Alterations in oocytes and early zygotes following oral exposure to di(2-ethylhexyl) phthalate in young adult female mice
Publication date: Available online 20 August 2019Source: Reproductive ToxicologyAuthor(s): Lyda Yuliana Parra-Forero, Arlet Veloz-Contreras, Shirley Vargas-Marín, María Angelica Mojica-Villegas, Elim Alfaro-Pedraza, Mayrut Urióstegui-Acosta, Isabel Hernández-OchoaAbstractBecause di(2-ethylhexyl) phthalate (DEHP) toxicity on ovarian function is incomplete, effects of DEHP oocyte fertilization and the resulting zygotes were investigated. Further, an analysis characterizing the stage of zygote arrest was performed. Female CD1 mice were dosed orally with DEHP (0, 20, 200 and 2000 µg/kg/day) for 30 days. Following an in ...
Source: Reproductive Toxicology - August 21, 2019 Category: Toxicology Source Type: research
In utero exposure to poly− and perfluoroalkyl substances (PFASs) and subsequent breast cancer
Publication date: Available online 16 July 2019Source: Reproductive ToxicologyAuthor(s): Barbara A. Cohn, Michele A. La Merrill, Nickilou Y. Krigbaum, Miaomiao Wang, June-Soo Park, Myrto Petreas, Gregory Yeh, Russell C. Hovey, Lauren Zimmermann, Piera M. CirilloAbstractWe tested the hypothesis that maternal perinatal serum levels of poly and perfluoroalkyl substances (PFASs) predict risk for breast cancer in daughters in a 54-year follow-up of 9300 daughters born 1959–1967 in the Child Health and Development Studies pregnancy cohort. Total cholesterol and PFASs were measured in archived maternal perinatal serum for 102 d...
Source: Reproductive Toxicology - August 20, 2019 Category: Toxicology Source Type: research
Sponsors and exhibitors 2019
Publication date: Available online 19 August 2019Source: Reproductive ToxicologyAuthor(s): (Source: Reproductive Toxicology)
Source: Reproductive Toxicology - August 20, 2019 Category: Toxicology Source Type: research
Congenital Heart Defects in West Virginia: Preliminary Findings from an Ecological Study of Effects of an Industrial Watershed on Increased Incidence
ConclusionThrough spatial analysis, there appears to be a direct point source exposure for observed cases of f CHD along the industrial watershed of Kanawha County, West Virginia (Source: Reproductive Toxicology)
Source: Reproductive Toxicology - August 17, 2019 Category: Toxicology Source Type: research
Prenatal toxicity of the environmental pollutants on neuronal and cardiac development derived from embryonic stem cells
Publication date: Available online 16 August 2019Source: Reproductive ToxicologyAuthor(s): Eul-Bee Ko, Kyung-A Hwang, Kyung-Chul ChoiAbstractPesticides, antibiotics, and industrial excipients are widely used in agriculture, medicine, and chemical industry, respectively. They often end up in the environment, not only being not easily decomposed but also being accumulated. Moreover, they may cause serious toxic problems such as reproductive and developmental defects, immunological toxicity, and carcinogenesis. Hence, they are called environmental pollutants. It is known that the environmental pollutants easily enter the body...
Source: Reproductive Toxicology - August 17, 2019 Category: Toxicology Source Type: research
Essential oils disrupt steroidogenesis in a feto-placental co-culture model
Publication date: Available online 16 August 2019Source: Reproductive ToxicologyAuthor(s): Debbie Yancu, Thomas SandersonAbstractWe determined whether 5 common essential oils (basil, fennel seed, orange, black pepper and sage) interfered with feto-placental steroidogenesis in a co-culture model composed of fetal-like adrenocortical (H295R) and placental trophoblast-like (BeWo) cells. After a 24 h exposure, only basil and fennel seed oil significantly increased hormone concentrations of estradiol, estrone, dehydroepiandrosterone (DHEA), androstenedione, progesterone, and estriol. Basil and fennel seed oil were shown to si...
Source: Reproductive Toxicology - August 17, 2019 Category: Toxicology Source Type: research
The Association Between Anogenital Distance, Reproductive and General Health in Adult Females- A Prospective Cohort of 17 years
ConclusionsWomen with short AGD are at increased risk for gynecological morbidities. AGD should be studied further, and may possibly be used for screening of women at risk for these conditions. (Source: Reproductive Toxicology)
Source: Reproductive Toxicology - August 15, 2019 Category: Toxicology Source Type: research
In Utero DDT Exposure and Breast Density in Early Menopause by Maternal History of Breast Cancer
We examined the relationship between intrauterine dichlorodiphenyltrichloroethane (DDT) exposure (o,p’-DDT, p,p’-DDT, and p,p’-DDE) and mammographic breast density (MBD) in midlife, one of the strongest risk factors for breast cancer. We focused our analyses on o,p’-DDT exposure given our previous report of a positive association between intrauterine o,p’-DDT exposure and daughter’s breast cancer (BC) risk. Here we estimated associations of intrauterine serum DDTs with MBD in 224 daughters of women in the Child Health and Development Studies pregnancy cohort whose mothers did not develop BC (MBCa-) and 156 daug...
