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Respirology,Volume 23, Issue 4, Page 359-368, April 2018. (Source: Respirology)
Source: Respirology - January 17, 2018 Category: Respiratory Medicine Source Type: research

Tuberculosis vaccines: Opportunities and challenges
ABSTRACT Tuberculosis (TB) is a serious disease around the world. Bacillus Calmette–Guérin (BCG) is the only TB vaccine licensed for use in human beings, and is effective in protecting infants and children against severe miliary and meningeal TB. However, BCG’s protective efficacy is variable in adults. Novel TB vaccine candidates being developed include whole‐cell vaccines (recombinant BCG (rBCG), attenuated Mycobacterium tuberculosis, killed M. tuberculosis or Mycobacterium vaccae), adjuvanted protein subunit vaccines, viral vector‐delivered subunit vaccines, plasmid DNA vaccines, RNA‐based vacci...
Source: Respirology - January 17, 2018 Category: Respiratory Medicine Authors: Bingdong Zhu, Hazel M. Dockrell, Tom H.M. Ottenhoff, Thomas G. Evans, Ying Zhang Tags: Invited Review Series: Tuberculosis Updates 2018 Source Type: research

Pulmonary hypertension in interstitial lung disease: Limitations of echocardiography compared to cardiac catheterization
Respirology, EarlyView. (Source: Respirology)
Source: Respirology - January 12, 2018 Category: Respiratory Medicine Source Type: research

Exercise desaturation and oxygen therapy in ILD and COPD: Similarities, differences and therapeutic relevance
Respirology,Volume 23, Issue 4, Page 350-351, April 2018. (Source: Respirology)
Source: Respirology - January 12, 2018 Category: Respiratory Medicine Source Type: research

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Respirology, Ahead of Print. (Source: Respirology)
Source: Respirology - January 12, 2018 Category: Respiratory Medicine Source Type: research

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Respirology,Volume 23, Issue 4, Page 350-351, April 2018. (Source: Respirology)
Source: Respirology - January 12, 2018 Category: Respiratory Medicine Source Type: research

Overlap of interstitial pneumonia with autoimmune features with undifferentiated connective tissue disease and contribution of UIP to mortality
Respirology, EarlyView. (Source: Respirology)
Source: Respirology - January 10, 2018 Category: Respiratory Medicine Source Type: research

Success rate of medical thoracoscopy and talc pleurodesis in malignant pleurisy: A single ‐centre experience
Respirology, EarlyView. (Source: Respirology)
Source: Respirology - January 10, 2018 Category: Respiratory Medicine Source Type: research

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Respirology, Ahead of Print. (Source: Respirology)
Source: Respirology - January 10, 2018 Category: Respiratory Medicine Source Type: research

Success rate of medical thoracoscopy and talc pleurodesis in malignant pleurisy: A single ‐centre experience
ABSTRACT Background and objectiveMalignant pleurisy is associated with advanced oncological disease and dyspnoea is the most common presenting symptom. Pleurodesis is the preferred palliative and supportive treatment option, targeting symptom relief. The identification of clinical and endoscopic features that determine the success of talc pleurodesis in malignant pleurisy could guide clinical decision‐making. MethodsAll symptomatic patients with malignant pleurisy subjected to talc pleurodesis through medical thoracoscopy between January 2012 and December 2015 were included. Univariate and multivariate analyses were perf...
Source: Respirology - January 10, 2018 Category: Respiratory Medicine Authors: Joke Leemans, Christophe Dooms, Vincent Ninane, Jonas Yserbyt Tags: Original Article Source Type: research

Moving pulmonary rehabilitation forward in COPD: Stepping towards (home ‐based) action
See related Article (Source: Respirology)
Source: Respirology - January 10, 2018 Category: Respiratory Medicine Authors: Christian R. Osadnik Tags: Editorial Source Type: research

Secondary spontaneous pneumothorax in idiopathic pulmonary fibrosis: Grim news
Respirology, EarlyView. (Source: Respirology)
Source: Respirology - January 9, 2018 Category: Respiratory Medicine Source Type: research

