Chemical constituents from the bark of the Cameroonian mahogany Trichilia emetica Vahl (Meliaceae)
Publication date: October 2019Source: Phytochemistry Letters, Volume 33Author(s): Willifred Dongmo T. Tsopgni, Gervais Mouthé Happi, Hans-Georg Stammler, Beate Neumann, Alexis Sylvain W. Mbobda, Siméon Fogué Kouam, Marcel Frese, Anatole Guy B. Azébazé, Bruno N. Lenta, Norbert SewaldAbstractPhytochemical investigation of the stem bark extract of Trichilia emetica led to the isolation of two new naturally occurring compounds including a prieurianin-class limonoid named trichirokin (1) and the steroid ergosta-5,24(28)-diene-3S,16S,20S-triol (4), along with nine known compounds characterized ...
Source: Phytochemistry Letters - August 1, 2019 Category: Chemistry Source Type: research

Editorial Board
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - July 25, 2019 Category: Chemistry Source Type: research

Graphical Abstract TOC
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - July 25, 2019 Category: Chemistry Source Type: research

Announcements of the Phytochemical Society of Europe
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - July 25, 2019 Category: Chemistry Source Type: research

Discovery of cycloartane-type triterpene saponins from Mussaenda glabra
Publication date: October 2019Source: Phytochemistry Letters, Volume 33Author(s): Vu Kim Thu, Nguyen Xuan Bach, Luu The Anh, Do Thi Trang, Nguyen Xuan Nhiem, Bui Huu Tai, Phan Van Kiem, Chau Van Minh, SeonJu Park, Yohan Seo, Wan Namkung, Seung Hyun KimAbstractFive new cycloartane saponins, mussaglaosides A–E (1–5) together with five known saponins, mussaendoside O, mussaendoside, G mussaendoside U, mussaendoside P, and mussaendoside Q (6–10) were isolated from the leaves of Mussaenda glabra. Their structures were determined on the basis of extensive spectroscopic methods, including 1D-, 2D-NMR, and MS dat...
Source: Phytochemistry Letters - July 21, 2019 Category: Chemistry Source Type: research

Cytotoxic eudesmane sesquiterpenes from Crepis sancta
Publication date: October 2019Source: Phytochemistry Letters, Volume 33Author(s): Sherif S. Ebada, Dina H. El-Kashef, Werner E.G. Müller, Peter ProkschAbstractChemical exploration of Crepis sancta (L.) Bornm. (Asteraceae) aerial parts afforded two new eudesmane sesquiterpenes (1 and 2) together with three known congeners (3-5) and two known methylated flavonoids (6 and 7). Structure elucidation of the new compounds was unambiguously performed based on HRESIMS, 1D and 2D NMR spectroscopic analyses. All isolated compounds were subjected to an in vitro cytotoxicity assay against mouse lymphoma (L5178Y) cells, revealing m...
Source: Phytochemistry Letters - July 21, 2019 Category: Chemistry Source Type: research

Three new eudesmane-type sesquiterpenoids from the mangrove-derived endophytic fungus Penicillium sp. J-54
Publication date: October 2019Source: Phytochemistry Letters, Volume 33Author(s): Huiqin Chen, Liuming Qiu, Pei Wang, Caihong Cai, Hao Wang, Haofu Dai, Wenli MeiAbstractThree previously undescribed eudesmane-type sesquiterpenoids penicieudesmols E-G were obtained from the endophytic fungus Penicillium sp. J-54 isolated from the leaves of mangrove plant Ceriops tagal. The structures of the new compounds were unambiguously elucidated by 1D and 2D NMR, and by HREIMS, as well as by comparison with the literature. Bioactivities results showed that compound 2 presented α-glucosidase inhibitory activity.Graphical abstract (...
Source: Phytochemistry Letters - July 18, 2019 Category: Chemistry Source Type: research

