Postponing pregnancy seeking and anticipating infertility treatments: an unwise combination
ConclusionsIn women older than 35, anticipation of the infertility work-up is associated with only a modest increase in the rate of success of IVF-ICSI. In most scenarios, this advantage may compare unfavorably with the chances of natural conception during the 6 months period. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - December 17, 2019 Category: Reproduction Medicine Source Type: research

The effect of follicular phase length on pregnancy outcomes and endometrial development in gonadotropin ovarian stimulation/intrauterine insemination (OS/IUI) cycles
Publication date: Available online 16 December 2019Source: Reproductive BioMedicine OnlineAuthor(s): Jennifer B. Bakkensen, Georgios Christou, Irene Dimitriadis, Kaitlyn James, Irene SouterAbstractResearch questionDoes a shorter follicular phase length (FPL) affect pregnancy outcomes and endometrial development among women undergoing gonadotropin ovarian stimulation/intrauterine insemination (OS/IUI)?DesignRetrospective cohort study of 4773 OS/IUI cycles among 2054 patients. FPL was analyzed first continuously, then dichotomously using an arbitrary cutoff at the 15th percentile (8 days) to divide cycles into shorter and lo...
Source: Reproductive BioMedicine Online - December 17, 2019 Category: Reproduction Medicine Source Type: research

Editorial Board
Publication date: December 2019Source: Reproductive BioMedicine Online, Volume 39, Issue 6Author(s): (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - December 12, 2019 Category: Reproduction Medicine Source Type: research

Contents
Publication date: December 2019Source: Reproductive BioMedicine Online, Volume 39, Issue 6Author(s): (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - December 12, 2019 Category: Reproduction Medicine Source Type: research

Fibrinogen alpha chain is up-regulated and affects the pathogenesis of endometriosis
Publication date: December 2019Source: Reproductive BioMedicine Online, Volume 39, Issue 6Author(s): Ying Chen, Hui Li, Hong-yan Cheng, Ma Rui-qiong, Xue Ye, Heng Cui, Zhu Hong-lan, Xiao-hong ChangAbstractResearch questionIn the group's previous study, fibrinogen alpha chain (FGA) was identified as an up-regulated differential protein that was highly expressed in women with endometriosis. The current study investigated the expression and effects of FGA in endometriosis. It also evaluated the effects of FGA on human endometrial stromal cells and studied the possible mechanism.DesignThis was a cross-sectional analysis of FGA...
Source: Reproductive BioMedicine Online - December 12, 2019 Category: Reproduction Medicine Source Type: research

Effect of embryo transfer difficulty on live birth rates studied in vitrified–warmed euploid blastocyst transfers
Publication date: December 2019Source: Reproductive BioMedicine Online, Volume 39, Issue 6Author(s): Manuel Alvarez, Francisca Martínez, Filipe M Bourroul, Nikolaos P Polyzos, Miquel Solé, Mónica Parriego, Ignacio Rodríguez, Pedro N Barri, Buenaventura CoroleuAbstractResearch questionThe aim of this study was to investigate the relationship between the different manoeuvres employed or degrees of difficulty during embryo transfer and live birth rate (LBR) in frozen euploid (blastocyst) embryo transfer (FEET).DesignA retrospective, observational study of women undergoing FEET was performed. If the...
Source: Reproductive BioMedicine Online - December 12, 2019 Category: Reproduction Medicine Source Type: research

Durations of Intrauterine Balloon therapy and Adhesion Reformation After Hysteroscopic Adhesiolysis: A Randomized Controlled Trial
Publication date: Available online 10 December 2019Source: Reproductive BioMedicine OnlineAuthor(s): Xue Yang, Yuhuan Liu, TC Li, Enlan Xia, Yu Xiao, Fengqiong Zhou, Dongmei Song, Qiaoyun ZhouAbstractResearch questionDoes placing an intrauterine balloon for different durations affect the recurrence of intrauterine adhesion after hysteroscopic adhesiolysis?DesignProspective randomized control trial involving 138 subjects recruited over a 12-month period and followed up post-operatively for 15 months.ResultsThe primary outcome measure was the rate of adhesion reformation at second- and third-look hysteroscopy. At second-look...
Source: Reproductive BioMedicine Online - December 11, 2019 Category: Reproduction Medicine Source Type: research

