Psychiatry and Clinical Neurosciences This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Randomized, double ‐blind, placebo‐controlled 8‐week trial of the efficacy, safety, and tolerability of 5, 10, and 20 mg/day vortioxetine in adults with major depressive disorder
ConclusionWhile vortioxetine failed to meet significance versus placebo in the primary efficacy analysis, there was evidence of efficacy for the 10‐ and 20‐mg doses in secondary analyses. Vortioxetine was safe and well tolerated. Additional studies appear warranted. (Source: Psychiatry and Clinical Neurosciences)
Source: Psychiatry and Clinical Neurosciences - October 3, 2017 Category: Neuroscience Authors: Akira Nishimura, Yutaka Aritomi, Kiyofumi Sasai, Tadayuki Kitagawa, Atul R. Mahableshwarkar Tags: Regular Article Source Type: research

MEF2C mRNA expression and cognitive function in Japanese patients with Alzheimer's disease
ConclusionMEF2C mRNA expression in leukocytes may be a biological marker for cognitive decline in AD. (Source: Psychiatry and Clinical Neurosciences)
Source: Psychiatry and Clinical Neurosciences - October 1, 2017 Category: Neuroscience Authors: Tomoko Sao, Yuta Yoshino, Kiyohiro Yamazaki, Yuki Ozaki, Yoko Mori, Shinichiro Ochi, Taku Yoshida, Takaaki Mori, Jun ‐ichi Iga, Shu‐ichi Ueno Tags: Regular Article Source Type: research

Short ‐ and long‐term evaluation of cognitive functions after electroconvulsive therapy in a Japanese population
ConclusionIn a Japanese population, adverse effects of ECT on verbal fluency function‐related and other cognitive impairments were transient. Over the longer term, we detected significant improvements in the performance of tasks that presumably reflected information processing speed and executive functions. (Source: Psychiatry and Clinical Neurosciences)
Source: Psychiatry and Clinical Neurosciences - October 1, 2017 Category: Neuroscience Authors: Shunsuke Takagi, Takashi Takeuchi, Naoki Yamamoto, Munehisa Fujita, Ko Furuta, Hiroyo Ishikawa, Nobutaka Motohashi, Toru Nishikawa Tags: Regular Article Source Type: research

Genome ‐wide association studies of bipolar disorder: A systematic review of recent findings and their clinical implications
Abstract AimRecent advances in molecular genetics have enabled assessments of the associations among genetic variants (e.g., single‐nucleotide polymorphisms) and susceptibility for complex diseases, including psychiatric disorders. Specifically, genome‐wide association studies (GWAS), meta‐analyses of the GWAS summary statistics and mega‐analyses, which use raw data (not summary statistics) of GWASs, have provided revolutionary results and identified numerous susceptibility genes or single‐nucleotide polymorphisms. By using several tens of thousands of subjects, >40 genes have been identified as being associat...
Source: Psychiatry and Clinical Neurosciences - October 1, 2017 Category: Neuroscience Authors: Masashi Ikeda, Takeo Saito, Kenji Kondo, Nakao Iwata Tags: PCN Frontier Review Source Type: research

A survey on the attitude towards renaming bipolar disorder in Japanese
For the revision of the International Statistical Classification of Diseases and Related Health Problems (ICD)‐10 into the ICD‐11, the Liaison Committee of Psychiatric Disease Names of Japanese Society of Psychiatry and Neurology concluded that “disorder” should be translated differently from the ICD‐10. According to this decision, related Japanese societies have started discussion on how to translate each disease name. (Source: Psychiatry and Clinical Neurosciences)
Source: Psychiatry and Clinical Neurosciences - October 1, 2017 Category: Neuroscience Authors: Tadafumi Kato, Shigenobu Kanba Tags: Letter to the Editor Source Type: research