Can we accurately classify schizophrenia patients from healthy controls using magnetic resonance imaging and machine learning? A multi-method and multi-dataset study
Machine learning is a powerful tool that has previously been used to classify schizophrenia (SZ) patients from healthy controls (HC) using magnetic resonance images. Each study, however, uses different datasets, classification algorithms, and validation techniques. Here, we perform a critical appraisal of the accuracy of machine learning methodologies used in SZ/HC classifications studies by comparing three machine learning algorithms (logistic regression [LR], support vector machines [SVMs], and linear discriminant analysis [LDA]) on three independent datasets (435 subjects total) using two tissue density estimates and co...
Source: Schizophrenia Research - December 21, 2017 Category: Psychiatry Authors: Julie L. Winterburn, Aristotle N. Voineskos, Gabriel A. Devenyi, Eric Plitman, Camilo de la Fuente-Sandoval, Nikhil Bhagwat, Ariel Graff-Guerrero, Jo Knight, M. Mallar Chakravarty Source Type: research

Premorbid IQ subgroups in first episode non affective psychosis patients: Long-term sex differences in function and neurocognition
Low IQ has been associated with schizophrenia, even to the point of being posited as a possible causal factor for psychosis. However, individuals with normal and high IQ also develop psychotic illnesses. The aim of this study was to characterize premorbid IQ subgroups at first episode of psychosis (FEP). (Source: Schizophrenia Research)
Source: Schizophrenia Research - December 21, 2017 Category: Psychiatry Authors: Rosa Ayesa-Arriola, Esther Seti én-Suero, Karl David Neergaard, Àuria Albacete Belzunces, Fernando Contreras, Neeltje E.M. van Haren, Benedicto Crespo-Facorro Source Type: research

Is the prevalence of anti-N-methyl-d-aspartate receptor antibodies in schizophrenia overestimated?
We read with great interest the article by Chen et al. (2017), who screened for antibodies against N-methyl-d-aspartate receptors (NMDAR) in blood samples from schizophrenia patients. Anti-NMDAR antibodies have previously been detected in schizophrenia patients; for example, Zandi et al. (2011) found three positive cases among 29 schizophrenia patients. Identifying anti-NMDAR antibodies has a crucial impact on the management of schizophrenia: immunotherapy can be effective, and tumor removal is recommended when the tumor is associated with the genesis of antibodies (Dalmau et al., 2008). (Source: Schizophrenia Research)
Source: Schizophrenia Research - December 21, 2017 Category: Psychiatry Authors: Yukako Nakagami, Genichi Sugihara, Akio Ikeda, Toshiya Murai Tags: Letter to the Editor Source Type: research

Neuroanatomical heterogeneity of schizophrenia revealed by semi-supervised machine learning methods
Schizophrenia is associated with heterogeneous clinical symptoms and neuroanatomical alterations. In this work, we aim to disentangle the patterns of neuroanatomical alterations underlying a heterogeneous population of patients using a semi-supervised clustering method. We apply this strategy to a cohort of patients with schizophrenia of varying extends of disease duration, and we describe the neuroanatomical, demographic and clinical characteristics of the subtypes discovered. (Source: Schizophrenia Research)
Source: Schizophrenia Research - December 21, 2017 Category: Psychiatry Authors: Nicolas Honnorat, Aoyan Dong, Eva Meisenzahl-Lechner, Nikolaos Koutsouleris, Christos Davatzikos Source Type: research

BDNF as a marker of response to cognitive remediation in patients with schizophrenia: A randomized and controlled trial
Brain-derived neurotrophic factor (BDNF) is considered to be a putative biomarker for cognitive recovery in schizophrenia. However, current evidence is still scarce for pharmacological treatments, and the use of BDNF as a biomarker has only been tested once with cognitive remediation treatment (CRT). (Source: Schizophrenia Research)
Source: Schizophrenia Research - December 20, 2017 Category: Psychiatry Authors: Rafael Penad és, Irene López-Vílchez, Rosa Catalán, Bárbara Arias, Alexandre González-Rodríguez, Clemente García-Rizo, Guillem Masana, Victoria Ruíz, Gisela Mezquida, Miquel Bernardo Source Type: research

