Revista Brasileira de Farmacognosia 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Enzymes inhibitory and radical scavenging potentials of two selected tropical vegetable (Moringa oleifera and Telfairia occidentalis) leaves relevant to type 2 diabetes mellitus
In this study, the inhibitory activities and the radical scavenging potentials of these vegetables on relevant enzymes of type 2-diabetes ( α -amylase and α -glucosidase) were evaluated in vitro. HPLC-DAD was used to characterize the phenolic constituents and Fe2+-induced lipid peroxidation in rat's pancreas was investigated. Various radical scavenging properties coupled with metal chelating abilities were also determined. However, phenolic extracts from the vegetables inhibited α -amylase, α -glucosidase and chelated the tested metals (Cu2+ and Fe2+) in a concentration-dependent manner. More so, the inhibitory propert...
Source: Revista Brasileira de Farmacognosia - March 26, 2018 Category: Drugs & Pharmacology Source Type: research
Hepatoprotective effect of Aegle marmelos augmented with piperine co-administration in paracetamol model
ABSTRACT The current study explored hepatoprotective effect of Aegle marmelos (L.) Corr êa, Rutaceae, leaves extract. Potentiation of A. marmelos hepatoprotective effect with piperine co-administration was also explored. Wistar rats were randomly divided into seven groups: (i) normal control, (ii) paracetamol group, (iii) silymarin group, (iv) extract-25 group (25 mg/kg body), (v) ext ract-50 group: (50 mg/kg), (vi) extract-100 group (100 mg/kg) and (vii) extract-25 + piperine group. Hepatotoxicity was induced by administering paracetamol orally in a dose of 400 mg/kg for seven days. The drugs were administered 30 min pri...
Source: Revista Brasileira de Farmacognosia - March 26, 2018 Category: Drugs & Pharmacology Source Type: research
Anti-inflammatory and antioxidant activities of the Impatiens noli-tangere and Stachys officinalis polyphenolic-rich extracts
This study evaluated the anti-inflammatory and antioxidant activities of Impatiens noli-tangere L., Balsaminaceae, and of Stachys officinalis L., Lamiaceae, polyphenolic-rich extracts obtained by nanofiltration process. Results showed the great potential and efficiency of the nanofiltration process to concentrate the herbal extract's main polyphenolic compounds (over 91% phenolic acids and flavonoids retention). S. officinalis polyphenolic-rich extracts had high antioxidant activities (IC50 2.5 µg/ml) compared to I. noli-tangere polyphenolic-rich extracts (IC50 19.3 µg/ml) and similar with that of ascorbic acid. Polyphen...
Source: Revista Brasileira de Farmacognosia - March 26, 2018 Category: Drugs & Pharmacology Source Type: research
Warifteine, an alkaloid of Cissampelos sympodialis, modulates allergic profile in a chronic allergic rhinitis model
This study evaluated the effect of inhaled warifteine in an allergic ovalbumin rhinitis model. Inhaled warifteine (2 mg/ml) treatment of ovalbumin-sensitized BALB/c mice significant decreased total and differential number of cells on the nasal cavity and decreased ovalbumin-specific IgE serum levels. Hematoxylin& eosin staining of histological preparations of ovalbumin nasal tissues showed changes such as congestion and a massive cell infiltration in the perivascular and subepithelial regions characterizing the nasal inflammatory process. However, inhaled warifteine or dexamethasone treatment decreased cell infiltratio...
