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 19, 2017 Category: Psychiatry Authors: Jingyi Cui, Huaqing Liu, Jing Shao, Dong-Mei Xu, Yi Wang, Zheng Fei, Jiyu Wei, Wei Lu, Chun-Rong Wang, Rui He, Yangya Tan, Yi Fan, Yuping Ning, Ryan M. Cassidy, Jair C. Soares, Xingbing Huang, Xiang Yang Zhang Source Type: research

Integrated analysis supports ATXN1 as a schizophrenia risk gene
Protein-protein interaction (PPI) is informative in identifying hidden disease risk genes that tend to interact with known risk genes usually working together in the same disease module. With the use of an integrated approach combining PPI information with pathway and expression analysis as well as genome-wide association study (GWAS), we intended to find new risk genes for schizophrenia (SCZ). We showed that ATXN1 was the only direct PPI partner of the know SCZ risk gene ZNF804A, and it also had direct PPIs with other 18 known SCZ risk genes. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 18, 2017 Category: Psychiatry Authors: Jiewei Liu, Bing Su Source Type: research

The association between changes in depression/anxiety and trajectories of psychotic-like experiences over a year in adolescence
Recent cross-sectional studies suggest that psychotic-like experiences (PLEs) are associated with depression and anxiety in adolescents. While longitudinal studies have observed that adolescents suffer more severe symptoms of depression/anxiety when PLEs persist, it remains unclear whether depression/anxiety worsens or improves with PLE emergence or remission, respectively. In this prospective school-based study, we investigated the association between longitudinal changes in depression/anxiety and one-year PLE trajectories in adolescence. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 18, 2017 Category: Psychiatry Authors: Syudo Yamasaki, Satoshi Usami, Ryo Sasaki, Shinsuke Koike, Shuntaro Ando, Yuko Kitagawa, Misato Matamura, Masako Fukushima, Hiromi Yonehara, Jerome Clifford Foo, Atsushi Nishida, Tsukasa Sasaki Source Type: research

Integrated analysis supports ATXN1 as a schizophrenia risk gene
Protein-protein interaction (PPI) is informative in identifying hidden disease risk genes that tend to interact with known risk genes usually working together in the same disease module. With the use of an integrated approach combining PPI information with pathway and expression analysis as well as genome-wide association study (GWAS), we intended to find new risk genes for schizophrenia (SCZ). We showed that ATXN1 was the only direct PPI partner of the know SCZ risk gene ZNF804A, and it also had direct PPIs with other 18 known SCZ risk genes. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 18, 2017 Category: Psychiatry Authors: Jiewei Liu, Bing Su Source Type: research

The association between changes in depression/anxiety and trajectories of psychotic-like experiences over a year in adolescence
Recent cross-sectional studies suggest that psychotic-like experiences (PLEs) are associated with depression and anxiety in adolescents. While longitudinal studies have observed that adolescents suffer more severe symptoms of depression/anxiety when PLEs persist, it remains unclear whether depression/anxiety worsens or improves with PLE emergence or remission, respectively. In this prospective school-based study, we investigated the association between longitudinal changes in depression/anxiety and one-year PLE trajectories in adolescence. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 18, 2017 Category: Psychiatry Authors: Syudo Yamasaki, Satoshi Usami, Ryo Sasaki, Shinsuke Koike, Shuntaro Ando, Yuko Kitagawa, Misato Matamura, Masako Fukushima, Hiromi Yonehara, Jerome Clifford Foo, Atsushi Nishida, Tsukasa Sasaki Source Type: research

Prevalence of underweight in patients with schizophrenia: A meta-analysis
Although the relationship between body mass index and all-cause mortality is U-shaped, underweight has received comparatively less attention than obesity. There is only limited evidence to date regarding underweight among patients with schizophrenia. This is the first meta-analysis to address the prevalence of underweight in these patients. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 17, 2017 Category: Psychiatry Authors: Norio Sugawara, Kazushi Maruo, Takuro Sugai, Yutaro Suzuki, Yuji Ozeki, Kazutaka Shimoda, Toshiyuki Someya, Norio Yasui-Furukori Source Type: research

Genetic correlates of insight in schizophrenia
We examined genetic contributions to insight by investigating if polygenic risk scores (PRS) and candidate regions were associated with insight. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 17, 2017 Category: Psychiatry Authors: Rose Mary Xavier, Allison Vorderstrasse, Richard S.E. Keefe, Jennifer R. Dungan Source Type: research

