Carcinogenicity and chronic toxicity of acrolein in rats and mice by two-year inhalation study
Publication date: April 2021Source: Regulatory Toxicology and Pharmacology, Volume 121Author(s): Michiharu Matsumoto, Shotaro Yamano, Hideki Senoh, Yumi Umeda, Shigeyuki Hirai, Arata Saito, Tatsuya Kasai, Shigetoshi Aiso (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - January 28, 2021 Category: Toxicology Source Type: research

Expanding the toxicologist's statistical toolbox: Using effect size estimation and dose-response modelling for holistic assessments instead of generic testing
Publication date: April 2021Source: Regulatory Toxicology and Pharmacology, Volume 121Author(s): Felix M. Kluxen, Signe M. Jensen (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - January 27, 2021 Category: Toxicology Source Type: research

Grouping of chemicals based on the potential mechanisms of hepatotoxicity of naphthalene and structurally similar chemicals using in vitro testing for read-across and its validation
Publication date: Available online 23 January 2021Source: Regulatory Toxicology and PharmacologyAuthor(s): Shota Nakagawa, Maiko Okamoto, Keita Yoshihara, Yuko Nukada, Osamu Morita (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - January 24, 2021 Category: Toxicology Source Type: research

Classic and evolving approaches to evaluating cross reactivity of mAb and mAb-like molecules – a survey of industry 2008-2019
Publication date: Available online 22 January 2021Source: Regulatory Toxicology and PharmacologyAuthor(s): Timothy K. MacLachlan, Shari Price, Joy Cavagnaro, Laura Andrews, Diann Blanset, Mary Ellen Cosenza, Maggie Dempster, Elizabeth Galbreath, Anna Maria Giusti, Kathleen Marie Heinz-Taheny, Renaud Fleurance, Esther Sutter, Michael W. Leach (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - January 24, 2021 Category: Toxicology Source Type: research

Mercury in Skin-Care Products in India and Consumer Exposure Risks
Publication date: Available online 22 January 2021Source: Regulatory Toxicology and PharmacologyAuthor(s): Supriti Pramanik, Mukesh Kumar, Asif Qureshi (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - January 24, 2021 Category: Toxicology Source Type: research

Toxicity of boric acid, borax and other boron containing compounds: A review
Publication date: Available online 22 January 2021Source: Regulatory Toxicology and PharmacologyAuthor(s): Niels Hadrup, Marie Frederiksen, Anoop K. Sharma (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - January 24, 2021 Category: Toxicology Source Type: research

Expanding the toxicologist’s statistical toolbox: using effect size estimation and dose-response modelling for holistic assessments instead of generic testing
Publication date: Available online 22 January 2021Source: Regulatory Toxicology and PharmacologyAuthor(s): Felix M. Kluxen, Signe M. Jensen (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - January 24, 2021 Category: Toxicology Source Type: research

Human Biomonitoring (HBM)-II values for perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) - description, derivation and discussion
Publication date: Available online 21 January 2021Source: Regulatory Toxicology and PharmacologyAuthor(s): Michael Schümann, Hellmuth Lilienthal, Jürgen Hölzer (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - January 23, 2021 Category: Toxicology Source Type: research

Nonclinical & Clinical Interface - Extrapolation of Nonclinical Data to Support Phase I Clinical Studies
Publication date: Available online 20 January 2021Source: Regulatory Toxicology and PharmacologyAuthor(s): Paul Baldrick, Andreas Reichl (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - January 20, 2021 Category: Toxicology Source Type: research

Carcinogenicity and chronic toxicity of acrolein in rats and mice by two-year inhalation study.
Publication date: Available online 17 January 2021Source: Regulatory Toxicology and PharmacologyAuthor(s): Michiharu Matsumoto, Shotaro Yamano, Hideki Senoh, Yumi Umeda, Shigeyuki Hirai, Arata Saito, Tatsuya Kasai, Shigetoshi Aiso (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - January 17, 2021 Category: Toxicology Source Type: research

Draize Human Repeat Insult Patch Test (HRIPT): Seven Decades of Pitfalls and Progress
Publication date: Available online 16 January 2021Source: Regulatory Toxicology and PharmacologyAuthor(s): Jordan L. Bormann, Howard I. Maibach (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - January 17, 2021 Category: Toxicology Source Type: research

Quantifying Bias in Epidemiologic Studies Evaluating the Association Between Acetaminophen Use and Cancer
Publication date: Available online 15 January 2021Source: Regulatory Toxicology and PharmacologyAuthor(s): Martijn J. Schuemie, Rachel Weinstein, Patrick B. Ryan, Jesse A. Berlin (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - January 16, 2021 Category: Toxicology Source Type: research

Compounded conservatism in European re-entry worker risk assessment of pesticides
Publication date: Available online 12 January 2021Source: Regulatory Toxicology and PharmacologyAuthor(s): Felix M. Kluxen, Edgars Felkers, Jenny Baumann, Neil Morgan, Christiane Wiemann, Franz Stauber, Christian Strupp, Sarah Adham, Christian J. Kuster (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - January 13, 2021 Category: Toxicology Source Type: research

Increasing Confidence in Waiving Dermal Toxicity Studies: A Comparison of Oral and Dermal Acute Data with Alternative Approaches for Agrochemicals and Products
Publication date: Available online 13 January 2021Source: Regulatory Toxicology and PharmacologyAuthor(s): Sophie van der Kamp, Claire Elliott (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - January 13, 2021 Category: Toxicology Source Type: research

Human Biomonitoring (HBM)-I values for perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) - description, derivation and discussion
Publication date: Available online 12 January 2021Source: Regulatory Toxicology and PharmacologyAuthor(s): Jürgen Hölzer, Hellmuth Lilienthal, Michael Schümann (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - January 12, 2021 Category: Toxicology Source Type: research