Two new indole alkaloids from Tabernaemontana contorta Stapf
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Gertrude Laura Foudjo Melacheu, Emmanuel Mfotie Njoya, Jean-Bosco Jouda, Brussine Nadege Wakeu Kweka, Céline Djama Mbazoa, Fei Wang, Jean WandjiAbstractTwo new indole alkaloid derivatives, 5,6-dioxo-11-methoxy voacangine (1) and (-)-apparicin-21-one (2), together with four known compounds, voacangine (3), ursolic acid (4), 3-methoxyursolic acid (5) and asiatic acid (6) were isolated from the fruits of Tabernaemontana contorta Stapf (Apocynaceae). Their structures were determined using 1D and 2D NMR and HRESI-MS measurements. The new indo...
Source: Phytochemistry Letters - February 8, 2019 Category: Chemistry Source Type: research

The chemical constituents of Penianthus longifolius Miers
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Georges Bellier Tabekoueng, Carine Mvot Akak, Moses K. Langat, Anatole Guy Blaise Azebaze, Alain Francois Kamdem Waffo, Dulcie A. Mulholland, Juliette Catherine VardamidesAbstractFourteen compounds were isolated from the roots, leaves and twigs of Penianthus longifolius Miers (Menispermaceae), including two previously unreported neo-clerodane diterpenoids, penianthin (1), its C-8 epimer (2). In addition, the previously reported O-methylmoschatoline (3), taraxerol (4), taraxerone (5), rubrosterone, (6), panuosterone (7), 22-epi-20-hydroxyecdyson...
Source: Phytochemistry Letters - February 7, 2019 Category: Chemistry Source Type: research

Allelochemicals and esters from leaves and inflorescences of Sambucus nigra L
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Josep Basas-Jaumandreu, F. Xavier C. de las HerasAbstractAllelochemical compounds were detected in leaves and inflorescences of Sambucus nigra L. by means of GC-EIMS. The identified compounds were characterized by their mass spectra and relative retention times as their trimethylsilyl derivatives. The pheromone L-isoleucine methyl ester extracted from inflorescences can attract pollinator insects during the flowering period and together with uncommon n-alkyl and benzyl esters were firstly identified in S. nigra. On the other hand, mandelonitril...
Source: Phytochemistry Letters - February 7, 2019 Category: Chemistry Source Type: research

Diphenethylpiperidine alkaloids with tracheal smooth muscle relaxation activity from Hippobroma longiflora (L.) G. Don
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Zi-Yang Chan, Kayatri Govindaraju, Premanand Krishnan, Yun-Yee Low, Kam-Weng Chong, Kien-Thai Yong, Kang-Nee Ting, Kuan-Hon LimAbstractPhytochemical investigations on the whole plant of Hippobroma longiflora (L.) G. Don have resulted in the isolation and elucidation of three new diphenethylpiperidine alkaloids, hippofoline A (1), hippofoline B (2), and (−)-cis-2′,2′′-diphenyllobelidiol N-oxide (5), alongside two known alkaloids, (−)-lobeline (3) and (−)-cis-2′,2′′-diphenyllobelidiol (4). The...
Source: Phytochemistry Letters - February 6, 2019 Category: Chemistry Source Type: research

4-Alkylcoumarins and a phloroglucinol from the stem bark of Calophyllum gracilentum
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Chan Kiang Lim, Yenn Pinn Ham, Li Qing Lim, Vivien Yi Mian JongAbstractThree new 4-alkylcoumarins, gracilenins A–C (1-3) and a new phloroglucinol, gracilenol (4), along with two known compounds, euxanthone and friedelin were isolated from the stem bark of Calophyllum gracilentum. Their structures were established on the basis of 1D and 2D NMR spectroscopic data and HRESIMS analysis. This is the first report of 4-(butan-2-yl)coumarin derivatives in this genus.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - February 6, 2019 Category: Chemistry Source Type: research

Cytotoxic Triterpenoids from the Bark of Chisocheton patens Blume (Meliaceae)
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Unang Supratman, Wiro Naibaho, Supriatno Salam, Rani Maharani, Ace Tatang Hidayat, Desi Harneti, Nurlelasari, Yoshihito ShionoAbstractFour new triterpenoids, namely, chisopaten A-D (1-4), were isolated from the n-hexane extract of the bark of Chisocheton patens Blume. The chemical structures of new compounds were elucidated on the basis of spectroscopic data interpretation. All isolated compounds were evaluated for their cytotoxic activity against MCF-7 breast cancer lines. Chisopaten A and C, showed strongest cytotoxicity activity with IC50 va...
Source: Phytochemistry Letters - February 4, 2019 Category: Chemistry Source Type: research