Large-for-gestational age is male-gender dependent in artificial frozen embryo transfers cycles: a cohort study of 1295 singleton live births
Publication date: Available online 24 October 2019Source: Reproductive BioMedicine OnlineAuthor(s): Kevin Coetzee, Kemal Ozgur, Hasan Bulut, Murat Berkkanoglu, Peter HumaidanAbstractResearch questionWhat is the effect of frozen embryo transfer (FET) on infant birth weight outcomes and which variables predic large-for-gestational age (LGA) infants.DesignIn a large cohort study, the birth weight of 1295 singleton live births from blastocyst freeze-all-IVF treatments carried out between February 2015 and February 2017 at a single IVF centre were analysed. All embryo transfers were vitrified–warmed blastocyst transfers i...
Source: Reproductive BioMedicine Online - December 11, 2019 Category: Reproduction Medicine Source Type: research

Guideline-based quality indicators for Early Pregnancy Assessment Units: Guideline-based quality indicators for EPAUs
Conclusions: We identified 19 quality indicators to measure early pregnancy care provided by EPAUs. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - December 8, 2019 Category: Reproduction Medicine Source Type: research

Context-based infertility care
Publication date: Available online 6 December 2019Source: Reproductive BioMedicine OnlineAuthor(s): N.S. Macklon, B.C.J.M. Fauser (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - December 7, 2019 Category: Reproduction Medicine Source Type: research

Key recommendations for high quality female oncofertility care based on international clinical practice guidelines
ConclusionA set of eleven key recommendations for high quality female oncofertility care was selected by a multidisciplinary expert panel. The involvement of patients’, referrers’ and counsellors’ perspectives led to this valid, acceptable and credible set of key recommendations. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - December 4, 2019 Category: Reproduction Medicine Source Type: research

Meet our new editor: Professor Nick Macklon
Publication date: Available online 3 December 2019Source: Reproductive BioMedicine OnlineAuthor(s): Nick Macklon (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - December 4, 2019 Category: Reproduction Medicine Source Type: research

Alternative patterns of partial embryo compaction: prevalence, morphokinetic history and possible implications
ConclusionsAlternative modalities of incomplete compaction were detected for the first time. Such patterns are characterized by different morphokinetic behaviours overarching the entire preimplantation development and by different developmental abilities. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - December 1, 2019 Category: Reproduction Medicine Source Type: research

In cases of familial primary ovarian insufficiency and disorders of gonadal development, consider NR5A1/SF-1 sequence variants
ConclusionSequence variation of the NR5A1 gene is a possibility that must be considered when a woman with POI or a diminished ovarian reserve has a family member or child with DGD. If a variant is identified, genetic counselling is essential for the patient and his/her family. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 30, 2019 Category: Reproduction Medicine Source Type: research

Cancer in IVF patients treated at age 40 and older: long term follow up
Conclusions: In this study, IVF treatment in older women was not found to be significantly associated with an excess risk of cancer at long term follow up. However, further studies are needed to confirm these findings. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 30, 2019 Category: Reproduction Medicine Source Type: research

Prevalence of thyroid autoimmunity and effect of levothyroxine treatment in a cohort of 1064 patients with recurrent pregnancy loss
ConclusionsTreatment of hypothyroidism in pregnancy should be initiated based on a TSH> 4 mIU/L. Treatment initiation based on thyroid autoimmunity or a TSH> 2.5 mIU/L may result in overtreatment. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 30, 2019 Category: Reproduction Medicine Source Type: research

Association between body mass index and oocyte maturation in patients triggered with GnRH agonist who are at high risk for severe ovarian hyperstimulation syndrome: an observational cohort study
ConclusionsAmong women at high risk for developing severe OHSS who are triggered with a standard dose (0.2 mg) of the GnRH agonist triptorelin, women with BMI 25 kg/m2 or greater had significantly fewer mature oocytes, required a higher total dose of recombinant FSH compared with women with BMI less than 25 kg/m2. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 29, 2019 Category: Reproduction Medicine Source Type: research

Polycystic ovarian syndrome novel proteins and significant pathways identified using graph clustering approach
ConclusionsThese results support that this approach can provide additional insight into the pathobiology of PCOS and these pathways have both biological and statistical support to its pathobiology. Thus, integrative analysis is able to unravel unknown mechanisms towards the development of accurate diagnosis and effective treatment in PCOS.Graphical abstract (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 29, 2019 Category: Reproduction Medicine Source Type: research