The polymer iridoid glucosides isolated from Dipsacus asper
Publication date: October 2019Source: Phytochemistry Letters, Volume 33Author(s): Xiao-Yan Duan, Lun-Qiang Ai, Cheng-Zhen Qian, Mei-De Zhang, Ren-Qiang MeiAbstractTwo new iridoid tetramers with four glucosides, dipsanosides H (1) and I (2), as well as one new bis-iridoid glucosides dipsanosides J (3), along with four known polymer iridoid glycosides dipsanosides A (4) and B (5), pterocephaline (6), triplostoside A (7) were isolated from Dipsacus asper. Their structures were determined by analysis of 1D and 2D NMR data. All of them were found to be inactive in anti-inflammatory activity.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - July 12, 2019 Category: Chemistry Source Type: research

New monoterpenoid indole alkaloids from Melodinus suaveolens
Publication date: October 2019Source: Phytochemistry Letters, Volume 33Author(s): Jie Zhou, Zhong-Ying Fang, Peng Zhou, Yin-Yin Wang, Lei Fang, Hua ZhangAbstractThree new monoterpenoid indole alkaloids (1–3), along with five known alkaloids (4–8), were isolated from the leaves of Melodinus suaveolens. Their structures were determined by extensive spectroscopic method and quantum chemical ECD calculation. All the new compounds were evaluated for their inhibitory effects on LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - July 12, 2019 Category: Chemistry Source Type: research

A new diphenylethane and a new dibenz[b,f]oxepin with estrogenic activity from the stems and leaves of Dioscorea oppositifolia L
Publication date: October 2019Source: Phytochemistry Letters, Volume 33Author(s): Ying-jie Ren, Meng-Nan Zeng, Yan-Gang Cao, Bei-bei zhang, Meng-Huan Guo, Man Qi, Yan-Li Zhang, Xuan Zhao, Xiao-ke Zheng, Wei-Sheng FengAbstractA new diphenylethane, 2′,4-dihydroxy-2,5-dimethoxybibenzyl (1), and a new dibenz[b,f]oxepin, 10,11-dihydro-2-methoxydibenz[b,f]oxepin-4-ol (2), as well as eight known compounds (3–10) were isolated from the stems and leaves of Dioscorea oppositifolia L. Their structures were elucidated by detailed analysis of comprehensive spectroscopic data. Estrogenic activity of all isolated compounds we...
Source: Phytochemistry Letters - July 12, 2019 Category: Chemistry Source Type: research

New bioactive Δ11(17)-furanoeunicellins from an octocoral Cladiella sp.
Publication date: October 2019Source: Phytochemistry Letters, Volume 33Author(s): Ying-Fa Chen, Wu-Fu Chen, Zhi-Hong Wen, Tsong-Long Hwang, Zhi-Jun Zhang, Ping-Jyun SungAbstractA new eunicellin diterpenoid, cladieunicellin U (1), along with a new natural eunicellin, cladieunicellin V (2), and two known analogues, sclerophytins A (3) and B (4), were obtained from an octocoral identified as Cladiella sp. The structures, including the absolute configurations, of eunicellins 1–4 were elucidated by using spectroscopic methods and compared with the spectroscopic and physical data reported in the literature. Eunicellins 1, ...
Source: Phytochemistry Letters - July 12, 2019 Category: Chemistry Source Type: research

Three new diterpenoid alkaloids from Delphinium naviculare var. lasiocarpum W. T. Wang
Publication date: October 2019Source: Phytochemistry Letters, Volume 33Author(s): Wen-Juan Xue, Bo Zhao, Jiang-Yu Zhao, Sh. Sh. Sagdullaev, Haji Akber AisaAbstractThree new diterpenoid alkaloids, designated naviconine (1), naviculine (2) and naviconitine (3), together with five known diterpenoid alkaloids (4)–(8) were isolated from the whole plant of Delphinium naviculare var. lasiocarpum W. T. Wang. The structures of the new compounds were established on the basis of spectroscopic analyses including HR-ESI-MS, 1D and 2D NMR analyses. All of the compounds were evaluated in vitro for cytotoxicity against HT-29, MDA-MB...
Source: Phytochemistry Letters - July 10, 2019 Category: Chemistry Source Type: research

