Progress in Biophysics and Molecular Biology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Editorial Board
Publication date: January 2019Source: Progress in Biophysics and Molecular Biology, Volume 141Author(s): (Source: Progress in Biophysics and Molecular Biology)
Source: Progress in Biophysics and Molecular Biology - March 21, 2019 Category: Molecular Biology Source Type: research
Editorial
Publication date: January 2019Source: Progress in Biophysics and Molecular Biology, Volume 141Author(s): Denis Noble, Tom L. Blundell, Peter Kohl (Source: Progress in Biophysics and Molecular Biology)
Source: Progress in Biophysics and Molecular Biology - March 21, 2019 Category: Molecular Biology Source Type: research
Biological effects of non-ionizing electromagnetic fields: Two sides of a coin
Publication date: January 2019Source: Progress in Biophysics and Molecular Biology, Volume 141Author(s): Timur Saliev, Dinara Begimbetova, Abdul-Razak Masoud, Bakhyt MatkarimovAbstractControversial, sensational and often contradictory scientific reports have triggered active debates over the biological effects of electromagnetic fields (EMFs) in literature and mass media the last few decades. This could lead to confusion and distraction, subsequently hampering the development of a univocal conclusion on the real hazards caused by EMFs on humans. For example, there are lots of publications indicating that EMF can induce apo...
Source: Progress in Biophysics and Molecular Biology - March 21, 2019 Category: Molecular Biology Source Type: research
Cancer mutational burden is shaped by G4 DNA, replication stress and mitochondrial dysfunction
Publication date: Available online 14 March 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Albino Bacolla, Zu Ye, Zamal Ahmed, John A. TainerABSTRACTA hallmark of cancer is genomic instability, which can enable cancer cells to evade therapeutic strategies. Here we employed a computational approach to uncover mechanisms underlying cancer mutational burden by focusing upon relationships between 1) translocation breakpoints and the thousands of G4 DNA-forming sequences within retrotransposons impacting transcription and exemplifying probable non-B DNA structures and 2) transcriptome profiling and cancer mu...
Source: Progress in Biophysics and Molecular Biology - March 15, 2019 Category: Molecular Biology Source Type: research
Modulation of protein oligomerization: An overview
Publication date: Available online 11 March 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Neha Kumari, Savita YadavAbstractA large section of cellular proteins in both prokaryotic and eukaryotic systems have oligomeric property. Intently, oligomerization of protein is an invaluable phenomenon from the point of view of protein evolution. This review comprises an overview on modulation of protein oligomerization. The comprehensive modulation of protein oligomerization can be supportive for effective drug designing in future. Most common mechanisms of protein oligomerization are domain swapping and ligand...
Source: Progress in Biophysics and Molecular Biology - March 13, 2019 Category: Molecular Biology Source Type: research
Multimodal on-axis platform for all-optical electrophysiology with near-infrared probes in human stem-cell-derived cardiomyocytes
We report a new “on-axis” configuration (combined single optical path for stimulation and for multiparameter imaging) of OptoDyCE, our all-optical platform for studying human induced pluripotent stem-cell-derived cardiomyocytes (hiPSC-CMs) and other cell types, optically driven by Channelrhodopsin2 (ChR2). This solid-state system integrates optogenetic stimulation with temporally-multiplexed simultaneous recording of membrane voltage (Vm) and intracellular calcium ([Ca2+]i) dynamics using a single photodetector. We demonstrate the capacity for combining multiple spectrally-compatible actuators and sensors, including ne...
Source: Progress in Biophysics and Molecular Biology - March 6, 2019 Category: Molecular Biology Source Type: research
Plugged into the Ku-DNA hub: The NHEJ network
Publication date: Available online 6 March 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Philippe Frit, Virginie Ropars, Mauro Modesti, Jean-Baptiste Charbonnier, Patrick CalsouAbstractIn vertebrates, double-strand breaks in DNA are primarily repaired by Non-Homologous End-Joining (NHEJ). The ring-shaped Ku heterodimer rapidly senses and threads onto broken DNA ends forming a recruiting hub. Through protein-protein contacts eventually reinforced by protein-DNA interactions, the Ku-DNA hub attracts a series of specialized proteins with scaffolding and/or enzymatic properties. To shed light on these dyna...
Source: Progress in Biophysics and Molecular Biology - March 6, 2019 Category: Molecular Biology Source Type: research
An integrated approach towards sustainable wastewater treatment and biofuel production: A phytotechnological study on defatted residual seed biomass of Datura stramonium L
Publication date: Available online 1 March 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Fatih DenizAbstractWater pollution and diminishing fossil based fuel reserves with their deleterious exhaust gases are worldwide major environmental and economic problems. Datura stramonium L. species greatly grows wild in the most parts of temperate regions of the world. The biodiesel production from the seed oil of D. stramonium L. have been reported in literature. However, no study has been found regarding the use of defatted residual seed biomass of D. stramonium L. for the wastewater treatment. An integrated a...