Drug- free in vitro activation of follicles and fresh tissue autotransplantation as a therapeutic option in primary ovarian insufficiency patients
ConclusionsDrug-Free IVA can be a useful therapeutic option in POI patients with hopeful IVF outcomes. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 29, 2019 Category: Reproduction Medicine Source Type: research

Analysis of 122 triplet and 1 quadruplet pregnancies after single embryo transfer in Japan
Publication date: Available online 29 November 2019Source: Reproductive BioMedicine OnlineAuthor(s): Satoko Yamashita, Yuko Ikemoto, Asako Ochiai, Satoshi Yamada, Keiichi Kato, Motoharu Ohno, Tomoya Segawa, Yoshiharu Nakaoka, Mayumi Toya, Satoshi Kawachiya, Yoshiaki Sato, Toshifumi Takahashi, Shigeto Takeuchi, Mari Nomiyama, Chisa Tabata, Toshihiro Fujiwara, Sumihide Okamoto, Toshihiro Kawamura, Jun Kawagoe, Mitsutoshi YamadaAbstractResearch questionTo estimate the prevalence of triplet and quadruplet pregnancies after single embryo transfer (SET) in Japan.DesignWe conducted a retrospective observational study on 274,605 p...
Source: Reproductive BioMedicine Online - November 29, 2019 Category: Reproduction Medicine Source Type: research

Adenomyotic glands are highly related to endometrial glands
CONCLUSIONSTaken together, our results show that the protein expression pattern of adenomyosis is nearly identical to those of the endometrium with and without endometriosis externa thus suggesting endometrial glands as the main source for adenomyotic glands. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 29, 2019 Category: Reproduction Medicine Source Type: research

The influence of stage and grade of breast cancer on fertility preservation outcome in reproductive aged women
ConclusionsHigh-grade breast cancer has a negative effect on the total number of mature oocytes and cryopreserved embryos. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 29, 2019 Category: Reproduction Medicine Source Type: research

A follow-up survey on the reproductive intentions and experiences of women undergoing planned oocyte cryopreservation
ConclusionsPlanned oocyte cryopreservation as a prophylactic intervention to reduce the risk of infertility at a later age appears to be generally well received by women who are mostly single and who wish to “buy time” while they seek a suitable partner to create a family. The majority of women who underwent OoC do not regret their experience and many have found a partner in subsequent years. The overall positive attitude of our respondents towards planned OoC contrasts with the paucity of published data pertaining to the efficacy of this approach in terms of live birth rates. Twenty-one percent of respondents ...
Source: Reproductive BioMedicine Online - November 29, 2019 Category: Reproduction Medicine Source Type: research

The Effect of Intra-Ovarian Androgen Priming on Ovarian Reserve Parameters in Bologna Poor Responders
ConclusionsLong-term intra-ovarian androgen priming in the current set-up had no significant effect on hormone levels, AFC and recruitable follicles after ovarian stimulation in Bologna POR patients undergoing IVF. Further studies are needed to explore other androgen priming protocols and the clinical value of priming regimens in IVF. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 29, 2019 Category: Reproduction Medicine Source Type: research

Ethnic discordance in serum müllerian hormone (AMH) in healthy women; population study from China and Europe
ConclusionsThere were independent effects of age and ethnicity on serum AMH concentrations, with Chinese women having a substantially lower AMH in adult life than their European counterparts from age 25 onwards. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 29, 2019 Category: Reproduction Medicine Source Type: research

Time-lapse imaging of cytoplasmic strings at the blastocyst stage indicates their association with spontaneous collapse
Publication date: Available online 28 November 2019Source: Reproductive BioMedicine OnlineAuthor(s): Ebner T, Sesli O, Kresic S, Enengl S, Stoiber B, Reiter E, Oppelt P, Mayer RB, Shebl OAbstractResearch questionTo study the origin and temporal behaviour of cytoplasmic strings spanning the blastocoel (main objective) and their influence on treatment outcome (secondary objective).DesignThis retrospective analysis of prospectively collected data was set up in a university medical centre. Patients who either underwent fresh (n = 95) or vitrified/warmed (n = 55) single blastocyst transfer were included. Time-lapse sequ...
Source: Reproductive BioMedicine Online - November 28, 2019 Category: Reproduction Medicine Source Type: research