MYB1 transcription factor regulation through floral scent in Cymbidium cultivar ‘Sael Bit’
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Mummadireddy Ramya, Su Young Lee, Hye Ryun An, Pil Man Park, Nan Sun Kim, Pue Hee ParkAbstractCymbidium belongs to Orchidaceae, one of the most abundant angiosperm families. Cymbidium cultivars have a high aesthetic value and commercially valued characteristics such as a pleasant scent and a variety of flower colors. Cymbidium cultivar ‘Sael Bit’, which was developed by National Institute of Horticultural & Herbal Science (NIHHS), is highly fragrant with small green and light yellow flowers. An analysis of ‘Sael Bit&rsquo...
Source: Phytochemistry Letters - July 3, 2019 Category: Chemistry Source Type: research

Megastigmane and abscisic acid glycosides from the leaves of Laurus nobilis L.
Publication date: October 2019Source: Phytochemistry Letters, Volume 33Author(s): Le Duc Dat, Ngo Viet Duc, Bui Thi Thuy Luyen, Ha Van Oanh, Hyun Jae Jang, Tran Thu Huong, Young Ho Kim, Nguyen Phuong ThaoAbstractTwo new megastigmane glycosides, laurusides E-F (1 and 3) and three known ones (2, 5, and 7), together with a new abscisic acid glycoside, lauruside G (4) and a known one (6), were isolated from a methanolic extract of Laurus nobilis L. leaves using various chromatographic techniques. The structures of these compounds were fully characterized using a combination of spectroscopic techniques including multinuclear an...
Source: Phytochemistry Letters - July 3, 2019 Category: Chemistry Source Type: research

Hedyosulide, a novel trypanosomicidal sesterterpene lactone from Hedyosmum brasiliense Mart. ex Miq
Publication date: October 2019Source: Phytochemistry Letters, Volume 33Author(s): Cynthia Murakami, Rodrigo Sant’Ana Cabral, Kaio S. Gomes, Thais A. Costa-Silva, Maiara Amaral, Maiara Romanelli, Andre G. Tempone, João Henrique G. Lago, Vanderlan da S. Bolzani, Paulo Roberto H. Moreno, Maria Cláudia M. YoungAbstractA new sesterterpene lactone, Hedyosulide, together with five previously described sesquiterpene lactones were isolated from the leaves of Hedyosmum brasiliense Mart. ex Miq. (Chloranthaceae). Their structures were established by NMR analysis and HRESIMS data. The isolated compounds were evalua...
Source: Phytochemistry Letters - July 3, 2019 Category: Chemistry Source Type: research

Cytotoxic prenylated indole alkaloid produced by the endophytic fungus Aspergillus terreus P63
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Juliana R. Gubiani, Michele C.S. Oliveira, Ricardo A.R. Neponuceno, Maria J. Camargo, Walmir S. Garcez, Andressa R. Biz, Marcos A. Soares, Angela R. Araujo, Vanderlan da S. Bolzani, Helen C.F. Lisboa, Paulo T. de Sousa, Leonardo G. de Vasconcelos, Tereza A.N. Ribeiro, Juliana M. de Oliveira, Thais P. Banzato, Carolina A. Lima, Giovanna B. Longato, João M. Batista, Roberto G.S. Berlinck, Helder L. TelesAbstractPrenyl indole alkaloids constitute a diverse class of natural products with complex chemical structures and potent biological act...
Source: Phytochemistry Letters - June 27, 2019 Category: Chemistry Source Type: research

Ergosterols from Ganoderma sinense and their anti-inflammatory activities by inhibiting NO production
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Ren-Qiang Mei, Feng-Jiao Zuo, Xiao-Yan Duan, Yi-Na Wang, Jun-Rong Li, Cheng-Zhen Qian, Ji-Ping XiaoAbstractThree new ergosterols, ganocalidophins A–C (1‒3), along with four known ones, were isolated from the fruiting bodies of Ganoderma sinense. Their structures were established on the basis of extensive NMR and MS technologies, as well as the single crystal X-ray diffraction. Compounds 1‒3 and 6 exhibited inhibitory activities against NO production with IC50 of 17.7–32.4 μM.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - June 27, 2019 Category: Chemistry Source Type: research

Effects and mechanism of inhibition of naringin in combination with atorvastatin on prostate cancer cells in vitro and in vivo
ConclusionsThe data suggest that the combination of atorvastatin and naringin may be an effective method for inhibiting the growth of prostate cancer. Further research is needed to determine the mechanism of action of the combination of atorvastatin and naringin.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - June 27, 2019 Category: Chemistry Source Type: research