Macrochaetosides A and B, new rare sesquiterpene glycosides from Echinops macrochaetus and their cytotoxic activity
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Taghreed A. Zamzami, Hossam M. Abdallah, Ibrahim A. Shehata, Gamal A. Mohamed, Mohammad Y. Alfaifi, Serag Eldin I. Elbehairi, Abdulrahman E. Koshak, Sabrin R.M. IbrahimAbstractTwo new rare sesquiterpene glycosides, macrochaetosides A (3) and B (4), together with two known metabolites: stigmasterol (1) and cyclostenol (2) were separated from the CHCl3 fraction of the aerial parts of Echinops macrochaetus Boiss. (Asteraceae). Their chemical structures were established based on various spectroscopic methods in addition to mass spectrometry and com...
Source: Phytochemistry Letters - February 4, 2019 Category: Chemistry Source Type: research

Bacterial biofilm inhibitor diterpenes from Dictyota pinnatifida collected from the Colombian Caribbean
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): P. Rubiano-Buitrago, F. Duque, M. Puyana, F.A. Ramos, L. CastellanosAbstractFour new diterpenes, 6-epipachydictyol A (1), 6-epidictyol C (2), dictyol L (3), 18-acetoxy-xenianol (4) and the known diterpene dictyoxepin (5) were isolated from the Caribbean alga Dictyota pinnatifida. The structures were deduced by NMR, MS, optical rotation and 3D modeling. Dictyota pinnatifida is a producer of diterpenes with chemotaxonomic significance of group I (prenylated germacrene and derivatives) and III (Xeniane and derivatives), this chemotaxonomic analysi...
Source: Phytochemistry Letters - February 2, 2019 Category: Chemistry Source Type: research

GC-MS analysis of steroids and triterpenoids occurring in leaves and tubers of Tamus edulis Lowe
Publication date: Available online 22 January 2019Source: Phytochemistry LettersAuthor(s): Agata Rogowska, Michał Styczyński, Cezary Pączkowski, Anna Szakiel, Miguel Ângelo A. Pinheiro de CarvalhoAbstractTamus edulis Lowe is an endemic perennial plant belonging to Dioscoreaceae family. The plant has long climbing stems, ovate leaves, flowers in spikes, fleshy red berries and long tuberous roots. Young shoots and tuberous roots of T. edulis were used traditionally for nourishment and as a herbal medicine. Leaves and roots analyzed in the present study were collected in the northwest of Madeira island. The GC–...
Source: Phytochemistry Letters - January 23, 2019 Category: Chemistry Source Type: research

Inside Front Cover (Editorial Board)
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - January 23, 2019 Category: Chemistry Source Type: research

Contents (graphical abstracts and research highlights)
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - January 23, 2019 Category: Chemistry Source Type: research

Announcements of the Phytochemical Society of Europe
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - January 23, 2019 Category: Chemistry Source Type: research

Mosquito larvicidal limonoids from the fruits of Chisocheton erythrocarpus Hiern
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Soon-Lim Chong, Arshia Hematpoor, Hazrina Hazni, Mohd Sofian-Azirun, Marc Litaudon, Unang Supratman, Michio Murata, Khalijah AwangAbstractA phytochemical investigation on the fruits of Chisocheton erythrocarpus Hiern (Meliaceae) afforded four new limonoids, erythrocarpines F–H (1–3) and 14-deoxy-Δ1415-xyloccensin K (4), along with seven known compounds (5-11). Erythrocarpines 1–3 are phragmalin-type limonoids with an 1,29-oxymethylene bridge, while 4 is a mexicanolide-type limonoid possessing a rare 3β,8β-ether...
Source: Phytochemistry Letters - January 21, 2019 Category: Chemistry Source Type: research

α-Furanones, secondary metabolites from the fungus Cephalotrichum microsporum and their antibacterial activities
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Yue An, He Zhu, Sa Deng, Shanshan Huang, Mengyue Zhang, Dawei Li, Chao Wang, Yingying Wu, Xiaochi Ma, Yixuan ZhangAbstractCephalotrichum microsporum is a fungus isolated from the rhizosphere soil of Panax notoginseng. Four secondary metabolites (three new and one known α-furanones) of this fungus cultivated on a sterilized moistened-rice medium were isolated using an EtOAc extract. The structures of these compounds were determined by extensive spectroscopic data analysis using 1D- and 2D-NMR, ECD, and HRESIMS. In the antibacterial bioassa...
Source: Phytochemistry Letters - January 20, 2019 Category: Chemistry Source Type: research