Source: Revista Brasileira de Farmacognosia - March 26, 2018 Category: Drugs & Pharmacology Source Type: research
Xanthorrhizol contents, α-glucosidase inhibition, and cytotoxic activities in ethyl acetate fraction of Curcuma zanthorrhiza accessions from Indonesia
In this study, C. zanthorrhiza accessions have a high in xanthorrhizol contents and cytotoxic activities that showed a high potential of studied accessions for breeding programs on a commercial scale. (Source: Revista Brasileira de Farmacognosia)
Source: Revista Brasileira de Farmacognosia - March 26, 2018 Category: Drugs & Pharmacology Source Type: research
Rhodolirium andicola: a new renewable source of alkaloids with acetylcholinesterase inhibitory activity, a study from nature to molecular docking
ABSTRACT Acetylcholinesterase is an important target for control of neurodegenerative diseases causing cholinergic signaling deficit. Traditionally, galanthamine has been used as an Amaryllidaceae-derived acetylcholinesterase inhibitor, although new Amaryllidaceae plants could serve as source for better acetylcholinesterase inhibitors. Therefore, the objective of this study was to characterize the alkaloid composition from bulbs of Rhodolirium andicola (Poepp.) Traub, a native Chilean Amaryllidaceae specie, and assess their inhibitory activity on acetylcholinesterase by in vitro and in silico methodologies. Alkaloidal extr...
Source: Revista Brasileira de Farmacognosia - March 26, 2018 Category: Drugs & Pharmacology Source Type: research
Cytotoxic activity of abietane diterpenoids from roots of Salvia sahendica by HPLC-based activity profiling
This study reveals that the HeLa cells are more sensitive to all tested compounds than the Caco-2 cells. In silico molecular docking study showed a rigid binding of the compounds to tyrosine kinase pp60src, and proved their cytotoxic activity. (Source: Revista Brasileira de Farmacognosia)
Source: Revista Brasileira de Farmacognosia - March 26, 2018 Category: Drugs & Pharmacology Source Type: research
Some triterpenic compounds in extracts of Cecropia and Bauhinia species for different sampling years
ABSTRACT The aim of this paper is to provide an overview on the chemical composition of triterpenes in widespread used folk medicine species, through the development and validation of eleven compounds using HPLC-UV detection. The compounds were separated using isocratic elution, on a reverse phase column (Kinetex C18, 250 mm × 4.6 mm, 5 µm) with mobile phase consisted of acetonitrile:tetrahydrofuran (90:10, v/v), flow-rate of 0.5 ml/min and detection in 210 nm. Diverse validation parameters were successfully evaluated. The samples of Bauhinia variegata L., B. variegata var. candida Voigt, Fabaceae, Cecropia palmata Wi ll...
Source: Revista Brasileira de Farmacognosia - March 26, 2018 Category: Drugs & Pharmacology Source Type: research
Chemical composition and seasonality variability of the Spiranthera odoratissima volatile oils leaves
This study analyzed the chemical composition of volatile oils from leaves of S. odoratissima and verified the seasonal variability of its chemical composition. The volatile oils were obtained by hydrodistillation using a Clevenger type apparatus and analyzed by gas chromatography coupled to mass spectrometry. The main chemical components found in samples of volatile oils were β -caryophyllene, bicyclogermacrene, δ -cadinene, amorphous-4,7(11)-diene, α -epi-muurolol, α -cadinol, α -muurolol and γ -cadinene. The hierarchical clustering identified three groups: the first was characterized by α -epi-muurolol, the second...
Source: Revista Brasileira de Farmacognosia - March 26, 2018 Category: Drugs & Pharmacology Source Type: research
Anatomy and microscopy of Piper caldense, a folk medicinal plant from Brazil
ABSTRACT Piper caldense C. DC., Piperaceae, commonly known as “ pimenta-d ’ água ” , “ pimenta-darda ” or “ paguarandy ” in Brazil, is a shrub that grows mainly in humid and shaded habitats. The present study investigates the anatomy of the leaves and stems of P. caldense by light and scanning electron microscopy in order to provide supporting data for correct identification of the species. The leaves are hypostomatic, have a 2-layered hypodermis, and posses pearl glands. The midrib shows a ‘ U ’ -shaped stele comprised of about ten collateral vascular bundles. The main anatomical marker of the stem is...
