Episodic memory retrieval is impaired in negative schizotypy under fast response deadline
Schizotypy offers a useful, multidimensional framework for understanding the development and expression of schizophrenia-spectrum psychopathology. Nonclinically ascertained young adults who endorse positive and negative schizotypy traits exhibit similar, albeit milder, versions of the symptoms and impairment seen in schizophrenia-spectrum disorders. Previous studies have demonstrated that negative, but not positive, schizotypy is associated with impairment in free-recall, recognition, and source memory. (Source: Schizophrenia Research)
Source: Schizophrenia Research - June 4, 2018 Category: Psychiatry Authors: Lili Sahakyan, Thomas R. Kwapil Source Type: research
Psychotic experiences as indicators of risk for cardiovascular disease
Recent studies have discovered that people who report psychotic experiences (PEs) –a milder but more prevalent expression of psychosis in the general population (Linscott and van Os, 2013) — also report a wide range of serious mental and physical health problems, such as comorbid psychiatric disorders (DeVylder et al., 2014), disabilities (Oh et al., 2018), chronic health pro blems (Moreno et al., 2013; Oh and DeVylder, 2015), shorter lifespan (Sharifi et al., 2015), and suicidal behaviors (DeVylder et al., 2015; Kelleher et al., 2013). (Source: Schizophrenia Research)
Source: Schizophrenia Research - June 4, 2018 Category: Psychiatry Authors: Hans Oh, Ai Koyanagi, Parveen Garg, Jordan DeVylder Source Type: research
Prescriber and institutional barriers and facilitators of clozapine use: A systematic review
As clozapine is under-prescribed in persons with treatment-resistant schizophrenia (TRS), it is necessary to better identify the determinants of health inequalities in access to clozapine use. (Source: Schizophrenia Research)
Source: Schizophrenia Research - June 4, 2018 Category: Psychiatry Authors: H élène Verdoux, Clélia Quiles, Christian J. Bachmann, Dan Siskind Source Type: research
Editorial Board
(Source: Schizophrenia Research)
Source: Schizophrenia Research - June 1, 2018 Category: Psychiatry Source Type: research
Age of onset of Cannabis use and cognitive function in first-episode non-affective psychosis patients: Outcome at three-year follow-up
In recent years, the effects of cannabis use on cognitive functions in patients with psychosis have been widely studied. Recently, special emphasis has been placed on the impact of age at the onset of consumption on cognition in these patients. (Source: Schizophrenia Research)
Source: Schizophrenia Research - May 31, 2018 Category: Psychiatry Authors: Esther Seti én-Suero, Obdulia Martínez-García, Víctor Ortiz-García de la Foz, Javier Vázquez-Bourgon, Patricia Correa-Ghisays, Adele Ferro, Benedicto Crespo-Facorro, Rosa Ayesa-Arriola Source Type: research
Physical activity pattern and cardiorespiratory fitness in individuals with schizophrenia compared with a population-based sample
Thorough description of objectively assessed physical activity (PA) and sedentary time in people with schizophrenia is lacking, and previous studies comparing PA and cardiorespiratory fitness levels with healthy controls are limited by their small sample size and/or poor methodology. (Source: Schizophrenia Research)
Source: Schizophrenia Research - May 31, 2018 Category: Psychiatry Authors: Eivind Andersen, Tom Langerud Holmen, Jens Egeland, Egil Wilhelm Martinsen, Therese Torgersen Bigseth, Gry Bang-Kittilsen, Sigmund Alfred Anderssen, Bj ørge Herman Hansen, John Abel Engh Source Type: research
Changes in metabolism and microbiota after 24-week risperidone treatment in drug na ïve, normal weight patients with first episode schizophrenia
This study was to examine the alterations in metabolic parameters, anti-oxidant superoxide dismutase (SOD), inflammatory marker high-sensitivity C-reactive protein (hs-CRP) and microbiota after 24-week risperidone treatment in drug na ïve, normal weight, first episode schizophrenia patients; the study further examined the relationship between metabolic changes and changes in microbiota. (Source: Schizophrenia Research)
Source: Schizophrenia Research - May 30, 2018 Category: Psychiatry Authors: Xiuxia Yuan, Peifen Zhang, Yaping Wang, Yafei Liu, Xue Li, Bachoo Upshant Kumar, Gangrui Hei, Luxian Lv, Xu-Feng Huang, Xiaoduo Fan, Xueqin Song Source Type: research
Lower glutamate level in temporo-parietal junction may predict a better response to tDCS in schizophrenia
Auditory hallucinations are highly distressing and functionally impairing to patients with schizophrenia. Brain areas which show activation during auditory hallucination periods have been targeted for neuromodulation treatment, such as the auditory cortex or temporo-parietal junction (TPJ) (Brunelin et al., 2012). Transcranial direct current stimulation (tDCS) is a non-invasive neuromodulation technique which uses weak electric currents to modulate targeted brain areas. Some studies have shown that tDCS may be useful in reducing psychotic symptoms such as auditory hallucinations by suppressing hyperactivity of the temporal...
Source: Schizophrenia Research - May 30, 2018 Category: Psychiatry Authors: Junhee Lee, Youngwoo Bryan Yoon, S. Andrea Wijtenburg, Laura M. Rowland, Hongji Chen, Frank E. Gaston, In Chan Song, Kang Ik K. Cho, Minah Kim, Tae Young Lee, Jun Soo Kwon Tags: Letter to the editor Source Type: research
Correlates of risk factors for reduced life expectancy in schizophrenia: Is it possible to develop a predictor profile?