New acylated iridoid glucosides from Scutellaria glaphyrostachys Rech.f. and chemotaxonomic importance for the genus Scutellaria
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Zeynep Dogan, Kan’ichiro Ishiuchi, Toshiaki Makino, Iclal SaracogluAbstractTwo new acylated iridoid glucosides, 6′-O-E-caffeoyl geniposidic acid (1) and 6′-O-E-caffeoyl 8-epi-loganic acid (2) with 8 known compounds (3-10) were isolated from the aerial parts of Scutellaria glaphyrostachys Rech.f. Known compounds were identified as 6′-O-E-p-coumaroyl 8-epi-loganic acid (3), catalpol (4), scutellarioside I (globularin, 5), scutellarioside II (6), 6′-O-E-caffeoyl mussaenosidic acid (7), albidoside (8), scutelloside (9...
Source: Phytochemistry Letters - June 24, 2019 Category: Chemistry Source Type: research

Irpexlacte A-D, four new bioactive metabolites of endophytic fungus Irpex lacteus DR10-1 from the waterlogging tolerant plant Distylium chinense
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Xiao-Xiang Duan, Dan Qin, Hong-Chuan Song, Tian-Cong Gao, Shi-Hao Zuo, Xiao Yan, Jun-Qi Wang, Xiao Ding, Ying-Tong Di, Jin-Yan DongAbstractOne new tremulane sesquiterpene, irpexlacte A (1), and three new furan derivatives, irpexlacte B–D (2-4), were isolated from the endophytic fungus Irpex lacteus DR10-1 waterlogging tolerant plant Distylium chinense, together with two known ones, irlactin E (5) and 3β-hydroxycinnamolide (6). Structures of these metabolites were characterized by HRESIMS and NMR spectroscopic methods. The antibacter...
Source: Phytochemistry Letters - June 15, 2019 Category: Chemistry Source Type: research

Structure, absolute configuration and biological evaluation of polyoxygenated meroterpenoids from the marine algal-derived Aspergillus terreus EN-539
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Hong-Lei Li, Xiao-Ming Li, Xin Li, Sui-Qun Yang, Bin-Gui WangAbstractTwo new meroterpenoids, aperterpenes N (1) and O (2), along with two known structurally related derivatives, terretonins A (3) and G (4), were isolated and identified from the marine algal-derived endophytic fungus Aspergillus terreus EN-539. Their structures and absolute configurations were determined by a detailed interpretation of spectroscopic data and by X-ray crystallographic analysis. This is the first establishment of the absolute configurations for terretonins A (3) ...
Source: Phytochemistry Letters - June 7, 2019 Category: Chemistry Source Type: research

The effects of mutation and temperature variation on monacolin K production by monascus sp. and relative statistical parameter analysis of monacolin K production
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Chung-Fu Huang, Shu-Min Shen, Wei-Ting Chen, Chih-Chun ChenAbstractMonacolin K is a secondary metabolite of the Monascus species that restrains cholesterol synthesis. Temperature control is an effective method of improving the rate of monacolin K synthesis. Ultraviolet (UV) irradiation and ethylmethane sulfonate (EMS) were employed to mutate the Monascus strain so that it could be studied. After mutation by UV and EMS, the best monacolin K production strain was scanned after the 2 -h UV irradiation treatment. Monascus U-2 is defined as ...
Source: Phytochemistry Letters - June 7, 2019 Category: Chemistry Source Type: research

New natural coumarins from Trichocline macrocephala (Asteraceae)
This study reports the isolation and elucidation of two undescribed compounds, named 7-methoxy-glaupalol and 8-hydroxy-isogerberacoumarin, along with glaupalol, 5-methoxycoumarin, 5,6-dimethoxycoumarin and 7-methoxycoumarin. Their structures were determined by application of 1D and 2D NMR techniques and HRESIMS analysis. The 5-methylcoumarin glaupalol exhibited antichemotactic activity on leukocytes migration at concentrations from 0.01 to 5 μg/mL.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - June 5, 2019 Category: Chemistry Source Type: research