Structural modification, fungicidal and insecticidal activity of 5-arylbenzofuran neolignan from Magnolia officinalis
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Ding Lin, Zhongzhong Yan, Yangjie Yi, Kangming Li, Jiao Ye, Aixi Hu, Chuyun Long, Aiping LiuAbstractAs shown in a number of previous researches, the extracts of Magnolia officinalis exhibited broad-spectrum fungicidal and insecticidal activity. In our preliminary study, 5-arylbenzofuran neolignans, the secondary metabolite of Magnolia officinalis, was found to inherit the activity of Magnolia officinalis. For developing novel agrochemicals, natural 5-arylbenzofuran neolignan was selected as lead compound. After structural optimization, the fung...
Source: Phytochemistry Letters - January 20, 2019 Category: Chemistry Source Type: research

Selective 1D-TOCSY and chemometrics to evaluate authenticity of Turnera diffusa and related botanical extracts
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): J. Ricardo Lucio-Gutiérrez, Cecilia Delgado-Montemayor, Jordi Coello-Bonilla, Noemí Waksman-Minsky, Alma L. SaucedoAbstractNuclear magnetic resonance (NMR) spectroscopy has emerged as a powerful tool for the development of new analytical methods in metabolomics and metabolic profiling of a plethora of biological samples, including natural products. NMR-based metabolomics enables characterisation of metabolites and biomarkers in plant extracts. Selective 1D- Total Correlation Spectroscopy TOCSY (1D-TOCSY) has been used in metabolom...
Source: Phytochemistry Letters - January 20, 2019 Category: Chemistry Source Type: research

Comparison of steroids and triterpenoids in leaf cuticular waxes of selected Polish and Russian cultivars and genotypes of edible honeysuckle
Publication date: Available online 18 January 2019Source: Phytochemistry LettersAuthor(s): Rafał Becker, Soyol Dashbaldan, Cezary Pączkowski, Tomasz Golis, Anna SzakielAbstractLonicera caerulea, known as edible honeysuckle, honeyberry, blue honeysuckle, sweet berry honeysuckle, or haskap, is a perennial fruit-bearing plant belonging to the Caprifoliaceae family. Currently, the cultivation of this plant species is becoming increasingly popular due to its early fruit ripening, exceptional resistance to frost, pests, and diseases, as well as its potential health-promoting and therapeutic properties. GC–MS analysis of ...
Source: Phytochemistry Letters - January 19, 2019 Category: Chemistry Source Type: research

Thymol derivatives from the roots of Xerolekia speciosissima an endemic species of the pre-Alpine area
Publication date: Available online 16 January 2019Source: Phytochemistry LettersAuthor(s): Natalia Kłeczek, Janusz Malarz, Maja Kosecka-Strojek, Bogdan Musielak, Anna StojakowskaAbstractA chloroform extract from roots of Xerolekia speciosissima, except for commonly distributed phenolic compounds, i.e.: syringaldehyde and 2,6-dimethoxy-p-benzoquinone, yielded five thymol derivatives. Two of the compounds, namely: 8-hydroxy-9-isobutyryloxy-10-isovaleryloxythymol (1) and 8-hydroxy-9,10-diisovaleryloxythymol (2) have not been previously reported and their structures were elucidated based on 1D and 2D NMR, HRESIMS and other sp...
Source: Phytochemistry Letters - January 17, 2019 Category: Chemistry Source Type: research

Phytochemical analysis of Brasolia, Elleanthus, and Sobralia. Three genera of orchids with antibacterial potential against Staphylococcus aureus
Publication date: Available online 17 January 2019Source: Phytochemistry LettersAuthor(s): Max Rykaczewski, Mirosława Krauze-Baranowska, Jerzy Żuchowski, Marta Krychowiak-Maśnicka, Jakub Fikowicz-Krośko, Aleksandra KrólickaAbstractThe purpose of the study was to determine the chemical composition of extracts from three species of orchids: Brasolia cattleya, Elleanthus oliganthus and Sobralia powellii, all belonging to the Sobralieae tribe, evaluate their antistaphylococcal activity and assess possible toxicity towards eukaryotic cells on the model organism Caenorhabditis elegans. The chemical composition of the ...
Source: Phytochemistry Letters - January 17, 2019 Category: Chemistry Source Type: research

Structures and biological activities of new carnosic acid- and carnosol-related compounds generated by heat treatment of rosemary
We examined their antioxidant activities and found that 2 and 3 showed strong activity. Furthermore, in PPARγ−transactivation and adipocyte-differentiation assays, compounds 3 and 5 showed more potent PPARγ agonistic activity than CA.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - January 17, 2019 Category: Chemistry Source Type: research