Respiratory symptoms and small airway dysfunction in current and former smokers without spirometric COPD
Respirology, EarlyView. (Source: Respirology)
Source: Respirology - January 9, 2018 Category: Respiratory Medicine Source Type: research

E ‐cigarettes unlikely to raise significant health concerns in airways disease
Respirology,Volume 23, Issue 4, Page 435-436, April 2018. (Source: Respirology)
Source: Respirology - January 9, 2018 Category: Respiratory Medicine Source Type: research

E ‐cigarettes unlikely to raise significant health concerns in airways disease – Reply
Respirology,Volume 23, Issue 4, Page 436-437, April 2018. (Source: Respirology)
Source: Respirology - January 9, 2018 Category: Respiratory Medicine Source Type: research

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Respirology, Ahead of Print. (Source: Respirology)
Source: Respirology - January 9, 2018 Category: Respiratory Medicine Source Type: research

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Respirology,Volume 23, Issue 4, Page 435-436, April 2018. (Source: Respirology)
Source: Respirology - January 9, 2018 Category: Respiratory Medicine Source Type: research

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Respirology,Volume 23, Issue 4, Page 436-437, April 2018. (Source: Respirology)
Source: Respirology - January 9, 2018 Category: Respiratory Medicine Source Type: research

Secondary spontaneous pneumothorax in idiopathic pulmonary fibrosis: Grim news
See related Article (Source: Respirology)
Source: Respirology - January 9, 2018 Category: Respiratory Medicine Authors: Jos é M. Porcel Tags: Editorial Source Type: research

Pathophysiology of severe asthma: We ’ve only just started
ABSTRACT Severe asthma is defined by the high treatment requirements to partly or fully control the clinical manifestations of disease. It remains a problem worldwide with a large burden for individuals and health services. The key to improving targeted treatments, reducing disease burden and improving patient outcomes is a better understanding of the pathophysiology and mechanisms of severe disease. The heterogeneity, complexity and difficulties in undertaking clinical studies in severe asthma remain challenges to achieving better understanding and better outcomes. In this review, we focus on the structural, mechanical an...
Source: Respirology - January 9, 2018 Category: Respiratory Medicine Authors: Gregory G. King, Alan James, Louise Harkness, Peter A.B. Wark Tags: Invited Review Series: Seeking Innovative solutions in Severe Asthma Source Type: research

E ‐cigarettes unlikely to raise significant health concerns in airways disease – Reply
See Letter (Source: Respirology)
Source: Respirology - January 9, 2018 Category: Respiratory Medicine Authors: Matthew J. Peters Tags: Correspondence Source Type: research

Comparison of respiratory system impedance in asthma and COPD: A prospective observational study
ConclusionΔX5 may be useful for long‐term assessment of airflow limitation in COPD. (Source: Respirology)
Source: Respirology - January 1, 2018 Category: Respiratory Medicine Authors: Takahiro Kamada, Masahiro Kaneko, Hiromi Tomioka Tags: Original Article Source Type: research

Management of venous thromboembolism: Time to measure our performance
(Source: Respirology)
Source: Respirology - January 1, 2018 Category: Respiratory Medicine Authors: Michael W.Y. Tan, Sanjeev Chunilal, Darren Mansfield Tags: Commentary Source Type: research

Exercise desaturation and oxygen therapy in ILD and COPD: Similarities, differences and therapeutic relevance
See related Article (Source: Respirology)
Source: Respirology - January 1, 2018 Category: Respiratory Medicine Authors: Christine F. McDonald Tags: Editorial Source Type: research

Pulmonary hypertension in interstitial lung disease: Limitations of echocardiography compared to cardiac catheterization
ABSTRACT Background and objectiveIn interstitial lung disease (ILD), pulmonary hypertension (PH) is a major adverse prognostic determinant. Transthoracic echocardiography (TTE) is the most widely used tool when screening for PH, although discordance between TTE and right heart catheter (RHC) measured pulmonary haemodynamics is increasingly recognized. We evaluated the predictive utility of the updated European Society of Cardiology/European Respiratory Society (ESC/ERS) TTE screening recommendations against RHC testing in a large, well‐characterized ILD cohort. MethodsTwo hundred and sixty‐five consecutive patients wit...
Source: Respirology - January 1, 2018 Category: Respiratory Medicine Authors: Gregory J. Keir, S. John Wort, Maria Kokosi, Peter M. George, Simon L.F. Walsh, Joseph Jacob, Laura Price, Simon Bax, Elisabetta A. Renzoni, Toby M. Maher, Peter MacDonald, David M. Hansell, Athol U. Wells Tags: Original Article Source Type: research