Substantia nigra ultrastructural pathology in schizophrenia
In this study, electron microscopy was used to examine neurons, oligodendrocytes, and myelinated axons in the SN of normal controls (NCs, n=9) and schizophrenia subjects with varying response to antipsychotic drugs [SZ, n=14; treatment resistant (TR)=6, treatment responsive (RESP)=6, unknown=2]. (Source: Schizophrenia Research)
Source: Schizophrenia Research - December 20, 2017 Category: Psychiatry Authors: Courtney K. Walker, Joy K. Roche, Vidushi Sinha, Rosalinda C. Roberts Source Type: research

Antipsychotics and mortality in a nationwide cohort of 29,823 patients with schizophrenia
It has remained controversial if antipsychotic treatment is associated with increased or decreased mortality among patients with schizophrenia, and if there are any clinically meaningful differences between specific agents and routes of administration. (Source: Schizophrenia Research)
Source: Schizophrenia Research - December 20, 2017 Category: Psychiatry Authors: Heidi Taipale, Ellenor Mittendorfer-Rutz, Kristina Alexanderson, Maila Majak, Juha Meht älä, Fabian Hoti, Erik Jedenius, Dana Enkusson, Amy Leval, Jan Sermon, Antti Tanskanen, Jari Tiihonen Source Type: research

BDNF as a marker of response to cognitive remediation in patients with schizophrenia: A randomized and controlled trial
Brain-derived neurotrophic factor (BDNF) is considered to be a putative biomarker for cognitive recovery in schizophrenia. However, current evidence is still scarce for pharmacological treatments, and the use of BDNF as a biomarker has only been tested once with cognitive remediation treatment (CRT). (Source: Schizophrenia Research)
Source: Schizophrenia Research - December 20, 2017 Category: Psychiatry Authors: Rafael Penad és, Irene López-Vílchez, Rosa Catalán, Bárbara Arias, Alexandre González-Rodríguez, Clemente García-Rizo, Guillem Masana, Victoria Ruíz, Gisela Mezquida, Miquel Bernardo Source Type: research

Substantia nigra ultrastructural pathology in schizophrenia
In this study, electron microscopy was used to examine neurons, oligodendrocytes, and myelinated axons in the SN of normal controls (NCs, n=9) and schizophrenia subjects with varying response to antipsychotic drugs [SZ, n=14; treatment resistant (TR)=6, treatment responsive (RESP)=6, unknown=2]. (Source: Schizophrenia Research)
Source: Schizophrenia Research - December 20, 2017 Category: Psychiatry Authors: Courtney K. Walker, Joy K. Roche, Vidushi Sinha, Rosalinda C. Roberts Source Type: research

Antipsychotics and mortality in a nationwide cohort of 29,823 patients with schizophrenia
It has remained controversial if antipsychotic treatment is associated with increased or decreased mortality among patients with schizophrenia, and if there are any clinically meaningful differences between specific agents and routes of administration. (Source: Schizophrenia Research)
Source: Schizophrenia Research - December 20, 2017 Category: Psychiatry Authors: Heidi Taipale, Ellenor Mittendorfer-Rutz, Kristina Alexanderson, Maila Majak, Juha Meht älä, Fabian Hoti, Erik Jedenius, Dana Enkusson, Amy Leval, Jan Sermon, Antti Tanskanen, Jari Tiihonen Source Type: research