Prevalence of underweight in patients with schizophrenia: A meta-analysis
Although the relationship between body mass index and all-cause mortality is U-shaped, underweight has received comparatively less attention than obesity. There is only limited evidence to date regarding underweight among patients with schizophrenia. This is the first meta-analysis to address the prevalence of underweight in these patients. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 17, 2017 Category: Psychiatry Authors: Norio Sugawara, Kazushi Maruo, Takuro Sugai, Yutaro Suzuki, Yuji Ozeki, Kazutaka Shimoda, Toshiyuki Someya, Norio Yasui-Furukori Source Type: research

Genetic correlates of insight in schizophrenia
We examined genetic contributions to insight by investigating if polygenic risk scores (PRS) and candidate regions were associated with insight. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 17, 2017 Category: Psychiatry Authors: Rose Mary Xavier, Allison Vorderstrasse, Richard S.E. Keefe, Jennifer R. Dungan Source Type: research

Importance of considering the role of tetraethyl lead when examining the relationship between environmental pollution and psychotic disorders
We read with great interest the systematic review by Attademo et al. (2017) on the link between environmental pollution and psychotic disorders. We are concerned that the authors failed to include search terms specific to the most extensively studied airborne neurotoxin, lead, thereby missing many important sources relevant to the link between air pollution and schizophrenia. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 16, 2017 Category: Psychiatry Authors: Esme Fuller-Thomson, Amy P. Munro Tags: Letter to the Editor Source Type: research

Effects of a nicotinic agonist on the Brief Psychiatric Rating Scale five-factor subscale model in schizophrenia
The excitatory, ligand-gated α7 nicotinic acetylcholine receptor (nAChR) has been implicated in the pathophysiology of schizophrenia based on convergent genetic, post-mortem, and psychopharmacological studies (reviewed in Freedman, 2014). Preclinical animal studies (reviewed in Lewis et al., 2017), as well as early phase clini cal studies of patients with schizophrenia (Olincy et al., 2006), suggest α7 nAChR agonists may be useful for treatment of cognitive dysfunction in schizophrenia. However, results of larger randomized placebo-controlled clinical trials of α7 nAChR agonists with a primary cognitive o...
Source: Schizophrenia Research - October 16, 2017 Category: Psychiatry Authors: Alan S. Lewis, Ann Olincy, Robert W. Buchanan, William R. Kem, Marina R. Picciotto, Robert Freedman Tags: Letter to the Editor Source Type: research

Importance of considering the role of tetraethyl lead when examining the relationship between environmental pollution and psychotic disorders
We read with great interest the systematic review by Attademo et al. (2017) on the link between environmental pollution and psychotic disorders. We are concerned that the authors failed to include search terms specific to the most extensively studied airborne neurotoxin, lead, thereby missing many important sources relevant to the link between air pollution and schizophrenia. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 16, 2017 Category: Psychiatry Authors: Esme Fuller-Thomson, Amy P. Munro Tags: Letter to the Editor Source Type: research

Effects of a nicotinic agonist on the Brief Psychiatric Rating Scale five-factor subscale model in schizophrenia
The excitatory, ligand-gated α7 nicotinic acetylcholine receptor (nAChR) has been implicated in the pathophysiology of schizophrenia based on convergent genetic, post-mortem, and psychopharmacological studies (reviewed in Freedman, 2014). Preclinical animal studies (reviewed in Lewis et al., 2017), as well as early phase clini cal studies of patients with schizophrenia (Olincy et al., 2006), suggest α7 nAChR agonists may be useful for treatment of cognitive dysfunction in schizophrenia. However, results of larger randomized placebo-controlled clinical trials of α7 nAChR agonists with a primary cognitive o...
Source: Schizophrenia Research - October 16, 2017 Category: Psychiatry Authors: Alan S. Lewis, Ann Olincy, Robert W. Buchanan, William R. Kem, Marina R. Picciotto, Robert Freedman Tags: Letter to the Editor Source Type: research

Addiction and schizophrenia: A translational perspective
Schizophrenia, a complex neuropsychiatric syndrome that affects nearly 1% of the population and includes positive, negative, and cognitive symptoms (Andreasen, 2000), is associated with a variety of co-occurring substance use disorders (Buckley et al., 2009). The Epidemiologic Catchment Area survey showed that individuals with schizophrenia have a high rate of substance (e.g., alcohol, cannabis, and cocaine) use disorders – nearly 5 times the rate seen in the general population (Regier et al., 1990). (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 15, 2017 Category: Psychiatry Authors: Alan I. Green, Jibran Y. Khokhar Source Type: research