New bicyclic [3.2.1] octane neolignans derivatives from Aniba firmula with potent in vivo anti-inflammatory activity on account of dual inhibition of PGE2 production and cell recruitment
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Mario F.C. Santos, Bianca G.V. Alcântara, Cristiane dos R. Feliciano, Aline F. Silva, Tatiane C.S. Maiolini, Albert K. Neto, Michael Murgu, Daniela A. Chagas de Paula, Marisi G. SoaresAbstractTwo new bicyclic octane neolignans, 1, 2, and the known bicyclic octane neolignan 3 were obtained by HPLC fractionation of the crude extract of aerial parts and the stem of Aniba firmula (Lauraceae’s family). The identification of its structures was made by spectroscopic analysis. The Lauraceae is well-known for its anti-inflammatory potential ...
Source: Phytochemistry Letters - January 17, 2019 Category: Chemistry Source Type: research

Three new limonene-derived bis-monoterpenoids from the aerial parts of Illigera cordata
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Min Zhou, Miao Dong, Xiao-Li Zeng, Xiang-Zhong HuangAbstractFrom the aerial parts of Illigera cordata, cordatins A–C (1–3), three limonene-derived bis-monoterpenoids plausibly biosynthesized via hetero-Diels-Alder cyclization and further sequential hydrolyses of monoterpene precursors, together with one known analogue (4), were isolated. The structures, including absolute configurations, were established by spectroscopic analysis and confirmed by X-ray crystallographic analysis of 5 (the common hydrolytic product of 1–4). All ...
Source: Phytochemistry Letters - January 17, 2019 Category: Chemistry Source Type: research

A new chlorinated diphenyl ether and a new sesquilignan from the stems of Mappianthus tomentosus
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Shan-Shan Zhu, Gui-Jie Zhang, Hai-Bing Liao, Heng-Shan Wang, Dong LiangAbstractA new chlorinated diphenyl ether, ethyl dichloroasterrate (1), and a new sesquilignan, mappilignan A (2), along with two known diphenyl ethers (3 and 4) and one known sesquilignan (5), were isolated from the stems of Mappianthus tomentosus. The structures of 1−5 were assigned by spectroscopic data analysis and by comparison with literature data. The absolute configuration of 2 was established using experimental and calculated ECD data. Compound 2 displayed inhi...
Source: Phytochemistry Letters - January 17, 2019 Category: Chemistry Source Type: research

Ligand-based virtual screening and molecular docking of two cytotoxic compounds isolated from Papaver lacerum
This study revealed that the Papaver lacerum extract strongly inhibited HeLa cell proliferation, resulting in 13% cell viability. As a result of phytochemical studies, one known compound, Tyrosol-1-O-β-xylopyranosyl-(1→6)-O-β-glucopyranoside) (I), and one new compound, 5-O-(6-O-α-rhamnopyronosyl-β-glucopyronosyl) mevalonic acid (II), were isolated. Compounds I and II were found to possess a moderate cytotoxic effect with an IC50 of 66.4 μM (p
Source: Phytochemistry Letters - January 12, 2019 Category: Chemistry Source Type: research

Butenolides, triterpenoids and phenylethanoid glycosides from Plantago depressa
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Xiu-Qing Song, Jie Bao, Jia Sun, Zhi-Qiang Cheng, Yuying Zhang, Jin-Hai Yu, Cheng-Shi Jiang, Hua ZhangAbstractFour new compounds, including two butenolides (1 and 2), an arborinane-type triterpenoid (3) and a phenylethanoid glycoside (4), along with the known triterpenoids (5–17) and phenylethanoid glycosides (18–29), were isolated from whole plants of Plantago depressa. The structures of the isolated compounds were elucidated by comprehensive spectroscopic analyses and were evaluated for their anti-inflammatory or antiradical activ...
Source: Phytochemistry Letters - January 11, 2019 Category: Chemistry Source Type: research

Oxidation of flavonolignan silydianin to unexpected lactone-acid derivative
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): David Biedermann, Veronika Moravcová, Kateřina Valentová, Marek Kuzma, Lucie Petrásková, Ivana Císařová, Vladimír KřenAbstractOne of the main flavonolignans from silymarin, an extract of the fruits of the milk thistle (Silybum marianum), is silydianin possessing an unusual bicyclic structure with the keto group next to the hemiacetal moiety. As its oxidation product 2,3-dehydrosilydianin was found to display strong chemoprotective activity and Na+/K+ ATPase inhibitory activity, the present wor...
Source: Phytochemistry Letters - January 9, 2019 Category: Chemistry Source Type: research

Sesquiterpenoids from the stems and leaves of Gochnatia decora
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Qihui Cao, Weifeng Dai, Baocai Li, Mi ZhangAbstractFour new lindenane sesquiterpenoid lactones (1-4), along with two known sesquiterpenoids (5 and 6) and one monoterpenoid (7), were isolated from the stems and leaves of Gochnatia decora (Kurz) A. L. Cabrera. Their 1D and 2D structures were ascertained on the basis of spectroscopic evidence, mainly including NMR, HRESIMS, and ECD spectra. All the compounds were found for the first time in this plant.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - January 6, 2019 Category: Chemistry Source Type: research