Pneumonia as a cardiovascular disease
ABSTRACT Community‐acquired pneumonia (CAP) is an important cause of death around the globe. Up to 30% of patients admitted to hospital for CAP develop cardiovascular complications (i.e. new/worsening heart failure, new/worsening arrhythmias, myocardial infarctions and/or strokes), acutely and up to 10 years thereafter. Cardiac complications result from complex interactions between preexisting conditions, relative ischaemia, upregulation of the sympathetic system, systemic inflammation and direct pathogen‐mediated damage to the cardiovascular system. The exact mechanisms underlying the direct host–pathogen...
Source: Respirology - January 1, 2018 Category: Respiratory Medicine Authors: Marcos I. Restrepo, Luis F. Reyes Tags: Invited Review Series: Respiratory Infections in the Asia ‐pacific Region Source Type: research

Overlap of interstitial pneumonia with autoimmune features with undifferentiated connective tissue disease and contribution of UIP to mortality
ConclusionCurrent IPAF criteria encompassed the majority of broadly defined UCTD‐ILD and included those with UIP findings. Survival compared with IPF in those with UIP was similar. Further studies are necessary to refine IPAF definitions for clinical use and guide directed management strategies. (Source: Respirology)
Source: Respirology - January 1, 2018 Category: Respiratory Medicine Authors: Bryan T. Kelly, Teng Moua Tags: Original Article Source Type: research

E ‐cigarettes unlikely to raise significant health concerns in airways disease
See Reply (Source: Respirology)
Source: Respirology - January 1, 2018 Category: Respiratory Medicine Authors: Riccardo Polosa Tags: Correspondence Source Type: research

Respiratory symptoms and small airway dysfunction in current and former smokers without spirometric COPD
See related Article (Source: Respirology)
Source: Respirology - January 1, 2018 Category: Respiratory Medicine Authors: Neil C Thomson Tags: Editorial Source Type: research

Severe asthma: We can fix it? We can try!
(Source: Respirology)
Source: Respirology - January 1, 2018 Category: Respiratory Medicine Authors: Vanessa M. McDonald, Steven Maltby, Peter G. Gibson Tags: Series Editorial ‐Epilogue: Seeking Innovative Solutions in Severe Asthma Source Type: research

Empiric antibiotics for community ‐acquired pneumonia: A macrolide and a beta‐lactam please!
See related Article (Source: Respirology)
Source: Respirology - December 26, 2017 Category: Respiratory Medicine Authors: Grant Waterer Tags: Editorial Source Type: research

Empiric antibiotics for community ‐acquired pneumonia: A macrolide and a beta‐lactam please!
Respirology, EarlyView. (Source: Respirology)
Source: Respirology - December 26, 2017 Category: Respiratory Medicine Source Type: research

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Respirology, Ahead of Print. (Source: Respirology)
Source: Respirology - December 26, 2017 Category: Respiratory Medicine Source Type: research

Importance of oesophageal ultrasound in mediastinal staging of lung cancer
See Reply (Source: Respirology)
Source: Respirology - December 22, 2017 Category: Respiratory Medicine Authors: Therese Maria Henriette Naur, Paul F. Clementsen, Ida S. Christiansen, Lars Konge Tags: Correspondence Source Type: research

Importance of oesophageal ultrasound in mediastinal staging of lung cancer
Respirology,Volume 23, Issue 4, Page 434-434, April 2018. (Source: Respirology)
Source: Respirology - December 22, 2017 Category: Respiratory Medicine Source Type: research