Functional network dysconnectivity as a biomarker of treatment resistance in schizophrenia
Schizophrenia may develop from disruptions in functional connectivity regulated by neurotransmitters such as dopamine and acetylcholine. The modulatory effects of these neurotransmitters might explain how antipsychotics attenuate symptoms of schizophrenia and account for the variable response to antipsychotics observed in clinical practice. Based on the putative mechanisms of antipsychotics and evidence of disrupted connectivity in schizophrenia, we hypothesised that functional network connectivity, as assessed using network-based statistics, would exhibit differences between treatment response subtypes of schizophrenia an...
Source: Schizophrenia Research - October 14, 2017 Category: Psychiatry Authors: Carolyn B. McNabb, Roger J. Tait, Meghan E. McIlwain, Valerie M. Anderson, John Suckling, Robert R. Kydd, Bruce R. Russell Source Type: research

Guided self-help cognitive-behaviour Intervention for VoicEs (GiVE): Results from a pilot randomised controlled trial in a transdiagnostic sample
Few patients have access to cognitive behaviour therapy for psychosis (CBTp) even though at least 16 sessions of CBTp is recommended in treatment guidelines. Briefer CBTp could improve access as the same number of therapists could see more patients. In addition, focusing on single psychotic symptoms, such as auditory hallucinations ( ‘voices’), rather than on psychosis more broadly, may yield greater benefits. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 13, 2017 Category: Psychiatry Authors: Cassie M. Hazell, Mark Hayward, Kate Cavanagh, Anna-Marie Jones, Clara Strauss Source Type: research

Combining actigraphy, ecological momentary assessment and neuroimaging to study apathy in patients with schizophrenia
Apathy can be defined as a reduction of goal-directed behavior and is a strong predictor for poor functional outcome in schizophrenia. However, no objective measure of apathy has been identified and assessment is limited to retrospective interview-based ratings. Here we aimed to identify more precise objective readouts of apathy for translational research and clinical practice. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 12, 2017 Category: Psychiatry Authors: Agne Kluge, Matthias Kirschner, Oliver M. Hager, Martin Bischof, Benedikt Habermeyer, Erich Seifritz, Sebastian Walther, Stefan Kaiser Source Type: research

DNA methylation age is not accelerated in brain or blood of subjects with schizophrenia
Individuals with schizophrenia (SZ) exhibit multiple premature age-related phenotypes and die ~20years prematurely. The accelerated aging hypothesis of SZ has been advanced to explain these observations, it posits that SZ-associated factors accelerate the progressive biological changes associated with normal aging. Testing the hypothesis has been limited by the absence of robust, meaningful, and multi-tissue measures of biological age. Recently, a method was described in which DNA methylation (DNAm) levels at 353 genomic sites are used to produce “DNAm age”, an estimate of biological age with advantages over ex...
Source: Schizophrenia Research - October 6, 2017 Category: Psychiatry Authors: Brandon C. McKinney, Huang Lin, Ying Ding, David A. Lewis, Robert A. Sweet Source Type: research

Using wearable technology to detect the autonomic signature of illness severity in schizophrenia
Research suggests that people with schizophrenia have autonomic dysfunctions. These have been linked to functioning problems, symptoms and considered a risk factor for illness chronicity. The aim of this study is to introduce a new Mobile Health (mHealth) method using wearable technology to assessing autonomic activity in people's everyday life. We aim to evaluate the new method acceptability and characterise the association between schizophrenia illness features and autonomic abnormalities. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 4, 2017 Category: Psychiatry Authors: Matteo Cella, Łukasz Okruszek, Megan Lawrence, Valerio Zarlenga, Zhimin He, Til Wykes Source Type: research

Schizophrenia in Wolfram Syndrome (DIDMOAD Syndrome): A case report in support of the mitochondrial dysfunction hypothesis
Schizophrenia is a chronic severe disabling psychiatric illness of neurodevelopmental origin with a lifetime prevalence of 1% (Saha et al., 2005). It is highly heritable and considered as a polygenic disorder whose origin or cause is still not clear (Cardno et al., 1999; Gottesman and Shields, 1967). Though it is considered to be a brain disorder, studies have shown that patient with schizophrenia may have various systemic abnormalities. Ultra-structural changes in the mitochondria have led to a proposal of Mitochondrial dysfunction as one of the promising pathways for the pathogenesis of schizophrenia (Park and Park, 2012...
Source: Schizophrenia Research - October 4, 2017 Category: Psychiatry Authors: Guru S. Gowda, Dev Rai, Ravi Kumar Nadella, Sarbesh Tiwari, Ravi Yadav, Suresh Bada Math Tags: Letter to the Editor Source Type: research

