Anethole compromises human sperm function by affecting the sperm intracellular calcium concentration and tyrosine phosphorylation
In this study, we examined the effect of anethole on human sperm in vitro. Different anethole doses (0.1, 1, 10, and 100 μM) were applied to ejaculated human sperm. Fertilization-essential functions, as well as the intracellular calcium concentration ([Ca2+]i) and tyrosine phosphorylation, two vital factors for regulating sperm function, were measured. The results indicated that 10 and 100 μM anethole significantly reduced the motility, hyperactivation, and penetration ability of human sperm (P < 0.05) and inhibited the increase in human sperm functions induced by progesterone, a hormone essential for sperm ...
Source: Reproductive Toxicology - January 29, 2020 Category: Toxicology Source Type: research
Trichostatin A alleviated ovarian tissue damage caused by cigarette smoke exposure
In this study, Female C57BL/6 mice were exposed to CS from six cigarettes mixed with indoor air for 120 minutes (one cigarette for 20 minutes) using a whole-body mainstream smoke exposure system twice daily for 30 days. TSA (0.6 mg/kg body weight) was injected intraperitoneally into mice in the Control + TSA group and CS + TSA group every two days for 30 days. We found that exposure to CS resulted in ovarian tissue damage and HDAC1/2 over-expression. TSA alleviated the structural changes of ovarian tissue induced by smoking and prevented the activation of HDAC1/2. Exposure to CS caused autophagy inhibition an...
Source: Reproductive Toxicology - January 25, 2020 Category: Toxicology Source Type: research
The association between gestational use of personal care products and neonatal urological abnormality at birth: The Japan Environment and Children’s Study
Publication date: Available online 22 January 2020Source: Reproductive ToxicologyAuthor(s): Yukiko Nishihama, Nozomi Tatsuta, Miyuki Iwai-Shimada, Kunihiko Nakai, Takahiro Arima, Ikuma Fujiwara, Nobuo Yaegashi, Ayano Takeuchi, Shoji F. Nakayama, the Japan Environment and Children’s Study (JECS) GroupAbstractCongenital anomalies of the kidney and urinary tract (CAKUT) include a broad group of birth defects. Exposure to endocrine disrupting chemicals (EDCs) is suspected to be one of the risk factors for CAKUT, and the use of personal care products (PCPs) is a source of EDC exposure. Therefore, this study aimed to investiga...
Source: Reproductive Toxicology - January 22, 2020 Category: Toxicology Source Type: research
Cannabidiol (CBD) but not tetrahydrocannabinol (THC) dysregulate in vitro decidualization of human endometrial stromal cells by disruption of estrogen signaling
In this study, we investigated the effects of phytocannabinoids, tetrahydrocannabinol (THC) and cannabidiol (CBD), in proliferation and differentiation of ESCs, as well as, in E2 metabolism/signaling. We found that CBD, but not THC, inhibits ESCs differentiation. We also show that CBD prevents the increase on transcript levels of CYP19A1 gene and the elevation of E2 levels that are observed in differentiating ESCs. Moreover, we found that CBD presents anti-aromatase activity. In overall, we highlight a novel effect of CBD on human endometrial differentiation, which may lead to infertility problems. (Source: Reproductive Toxicology)
Source: Reproductive Toxicology - January 15, 2020 Category: Toxicology Source Type: research
Editorial Board
Publication date: January 2020Source: Reproductive Toxicology, Volume 91Author(s): (Source: Reproductive Toxicology)
Source: Reproductive Toxicology - January 14, 2020 Category: Toxicology Source Type: research
Manganese is associated with increased plasma interleukin-1β during pregnancy, within a mixtures analysis framework of urinary trace metals
In conclusion, trace metal exposures were associated with biomarkers of immune perturbations, and this warrants further investigation. (Source: Reproductive Toxicology)
Source: Reproductive Toxicology - January 12, 2020 Category: Toxicology Source Type: research
Melatonin ameliorates the fertilization capacity of oocytes exposed to 17α-ethynylestradiol
Publication date: Available online 10 January 2020Source: Reproductive ToxicologyAuthor(s): Xiaoxin Dai, Lijun Qiu, Bo Zhao, Yang Gao, Yi Mu, Zhangjie Chu, Lijie Du, Bo XiongAbstract17α-ethynylestradiol (EE2), a synthetic hormone that derives from the natural hormone estradiol, has been reported to alter the sex determination, sexual maturity and secondary sexual characteristics of exposed organisms. However, the adverse effects of EE2 on the oocyte quality have not fully determined. Here, we found that EE2 exposure compromised the fertilization capacity of mouse oocytes, while treatment of melatonin remarkably elevated t...
Source: Reproductive Toxicology - January 11, 2020 Category: Toxicology Source Type: research
Corrigendum to “Elevated blood mercury level has a non-linear association with infertility in U.S. women: Data from the NHANES 2013-2016” [Reprod. Toxicol. 91C (2020) 53–58]
Publication date: Available online 8 January 2020Source: Reproductive ToxicologyAuthor(s): Fangfang Zhu, Chi Chen, Yingxuan Zhang, Si Chen, Xian Huang, Jingwei Li, Yanxi Wang, Xiaorong Liu, Gaopi Deng, Jie Gao (Source: Reproductive Toxicology)
Source: Reproductive Toxicology - January 9, 2020 Category: Toxicology Source Type: research
Anti-Müllerian hormone participates in ovarian granulosa cell damage due to cadmium exposure by negatively regulating stem cell factor
This study was designed to examine the characteristics of 0, 5, 10, and 20 μM cadmium toxicity in granulosa cells culture for 12 hours, and the subsequent effect of cadmium exposure on AMH production and formation. Here we demonstrate that the viability of granulosa cells cadmium exposed was decreased, and the apoptosis was increased. Intriguingly, After exposure to cadmium the SCF was decreased and the AMH was increased in granulosa cells. This study may demonstrate that AMH signaling is involved in Cd action through SCF activation. The signaling pathways may play a role in the reproductive effects caused by environm...