Source: Progress in Biophysics and Molecular Biology - March 4, 2019 Category: Molecular Biology Source Type: research
Plants as electromic plastic interfaces: A mesological approach
Publication date: Available online 28 February 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Marc-Williams Debono, Gustavo Maia SouzaAbstractIn this manuscript we propose the working hypothesis of plants as eco-plastic and electromic interfaces able to drive emergent intelligent behaviors from synchronized electrical networks. Behind the semantic and anthropocentric problems related by many authors to the extensive use of the terms cognition, intelligence or even ‘consciousness’ for plants, we preconize a more pragmatic point of view considering the vegetal world as a complex biosystemic entity abl...
Source: Progress in Biophysics and Molecular Biology - March 1, 2019 Category: Molecular Biology Source Type: research
The influence of hERG1a and hERG1b isoforms on drug safety screening in iPSC-CMs
In this study we show that the activation kinetics in iPSC-CMs resemble hERG1b kinetics using Cs+ as a charge carrier. Not including hERG1b in drug safety testing might underestimate the actual role of hERG1b in repolarization and drug response, and might lead to inappropriate conclusions. We stress to focus more on including hERG1b in drug safety testing concerning IKr. (Source: Progress in Biophysics and Molecular Biology)
Source: Progress in Biophysics and Molecular Biology - February 28, 2019 Category: Molecular Biology Source Type: research
Targeting the CINful genome: Strategies to overcome tumor heterogeneity
Publication date: Available online 25 February 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Chelsea E. Cunningham, Mackenzie J. MacAuley, Garima Yadav, Frederick S. Vizeacoumar, Andrew Freywald, Franco J. VizeacoumarAbstractGenomic instability, and more specifically chromosomal instability (CIN), arises from a number of processes that are defective in cancer, such as aberrant mitotic cell division, replication stress, defective DNA damage repair, and ineffective telomere maintenance. CIN is an emerging hallmark of cancer that contributes to tumor heterogeneity through increased rates of genetic altera...
Source: Progress in Biophysics and Molecular Biology - February 25, 2019 Category: Molecular Biology Source Type: research
Integrative meta-analysis of transcriptomic responses to abiotic stress in cotton
In this study, an integrative meta-analysis and a system-biology analysis were performed to explore the underlying transcriptomic mechanisms that are critical for response to stresses. From the meta-analysis, it was observed that a total of 1465 differentially expressed genes (DEGs) between normal and stress conditions. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis revealed that DEGs were significantly enriched in the ubiquitin-dependent process, biosynthesis of secondary metabolites, plant hormone, and signaled transduction. The results also indicated that some of DEGs w...
Source: Progress in Biophysics and Molecular Biology - February 23, 2019 Category: Molecular Biology Source Type: research
Symmetry breaking and functional incompleteness in biological systems
Publication date: Available online 15 February 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Andrej Korenić, Slobodan Perović, Milan M. Ćirković, Paul-Antoine MiquelAbstractSymmetry-based explanations using symmetry breaking (SB) as the key explanatory tool have complemented and replaced traditional causal explanations in various domains of physics. The process of spontaneous SB is now a mainstay of contemporary explanatory accounts of large chunks of condensed-matter physics, quantum field theory, nonlinear dynamics, cosmology, and other disciplines. A wide range of empirical research into various...
Source: Progress in Biophysics and Molecular Biology - February 16, 2019 Category: Molecular Biology Source Type: research
A combinatorial bioinnovative approach integrating synthetic dye bioremediation and bioenergy production using waste pepper seed biomass
Publication date: Available online 21 January 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Fatih DenizAbstractA combinatorial study integrating synthetic dye bioremediation and biodiesel production using discarded pepper seed biomass was performed for a cleaner and more sustainable environment/energy in the present work. The vegetal oil was extracted from the pepper seed biomass and the defatted residual biomass was mainly investigated as a sustainable green generation alternative biosorbent source for the treatment of colored aqueous effluents. To test the wastewater cleaning ability of biosorbent, b...
Source: Progress in Biophysics and Molecular Biology - January 22, 2019 Category: Molecular Biology Source Type: research
Bioremediation potential of waste biomaterials originating from coastal Zostera marina L. meadows for polluted aqueous media with industrial effluents
Publication date: Available online 5 January 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Fatih DenizAbstractThe studies on novel and efficient biosorbent materials for the promotion of environmental and economic sustainability have been become an up-to-date attempt by scientists for the removal of synthetic dyes from industrial effluents. The biosorbents prepared from biomass based resources are emerging as an alternative promising material for the environmental clean-up because of their low-cost, renewability, eco-friendly, easy availability and so forth characteristics. Hence, for the first time, t...
Source: Progress in Biophysics and Molecular Biology - January 5, 2019 Category: Molecular Biology Source Type: research