Three new 2-(2-phenylethyl)chromone derivatives from agarwood of Aquilaria crassna Pierre ex Lecomte (Thymelaeaceae) in Laos
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Yang-Mei Zhao, Li Yang, Wen-Hua Dong, Wei Li, Hui-Qin Chen, Hao Wang, Cai-Hong Cai, Cui-Juan Gai, Wen-Li Mei, Hao-Fu DaiAbstractIn our ongoing effort to study the metabolites from agarwood of Aquilaria crassna Pierre ex Lecomte (Thymelaeaceae) produced in Laos, three new 2-(2-phenylethyl)chromone derivatives (1−3) were isolated. Their structures were elucidated by comprehensive spectroscopic analyses, predominantly by 1D and 2D NMR spectroscopic methods, and by comparison with the reported data. Compound 2 exhibited tyrosinase inhibitory...
Source: Phytochemistry Letters - June 5, 2019 Category: Chemistry Source Type: research

Three new resveratrol trimer Di-C-glucosides in Shorea uliginosa
In this study, the acetone-soluble parts of the stem bark of Shorea uliginosa were analyzed and three new resveratrol trimers, that is, uliginosides E–G (1–3), were isolated. The structures of these isolates were established on the basis of spectroscopic analyses, including detailed NMR and CD spectroscopy. Trimers 1–3 are rare di-C-glucosylated derivatives with two RS-4-C-β-glucopyranoside building blocks.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - June 5, 2019 Category: Chemistry Source Type: research

Inside Front Cover (Editorial Board)
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - May 31, 2019 Category: Chemistry Source Type: research

Contents (graphical abstracts and research highlights)
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - May 31, 2019 Category: Chemistry Source Type: research

Announcements of the Phytochemical Society of Europe
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - May 31, 2019 Category: Chemistry Source Type: research

Cadinane-type sesquiterpenoids and an indolizine alkaloid from the rice fermentation of the fungus Rigidoporus microporus
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Qian Li, He-Ping Chen, Rong Huang, Hui-Xiang Yang, Rui Ma, Yue-Ling Peng, Zheng-Hui Li, Tao Feng, Ji-Kai LiuAbstractTwo previously undescribed cadinane-type sesquiterpenoids, rigidoporones A and B (1 and 2), along with an undescribed racemic indolizine alkaloid, (±)-rigidoporine A (3), were isolated from the rice fermentation of the wood-decay fungus Rigidoporus microporus. The structures of the compounds were established by extensive spectroscopic methods, including 1D & 2D NMR and HRMS spectroscopic analysis. Compounds 1 and 3 wer...
Source: Phytochemistry Letters - May 31, 2019 Category: Chemistry Source Type: research

A lignan and a lignan derivative from the fruit of Forsythia suspensa
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Chang Li, Qian Wei, Zhi-Hao Zou, Chen-Zhi Sun, Qin Wang, Gang Zhao, Xin-Jia Yan, Tian-Yi Yu, Chun-Li GanAbstractThe chemical investigation of a 95% ethanol extract of the fruit of Forsythia suspensa resulted in the isolation of one new lignan and one new lignan derivative, forsythialan E-F, along with two known lignans. Their structures were established based on extensive spectroscopic data analyses, including UV, IR, HRESIMS, 1D NMR and 2D NMR. Absolute configurations of 1-2 were determined by the CD method. In addition, compounds 1-2 were ev...
Source: Phytochemistry Letters - May 30, 2019 Category: Chemistry Source Type: research

Investigation of the antifungal activity of Pterocarpus erinaceus led to the identification of two new diarylpropanoids from its roots
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Nassifatou Koko Tittikpina, Louis P. Sandjo, Frédéric Nana, Véronique Vaillant, Stéphane Fontanay, Stéphanie Philippot, Yerim M. Diop, Komlan Batawila, Koffi Akpagana, Gilbert Kirsch, Raphaël Emmanuel Duval, Claus Jacob, Patrick ChaimbaultAbstractThe popular use of Pterocarpus erinaceus as antimicrobial prompted us to study the antifungal properties of its bark, leaves and roots against Candida albicans, Aspergillus fumigatus, and Aspergillus niger. Thus, the broth microdilution method was used to perfor...
Source: Phytochemistry Letters - May 27, 2019 Category: Chemistry Source Type: research

