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Vitreous and vision degrading myodesopsia
Publication date: Available online 6 March 2020Source: Progress in Retinal and Eye ResearchAuthor(s): J. Sebag (Source: Progress in Retinal and Eye Research)
Source: Progress in Retinal and Eye Research - March 7, 2020 Category: Opthalmology Source Type: research

Cell types and cell circuits in human and non-human primate retina
Publication date: Available online 5 February 2020Source: Progress in Retinal and Eye ResearchAuthor(s): Ulrike Grünert, Paul R. Martin (Source: Progress in Retinal and Eye Research)
Source: Progress in Retinal and Eye Research - March 4, 2020 Category: Opthalmology Source Type: research

The Cell Biology of the Retinal Pigment Epithelium
Publication date: Available online 24 February 2020Source: Progress in Retinal and Eye ResearchAuthor(s): Aparna Lakkaraju, Ankita Umapathy, Li Xuan Tan, Lauren Daniele, Nancy J. Philp, Kathleen Boesze-Battaglia, David S. Williams (Source: Progress in Retinal and Eye Research)
Source: Progress in Retinal and Eye Research - February 25, 2020 Category: Opthalmology Source Type: research

No flow through the vitreous humor: how strong is the evidence?
Publication date: Available online 6 February 2020Source: Progress in Retinal and Eye ResearchAuthor(s): David W. Smith, Chang-Joon Lee, Bruce S. GardinerAbstractWhen analyzing vitreal drug delivery, or the pharmacological effects of drugs on intraocular pressure, or when interpreting outflow facility measurements, it is generally accepted that the fluid in the vitreous humor is stagnant. It is accepted that for all practical purposes, the aqueous fluid exits the eye via anterior pathways only, and so there is negligible if any posteriorly directed flow of aqueous through the vitreous humor. This assumption is largely base...
Source: Progress in Retinal and Eye Research - February 6, 2020 Category: Opthalmology Source Type: research

Cell types and cell circuits in primate retina
Publication date: Available online 5 February 2020Source: Progress in Retinal and Eye ResearchAuthor(s): Ulrike Grünert, Paul R. MartinAbstractThis review summarises our current knowledge of primate including human retina focusing on bipolar, amacrine and ganglion cells and their connectivity. We have two main motivations in writing. Firstly, recent progress in non-invasive imaging methods to study retinal diseases mean that better understanding of the primate retina is becoming an important goal both for basic and for clinical sciences. Secondly, genetically modified mice are increasingly used as animal models for human ...
Source: Progress in Retinal and Eye Research - February 5, 2020 Category: Opthalmology Source Type: research

Biochemical mechanisms of aggregation in TGFBI-linked corneal dystrophies
Publication date: Available online 29 January 2020Source: Progress in Retinal and Eye ResearchAuthor(s): Nadia Sukusu Nielsen, Ebbe Toftgaard Poulsen, Marie V. Lukassen, Connie Chao Shern, Emilie Hage Mogensen, Christian E. Weberskov, Larry DeDionisio, Leif Schauser, Tara C.B. Moore, Daniel E. Otzen, Jesper Hjortdal, Jan J. EnghildAbstractTransforming growth factor-β-induced protein (TGFBIp), an extracellular matrix protein, is the second most abundant protein in the corneal stroma. In this review, we summarize the current knowledge concerning the expression, molecular structure, binding partners, and functions of human T...
Source: Progress in Retinal and Eye Research - January 30, 2020 Category: Opthalmology Source Type: research

Advances in the diagnosis and treatment of dry eye
Publication date: Available online 29 January 2020Source: Progress in Retinal and Eye ResearchAuthor(s): Takashi Kojima, Murat Dogru, Motoko Kawashima, Shigeru Nakamura, Kazuo TsubotaAbstractThe core mechanism of dry eye is the tear film instability. Tear film-oriented diagnosis (TFOD) is a concept to clarify the cause of tear film instability by tear film, and tear film-oriented treatment (TFOT) is a concept to treat dry eye disease by replacing the lacking components of the tear film layer based on the TFOD. In TFOD, the fluorescein breakup pattern of the tear film is important, and the subtype of dry eye can be judged t...
Source: Progress in Retinal and Eye Research - January 30, 2020 Category: Opthalmology Source Type: research

Ocular blood flow as a clinical observation: value, limitations and data analysis
This article reviews the state of the art and major unanswered questions related to ocular vascular anatomy and physiology, ocular imaging techniques, clinical findings in glaucoma and other eye diseases, and mechanistic modeling predictions, while laying a path for integrating clinical observations with mathematical models and artificial intelligence. Viable alternatives for integrated data analysis are proposed that aim to overcome the limitations of standard statistical approaches and enable individually tailored precision medicine in ophthalmology. (Source: Progress in Retinal and Eye Research)
Source: Progress in Retinal and Eye Research - January 25, 2020 Category: Opthalmology Source Type: research

Editorial Board
Publication date: January 2020Source: Progress in Retinal and Eye Research, Volume 74Author(s): (Source: Progress in Retinal and Eye Research)
Source: Progress in Retinal and Eye Research - January 25, 2020 Category: Opthalmology Source Type: research

