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The N-Space Episenome Unifies Cellular Information Space-Time within Cognition-Based Evolution
Publication date: Available online 12 August 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): William B. Miller, John S. Torday, František BaluškaAbstractSelf-referential cellular homeostasis is maintained by the measured assessment of both internal status and external conditions based within an integrated cellular information field. This cellular field attachment to biologic information space-time coordinates environmental inputs by connecting the cellular senome, as the sum of the sensory experiences of the cell, with its genome and epigenome. In multicellular organisms, individual cellular informatio...
Source: Progress in Biophysics and Molecular Biology - August 13, 2019 Category: Molecular Biology Source Type: research

PBMB Editorial
Publication date: Available online 6 August 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Denis Noble, Tom Blundell, Peter Kohl (Source: Progress in Biophysics and Molecular Biology)
Source: Progress in Biophysics and Molecular Biology - August 11, 2019 Category: Molecular Biology Source Type: research

Editorial
Publication date: Available online 6 August 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Denis Noble, Tom Blundell, Peter Kohl (Source: Progress in Biophysics and Molecular Biology)
Source: Progress in Biophysics and Molecular Biology - August 7, 2019 Category: Molecular Biology Source Type: research

Comment on “Polygenic Scores: a public health hazard?”
Publication date: Available online 6 August 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Michael J. Joyner (Source: Progress in Biophysics and Molecular Biology)
Source: Progress in Biophysics and Molecular Biology - August 7, 2019 Category: Molecular Biology Source Type: research

Polygenic Scores: a public health hazard?
Publication date: Available online 6 August 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Keith Baverstock (Source: Progress in Biophysics and Molecular Biology)
Source: Progress in Biophysics and Molecular Biology - August 7, 2019 Category: Molecular Biology Source Type: research

From epithelial remodelling to carcinogenesis
Publication date: Available online 2 August 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Leszek Satora, Jennifer Mytych, Anna Bilska-Kos, Katarzyna KoziołAbstractThe novel cancer theory named ‘The tissue organization field theory’ (TOFT) suggests that carcinogenesis is a process analogous to embryonic development, whereby organs are formed through interactions among different cell types. The suggested ‘morphological remodelling’ of the epithelium under hypoxia in gut breathing fish (GBF) has many common features with carcinogenesis. It appears that research into the relationship among epiderm...
Source: Progress in Biophysics and Molecular Biology - August 3, 2019 Category: Molecular Biology Source Type: research

Towards a clearer view of sympathetic innervation of cardiac and skeletal muscles
Publication date: Available online 20 July 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Anna Di Bona, Veronica Vita, Irene Costantini, Tania ZagliaAbstractIt is well appreciated that autonomic neurons have a central role in the homeostatic regulation of organs and systems and participate to the pathogenesis of several disease conditions. As such, the function and signalling pathways activated by sympathetic neurons (SNs) in different cell types and organs have become a matter of intense investigation throughout the years of modern biomedical research. This review is focused on the methods used to addr...
Source: Progress in Biophysics and Molecular Biology - July 21, 2019 Category: Molecular Biology Source Type: research

AI- modelling of molecular identification and feminization of wolbachia infected Aedes aegypti
ConclusionsFrom our analysis, we have concluded that the genetic control strategy is a promising technique and the role of Wolbachia infected male mosquitos, in genetic control strategies, can be better interpreted in an inexpensive manner with the aid of a theoretical model. (Source: Progress in Biophysics and Molecular Biology)
Source: Progress in Biophysics and Molecular Biology - July 12, 2019 Category: Molecular Biology Source Type: research

Modeling the action of environment on proton tunneling in the adenine–thymine base pair
Publication date: Available online 9 July 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Ashkan Shekaari, Mahmoud JafariAbstractEffect of environment coupling on the quantum-biological phenomenon of proton tunneling in the hydrogen bonds of the adenine–thymine base pair in DNA was modeled within the framework of quantum statistics and perturbation theory. A number of important thermodynamic indicators including partition function, free energy, and entropy were then calculated and examined. The proton was then assumed to be subject to an attraction represented by a double-well potential energy surface ...
Source: Progress in Biophysics and Molecular Biology - July 10, 2019 Category: Molecular Biology Source Type: research

Systems plant physiology: An integrated view of plants life
Publication date: Available online 28 June 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Gustavo M. Souza, Tony Trewavas, Danilo de Menezes Daloso (Source: Progress in Biophysics and Molecular Biology)
Source: Progress in Biophysics and Molecular Biology - June 30, 2019 Category: Molecular Biology Source Type: research

Studying β1 and β2 adrenergic receptor signals in cardiac cells using FRET-based sensors
Publication date: Available online 29 June 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Francesca Grisan, Alex Burdyga, Liliana F. Iannucci, Nicoletta C. Surdo, Tullio Pozzan, Giulietta Di Benedetto, Konstantinos LefkimmiatisAbstractCyclic 3′-5′ adenosine monophosphate (cAMP) is a key modulator of cardiac function. Thanks to the sophisticated organization of its pathway in distinct functional units called microdomains, cAMP is involved in the regulation of both inotropy and chronotropy as well as transcription and cardiac death. While visualization of cAMP microdomains can be achieved thanks to cA...
Source: Progress in Biophysics and Molecular Biology - June 30, 2019 Category: Molecular Biology Source Type: research

Editorial Board
Publication date: August 2019Source: Progress in Biophysics and Molecular Biology, Volume 145Author(s): (Source: Progress in Biophysics and Molecular Biology)
Source: Progress in Biophysics and Molecular Biology - June 30, 2019 Category: Molecular Biology Source Type: research

“Systems Plant Physiology: an integrated view of plants life”
Publication date: Available online 28 June 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Gustavo M. Souza, Tony Trewavas, Danilo de Menezes Daloso (Source: Progress in Biophysics and Molecular Biology)
Source: Progress in Biophysics and Molecular Biology - June 30, 2019 Category: Molecular Biology Source Type: research

Structural insights into the critical DNA damage sensors DNA-PKcs, ATM and ATR
Publication date: Available online 27 June 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Domagoj Baretic, Taiana Maia de Oliveira, Martina Niess, Paul Wan, Hannah Pollard, Christopher M. Johnson, Caroline Truman, Eileen McCall, David Fisher, Roger Williams, Christopher PhillipsAbstractATM, ATR and DNA-PKCs are key effectors of DNA Damage response and have been extensively linked to tumourigenesis and survival of cancer cells after radio/chemotherapy. Despite numerous efforts, the structures of these proteins remained elusive until very recently. The resolution revolution in Cryo-EM allowed for molecula...
Source: Progress in Biophysics and Molecular Biology - June 28, 2019 Category: Molecular Biology Source Type: research

From non-excitable single-cell to multicellular bioelectrical states supported by ion channels and gap junction proteins: Electrical potentials as distributed controllers
Publication date: Available online 27 June 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Javier Cervera, Vaibhav P. Pai, Michael Levin, Salvador MafeAbstractEndogenous bioelectric patterns within tissues are an important driver of morphogenesis and a tractable component of a number of disease states. Developing system-level understanding of the dynamics by which non-neural bioelectric circuits regulate complex downstream cascades is a key step towards both, an evolutionary understanding of ion channel genes, and novel strategies in regenerative medicine. An important capability gap is deriving rational...
Source: Progress in Biophysics and Molecular Biology - June 27, 2019 Category: Molecular Biology Source Type: research