Peripersonal space boundary in schizotypy and schizophrenia
Self-disturbances are core features of the phenomenology of schizophrenia, since the prodromal period (Nelson et al., 2012). They are associated with abnormal bodily-self experiences, such as blurred body boundaries. We hypothesized that specific deficits of the representation of the space immediately surrounding the body, i.e. the peripersonal space (PPS), affect schizophrenic patients (SCZ). Moreover, according to the idea of a psychosis continuum (Nelson et al., 2013), we thought that early signs of PPS disruption could be find already in individuals at higher risk for psychosis, such as those with high schizotypal trai...
Source: Schizophrenia Research - December 18, 2017 Category: Psychiatry Authors: Giulio Di Cosmo, Marcello Costantini, Anatolia Salone, Giovanni Martinotti, Giuseppe Di Iorio, Massimo Di Giannantonio, Francesca Ferri Tags: Letter to the Editor Source Type: research

The Early Psychosis Screener (EPS): Item development and qualitative validation
A panel of experts assembled and analyzed a comprehensive item bank from which a highly sensitive and specific early psychosis screener could be developed. Twenty well-established assessments relating to the prodromal stage, early psychosis, and psychosis were identified. Using DSM-5 criteria, we identified the core concepts represented by each of the items in each of the assessments. These granular core concepts were converted into a uniform set of 490 self-report items using a Likert scale and a ‘past 30days’ time frame. (Source: Schizophrenia Research)
Source: Schizophrenia Research - December 15, 2017 Category: Psychiatry Authors: B.B. Brodey, J. Addington, M.B. First, D.O. Perkins, S.W. Woods, E.F. Walker, B. Walsh, J.M. Nieri, M.B. Nunn, J. Putz, I.S. Brodey Source Type: research

Cultural and linguistic diversity increases the likelihood of compulsory community treatment
People from culturally and linguistically diverse (CALD) backgrounds are over-represented in compulsory admissions to hospital but little is known about whether this also applies to community treatment orders (CTOs). (Source: Schizophrenia Research)
Source: Schizophrenia Research - December 14, 2017 Category: Psychiatry Authors: Steve Kisely, Jianguo Xiao Source Type: research

Aging of the body and the brain in schizophrenia
Schizophrenia has long been recognized to be accompanied by greater physical morbidity and elevated mortality (Meyer and Nasrallah, 2009). Yet, it is only relatively recently that investigators have begun to fully explore the possibility that the schizophrenia syndrome affects not only the brain but the rest of the body as well. This multi-systemic view of the disorder was initially proposed in a review by Kirkpatrick and Galderisi (2008) who posed the question of whether schizophrenia was a disease of accelerated aging. (Source: Schizophrenia Research)
Source: Schizophrenia Research - December 9, 2017 Category: Psychiatry Authors: Lisa T. Eyler, Dilip V. Jeste Source Type: research

Olanzapine, blonanserin, and aripiprazole associated with different frontostriatal reward system activation in patients with schizophrenia
The “Monetary Incentive Delay” (MID) task assesses the dopaminergic reward system using functional magnetic resonance imaging (fMRI). Knutson and colleagues developed this experimental paradigm to measure activation of frontostriatal networks including the ventral striatum (VS) and the medial prefro ntal cortex (MPFC) during the presentation of stimuli predicting monetary gains or losses (Knutson et al., 2000). (Source: Schizophrenia Research)
Source: Schizophrenia Research - December 7, 2017 Category: Psychiatry Authors: Naoki Hashimoto, Atsuhito Toyomaki, Tamaki Miyamoto, Akane Miyazaki, Ichiro Kuksumi Tags: Letter to the editor Source Type: research

Relationship between hallucination proneness and musical aptitude is mediated by microstructure in the corpus callosum
Poor interhemispheric communication is reported in schizophrenia patients (Endrass et al., 2002) and offers a potential explanation for the misattribution of internal events to external sources, which is a dominant theory for the genesis of auditory verbal hallucinations (AVH). Consistent with this, the corpus callosum (CC), the white matter (WM) tract connecting the two brain hemispheres, is reduced in volume in schizophrenia patients (Shenton et al., 2001). Furthermore, the WM integrity metric derived from diffusion tensor imaging (DTI), fractional anisotropy (FA) (Beaulieu, 2002), is reduced within the CC of schizophren...
Source: Schizophrenia Research - December 4, 2017 Category: Psychiatry Authors: Amy Spray, Anton L. Beer, Richard P. Bentall, Vanessa Sluming, Georg Meyer Tags: Letter to the Editor Source Type: research