Ovarian reserve markers after discontinuing long-term use of combined oral contraceptives
Publication date: Available online 15 October 2019Source: Reproductive BioMedicine OnlineAuthor(s): Selma Kloeve Landersoe, Kathrine Birch Petersen, Anne Lyngholm Sørensen, Elisabeth Clare Larsen, Torben Martinussen, Stine Aagaard Lunding, Mie Stougaard Kroman, Henriette Svarre Nielsen, Anders Nyboe AndersenAbstractResearch questionHow early do the ovarian reserve markers anti-Müllerian hormone (AMH) and antral follicle count (AFC) normalize after discontinuation of the long-term use of combined oral contraceptives (COC).DesignThis was a prospective cohort study of 68 women with a history of long-term COC use. ...
Source: Reproductive BioMedicine Online - November 28, 2019 Category: Reproduction Medicine Source Type: research

In-vitro development of embryos derived from vitrified–warmed oocytes is delayed compared with embryos derived from fresh oocytes: a time-lapse sibling oocyte study
ConclusionsTiming of development is altered and blastocyst formation is delayed in embryos derived from vitrified–warmed donor oocytes compared with their fresh sibling counterparts. Although preliminary results suggest that the clinical impact of this delay may be limited, this needs further investigation in larger randomized studies. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 23, 2019 Category: Reproduction Medicine Source Type: research

Endometrial thickness and IVF cycle outcomes: a meta-analysis
Publication date: Available online 18 September 2019Source: Reproductive BioMedicine OnlineAuthor(s): Ge Gao, Xianfeng Cui, Shuang Li, Pan Ding, Shuai Zhang, Yunshan ZhangAbstractResearch questionIn this meta-analysis, the association between endometrial thickness (EMT) and cycle outcomes after IVF is explored. Associations between EMT and cycle outcomes according to study and individual characteristics were also assessed.DesignStudies evaluating associations between EMT and pregnancy, implantation, miscarriage, live birth or ongoing pregnancy and ectopic pregnancy rates in individuals after IVF were identified on PubMed, ...
Source: Reproductive BioMedicine Online - November 21, 2019 Category: Reproduction Medicine Source Type: research

‘There is only one thing that is truly important in an IVF laboratory: everything’ Cairo Consensus Guidelines on IVF Culture Conditions
Publication date: Available online 10 October 2019Source: Reproductive BioMedicine OnlineAuthor(s): Jacques Cohen, Cairo 2018 Consensus GroupAbstractThis proceedings report presents the outcomes from an international expert meeting to establish consensus guidelines on IVF culture conditions. Topics reviewed and discussed were: embryo culture – basic principles and interactions; temperature in the IVF laboratory; humidity in culture; carbon dioxide control and medium pH; oxygen tension for embryo culture; workstations – design and engineering; incubators – maintaining the culture environment; micromanipula...
Source: Reproductive BioMedicine Online - November 20, 2019 Category: Reproduction Medicine Source Type: research

Cross-disorder analysis of endometriosis and its comorbid diseases reveals shared genes and molecular pathways and proposes putative biomarkers of endometriosis
Conclusionsour study results highlight the molecular processes underlying the etiopathogenesis of endometriosis and its comorbid conditions, and identify putative endometriosis biomarkers. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 20, 2019 Category: Reproduction Medicine Source Type: research

Transvaginal hydrolaparoscopy and laparoscopy
ConclusionTHL in an outpatient setting can detect anatomical abnormalities comparable to the, more invasive, reference standard diagnostic laparoscopy. If THL succeeds, there is no need to add a diagnostic laparoscopy in the work-up. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 18, 2019 Category: Reproduction Medicine Source Type: research

HPV infection and female Infertility: A systematic Review and meta-Analysis
Publication date: Available online 16 November 2019Source: Reproductive BioMedicine OnlineAuthor(s): Shuang Yuan, Yichao Qiu, Yuanyuan Xu, Hongjing WangAbstractIncreasing evidence shows that HPV infection affects reproductive health and fertility, although its impact on female fertility has not been thoroughly studied. We conducted a meta-analysis of 12 studies including 15450 female subjects that compared HPV prevalence between the infertile and general population, and evaluated the association between HPV positivity and female infertility. Seven case-controlled studies on 3581 participants reported indiscriminate genotyp...
Source: Reproductive BioMedicine Online - November 16, 2019 Category: Reproduction Medicine Source Type: research