Source: Reproductive Toxicology - August 15, 2019 Category: Toxicology Source Type: research
Python BMDS: A Python interface library and web application for the canonical EPA dose-response modeling software
Publication date: Available online 12 August 2019Source: Reproductive ToxicologyAuthor(s): Ly Ly Pham, Sean Watford, Katie Paul Friedman, Jessica Wignall, Andrew J. ShapiroAbstractSeveral primary sources of publicly available, quantitative dose-response data from traditional toxicology study designs relevant to predictive toxicology applications are now available, including the redeveloped U.S. Environmental Protection Agency’s Toxicity Reference Database (ToxRefDB v2.0), the Health Assessment Workspace Collaborative (HAWC), and the National Toxicology Program’s Chemical Program’s Chemical Effects in Biological Syste...
Source: Reproductive Toxicology - August 13, 2019 Category: Toxicology Source Type: research
Maternal serum concentrations of perfluoroalkyl substances during pregnancy and gestational weight gain: The Avon Longitudinal Study of Parents and Children
Publication date: Available online 12 August 2019Source: Reproductive ToxicologyAuthor(s): Kristin J. Marks, Zuha Jeddy, W. Dana Flanders, Kate Northstone, Abigail Fraser, Antonia M. Calafat, Kayoko Kato, Terryl J. HartmanAbstractPerfluoroalkyl substances (PFAS) are chemicals used in the manufacture of consumer products. PFAS may act as endocrine disruptors, influencing metabolic pathways and weight-related outcomes. We analyzed associations of maternal serum pregnancy concentrations of PFAS with gestational weight gain (GWG). We used data from 905 women in a subsample of the Avon Longitudinal Study of Parents and Children...
Source: Reproductive Toxicology - August 13, 2019 Category: Toxicology Source Type: research
The effects of perfluorooctanoic acid (PFOA) on fetal and adult rat testis
This study shows that the levels of cAMP, progesterone, testosterone and expression of StAR decreased significantly in PFOA 50 and 100 µg/ml. PFOA affected cell populations significantly by decreasing the amount of diploid, proliferating, meiotic I and G2/M-phase cells in adult rat testis. However, PFOA did not affect fetal, proliferating or adult rat Sertoli cells but an increased tendency of apoptosis in fetal Leydig cells was observed. (Source: Reproductive Toxicology)
Source: Reproductive Toxicology - August 13, 2019 Category: Toxicology Source Type: research
Exposure to Low Doses of Oxybenzone During Perinatal Development Alters Mammary Gland Morphology in Male and Female Mice
Publication date: Available online 10 August 2019Source: Reproductive ToxicologyAuthor(s): Klara Matouskova, D. Joseph Jerry, Laura N. VandenbergAbstractOxybenzone (benzophenone-3) is an ultraviolet radiation filter commonly used in personal care products including sunscreens, textiles and inks, and food and beverage containers, among others. Due to its widespread use, human exposures to oxybenzone are widespread. Oxybenzone is considered an endocrine disrupting chemical due to its antiestrogenic and antiandrogenic properties. We evaluated the effects of oral exposures to oxybenzone on the growth and morphology of the mamm...
Source: Reproductive Toxicology - August 11, 2019 Category: Toxicology Source Type: research
Editorial
Publication date: Available online 6 August 2019Source: Reproductive ToxicologyAuthor(s): Nicola Powles-Glover (Source: Reproductive Toxicology)
Source: Reproductive Toxicology - August 7, 2019 Category: Toxicology Source Type: research
Effect on the offspring of pregnant females CD-1 mice treated with a single thallium(I) application
In conclusion, the Intraperitoneal injection of Tl(I) acetate to pregnant mice induced morphological variations and a delay of the fetus ossification. (Source: Reproductive Toxicology)
Source: Reproductive Toxicology - August 4, 2019 Category: Toxicology Source Type: research
Developmental milestones in neonatal and juvenile C57Bl/6 mouse – indications for the design of juvenile toxicity studies
Publication date: Available online 3 August 2019Source: Reproductive ToxicologyAuthor(s): Aleksandra ZalewskaAbstractThere is a growing demand for wild type mice and mouse models of disease that may be more representative of human conditions but there is little information on neonatal and juvenile mouse anatomy. This project produces sound and comprehensive histology background data on the developing neonatal mouse at different time points from Day 0 until Day 28.The work describes optimal methods for tissue harvesting, fixation and processing from the neonatal and juvenile mice which can be used in routine toxicology stud...
Source: Reproductive Toxicology - August 4, 2019 Category: Toxicology Source Type: research