Glycosidic compounds from Cassia obtusifolia seeds and their inhibitory effects on OATs, OCTs and OATPs
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Shuangyan Wang, Keyu Feng, Lifeng Han, Xin Fang, Youcai Zhang, Heshui Yu, Xu PangAbstractPhytochemical work on water-soluble ingredients extracted from Cassia obtusifolia seeds led to the isolation of twelve glycosidic compounds including three chromone C-glycosides (1-3), two anthraquinone glycosides (4, 5), six naphthopyran glycosides (6-11), and one naphthalene glycoside (12). The structures of all compounds were identified mainly by spectroscopic data analysis; 1-3 were three new chromone C-glycosides, and 4 was a new anthraquinone glycosi...
Source: Phytochemistry Letters - May 27, 2019 Category: Chemistry Source Type: research

Two new diarylheptanoids from the green husks of Juglans regia L. and their cytotoxic activities
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Yue-Xian Jin, Xiao-Ling Ma, Hong-Yan Wei, Xiong-Fei Guo, Guo-Xu Ma, Lei-Ling Shi, Jing ZhangAbstractTwo new diarylheptanoids, 3- hydroxy- 3′,4″- epoxy- 1- (4′- methoxyphenyl) - 7- (3″- hydroxylphenyl)– heptane (1) and 2,3- dihydroxy- 1- (4′- hydroxy- 3′- methoxyphenyl)- 7- (4″- hydroxyphenyl)– heptanes (2), along with two known compounds, JuglaninB (3) and 4,17- dimethoxy- 2- oxatricyclo [13.2.2.13,7] eicosa- 3,5,7 (20),15,17,18- hexaene- 10,16- diol (4), were isolated from the green husks ...
Source: Phytochemistry Letters - May 25, 2019 Category: Chemistry Source Type: research

Cycloschimperols A and B, new cytotoxic cycloartane triterpenoids from Euphorbia schimperi
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Mohamed F.S. Banjar, Gamal A. Mohamed, Ibrahim A. Shehata, Hossam M. Abdallah, Ali A. Shati, Mohammad Y. Alfaifi, Serag Eldin I. Elbehairi, Abdulrahman E. Koshak, Sabrin R.M. IbrahimAbstractTwo new cycloartane-type triterpenoids, cycloschimperols A [cycloart-20,24-dien-3β-ol] (3) and B [26,27-dinor-3β-hydroxy cycloartan-25-al] (4) and two known compounds, 24-methylenecycloartane (1) and cycloart-25-en-3-one (2) were separated from the aerial parts of Euphorbia schimperi C. Presl (Euphorbiaceae). The structural characterization of the...
Source: Phytochemistry Letters - May 22, 2019 Category: Chemistry Source Type: research

New olean-15-ene type gymnemic acids from Gymnema sylvestre (Retz.) R.Br. and their antihyperglycemic activity through α-glucosidase inhibition
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Naila Hassan Ali Alkefai, Saima Amin, Manju Sharma, Javed Ahamad, Showkat R. MirAbstractA mixture of gymnemic acids was precipitated from the water extract of leaves of Gymnema sylvestre (Retz.) R.Br. ex Sm. (Asclepiadaceae) by acidification with 2 N H2SO4. The chromatographic separation of the mixture afforded five new gymnemic acids (1-5). The compounds were characterized as Δ15 oleanane glycosides on the basis of extensive spectral data analysis. The compounds (1-5) showed dose dependent inhibition of α-glucosidase, which...
Source: Phytochemistry Letters - May 22, 2019 Category: Chemistry Source Type: research

Three new ursane-type triterpenoids from the roots of Sanguisorba officinalis L. and their cytotoxic activity
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Rongshen Wang, Mei Jin, Chunshi Jin, Jinfeng Sun, Chao Ye, Tieqiang Zong, Guoqing Chen, Wei Zhou, Gao LiAbstractThree new ursane-type triterpenoids, 3-oxo-15α,19α-dihydroxyurs-12-en-28-oic acid (1), 3-oxo-7β,19α-dihydroxyurs-12-en-28-oic acid (2), and 18,19-seco,1β-hydroxyl-3,19-dioxo-urs-11,13(18)-dien-28-oic acid (3), together with eleven known triterpenoids (4 – 14) were isolated from the roots of Sanguisorba officinalis L. Their structures were characterized from spectroscopic data (1D, 2D NMR and HR-ESI-M...
Source: Phytochemistry Letters - May 22, 2019 Category: Chemistry Source Type: research