Delusions of control in schizophrenia: Resistant to the mind's best trick?
The existence of a free will is fiercely debated in neuroscience and philosophy. The debate has great impact on society and our self-understanding as human beings. Behavioral and electrophysiological data have challenged the intuitive assumption that human behavior is the result of conscious intentions. This notion has important implications for delusions of control in schizophrenia, where patients experience bodily movements as not being controlled by themselves. Current theories explain control delusions as a deficit to perceive certain aspects of motor control, but many findings are inconsistent with this idea. (Source:...
Source: Schizophrenia Research - December 2, 2017 Category: Psychiatry Authors: Martin Riemer Source Type: research

Support vector machine-based classification of first episode drug-na ïve schizophrenia patients and healthy controls using structural MRI
Although regional brain deficits have been demonstrated in schizophrenia patients by structural MRI studies, one important question that remains largely unanswered is whether the complex and subtle deficits revealed by MRI could be used as objective biomarkers to discriminate patients from healthy controls individually. To address this question, a total of 326 right-handed participants were recruited, including 163 drug-na ïve first-episode schizophrenia (FES) patients and 163 demographically matched healthy controls. (Source: Schizophrenia Research)
Source: Schizophrenia Research - December 2, 2017 Category: Psychiatry Authors: Yuan Xiao, Zhihan Yan, Youjin Zhao, Bo Tao, Huaiqiang Sun, Fei Li, Li Yao, Wenjing Zhang, Shah Chandan, Jieke Liu, Qiyong Gong, John A. Sweeney, Su Lui Source Type: research

Delusions of control in schizophrenia: Resistant to the mind's best trick?
The existence of a free will is fiercely debated in neuroscience and philosophy. The debate has great impact on society and our self-understanding as human beings. Behavioral and electrophysiological data have challenged the intuitive assumption that human behavior is the result of conscious intentions. This notion has important implications for delusions of control in schizophrenia, where patients experience bodily movements as not being controlled by themselves. Current theories explain control delusions as a deficit to perceive certain aspects of motor control, but many findings are inconsistent with this idea. (Source:...
Source: Schizophrenia Research - December 2, 2017 Category: Psychiatry Authors: Martin Riemer Source Type: research

Support vector machine-based classification of first episode drug-na ïve schizophrenia patients and healthy controls using structural MRI
Although regional brain deficits have been demonstrated in schizophrenia patients by structural MRI studies, one important question that remains largely unanswered is whether the complex and subtle deficits revealed by MRI could be used as objective biomarkers to discriminate patients from healthy controls individually. To address this question, a total of 326 right-handed participants were recruited, including 163 drug-na ïve first-episode schizophrenia (FES) patients and 163 demographically matched healthy controls. (Source: Schizophrenia Research)
Source: Schizophrenia Research - December 2, 2017 Category: Psychiatry Authors: Yuan Xiao, Zhihan Yan, Youjin Zhao, Bo Tao, Huaiqiang Sun, Fei Li, Li Yao, Wenjing Zhang, Shah Chandan, Jieke Liu, Qiyong Gong, John A. Sweeney, Su Lui Source Type: research

Does this robot have a mind? Schizophrenia patients' mind perception toward humanoid robots
The introduction of social robots in our homes has become a reality. Numerous companies are currently developing robots that are accessible to everyone in order to help people to live easier and safer lives. At the same time, robotic therapies for the rehabilitation of social deficits have recently emerged in the field of autism disorder and dementia (Scassellati et al., 2012). Technological advances have enabled robots to fulfill a variety of human-like functions, as well as to support improvements in social skills in clinical populations. (Source: Schizophrenia Research)
Source: Schizophrenia Research - December 1, 2017 Category: Psychiatry Authors: St éphane Raffard, Catherine Bortolon, Laura Cohen, Mahdi Khoramshahi, Robin N. Salesse, Aude Billard, Delphine Capdevielle Tags: Letter to the Editor Source Type: research