Adjunctive role of Calyptranthes tricona extract with probiotic Kluyveromyces marxianus on colorectal adenocarcinoma Caco-2 cells
In conclusion, this preliminary study demonstrates that C. tricona extract has effects on enzyme inhibition and immune function. In addition, when associated with K. marxianus, C. tricona may possess beneficial properties for application as enhancer of probiotic’s protective role on CRC cells. However, further studies are necessary in order to elucidate the mechanisms involved.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - January 6, 2019 Category: Chemistry Source Type: research

Diarylheptanoids with anti-inflammatory activity from the rhizomes of Pleuranthodium racemigerum (Zingiberaceae)
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Ritesh Raju, Ahilya Singh, Dhanushka Gunawardena, Paul Reddell, Gerald MünchAbstractThree new metabolites, 1-(4′′-Methoxyphenyl)-7-(3′,4′-di-hydroxyphenyl)-(E)-hept-2-ene (1), 1-(4′′-Methoxyphenyl)-7-(3′,4′-di-methoxyphenyl)-(E)-hept-2-ene (2), 1-(4′′-Methoxyphenyl)-7-(4′-methoxyphenyl)-(E)-hept-2-ene (3), and the known diaryl heptanoid (4) were identified following anti-inflammatory activity guided fractionation from the rhizomes of Pleuranthodium racemigerum (Zingiberaceae...
Source: Phytochemistry Letters - January 6, 2019 Category: Chemistry Source Type: research

Anthocyanins from mauve flowers of Erlangea tomentosa (Bothriocline longipes) based on erlangidin – The first reported natural anthocyanidin with C-ring methoxylation
In this study two new anthocyanins, erlangidin 5-O-(4″-(E-caffeoyl)-6″-(malonyl)-β-glucopyranoside)-3′-O-(6‴-(3II-(β-glucopyranosyl)-E-caffeoyl)-β-glucopyranoside) and erlangidin 5-O-(6″-(malonyl)-β-glucopyranoside)-3′-O-(6‴-(3II-(β-glucopyranosyl)-E-caffeoyl)-β-glucopyranoside) were isolated from purple flowers of Erlangea tomentosa (Bothriocline longipes) Oliv. & Hiern (Asteraceae) in amounts of ∼1.6 and 0.6 mg/g fr. wt., respectively. They were found to contain the first reported natural anthocyanidin with a methoxy-group on the heterocyclic ...
Source: Phytochemistry Letters - December 26, 2018 Category: Chemistry Source Type: research

Anti-angiogenic activities of glycoalkaloids isolated from Solanum lyratum in tumor-derived vascular endothelial cells
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Lin Han, Jian-nong Wang, Cai-xia Sun, Xiao-qiang Cao, Xiao DuAbstractWe previously identified alkaloids as being the main antitumor constituents of Solanum lyratum Thunb. In this follow-up study to identify the specific active principles, three new glycoalkaloids (1–3) were isolated from S. lyratum with one known glycoalkaloid (4). The structures of the four compounds were determined by means of integrated spectroscopic techniques, as well as by comparison with those in literature. Furthermore, the effects of compounds 1–4 were i...
Source: Phytochemistry Letters - December 20, 2018 Category: Chemistry Source Type: research

In silico identification and evolutionary analysis of candidate genes involved in the biosynthesis methylproline genes in cyanobacteria strains of Iran
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Bahareh Nowruzi, Saúl BlancoAbstractCyanobacteria have the ability to produce a wide variety of natural bioactive compounds. In order to reveal the diversity of Cyanobacteria in Iran, and their potential to synthesise various natural products, we isolated 25 strains from different climatic/geographic regions and habitats, and screened the genes that are responsible for the synthesis of natural products (such as nonribosomal peptide synthetase or polyketide synthase and 4-methylproline) by means of PCR. In addition, we analysed ...
Source: Phytochemistry Letters - December 20, 2018 Category: Chemistry Source Type: research

New tirucallane triterpenoids from the dried latex of Euphorbia resinifera
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Shu-Yun Wang, Chao Huang, Ren-Kuan Sun, Li-Na Lu, Hong-Gang Liang, Le Gao, Jian Huang, Jin-Hui Wang, Bao-Feng YangAbstractAs a part of our ongoing search for bioactive compounds from the dried latex of Euphorbia resinifera (Euphorbium), a new rearranged tirucallane triterpene with a spiro [5,6] ring system, euphorol K (1), and a novel euphane triterpene hydroperoxide, euphorol J (2), together with a known compound, kansuinone (3) have been isolated. Their structures were established on the basis of extensive analyses of their spectroscopic, ...
Source: Phytochemistry Letters - December 20, 2018 Category: Chemistry Source Type: research