Factors related to early spontaneous miscarriage during IVF/ICSI treatment: an analysis of 21,485 clinical pregnancies
Publication date: Available online 14 November 2019Source: Reproductive BioMedicine OnlineAuthor(s): Zhiqin Bu, Linli Hu, Yingchun Su, Yihong Guo, Jun Zhai, Yingpu SunAbstractResearch questionThe aim was to investigate factors related to early spontaneous miscarriage during in vitro fertilization (IVF)/ intracytoplasmic sperm injection (ICSI) treatment.DesignA total of 21,485 clinical pregnancy cycles were included in the analysis. First, early spontaneous miscarriage rates were compared among different groups according to female age, body mass index (BMI), number of previous miscarriages, etc. Then, the spontaneous miscar...
Source: Reproductive BioMedicine Online - November 15, 2019 Category: Reproduction Medicine Source Type: research

Cannabis consumption might exert deleterious effects on sperm nuclear quality in infertile males
ConclusionsCannabis consumption might have deleterious effects on sperm nuclear quality in infertile males by increasing numerical chromosome abnormalities and DNA fragmentation. Cannabis consumption induces additional detrimental effects on the progression of spermatogenesis from meiotic stages to spermiogenesis and potentially on post-testicular sperm maturation in infertile males. However, any potential findings need to be validated with larger sample size and our data are only exploratory findings. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 15, 2019 Category: Reproduction Medicine Source Type: research

Birthweight of IVF children is still a current issue and still related to maternal factors
ConclusionsMaternal background and obstetric parameters are more likely to influence the SGA rate than fresh embryo transfer conception. FET conception could be associated with an increase in LGA rate. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 12, 2019 Category: Reproduction Medicine Source Type: research

Drug-free in-vitro activation of follicles for infertility treatment in poor ovarian response patients with decreased ovarian reserve
ConclusionsThe present drug-free IVA approach may be suitable for POR patients with DOR, as it increased the number of antral follicles. The procedure also eliminated the need for 2-day incubation with drugs and required only one surgery. This approach could allow the retrieval of more oocytes in middle-aged women to achieve higher pregnancy rates and deserves proper evaluation in future randomized controlled trials. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 10, 2019 Category: Reproduction Medicine Source Type: research

Female age affects the utility of sperm DNA fragmentation in predicting IVF and ICSI outcomes
ConclusionFemale age has a negative effect and should be considered in predicting the effects of sperm DNA fragmentation on pregnancy outcomes. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 10, 2019 Category: Reproduction Medicine Source Type: research

Vitrification negatively affects the Ca2+-releasing and activation potential of mouse oocytes, but vitrified oocytes are potentially useful for diagnostic purposes
ConclusionsVitrified–warmed mouse oocytes display reduced Ca2+-releasing potential upon oocyte activation, caused by cryoprotectant exposure. With adapted classification criteria, these oocytes could be used for diagnosing oocyte activation deficiencies in patients. Evaluating the Ca2+-signalling machinery in vitrified–warmed human oocytes is required. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 10, 2019 Category: Reproduction Medicine Source Type: research

Editorial Board
Publication date: November 2019Source: Reproductive BioMedicine Online, Volume 39, Issue 5Author(s): (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 9, 2019 Category: Reproduction Medicine Source Type: research

Contents
Publication date: November 2019Source: Reproductive BioMedicine Online, Volume 39, Issue 5Author(s): (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 9, 2019 Category: Reproduction Medicine Source Type: research

Cryopreserving testicular tissue is the preferred method to preserve SSCs prior to spermatogonial stem cell transplantation.
Conclusion(s)Cryopreservation of TT is the preferred method to cryopreserve spermatogonial stem cells (SSCs) prior to SSCT. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 7, 2019 Category: Reproduction Medicine Source Type: research

Impact of the mode of conception on gestational hypertensive disorders at very advanced maternal age
Publication date: Available online 7 November 2019Source: Reproductive BioMedicine OnlineAuthor(s): R. Meyer, R. Orvieto, Y. Timerman, T. Gorodesky, S. Toussia-Cohen, A. Kedem, M.J. Simchen, R. MachtingerAbstractResearch questionTo study gestational hypertensive disorders in oocyte donation pregnancies compared with other modes of conception at very advanced maternal age.DesignA historical cohort study of all women aged 45-47 years who gave birth to singletons at a tertiary medical center between 3.2011-5.2018, at 24 weeks gestation or later. Pregnancy outcomes were compared between donor oocyte (IVF-OD), IVF using autolog...
Source: Reproductive BioMedicine Online - November 7, 2019 Category: Reproduction Medicine Source Type: research