In this Issue November 2017
A high priority to the field is being able to predict who among those people at high risk for schizophrenia actually will develop the illness. In this month's issue Choi and colleagues (pages 1-2) report a method combining results from Diffusion Tensor Imaging with resting state f-MRI to calculate what they call the amount of global and regional network efficiency. Using this measure, they were able to separate out a group of clinically high-risk people who had efficiency levels similar to patients with schizophrenia and another group that were more like healthy controls. (Source: Schizophrenia Research)
Source: Schizophrenia Research - December 1, 2017 Category: Psychiatry Authors: Lynn E. DeLisi Source Type: research

Does this robot have a mind? Schizophrenia patients' mind perception toward humanoid robots
The introduction of social robots in our homes has become a reality. Numerous companies are currently developing robots that are accessible to everyone in order to help people to live easier and safer lives. At the same time, robotic therapies for the rehabilitation of social deficits have recently emerged in the field of autism disorder and dementia (Scassellati et al., 2012). Technological advances have enabled robots to fulfill a variety of human-like functions, as well as to support improvements in social skills in clinical populations. (Source: Schizophrenia Research)
Source: Schizophrenia Research - December 1, 2017 Category: Psychiatry Authors: St éphane Raffard, Catherine Bortolon, Laura Cohen, Mahdi Khoramshahi, Robin N. Salesse, Aude Billard, Delphine Capdevielle Tags: Letter to the Editor Source Type: research

Hallucinations in Indigenous and non-Indigenous Australians: Findings from the second Australian national survey of psychosis
Recent evidence suggests that the expression of some, but perhaps not all, hallucinations in people with psychotic disorders may vary across cultures (e.g. Luhrmann et al., 2015). For example, both visual and olfactory hallucinations are relatively rare in Tamil Brahmin (India), compared to Iban people (Sarawak) or European Australians, whilst the frequency of auditory hallucinations with running commentary or 3rd person conversations is similar between these groups (e.g. McLean et al., 2014). Using extant data collected as part of the second Australian National Survey of High Impact Psychosis (SHIP; Morgan et al., 2012) w...
Source: Schizophrenia Research - November 28, 2017 Category: Psychiatry Authors: Johanna C. Badcock, Melanie Clark, Vera A. Morgan Tags: Letter to the Editor Source Type: research

Association between migrant worker experience, limitations on insurance coverage, and hospitalization for schizophrenia in Hunan Province, China
While transnational migration has been shown to be a risk factor for schizophrenia, studies have not examined whether massive internal rural-to-urban migration in China in recent years has increased the risk of hospitalization for schizophrenia, or schizophrenia symptom severity among migrants. (Source: Schizophrenia Research)
Source: Schizophrenia Research - November 28, 2017 Category: Psychiatry Authors: Yifan Zhu, Xinran Hu, Bo Yang, Guowei Wu, Zheng Wang, Zhimin Xue, Jincheng Shi, Xuan Ouyang, Zhening Liu, Robert Rosenheck Source Type: research

Somatic mosaicism for SLC1A1 mutation supports threshold effect and familial aggregation in schizophrenia spectrum disorders
Schizotypal personality disorder (SPD) is associated with psychotic-like traits and an increased risk for schizophrenia (SCZ). SPD represents therefore a relevant condition to investigate the mechanism of disease progression in schizophrenia spectrum disorders (Barrantes-Vidal et al., 2015). Since the original description by Kallman in 1938 (Kallman, 1938), various psychiatric disorders were reportedly found to aggregate among relatives of SCZ individuals. Conversely, a high risk of SCZ has been reported in offspring of SPD parents (Tsuang, 2000). (Source: Schizophrenia Research)
Source: Schizophrenia Research - November 28, 2017 Category: Psychiatry Authors: Caroline Demily, Laurence Hubert, Nicolas Franck, Alice Poisson, Arnold Munnich, Claude Besmond Tags: Letter to the editor Source Type: research

