Progress in Retinal and Eye Research 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Recapitulating developmental mechanisms for retinal regeneration
Publication date: Available online 14 December 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Iqbal Ahmad, Pooja Teotia, Helen Erickson, Xiaohuan XiaAbstractDegeneration of specific retinal neurons in diseases like glaucoma, age-related macular degeneration, and retinitis pigmentosa is the leading cause of irreversible blindness. Currently, there is no therapy to modify the disease-associated degenerative changes. With the advancement in our knowledge about the mechanisms that regulate the development of the vertebrate retina, the approach to treat blinding diseases through regenerative medicine appears a near ...
Source: Progress in Retinal and Eye Research - December 14, 2019 Category: Opthalmology Source Type: research
Editorial Board
Publication date: November 2019Source: Progress in Retinal and Eye Research, Volume 73Author(s): (Source: Progress in Retinal and Eye Research)
Source: Progress in Retinal and Eye Research - December 3, 2019 Category: Opthalmology Source Type: research
Evolution of the genes mediating phototransduction in rod and cone photoreceptors
Publication date: Available online 29 November 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Trevor D. LambAbstractThis paper reviews current knowledge of the evolution of the multiple genes encoding proteins that mediate the process of phototransduction in rod and cone photoreceptors of vertebrates. The approach primarily involves molecular phylogenetic analysis of phototransduction protein sequences, combined with analysis of the syntenic arrangement of the genes. At least 35 of these phototransduction genes appear to reside on no more than five paralogons – paralogous regions that each arose from a common...
Source: Progress in Retinal and Eye Research - November 30, 2019 Category: Opthalmology Source Type: research
Contact lens-related corneal infection: Intrinsic resistance and its compromise
Publication date: Available online 20 November 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Suzanne M.J. Fleiszig, Abby R. Kroken, Vincent Nieto, Melinda R. Grosser, Stephanie J. Wan, Matteo M.E. Metruccio, David J. EvansAbstractContact lenses represent a widely utilized form of vision correction with more than 140 million wearers worldwide. Although generally well-tolerated, contact lenses can cause corneal infection (microbial keratitis), with an approximate annualized incidence ranging from ∼2 to ∼20 cases per 10,000 wearers, and sometimes resulting in permanent vision loss. Research suggests that the ...
Source: Progress in Retinal and Eye Research - November 20, 2019 Category: Opthalmology Source Type: research
Interactions of the choroid, Bruch's membrane, retinal pigment epithelium, and neurosensory retina collaborate to form the outer blood-retinal-barrier
Publication date: Available online 5 November 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Mark A. Fields, Lucian V. Del Priore, Ron A. Adelman, Lawrence J. RizzoloAbstractThe three interacting components of the outer blood-retinal barrier are the retinal pigment epithelium (RPE), choriocapillaris, and Bruch's membrane, the extracellular matrix that lies between them. Although previously reviewed independently, this review integrates these components into a more wholistic view of the barrier and discusses reconstitution models to explore the interactions among them. After updating our understanding of each co...
Source: Progress in Retinal and Eye Research - November 16, 2019 Category: Opthalmology Source Type: research
Interactions of the choroid, Bruch’s membrane, retinal pigment epithelium, and neurosensory retina collaborate to form the outer blood-retinal-barrier
Publication date: Available online 5 November 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Mark Fields, Lucian V. Del Priore, Ron A. Adelman, Lawrence J. RizzoloAbstractThe three interacting components of the outer blood-retinal barrier are the retinal pigment epithelium (RPE), choriocapillaris, and Bruch’s membrane, the extracellular matrix that lies between them. Although previously reviewed independently, this review integrates these components into a more wholistic view of the barrier and discusses reconstitution models to explore the interactions among them. After updating our understanding of each com...
Source: Progress in Retinal and Eye Research - November 6, 2019 Category: Opthalmology Source Type: research
Spatiotemporal changes in the human lens proteome: critical insights into long-lived proteins
Publication date: Available online 6 November 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Kevin L. Schey, Zhen Wang, Michael Friedrich, Donita L. Garland, Roger J.W. TruscottAbstractThe ocular lens is a unique tissue that contains an age gradient of cells and proteins ranging from newly differentiated cells containing newly synthesized proteins to cells and proteins that are as old as the organism. Thus, the ocular lens is an excellent model for studying long-lived proteins (LLPs) and the effects of aging and post-translational modifications on protein structure and function. Given the architecture of the le...