Four new honokiol derivatives from the stem bark of Magnolia officinalis and their anticholinesterase activities
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Baobao Zhang, Haitao Yu, Wei Lu, Bo Yu, Lei Liu, Weijuan Jia, Zongtao Lin, Hong Wang, Shizhong ChenAbstractFour new honokiol derivatives, namely 8′,9′-dihydroxymagnaldehyde E (1), 8′,9′-dihydroxyhonokiol (2), erythro-7-O-methylhonokitriol (3), and threo-7-O-methylhonokitriol (4), together with seven known compounds, erythro-honokitriol (5), threo-honokitriol (6), magnaldehyde E (7), magnotriol B (8), magnaldehyde B (9), honokiol (10), and magnolol (11), were isolated from the stem bark of Magnolia officinalis. Their s...
Source: Phytochemistry Letters - December 19, 2018 Category: Chemistry Source Type: research

Bioassay-guided isolation of anti-inflammatory O-sulfated withanolides from Acnistus arborescens (Solanaceae)
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Clara Steinbrueck, Nohelia Mora-Ugalde, Carlos Morales, Randall Loiaza, Alfonso J. García-Piñeres, Juan J. ArayaAbstractBioassay-guided fractionation of Acnistus arborescens (Solanaceae) organic extract afforded two anti-inflammatory withanolides: 2,3-Dihydro-3β-O-sulfate withacnistin (1) and 2,3-Dihydro-3β-O-sulfate withaferin A (2) showing IC50 values of 1.0 ± 0.1 and 14 ± 1 μM respectively in a LPS-stimulated RAW 264.7 murine macrophage assay. These compounds were also e...
Source: Phytochemistry Letters - December 18, 2018 Category: Chemistry Source Type: research

Plaxenone A and B: Cytotoxic halogenated monoterpenes from the South African red seaweed Plocamium maxillosum
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Michael G. Knott, Jo-Anne de la Mare, Adrienne L. Edkins, Angel Zhang, Martin J. Stillman, John J. Bolton, Edith M. Antunes, Denzil R. BeukesAbstractThe endemic South African red seaweed Plocamium maxillosum (Poiret) Lamouroux produces two unusual isomeric dichlorinated cyclohexenone monoterpenes, plaxenone A and B (1 and 2). The structures of the isolated compounds were determined from spectroscopic data and their absolute configuration was determined by comparison of the experimental and calculated ECD spectra. Compounds 1 and 2 inhibit th...
Source: Phytochemistry Letters - December 15, 2018 Category: Chemistry Source Type: research

Fomitopsins I and J, 24-methyl-lanostane triterpenoids from fruiting bodies of the wood-rot basidiomycete Fomitopsis sp.
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Masahiko Isaka, Panida Chinthanom, Rapheephat Suvannakad, Tuksaporn Thummarukcharoen, Tao Feng, Ji-Kai LiuAbstractTwo new 24-methyl-lanostane triterpenoids, fomitopsins I (1) and J (2), were isolated together with seven known compounds (3–9), from fruiting bodies of the basidiomycete Fomitopsis species. The structures were elucidated by spectroscopic analysis. Their antibacterial and cytotoxic activities were evaluated. One of the known compounds (6) exhibited antibacterial activity against Gram-positive bacteria, Bacillus cereus (MIC ...
Source: Phytochemistry Letters - December 15, 2018 Category: Chemistry Source Type: research

Cytotoxic butenolides and diphenyl ethers from the endophytic fungus Pestalotiopsis sp.
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Beiye Yang, Qingyi Tong, Shuang Lin, Jieru Guo, Jinwen Zhang, Junjun Liu, Jianping Wang, Hucheng Zhu, Zhengxi Hu, Yonghui ZhangAbstractChemical investigation of the plant endophytic fungus Pestalotiopsis sp. afforded two new butenolides, pestalolides B and C (1 and 2), two new diphenyl ethers, pestalotethers E and F (3 and 4), together with seven known compounds (5–11). Their structures were established by extensive spectroscopic analyses and the absolute configuration of 1 was further confirmed by ECD calculation. Structurally, compou...
Source: Phytochemistry Letters - December 15, 2018 Category: Chemistry Source Type: research

Gut microbiota-assisted isolation of flavonoids with a galloyl moiety from flowers of meadowsweet, Filipendula ulmaria (L.) Maxim
Publication date: Available online 13 December 2018Source: Phytochemistry LettersAuthor(s): Dominik Popowski, Karolina A. Pawłowska, Jakub P. Piwowarski, Sebastian GranicaAbstractThe consideration of natural product metabolism by human gut microbiota has become a crucial issue, which needs to be addressed during examinations of their bioactivity. The gut microbiota metabolism of Filipendulae ulmariae flos extract was studied. Differences in the dynamics of the deconjugation of flavonoid glycosides depending on their chemical structure were observed. The metabolism of galloylated flavonol glycosides was slower than that of...
Source: Phytochemistry Letters - December 14, 2018 Category: Chemistry Source Type: research