Qualitative and quantitative aspects of sex life in the context of endometriosis: a multicentre case control study
Publication date: Available online 7 November 2019Source: Reproductive BioMedicine OnlineAuthor(s): Valerie Bernays, Alexandra Kohl Schwartz, Kirsten Geraedts, Martina Rauchfuss, Monika Maria Wölfler, Felix Haeberlin, Stephanie von Orelli, Markus Eberhard, Bruno Imthurn, Daniel Fink, Patrick Imesch, Brigitte LeenersAbstractResearch questionWhat are the specific characteristics of sexual activity in women with endometriosis compared to women without endometriosis?DesignMulticentre case control study. Participants were recruited in university hospitals, district hospitals, and doctor's offices in Germany, Switzerland an...
Source: Reproductive BioMedicine Online - November 7, 2019 Category: Reproduction Medicine Source Type: research

First trimester depression and/or anxiety disorders increase the risk of low birthweight in IVF offspring: a prospective cohort study
Publication date: Available online 11 September 2019Source: Reproductive BioMedicine OnlineAuthor(s): Jingwen Lang, Bingqian Zhang, Yueru Meng, Yanzhi Du, Linlin Cui, Weiping LiAbstractResearch questionAre maternal depression and/or anxiety disorders (MDAD) before and during pregnancy associated with IVF outcomes?DesignA total of 5661 women starting their first IVF cycle between 15 August 2014 and 31 December 2015 were pooled from a prospective cohort of IVF-conceived children. The self-rating depression scale (SDS) and self-rating anxiety scale (SAS) were used to determine MDAD. IVF outcomes were compared between MDAD+ an...
Source: Reproductive BioMedicine Online - November 6, 2019 Category: Reproduction Medicine Source Type: research

Investigation of soluble anti-Müllerian hormone receptor type 2 as a biomarker for diagnosis of female fertility disorders
Publication date: Available online 27 August 2019Source: Reproductive BioMedicine OnlineAuthor(s): Lena Sophie Olivier, Osman Evliyaoglu, Ralf Weiskirchen, Josef van HeldenAbstractResearch questionThe ectodomain of the anti-Müllerian hormone (AMH) type 2 receptor is shed by proteases under certain conditions, which makes it measurable in the blood. The aim of this study was to identify correlations of soluble anti-Müllerian hormone receptor type 2 (sAMHR2) with other sex hormone concentrations and to assess whether sAMHR2 may serve as a new biomarker in fertility disorders.DesignIn a retrospective cross-sectional...
Source: Reproductive BioMedicine Online - November 3, 2019 Category: Reproduction Medicine Source Type: research

Identification of research priorities in infertility and assisted reproduction: an international, multicenter study
CONCLUSIONSResearchers and clinicians should keep in mind that, in addition to success rates and safety, patients greatly value research on causes, prevention and emotional aspects of infertility. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 1, 2019 Category: Reproduction Medicine Source Type: research

Mapping research in assisted reproduction worldwide
ConclusionsWe identify here the current hot topics on Human Assisted Reproduction worldwide and their temporal trends for 2005-2016. We provide an innovative picture of the current research that could help to explore the areas where further research is needed. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 1, 2019 Category: Reproduction Medicine Source Type: research

How common is real Repeated Implantation Failure? An indirect estimate of the prevalence
ConclusionsBased on our analyses, the estimated prevalence of RIF is 15%. The frequently used definition of RIF based on three failed attempts (but not two) in good prognosis couples seems justified. However, physicians should keep in mind that couples may be inappropriately labeled with this condition in one out of four cases. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - October 29, 2019 Category: Reproduction Medicine Source Type: research

Short Versus Extended Progesterone Supplementation for Luteal Phase Support in fresh IVF cycles: a systematic review and meta-analysis
Publication date: Available online 24 October 2019Source: Reproductive BioMedicine OnlineAuthor(s): M Watters, M Noble, T Child, SM NelsonAbstractThis review and meta-analysis aims to assess the effect of prolonged progesterone support on pregnancy outcomes in women undergoing a fresh embryo transfer after IVF/ICSI.Two independent reviewers searched EMBASE, MEDLINE and grey literature from inception to January 2019 for RCTs of prolonged progesterone support vs early cessation. Risk of bias was assessed. Outcome measures were live birth, miscarriage and ongoing pregnancy rate. Study protocol CRD42018088605.Seven trials invo...
Source: Reproductive BioMedicine Online - October 25, 2019 Category: Reproduction Medicine Source Type: research