The importance of oesophageal ultrasound in mediastinal staging of lung cancer – Reply
Respirology,Volume 23, Issue 4, Page 434-435, April 2018. (Source: Respirology)
Source: Respirology - December 22, 2017 Category: Respiratory Medicine Source Type: research

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Respirology,Volume 23, Issue 4, Page 434-434, April 2018. (Source: Respirology)
Source: Respirology - December 22, 2017 Category: Respiratory Medicine Source Type: research

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Respirology,Volume 23, Issue 4, Page 434-435, April 2018. (Source: Respirology)
Source: Respirology - December 22, 2017 Category: Respiratory Medicine Source Type: research

The importance of oesophageal ultrasound in mediastinal staging of lung cancer – Reply
See Letter (Source: Respirology)
Source: Respirology - December 22, 2017 Category: Respiratory Medicine Authors: Macarena R. Vial, George Eapen Tags: Correspondence Source Type: research

Tuberculosis updates 2018: Innovations and developments to end TB
(Source: Respirology)
Source: Respirology - December 21, 2017 Category: Respiratory Medicine Authors: Chi Chiu Leung, Cynthia B.E. Chee, Ying Zhang Tags: Series Editorial ‐Prologue: Tuberculosis Updates 2018 Source Type: research

Tuberculosis updates 2018: Innovations and developments to end TB
Respirology,Volume 23, Issue 4, Page 356-358, April 2018. (Source: Respirology)
Source: Respirology - December 21, 2017 Category: Respiratory Medicine Source Type: research

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Respirology,Volume 23, Issue 4, Page 356-358, April 2018. (Source: Respirology)
Source: Respirology - December 21, 2017 Category: Respiratory Medicine Source Type: research

Respiratory infections in the Asia ‐Pacific region: Problems and cautious optimism
(Source: Respirology)
Source: Respirology - December 21, 2017 Category: Respiratory Medicine Authors: Grant Waterer Tags: Series Editorial —Epilogue Respiratory infections in the Asia‐Pacific region Source Type: research

Patterns of use of long ‐acting bronchodilators in patients with COPD: A nationwide follow‐up study of new users in New Zealand
ConclusionIn this nationwide study, patterns of use of LABAs, LAMAs and ICSs were complex and often did not comply with treatment guidelines. Further work is required to address the discrepancy between guidelines and prescribing practices. (Source: Respirology)
Source: Respirology - December 18, 2017 Category: Respiratory Medicine Authors: Lianne Parkin, David Barson, Jiaxu Zeng, Simon Horsburgh, Katrina Sharples, Jack Dummer Tags: Original Article Source Type: research

Co ‐morbidity and mortality among patients with interstitial lung diseases: A population‐based study
The objective of this study was to investigate their impact on mortality. MethodsWe used the Danish National Patient Registry (DNPR) to identify all patients with a first‐time diagnosis of ILD between 1998 and 2010. Patients with ILD were matched 1:4 with controls from the background population. The burden of co‐morbidity was assessed using the Deyo–Charlson co‐morbidity score (DCcs). Mortality risks were assessed using Kaplan–Meier survival curves, and hazard rate ratios (HRR) for death were estimated using Cox proportional hazards regression models. ResultsWe identified 10 629 patients with ILD w...
Source: Respirology - December 18, 2017 Category: Respiratory Medicine Authors: Ole Hilberg, Elisabeth Bendstrup, Anders L økke, Rikke Ibsen, Andreas Fløe, Charlotte Hyldgaard Tags: Original Article Source Type: research

Patterns of use of long ‐acting bronchodilators in patients with COPD: A nationwide follow‐up study of new users in New Zealand
Respirology, EarlyView. (Source: Respirology)
Source: Respirology - December 18, 2017 Category: Respiratory Medicine Source Type: research

Co ‐morbidity and mortality among patients with interstitial lung diseases: A population‐based study
Respirology, EarlyView. (Source: Respirology)
Source: Respirology - December 18, 2017 Category: Respiratory Medicine Source Type: research

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Respirology, Ahead of Print. (Source: Respirology)
Source: Respirology - December 18, 2017 Category: Respiratory Medicine Source Type: research