Acylsugar diversity in the resin glycosides from Ipomoea tricolor seeds as chemosensitizers in breast cancer cells
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Jhon Castañeda-Gómez, Pedro Lavias-Hernández, Mabel Fragoso-Serrano, Argelia Lorence, Rogelio Pereda-MirandaAbstractMexican morning glory, Ipomoea tricolor Cav., is native to America and widely cultivated as an ornamental plant. High performance liquid chromatography profiling coupled with off-line electrospray mass spectrometry detection was applied to identify novel acylsugar from the CHCl3-soluble resin glycoside from seeds. Dereplication of known tricolorins A-J included the recording of mass values for ions [M ...
Source: Phytochemistry Letters - May 18, 2019 Category: Chemistry Source Type: research

Three new constituents from the fungus of Monascus purpureus and their anti-inflammatory activity
Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Ho-Cheng Wu, Ming-Jen Cheng, Ming-Der Wu, Jih-Jung Chen, Yen-Lin Chen, Hsun-Shuo ChangAbstractA chemical study on the EtOAc-soluble fraction of the 95% EtOH extract of red yeast rice fermented with the fungus Monascus purpureus BCRC 38110 (Eurotiaceae) has resulted in the isolation of three new compounds, i.e., two new 5′,6′-dihydrospiro[isochromane-1,2′-pyran]-4′(3′H)-one derivatives, designated as monascuspirolide A (1) and monascuspirolide B (2) and one benzenoid derivative, monapurpureusin B (3), together with t...
Source: Phytochemistry Letters - May 16, 2019 Category: Chemistry Source Type: research

Flavonoids from the seeds of Oroxylum indicum and their anti-inflammatory and cytotoxic activities
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Bing-Lan Wu, Zhou-Wei Wu, Fan Yang, Xiao-Fei Shen, Lun Wang, Bin Chen, Fu Li, Ming-Kui WangAbstractTwo new flavonoid glycosides, named oroxin C (1) and oroxin D (scutellarein 4'-methyl ether 7-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside, 2), together with eight known flavonoids (3–10), were isolated from the seeds of Oroxylum indicum. Their structures were elucidated unambiguously by spectroscopic techniques and chemical methods. Anti-inflammatory and cytotoxic activities of all the isolated compounds were evaluated. Ch...
Source: Phytochemistry Letters - May 16, 2019 Category: Chemistry Source Type: research

New secondary metabolites from the mangrove endophytic fungus Aspergillus versicolor
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Marwa Elsbaey, Chiaki Tanaka, Tomofumi MiyamotoAbstractTwo new oxoindolo diterpene epimers, anthcolorin G 1 and anthcolorin H 2, nine new meroterpenes, (7R,8R)-8-hydroxysydowic acid 4, (7S,10S)-10-hydroxy-sydowic acid 5, (7S,11R)-12-hydroxy-sydowic acid 6, (7S,11R)-12-acetoxy-sydowic acid 7, (7R,8R)-1,8-epoxy-11-hydroxy-sydonic acid 9, 7-deoxy-7,14-didehydro-11-hydroxy-sydonic acid 11, 7-deoxy-7,14-didehydro-12-acetoxy-sydonic acid 14, and (E)-7-deoxy-7,8-didehydro-12-acetoxy-sydonic acid 15, (7R)-11-hydroxy-sydonic acid methyl ester 18, and a...
Source: Phytochemistry Letters - May 16, 2019 Category: Chemistry Source Type: research

Acacetin—A simple flavone exhibiting diverse pharmacological activities
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Ruchi Badoni Semwal, Deepak Kumar Semwal, Sandra Combrinck, Jeanne Trill, Simon Gibbons, Alvaro ViljoenAbstractAcacetin (5,7-dihydroxy-4-methoxyflavone) is a naturally occurring flavonoid, known to possess numerous pharmacological properties, including neuroprotective, cardioprotective, anticancer, anti-inflammatory, antidiabetic, and antimicrobial activities. The molecule is widespread throughout the Plant Kingdom, but is particularly abundant in the Asteraceae, Euphorbiaceae, Passifloraceae, Lamiaceae and Malvaceae families. It has been show...
Source: Phytochemistry Letters - May 13, 2019 Category: Chemistry Source Type: research