Source: Revista Brasileira de Farmacognosia - March 26, 2018 Category: Drugs & Pharmacology Source Type: research
Anatomical characters and chemical profile of leaves of three species in Lauraceae family
ABSTRACT The Lauraceae family is widely distributed in tropical and subtropical climates, has more than 2500 species and in the taxonomic point of view, it is one of the most difficult families to identify species. The aim of this study was to analyze the leaf anatomy of three species of Lauraceae (Ocotea indecora (Schott) Mez, Nectandra barbellata Coe-Teix. and Endlicheria paniculata (Spreng.) J.F.Macbr.) and identify the chemical profile of essential oil extracted from the leaves by hydrodistillation method. The leaves of the three species were obtained in “ Parque Estadual Intervales ” , Atlantic Forest, S ão Paulo...
Source: Revista Brasileira de Farmacognosia - March 26, 2018 Category: Drugs & Pharmacology Source Type: research
Justicia pectoralis, a coumarin medicinal plant have potential for the development of antiasthmatic drugs?
ABSTRACT Justicia pectoralis Jacq., Acanthaceae, is a medicinal plant found Central America. In the Northeast of Brazil, it is popularly known as “ chamb á ” being extensively used in homemade preparations for the treatment of cough, bronchitis and asthma. The species is part of a public phytotherapy program in Brazil entitled “ Farm ácias Vivas ” , National Record of Plants of Interest to the National Health System and the National Formulary of Herbal medicines. This paper aims to critically review the available scientific literature regarding the health promoting effects of J. pectoralis var. stenophylla. The ...
Source: Revista Brasileira de Farmacognosia - January 11, 2018 Category: Drugs & Pharmacology Source Type: research
Himatanthus drasticus: a chemical and pharmacological review of this medicinal species, commonly found in the Brazilian Northeastern region
In conclusion, although the literature shows several works on species of the Himatanthus genus, including H. drasticus, dealing with some bioactive compounds as triterpenes, translational studies focusing upon the clinical uses of this medicinal species are still in great need. (Source: Revista Brasileira de Farmacognosia)
Source: Revista Brasileira de Farmacognosia - January 11, 2018 Category: Drugs & Pharmacology Source Type: research
Chemical constituents from Casearia spp. (Flacourtiaceae/Salicaceae sensu lato)
ABSTRACT Chemical investigation of the leaves of Casearia gossypiosperma Briq., Salicaceae, led to the isolation of two known flavonoids, (+)-taxifolin and quercetin, the leaves of Casearia decandra Jacq. have afforded hydroquinone, the leaves of Casearia rupestris Eichler and Casearia lasiophylla Eichler have afforded a diterpene, (E)-phytol, and the leaves of C. rupestris and Casearia obliqua Spreng. have afforded sitosterol. The twigs of Casearia lasiophylla Eichler led to the isolation of two compounds (+)-pinoresinol, and N-trans-feruloyltyramine, and the twigs of C. obliqua have afforded N-trans-feruloyltyramine, N-t...
Source: Revista Brasileira de Farmacognosia - January 11, 2018 Category: Drugs & Pharmacology Source Type: research
Chrysosplenetin, in the absence and presence of artemsininin, alters breast cancer resistance protein-mediated transport activity in Caco-2 cell monolayers using aristolochic acid I as a specific probe substrate
ABSTRACT The present study describes the impact of chrysosplenetin, in the absence and presence of artemisinin, on in vitro breast cancer resistance protein-mediated transport activity in Caco-2 cell monolayers using aristolochic acid I as a specific probe substrate. We observed that novobiocin, a known breast cancer resistance protein active inhibitor, increased Papp (AP-BL) of aristolochic acid I 3.13 fold (p< 0.05) but had no effect on Papp (BL-AP). Efflux ratio (PBA/PAB) declined 4.44 fold (p< 0.05). Novobiocin, consequently, showed a direct facilitation on the uptake of AAI instead of its excretion. Oppositely, ...
Source: Revista Brasileira de Farmacognosia - January 11, 2018 Category: Drugs & Pharmacology Source Type: research