Patients with schizophrenia have significantly greater mortality rates than the general population, with an estimated reduced lifespan of 10 –20 years. We previously reported on a link between impairment in cognition and premature death in a prospective 20-year study. Patients who had died prematurely showed neurocognitive impairment in nine different cognitive tests compared to those who did not. Based on those findings, in this stu dy the surviving patients in the cohort were divided into three different groups based on neurocognitive impairment and compared on symptom severity including remission status, RAND-36, we...
Source: Schizophrenia Research - May 30, 2018 Category: Psychiatry Authors: Hawar Moradi, Philip D. Harvey, Lars Helldin Source Type: research
Comparison of neurocognitive domains in patients with schizophrenia with and without co-morbid obsessive compulsive disorder
Neurocognitive deficits have been well documented in patients with schizophrenia. Research has shown that a significant proportion of patients with schizophrenia have co-morbid obsessive-compulsive symptoms/disorder (OCS/OCD). However, the impact of OCS/OCD on various neurocognitive domains in patients with schizophrenia is less understood. (Source: Schizophrenia Research)
Source: Schizophrenia Research - May 29, 2018 Category: Psychiatry Authors: Swapnajeet Sahoo, Sandeep Grover, Ritu Nehra Source Type: research
The M üller-Lyer illusion in patients with schizophrenia and Parkinson's disease
Visuo-spatial perception refers to our ability to process and interpret visual information about where objects are located in space. Geometrical-optical illusions are visual illusions, in which the perceived geometrical properties of the corresponding object or visual scene differ from the objective reality. The M üller-Lyer illusion is a well-known geometrical-optical illusion, first described by German psychiatrist Franz Carl Müller-Lyer (1896). The major theory on the origin of the Müller-Lyer illusion, proposed by R. (Source: Schizophrenia Research)
Source: Schizophrenia Research - May 28, 2018 Category: Psychiatry Authors: Elena Alexandrovna Tolmacheva, Vasiliy Valerievich Ognivov, Tatjana Dmitrievna Shevelenkova, Vladimir Antoninovich Bastakov Tags: Letter to the Editor Source Type: research
Latent toxoplasma infection in real-world schizophrenia: Results from the national FACE-SZ cohort
The objective of the present study were (i) to determine if latent Toxoplasma infection was associated with specific clinical features in stabilized SZ subjects, with cognitive impairment and with increased low-grade peripheral inflammation and (ii) to determine if Treatments with Anti-Toxoplasmic Activity (TATA) were associated with improved outcomes in subjects with latent Toxoplasma infection. (Source: Schizophrenia Research)
Source: Schizophrenia Research - May 27, 2018 Category: Psychiatry Authors: G. Fond, L. Boyer, F. Sch ürhoff, F. Berna, O. Godin, E. Bulzacka, M. Andrianarisoa, L. Brunel, B. Aouizerate, D. Capdevielle, I. Chereau, N. Coulon, T. D'Amato, C. Dubertret, J. Dubreucq, C. Faget, C. Lançon, S. Leignier, J. Mallet, D. Misdrahi, C. Pas Source Type: research
Auditory steady state response deficits are associated with symptom severity and poor functioning in patients with psychotic disorder
Gamma oscillation is important for cortico-cortical coordination and the integration of information across neural networks. The 40 Hz auditory steady-state response (ASSR), which reflects neural synchrony in the gamma band (30–100 Hz), is abnormal in patients with schizophrenia (SZ). The present study used the ASSR at multiple frequencies to examine (1) gamma dysfunction in patients with SZ, schizoaffective (SA), and bip olar disorder (BD) compared with controls, (2) the relationship between ASSR measures and clinical symptom severity, and (3) the relationship between ASSR measures and real-life community functionin...
Source: Schizophrenia Research - May 26, 2018 Category: Psychiatry Authors: Tian-Hang Zhou, Nora E. Mueller, Kevin M. Spencer, Sonal G. Mallya, Kathryn Eve Lewandowski, Lesley A. Norris, Deborah L. Levy, Bruce M. Cohen, Dost Öngür, Mei-Hua Hall Source Type: research
Machine learning improved classification of psychoses using clinical and biological stratification: Update from the bipolar-schizophrenia network for intermediate phenotypes (B-SNIP)
Psychiatry continues to suffer from challenges to diagnostic validity due to lack of biological markers. Distinctions between diagnostic categories are still largely informed on symptom clusters, while underlying biology is complex and largely indiscernible. (Insel et al., 2010; Keshavan et al., 2013) While the reliability of diagnoses has improved with successive revisions of the classificatory systems such as the latest Diagnostic and Statistical Manual of Mental Disorders (DSM-V), whether these disorders have natural biological distinctions is uncertain. (Source: Schizophrenia Research)
Source: Schizophrenia Research - May 25, 2018 Category: Psychiatry Authors: Suraj Sarvode Mothi, Mukund Sudarshan, Neeraj Tandon, Carol Tamminga, Godfrey Pearlson, John Sweeney, Brett Clementz, Matcheri S. Keshavan Source Type: research
Developmental vulnerability to psychosis: Selective aggregation of basic self-disturbance in early onset schizophrenia
Trait-like anomalies of subjective experience (aka, Basic Self-disturbance or Self-disorder, SD) have been empirically identified as schizophrenia-specific markers of vulnerability in several clinical and genetic high-risk populations. However, such specificity is still to be tested in developmental years, where emerging psychopathology is less crystallized and diagnostic boundaries more blurred. Thus, the current study explores the distribution of SD in adolescent help-seekers (age range 14 to 18) and tests the specificity of SD with respect to the severity of their diagnostic staging (Early Onset schizophrenia-spectrum p...
Source: Schizophrenia Research - May 25, 2018 Category: Psychiatry Authors: Andrea Raballo, Elena Monducci, Mauro Ferrara, Paolo Fiori Nastro, Claudia Dario, RODIN group Source Type: research