A neuroglia-based interpretation of glaucomatous neuroretinal rim thinning in the optic nerve head
Publication date: Available online 23 January 2020Source: Progress in Retinal and Eye ResearchAuthor(s): Eun Jung Lee, Jong Chul Han, Do Young Park, Changwon KeeAbstractNeuroretinal rim thinning (NRR) is a characteristic glaucomatous optic disc change. However, the precise mechanism of the rim thinning has not been completely elucidated. This review focuses on the structural role of the glioarchitecture in the formation of the glaucomatous NRR thinning. The NRR is a glia-framed structure, with honeycomb geometry and mechanically reinforced astrocyte processes along the transverse plane. When neural damage selectively invol...
Source: Progress in Retinal and Eye Research - January 24, 2020 Category: Opthalmology Source Type: research

Exploring choroidal angioarchitecture in health and disease using choroidal vascularity index
Publication date: Available online 10 January 2020Source: Progress in Retinal and Eye ResearchAuthor(s): Rupesh Agrawal, Jianbin Ding, Parveen Sen, Andres Rousselot, Amy Chan, Lisa Nivison-Smith, Xin Wei, Sarakshi Mahajan, Ramasamy Kim, Chitaranjan Mishra, Manisha Agarwal, Min Hee Suh, Saurabh Luthra, Marion R. Munk, Carol Y. Cheung, Vishali Gupta, CVI.gridAbstractThe choroid is one of the most vascularized structures of the human body and plays an irreplaceable role in nourishing photoreceptors. As such, choroidal dysfunction is implicated in a multitude of ocular diseases. Studying the choroid can lead to a better unders...
Source: Progress in Retinal and Eye Research - January 10, 2020 Category: Opthalmology Source Type: research

Interpretation of OCT and OCTA images from a histological approach: clinical and experimental implications.
Publication date: Available online 3 January 2020Source: Progress in Retinal and Eye ResearchAuthor(s): Nicolás Cuenca, Isabel Ortuño-Lizarán, Xavier Sánchez-Sáez, Oksana Kutsyr, Henar Albertos-Arranz, Laura Fernández-Sánchez, Natalia Martínez-Gil, Agustina Noailles, José Antonio López-Garrido, Maribel López-Gálvez, Pedro Lax, Victoria Maneu, Isabel PinillaAbstract:Optical coherence tomography (OCT) and OCT angiography (OCTA) have been a technological breakthrough in the diagnosis, treatment, and follow-up of many retinal diseases, thanks to its resolution and its ability to inform of the retinal state in secon...
Source: Progress in Retinal and Eye Research - January 4, 2020 Category: Opthalmology Source Type: research

Age-related macular degeneration: A two-level model hypothesis
Publication date: Available online 30 December 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Maarten P. Rozing, Jon A. Durhuus, Marie Krogh Nielsen, Yousif Subhi, Thomas BL. Kirkwood, Rudi GJ. Westendorp, Torben Lykke SørensenAbstractAge-related diseases, including age-related macular degeneration (AMD), are of growing importance in a world where population ageing has become a dominant global trend. Although a wide variety of risk factors for AMD have been identified, age itself remains by far the most important risk factor, making it an urgent priority to understand the connections between underlying ageing ...
Source: Progress in Retinal and Eye Research - December 31, 2019 Category: Opthalmology Source Type: research

Progress in treating inherited retinal diseases: Early subretinal gene therapy clinical trials and candidates for future initiatives
Publication date: Available online 30 December 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Alexandra V. Garafalo, Artur V. Cideciyan, Elise Heon, Rebecca Sheplock, Alexander Pearson, Caberry WeiYang Yu, Alexander Sumaroka, Gustavo D. Aguirre, Samuel G. JacobsonAbstractDue to improved phenotyping and genetic characterization, the field of ‘incurable’ and ‘blinding’ inherited retinal diseases (IRDs) has moved substantially forward. Decades of ascertainment of IRD patient data from Philadelphia and Toronto centers illustrate the progress from Mendelian genetic types to molecular diagnoses. Molecular gen...
Source: Progress in Retinal and Eye Research - December 30, 2019 Category: Opthalmology Source Type: research

Mystery Eye: Human Adenovirus and the Enigma of Epidemic Keratoconjunctivitis
Publication date: Available online 28 December 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Rahul A. Jonas, Lawson Ung, Jaya Rajaiya, James ChodoshAbstractKnown to occur in widespread outbreaks, epidemic keratoconjunctivitis (EKC) is a severe ocular surface infection with a strong historical association with human adenovirus (HAdV). While the conjunctival manifestations can vary from mild follicular conjunctivitis to hyper-acute, exudative conjunctivitis with formation of conjunctival membranes, EKC is distinct as the only form of adenovirus conjunctivitis in which the cornea is also involved, likely due to s...
Source: Progress in Retinal and Eye Research - December 30, 2019 Category: Opthalmology Source Type: research