Source: Progress in Retinal and Eye Research - November 6, 2019 Category: Opthalmology Source Type: research
Beyond Intraocular Pressure: Optimizing Patient-Reported Outcomes In Glaucoma
Publication date: Available online 31 October 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Eva Fenwick, Ryan Man, Tin Aung, Pradeep Ramulu, Ecosse LamoureuxAbstractGlaucoma, an irreversible blinding condition affecting 3-4% adults aged above 40 years worldwide, is set to increase with a rapidly aging global population. Raised intraocular pressure (IOP) is a major risk factor for glaucoma where the treatment paradigm is focused on managing IOP using medications, laser, or surgery regimens. However, notwithstanding IOP and other clinical parameters, patient-reported outcomes, including daily functioning, emotio...
Source: Progress in Retinal and Eye Research - November 1, 2019 Category: Opthalmology Source Type: research
Uveal melanoma: towards a molecular understanding
Publication date: Available online 26 September 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Kyra N. Smit, Martine J. Jager, Annelies de Klein, Emine KiliҫAbstractUveal melanoma is an aggressive malignancy that originates from melanocytes in the eye. Even if the primary tumor has been successfully treated with radiation or surgery, up to half of all UM patients will eventually develop metastatic disease. Despite the common origin from neural crest-derived cells, uveal and cutaneous melanoma have few overlapping genetic signatures and uveal melanoma has been shown to have a lower mutational burden. As a conse...
Source: Progress in Retinal and Eye Research - September 28, 2019 Category: Opthalmology Source Type: research
Melatonin and the control of intraocular pressure
Publication date: Available online 25 September 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Hanan Awad Alkozi, Gemma Navarro, Rafael Franco, Jesus Pintor (Source: Progress in Retinal and Eye Research)
Source: Progress in Retinal and Eye Research - September 25, 2019 Category: Opthalmology Source Type: research
Inducible Rodent Models of Glaucoma
Publication date: Available online 23 September 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Iok-Hou Pang, Abbot F. ClarkAbstractGlaucoma is one of the leading causes of vision impairment worldwide. In order to further understand the molecular pathobiology of this disease and to develop better therapies, clinically relevant animal models are necessary. In recent years, both the rat and mouse have become popular models in glaucoma research. Key reasons are: many important biological similarities shared among rodent eyes and the human eye; development of improved methods to induce glaucoma and to evaluate glauc...
Source: Progress in Retinal and Eye Research - September 24, 2019 Category: Opthalmology Source Type: research
Membrane-associated mucins of the ocular surface: New genes, new protein functions and new biological roles in human and mouse
Publication date: Available online 4 September 2019Source: Progress in Retinal and Eye ResearchAuthor(s): M. Elizabeth Fini, Shinwu Jeong, Haiyan Gong, Rafael Martinez-Carrasco, Nora M.V. Laver, Minako Hijikata, Naoto Keicho, Pablo ArgüesoAbstractThe mucosal glycocalyx of the ocular surface constitutes the point of interaction between the tear film and the apical epithelial cells. Membrane-associated mucins (MAMs) are the defining molecules of the glycocalyx in all mucosal epithelia. Long recognized for their biophysical properties of hydration, lubrication, anti-adhesion and repulsion, MAMs maintain the wet ocular surfac...
Source: Progress in Retinal and Eye Research - September 19, 2019 Category: Opthalmology Source Type: research
Editorial Board
Publication date: September 2019Source: Progress in Retinal and Eye Research, Volume 72Author(s): (Source: Progress in Retinal and Eye Research)
Source: Progress in Retinal and Eye Research - September 11, 2019 Category: Opthalmology Source Type: research
Publisher's Note
Publication date: September 2019Source: Progress in Retinal and Eye Research, Volume 72Author(s): (Source: Progress in Retinal and Eye Research)
Source: Progress in Retinal and Eye Research - September 11, 2019 Category: Opthalmology Source Type: research
Optical coherence tomography diagnostic signs in posterior uveitis
Publication date: Available online 9 September 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Francesco Pichi, Alessandro Invernizzi, William R. Tucker, Marion R. MunkAbstractA diagnostic sign refers to a quantifiable biological parameter that is measured and evaluated as an indicator of normal biological, pathogenic, or pharmacologic responses to a therapeutic intervention. When used in translational research discussions, the term itself often alludes to a signs used to accelerate or aid in diagnosis or monitoring and provide insight into “personalized” medicine. Many new diagnostic signs are being develop...
Source: Progress in Retinal and Eye Research - September 10, 2019 Category: Opthalmology Source Type: research