Association between mismatch negativity and global functioning is specific to duration deviance in early stages of psychosis
Mismatch negativity (MMN) is a candidate biomarker for early stages of psychosis. Although an association among duration MMN (dMMN), cognitive deficits, and functional outcome in chronic schizophrenia has been shown by a large-scale study, the effects of deviant type and clinical stages have not been investigated. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 4, 2017 Category: Psychiatry Authors: Daisuke Koshiyama, Kenji Kirihara, Mariko Tada, Tatsuya Nagai, Mao Fujioka, Shinsuke Koike, Motomu Suga, Tsuyoshi Araki, Kiyoto Kasai Source Type: research

Using wearable technology to detect the autonomic signature of illness severity in schizophrenia
Research suggests that people with schizophrenia have autonomic dysfunctions. These have been linked to functioning problems, symptoms and considered a risk factor for illness chronicity. The aim of this study is to introduce a new Mobile Health (mHealth) method using wearable technology to assessing autonomic activity in people's everyday life. We aim to evaluate the new method acceptability and characterise the association between schizophrenia illness features and autonomic abnormalities. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 4, 2017 Category: Psychiatry Authors: Matteo Cella, Łukasz Okruszek, Megan Lawrence, Valerio Zarlenga, Zhimin He, Til Wykes Source Type: research

Schizophrenia in Wolfram Syndrome (DIDMOAD Syndrome): A case report in support of the mitochondrial dysfunction hypothesis
Schizophrenia is a chronic severe disabling psychiatric illness of neurodevelopmental origin with a lifetime prevalence of 1% (Saha et al., 2005). It is highly heritable and considered as a polygenic disorder whose origin or cause is still not clear (Cardno et al., 1999; Gottesman and Shields, 1967). Though it is considered to be a brain disorder, studies have shown that patient with schizophrenia may have various systemic abnormalities. Ultra-structural changes in the mitochondria have led to a proposal of Mitochondrial dysfunction as one of the promising pathways for the pathogenesis of schizophrenia (Park and Park, 2012...
Source: Schizophrenia Research - October 4, 2017 Category: Psychiatry Authors: Guru S. Gowda, Dev Rai, Ravi Kumar Nadella, Sarbesh Tiwari, Ravi Yadav, Suresh Bada Math Tags: Letter to the Editor Source Type: research

Association between mismatch negativity and global functioning is specific to duration deviance in early stages of psychosis
Mismatch negativity (MMN) is a candidate biomarker for early stages of psychosis. Although an association among duration MMN (dMMN), cognitive deficits, and functional outcome in chronic schizophrenia has been shown by a large-scale study, the effects of deviant type and clinical stages have not been investigated. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 4, 2017 Category: Psychiatry Authors: Daisuke Koshiyama, Kenji Kirihara, Mariko Tada, Tatsuya Nagai, Mao Fujioka, Shinsuke Koike, Motomu Suga, Tsuyoshi Araki, Kiyoto Kasai Source Type: research

The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) consortium: A collaborative cognitive and neuroimaging genetics project
This article describes the GENUS Consortium sample collection. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 2, 2017 Category: Psychiatry Authors: Gabri ëlla A.M. Blokland, Elisabetta C. del Re, Raquelle I. Mesholam-Gately, Jorge Jovicich, Joey W. Trampush, Matcheri S. Keshavan, Lynn E. DeLisi, James T.R. Walters, Jessica A. Turner, Anil K. Malhotra, Todd Lencz, Martha E. Shenton, Aristotle N. Voin Source Type: research

Depression during first episode psychosis and subsequent suicide risk: A systematic review and meta-analysis of longitudinal studies
Evidence suggests first episode psychosis (FEP) is associated with suicide, and the influence of depression on suicidal behaviour in cross sectional studies is clear. However the influence of depression during FEP on longer-term mortality is not certain. Existing evidence was synthesised to understand the influence of depressive symptoms during FEP on subsequent suicidal behaviour. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 2, 2017 Category: Psychiatry Authors: Jessica McGinty, M. Sayeed Haque, Rachel Upthegrove Source Type: research