Two new bisabolane-type sesquiterpenoids from the cooking liquid of Curcuma longa rhizomes
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Xiaoli Cheng, Hanxiang Li, Ping Wu, Liangxiong Xu, Jinghua Xue, Xiaoyi WeiAbstractTwo new bisabolane-type sesquiterpenoids, (3R,4S,5R,7S)-3,4,5-trihydroxybisabola-10-ene-9-one (1), (1R,2S,5R,7R,8S)-2,8-epoxy-5-hydroxybisabola-3,10-diene-9-one (2), together with seven known anologues (3–9), were isolated from the cooking liquid of Curcuma longa rhizomes. Their structures were elucidated by a combination of 1D and 2D NMR spectroscopic and HRESIMS data. The absolute configurations of compounds 1 and 2 were assigned by electronic circular ...
Source: Phytochemistry Letters - December 14, 2018 Category: Chemistry Source Type: research

Thymol derivatives from the roots of Eupatorium chinense and their cytotoxic activities
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Qing-Qing Zhang, Zhi-Ying Sun, Xue-Yun Feng, Run-Jie Chen, Wen Deng, Yong-Li Tang, Zhi-Yong Guo, Cheng-Xiong Liu, Jian-Feng Chen, Kun ZouAbstractTwo new thymol derivatives (compounds 1–2) were isolated from the roots of Eupatorium chinense. Their structures were elucidated by analysis of MS data and extensive 1D and 2D NMR spectroscopy (1H-1H COSY, HMBC, HSQC and NOESY). The absolute configuration of compound 1 was assigned based on a comparison of calculated and experimental ECD. Compounds 1–2 were tested in vitro for their cyto...
Source: Phytochemistry Letters - December 14, 2018 Category: Chemistry Source Type: research

Four new steroidal components from Smilacina henryi and their cytotoxic activities
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Fan Qiao, Jie Yang, Jie Lin, Sheng YaoAbstractFour new steroidal components (1−4) along with two known analogues (5−6) were obtained from the roots and rhizomes of Smilacina henryi. The components’ structures were determined as (25S)-5α-spirost-9(11)-ene-3β, 17α, 21-triol (1), (24S, 25S)-5α-spirost-9(11)-ene-3β, 17α, 24-triol (2), (25S)-5α-spirost-9(11)-ene-3β, 17α-dihydroxy-12-one (3), 5α-cholest-9(11)-ene-3β, 26-dihydroxy-16, 22-dione (4), (25S)-5α-spiros...
Source: Phytochemistry Letters - December 14, 2018 Category: Chemistry Source Type: research

Bioassay-guided isolation of lanostane-type triterpenoids as α-glucosidase inhibitors from Ganoderma hainanense
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Lie-Feng Ma, Jia-Jie Yan, Huang-Yan Lang, Li-Chao Jin, Fei-Jun Qiu, Yue-Jun Wang, Zhi-Fang Xi, Wei-Guang Shan, Zha-Jun Zhan, You-Min YingAbstractGanoderma hainanense, an edible mushroom mainly distributed in Southern China, has long been used as a functional food with considerable health benefits. Bioassay-guided phytochemical research on the fruiting bodies of G. hainanense led to the isolation of 22 lanostane-type triterpenoids, including two new compounds 3-acetyl-ganodermadiol (1) and 3-acetyl-lucidumol B (2). In an in-vitro assay, sixte...
Source: Phytochemistry Letters - December 12, 2018 Category: Chemistry Source Type: research

A new constituent against rheumatoid arthritis from the flower buds of Lonicera japonica
In this study, two new compounds named as 8,4′-di-O-methylquercetin-3′-O-β-galactosyl-3-O-β-glucopyranoside (1) and 6-formyl-5-hydroxyl-4-ethyl-2-hydroxymethyl-1H-indene (2), were isolated from the flower buds of Lonicera japonica. Structures of compound 1 and 2 were determined by spectroscopic methods. Additionally, compound 1 showed therapeutic effects against rheumatoid arthritis (RA) in collagen-induced arthritis (CIA) mice through significantly reducing the inflammatory responses in the joint tissues. These results suggested that compound 1 exerted potent chondroprotective and anti-inflammatory e...
Source: Phytochemistry Letters - December 12, 2018 Category: Chemistry Source Type: research