Source: Reproductive Toxicology - January 9, 2020 Category: Toxicology Source Type: research
Can maternal exposure to paracetamol impair reproductive parameters of male rat offspring?
Publication date: Available online 9 January 2020Source: Reproductive ToxicologyAuthor(s): Marina Rangel Ferro Pereira, Jeberson Fernando Aleixo, Liara de Freitas Cavalcanti, Nathalia Orlandini Costa, Milene Leivas Vieira, Graziela Scalianti Ceravolo, Estefania Gastaldello Moreira, Daniela Cristina Ceccatto GerardinAbstractParacetamol is a widely used medication during gestation and lactation periods for the treatment of pain and fever. Several studies have shown that exposure to paracetamol can increase the incidence of cryptorchidism and decrease testosterone production. Therefore, the present study aimed to evaluate if ...
Source: Reproductive Toxicology - January 9, 2020 Category: Toxicology Source Type: research
Reprint of “Metabolome Wide Association Study of Serum Poly and Perfluoroalkyl Substances (PFASs) in Pregnancy and Early Postpartum”
Publication date: Available online 8 January 2020Source: Reproductive ToxicologyAuthor(s): Xin Hu, Shuzhao Li, Piera M. Cirillo, Nickilou Y. Krigbaum, ViLinh Tran, Dean P. Jones, Barbara A. CohnAbstractHigh-resolution metabolomics (HRM) profiling of metabolic fingerprints can improve understanding of how poly and perfluoroalkyl substances (PFASs) induce metabolic alterations of in utero environment and impact fetal health. HRM profiling and quantification of PFASs were performed for 397 maternal perinatal serum samples collected from 1959-1967 in the Child Health and Development Studies (CHDS). We used Metabolome-Wide Asso...
Source: Reproductive Toxicology - January 8, 2020 Category: Toxicology Source Type: research
Late-Life Consequences of Short-Term Exposure to Di(2-ethylhexyl) Phthalate and Diisononyl Phthalate During Adulthood in Female Mice
Publication date: Available online 2 January 2020Source: Reproductive ToxicologyAuthor(s): Catheryne Chiang, Lily R. Lewis, Grace Borkowski, Jodi A. FlawsAbstractDi(2-ethylhexyl) phthalate (DEHP) is a known endocrine disruptor and diisononyl phthalate (DiNP) is a common DEHP replacement chemical. However, little is known about late-life consequences due to DEHP or DiNP exposure during adulthood. Thus, this study tested the hypothesis that adult exposure to DEHP or DiNP affects female reproductive parameters during late-life in female mice. Female CD-1 mice (age 39-40 days) were dosed with either vehicle control, DEHP (20...
Source: Reproductive Toxicology - January 3, 2020 Category: Toxicology Source Type: research
Title: Manganese is associated with increased plasma interleukin-1β during pregnancy, within a mixtures analysis framework of urinary trace metals
In conclusion, trace metal exposures were associated with biomarkers of immune perturbations, and this warrants further investigation. (Source: Reproductive Toxicology)
Source: Reproductive Toxicology - December 26, 2019 Category: Toxicology Source Type: research
Maternal benzo[a]pyrene exposure is correlated with the meiotic arrest and quality deterioration of offspring oocytes in mice
Publication date: Available online 23 December 2019Source: Reproductive ToxicologyAuthor(s): Lumin Sui, Junyu Nie, Peng Xiao, Ke Yan, Huiting Zhang, Jiahao Liu, Hengye Zhang, Kexin Cui, Kehuan Lu, Xingwei LiangAbstractBenzo[a]pyrene (BaP) is a polycyclic aromatic hydrocarbon (PAH) in particulate matter that has a diameter of ≤2.5 µm (PM2.5). Studies have demonstrated that BaP exposure causes oocyte meiotic arrest in mice. However, whether BaP exposure also affects oocyte maturation in offspring remains unclear. To test this, female mice were administered BaP before pregnancy to generate BaP-exposed offspring. Our find...
Source: Reproductive Toxicology - December 24, 2019 Category: Toxicology Source Type: research
Kallikrein-kinin system and oxidative stress in cisplatin-induced ovarian toxicity
Publication date: Available online 23 December 2019Source: Reproductive ToxicologyAuthor(s): Laura Silveira Ayres, Markus Berger, Isabel Cirne Lima de Oliveira Durli, Cristiana Palma Kuhl, Paula Barros Terraciano, Tuane Nerissa Alves Garcez, Bruna Gomes dos Santos, Jorge Almeida Guimarães, Eduardo Pandolfi Passos, Elizabeth Obino Cirne-LimaAbstractKallikrein-kinin system (KKS) is involved in vascular reactivity and inflammatory response to cytotoxic drugs. Since cisplatin is a widely used chemotherapy and its cytotoxic mechanism can trigger inflammation and oxidative damage, in this work we evaluated the role of KKS in an...
Source: Reproductive Toxicology - December 24, 2019 Category: Toxicology Source Type: research