Hallucinations in Indigenous and non-Indigenous Australians: Findings from the second Australian national survey of psychosis
Recent evidence suggests that the expression of some, but perhaps not all, hallucinations in people with psychotic disorders may vary across cultures (e.g. Luhrmann et al., 2015). For example, both visual and olfactory hallucinations are relatively rare in Tamil Brahmin (India), compared to Iban people (Sarawak) or European Australians, whilst the frequency of auditory hallucinations with running commentary or 3rd person conversations is similar between these groups (e.g. McLean et al., 2014). Using extant data collected as part of the second Australian National Survey of High Impact Psychosis (SHIP; Morgan et al., 2012) w...
Source: Schizophrenia Research - November 28, 2017 Category: Psychiatry Authors: Johanna C. Badcock, Melanie Clark, Vera A. Morgan Tags: Letter to the Editor Source Type: research

Association between migrant worker experience, limitations on insurance coverage, and hospitalization for schizophrenia in Hunan Province, China
While transnational migration has been shown to be a risk factor for schizophrenia, studies have not examined whether massive internal rural-to-urban migration in China in recent years has increased the risk of hospitalization for schizophrenia, or schizophrenia symptom severity among migrants. (Source: Schizophrenia Research)
Source: Schizophrenia Research - November 28, 2017 Category: Psychiatry Authors: Yifan Zhu, Xinran Hu, Bo Yang, Guowei Wu, Zheng Wang, Zhimin Xue, Jincheng Shi, Xuan Ouyang, Zhening Liu, Robert Rosenheck Source Type: research

Somatic mosaicism for SLC1A1 mutation supports threshold effect and familial aggregation in schizophrenia spectrum disorders
Schizotypal personality disorder (SPD) is associated with psychotic-like traits and an increased risk for schizophrenia (SCZ). SPD represents therefore a relevant condition to investigate the mechanism of disease progression in schizophrenia spectrum disorders (Barrantes-Vidal et al., 2015). Since the original description by Kallman in 1938 (Kallman, 1938), various psychiatric disorders were reportedly found to aggregate among relatives of SCZ individuals. Conversely, a high risk of SCZ has been reported in offspring of SPD parents (Tsuang, 2000). (Source: Schizophrenia Research)
Source: Schizophrenia Research - November 28, 2017 Category: Psychiatry Authors: Caroline Demily, Laurence Hubert, Nicolas Franck, Alice Poisson, Arnold Munnich, Claude Besmond Tags: Letter to the editor Source Type: research

Associations of ABCB1 gene polymorphisms with aripiprazole-induced autonomic nervous system dysfunction in schizophrenia
Antipsychotic medications exacerbate autonomic nervous system (ANS) dysfunction in patients with schizophrenia (Huang et al., 2013), and diminished ANS activity is associated with morbidity and sudden death due to cardiovascular disease (Thayer et al., 2010). Thus, understanding of the effects of antipsychotics on the ANS is vital for their safe use in schizophrenia. (Source: Schizophrenia Research)
Source: Schizophrenia Research - November 27, 2017 Category: Psychiatry Authors: Saki Hattori, Akira Suda, Ikuko Kishida, Masatoshi Miyauchi, Yohko Shiraishi, Mami Fujibayashi, Natsuki Tsujita, Chie Ishii, Norio Ishii, Toshio Moritani, Masataka Taguri, Yoshio Hirayasu Tags: Letter to the Editor Source Type: research