Efficient extraction and isolation of skimmianine from New Caledonian plant Medicosma leratii and evaluation of its effects on apoptosis, necrosis, and autophagy
This study was aimed at improving the current knowledge about the new Caledonian plant species Medicosma leratii, by developing efficient methods of extraction and isolation of specialized metabolites. Ultrasound-assisted extraction (UAE) significantly gave higher yields of the furoquinoline alkaloid skimmianine (22.34 mg/100 g) than accelerated solvent extraction (ASE, 1.37–12.36 mg/100 g). High-performance countercurrent chromatographic (HPCCC) separation of the methanol leaf extract with n-hexane-ethyl acetate-methanol-water (6:5:6:5 v/v) afforded skimmianine (1, 7.55 mg, HPLC-DA...
Source: Phytochemistry Letters - December 11, 2018 Category: Chemistry Source Type: research

Bioactive acridone alkaloids and their derivatives from Citrus aurantium (Rutaceae)
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Samuel Bissim, Sidonie Béatrice Kenmogne, Alain Tadjong Tcho, Mehreen Lateef, Ayaz Ahmed, Emmanuel Ngeufa Happi, Jean Duplex Wansi, Muhammad Shaiq Ali, Alain François Kamdem WaffoAbstractPhytochemical studies on Citrus aurantium led to the isolation and characterization of a new secotirucallane, namely 1β-hydroxy-3,4-secotirucalla-4(28)-7,24-trien-3,21-dioic acid (1), together with the previously reported compounds citracridone I (2), citruisinine II (3), citracridone II (4), 5-hydroxynoracronycine (5), citpressine II (6),...
Source: Phytochemistry Letters - December 11, 2018 Category: Chemistry Source Type: research

Two antiproliferative seco-4,5-abietane diterpenoids from roots of Salvia ceratophylla L.
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Hossein Hadavand Mirzaei, Omidreza Firuzi, Jima N. Chandran, Bernd Schneider, Amir Reza JassbiAbstractTwo previously undescribed rearranged abietanes, ceratol (1) and ceratodiol (2), and three known abietane-diterpenoids, including 1-ketoaethiopinone (3), ferruginol (4) and 12-deoxysalvipisone (5), were isolated from roots of Salvia ceratophylla. The structures of the purified compounds (1–5) were characterized based on analyses of their spectroscopic data, including 1D and 2D NMR and high-resolution electrospray mass spectra. The anal...
Source: Phytochemistry Letters - December 6, 2018 Category: Chemistry Source Type: research

Two novel anthraquinones with cytotoxicity from Hedyotis caudatifolia
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Yi Jing, Hai-Jiang Zhang, Kui-Wu Wang, Xiao-Xin Wang, Ming-Long Chen, Hong Wang, Bin WuAbstractSeven anthraquinones, including two new natural products, hedyanthraquinones A and B (1, 2), were isolated from Hedyotis caudatifolia. The structures were elucidated based on NMR, MS data and physico-chemical properties. Compounds 1 and 2 displayed moderate cytotoxic activities against a panel of cultured tumor cell lines (HL-60, Bcap37, SMMC7721) with IC50 values of 13.71 ∼ 26.29 μM. The result showed that anthraquinones are typical compoun...
Source: Phytochemistry Letters - December 6, 2018 Category: Chemistry Source Type: research

Prenylflavanones isolated from Sophora flavescens
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Jing-Yong Ma, De-Rui Zhao, Tao Yang, Dan Liu, Rong-Tao Li, Hong-Mei LiAbstractIn the ongoing investigation of bioactive compounds from the roots of Sophora flavescens, six prenylflavanones, including two new ones, sophoraflavanones M (1) and N (2), were isolated. The structures of the new compounds were elucidated on the basis of their spectroscopic data. In addition, compound 5 exhibited moderate anti-influenza virus activity, with EC50 value of 43.9 μM.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - December 6, 2018 Category: Chemistry Source Type: research

Chemical constituents from the twigs and leaves of Trichilia sinensis and their biological activities
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Dong-Hua Cao, Peng Sun, Shang-Gao Liao, Li-She Gan, Lin Yang, Jian-Neng Yao, Zong-Yi Zhang, Jin-Feng Li, Xiao-Ling Zheng, Yi-Dian Xiao, Chun-Fen Xiao, Ping Zhang, Hua-Bin Hu, You-Kai XuAbstractPhytochemical investigation on the twigs and leaves of Trichilia sinensis led to the isolation of two previously undescribed limonoids (i.e., trichiliasinenoids D and E, 1 and 2), two previously undescribed phenolic acids (3 and 4), and one previously undescribed natural phenolic acid dimer (5), together with 11 known compounds (6-16). Their structures...
Source: Phytochemistry Letters - December 6, 2018 Category: Chemistry Source Type: research