Cytokines dysregulation in schizophrenia: A systematic review of psychoneuroimmune relationship
Introduction: Schizophrenia is a multifactorial psychiatric disease with complex interactions among the brain and the immune system. A psycho-immune relationship underling schizophrenia is supported by several studies and integrates a specific area of knowledge - psychoneuroimmunology. (Source: Schizophrenia Research)
Source: Schizophrenia Research - November 24, 2017 Category: Psychiatry Authors: Daniela Rodrigues-Amorim, Tania Rivera-Baltan ás, Carlos Spuch, Hector J. Caruncho, África González-Fernandez, Jose M. Olivares, Roberto C. Agís-Balboa Source Type: research

Is there a common vulnerability in cannabis phenomenology and schizotypy? The role of the N170 ERP
Cannabis use is a known risk factor for the development of psychosis, although the precise nature of this relationship is unclear. The phenomenological experiences associated with cannabis use vary dramatically, and for some resemble certain features of psychosis. We hypothesized that individuals who report particularly unusual experiences associated with cannabis use would demonstrate similar electrophysiological patterns to those who score high on schizotypal personality traits. The Cannabis Experiences Questionnaire (CEQ) and the Schizotypal Personality Questionnaire (SPQ) were used to measure these experiences and trai...
Source: Schizophrenia Research - November 22, 2017 Category: Psychiatry Authors: Gabriel A. Brooks, Colleen A. Brenner Source Type: research

Identification of genes carrying rare variants of moderate to large effect in schizophrenia: A replication study
The discovery of copy number variants (CNVs) of moderate to high risk for schizophrenia opens the door to genetic counseling for families with segregating variants (Kirov, 2015), and justifies the search for additional rare variants of moderate to high risk, such as single nucleotide variants (SNVs). Pioneer work by Need et al. (2012) revealed the inexistence of low-frequency exonic variants with moderate risk; therefore, collapsing rare variants before the analysis emerged as an appropriate alternative. (Source: Schizophrenia Research)
Source: Schizophrenia Research - November 21, 2017 Category: Psychiatry Authors: Julio Rodr íguez-López, Jorge Amigo, Beatriz Sobrino, Eduardo Paz, Ángel Carracedo, Mario Páramo, Manuel Arrojo, Javier Costas Tags: Letter to the Editor Source Type: research

Relationship between objectively measured sedentary behavior and health outcomes in schizophrenia patients: The PsychiActive project
This study aimed to investigate possible relationships between sedentary behavior and body mass index (BMI), cardiorespiratory fitness (CRF), and health-related quality of life (HRQoL) in schizophrenia patients. Variables contributing to the variability in sedentary behavior were identified. Eighty-two schizophrenia outpatients (mean age ±SD: 41.0±8.7years, 87% men, mean illness duration±SD: 17.1±8.9years) wore a multisensor armband for 7 consecutive full days to objectively measure sedentary behavior. (Source: Schizophrenia Research)
Source: Schizophrenia Research - November 21, 2017 Category: Psychiatry Authors: Javier Bueno-Antequera, Miguel Ángel Oviedo-Caro, Diego Munguía-Izquierdo Source Type: research

Identification of genes carrying rare variants of moderate to large effect in schizophrenia: A replication study
The discovery of copy number variants (CNVs) of moderate to high risk for schizophrenia opens the door to genetic counseling for families with segregating variants (Kirov, 2015), and justifies the search for additional rare variants of moderate to high risk, such as single nucleotide variants (SNVs). Pioneer work by Need et al. (2012) revealed the inexistence of low-frequency exonic variants with moderate risk; therefore, collapsing rare variants before the analysis emerged as an appropriate alternative. (Source: Schizophrenia Research)
Source: Schizophrenia Research - November 21, 2017 Category: Psychiatry Authors: Julio Rodr íguez-López, Jorge Amigo, Beatriz Sobrino, Eduardo Paz, Ángel Carracedo, Mario Páramo, Manuel Arrojo, Javier Costas Tags: Letter to the Editor Source Type: research

Relationship between objectively measured sedentary behavior and health outcomes in schizophrenia patients: The PsychiActive project
This study aimed to investigate possible relationships between sedentary behavior and body mass index (BMI), cardiorespiratory fitness (CRF), and health-related quality of life (HRQoL) in schizophrenia patients. Variables contributing to the variability in sedentary behavior were identified. Eighty-two schizophrenia outpatients (mean age ±SD: 41.0±8.7years, 87% men, mean illness duration±SD: 17.1±8.9years) wore a multisensor armband for 7 consecutive full days to objectively measure sedentary behavior. (Source: Schizophrenia Research)
Source: Schizophrenia Research - November 21, 2017 Category: Psychiatry Authors: Javier Bueno-Antequera, Miguel Ángel Oviedo-Caro, Diego Munguía-Izquierdo Source Type: research

A randomized, double-blind, placebo-controlled proof of concept study to evaluate samidorphan in the prevention of olanzapine-induced weight gain in healthy volunteers
Antipsychotic medications are associated with weight gain and adverse metabolic effects that complicate the treatment and management of schizophrenia. Olanzapine (OLZ) in particular is associated with significant weight gain and adverse metabolic effects. The present Phase 1, proof of concept, multicenter, randomized, double-blind, placebo-controlled study investigated the safety and effect on weight of a combination of OLZ (10mg) and the opioid modulator samidorphan (SAM; 5mg) in comparison to OLZ alone in healthy, male normal weight volunteers. (Source: Schizophrenia Research)
Source: Schizophrenia Research - November 20, 2017 Category: Psychiatry Authors: Bernard L. Silverman, William Martin, Asli Memisoglu, Lauren DiPetrillo, Christoph U. Correll, John M. Kane Source Type: research

In and out of schizophrenia: Activation and deactivation of the negative and positive schemas
We report literature supporting the relationship between each facet of the negative triad and each of the key symptoms: expressive negative symptoms, delusions, and verb al hallucinations. (Source: Schizophrenia Research)
Source: Schizophrenia Research - November 20, 2017 Category: Psychiatry Authors: Aaron T. Beck, Robyn Himelstein, Paul M. Grant Source Type: research

Association study of schizophrenia with variants in miR-137 binding sites
There is strong cumulative evidence for the involvement of miR-137 and its targets in the aetiology of schizophrenia. Here we test whether variants, especially rare variants, in miR-137 binding sites are associated with schizophrenia in an exome-sequenced sample of 4225 cases and 5834 controls. Only a small proportion of binding sites were covered by the capture system which had been used. A weighted burden test using the 372 detected variants demonstrated an excess among cases significant at p=0.024. (Source: Schizophrenia Research)
Source: Schizophrenia Research - November 20, 2017 Category: Psychiatry Authors: David Curtis, Warren Emmett Source Type: research

In and out of schizophrenia: Activation and deactivation of the negative and positive schemas
We report literature supporting the relationship between each facet of the negative triad and each of the key symptoms: expressive negative symptoms, delusions, and verb al hallucinations. (Source: Schizophrenia Research)
Source: Schizophrenia Research - November 20, 2017 Category: Psychiatry Authors: Aaron T. Beck, Robyn Himelstein, Paul M. Grant Source Type: research

A randomized, double-blind, placebo-controlled proof of concept study to evaluate samidorphan in the prevention of olanzapine-induced weight gain in healthy volunteers
Antipsychotic medications are associated with weight gain and adverse metabolic effects that complicate the treatment and management of schizophrenia. Olanzapine (OLZ) in particular is associated with significant weight gain and adverse metabolic effects. The present Phase 1, proof of concept, multicenter, randomized, double-blind, placebo-controlled study investigated the safety and effect on weight of a combination of OLZ (10mg) and the opioid modulator samidorphan (SAM; 5mg) in comparison to OLZ alone in healthy, male normal weight volunteers. (Source: Schizophrenia Research)
Source: Schizophrenia Research - November 20, 2017 Category: Psychiatry Authors: Bernard L. Silverman, William Martin, Asli Memisoglu, Lauren DiPetrillo, Christoph U. Correll, John M. Kane Source Type: research