Two new cytochalasans from the marine sediment-derived fungus Westerdykella dispersa and their antibacterial activities
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Dan Xu, Xia Zhang, Xiong Shi, Peng-Jie Xian, Liu Hong, Yan-Duo Tao, Xiao-Long YangAbstractTwo new cytochalasans, 16α-methylaspochalasin J (1) and 16-hydroxymethylaspergillin PZ (2), have been characterized from the solid fermentation culture of Westerdykella dispersa isolated from the marine sediments. The structures and relative configurations of 1-2 were elucidated by a combination of spectroscopic methods, as well as by comparison with related known compounds. Compounds 1 and 2 showed moderate antibacterial activity with MIC values ra...
Source: Phytochemistry Letters - May 13, 2019 Category: Chemistry Source Type: research

New friedelane triterpenes from Anchietea pyrifolia
We report the identification of three new friedelane-type triterpenes (1, 2a, 2b) and a new 30-norfriedelane triterpene (3) together with nine known compounds (4-12) that were isolated from the liana stems of A. pyrifolia. The structures of these compounds were elucidated by spectroscopic methods, including HRMS, and 1D/2D-NMR. In vitro cytotoxicity was assessed against two human cancer cell lines, HeLa and HL-60. The new triterpenes 1-3 and known compounds 9, 11, and 12 exhibited moderate activity with IC50 values ranging from 5.7 to 45.0 μM.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - May 11, 2019 Category: Chemistry Source Type: research

Three new triterpenoids transformed from ursolic acid by Mucor spinosus AS3.3450 and their cytotoxicity
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Shan-Shan Zhang, Ling-Shuang He, Yan-Min Zhao, Shan Fu, Dai-Lin Liu, Zi-He Yu, Bai-Chuan LiuAbstractMicrobial transformation of ursolic acid by Mucor spinosus AS 3.3450 was carried out in this paper. Three new compounds (1-3) were isolated and their structures were identified as 3β, 7β-dihydroxy-ursolic acid-28-ethanone (1), 3β, 7β, 21β-trihydroxy-ursolic acid (2), and 3β, 21β-dihydroxy-ursolic acid-3-O-β-D-glucopyranoside (3) based on extensive spectral analysis including HRESI-MS, 1H-NMR, 13C-NMR, HMQC...
Source: Phytochemistry Letters - May 11, 2019 Category: Chemistry Source Type: research

Harziane and cadinane terpenoids from the alga-endophytic fungus Trichoderma asperellum A-YMD-9-2
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Yin-Ping Song, Feng-Ping Miao, Xiao-Rui Liang, Xiu-Li Yin, Nai-Yun JiAbstractIn addition to the known harziandione (1), one new diterpenoid, 3S-hydroxyharzianone (2), and two new sesquiterpenoids, 4-cadinen-11,12-diol (3) and 4-cadinen-11,13-diol (4), were isolated from the culture of Trichoderma asperellum A-YMD-9-2, an endophytic fungal strain from the marine red alga Gracilaria verrucosa. The structures and relative configurations of new isolates were established by analysis of spectroscopic techniques, including 1D/2D NMR, IR, and MS, and ...
Source: Phytochemistry Letters - May 11, 2019 Category: Chemistry Source Type: research

Alkaloid glycosides and their cytotoxic constituents from Zanthoxylum nitidum
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Nguyen Thi Hong Van, Tran Thi Tuyen, Pham Minh Quan, Pham Quoc Long, Nguyen Xuan Nhiem, Bui Huu Tai, Cam Thi Inh, Vu Dinh Hoang, Phan Van Kiem, Chau Van Minh, SeonJu Park, Seung Hyun KimAbstractFour new alkaloid glycosides, zanthonitisides A–D (1-4), together with five known compounds (5–9) were isolated from the aqueous fraction of stems and twigs of Zanthoxylum nitidum (Roxb.) DC. Their structures were determined on the basis of extensive spectroscopic methods, including 1D-, 2D-NMR, MS, and CD data. All isolated compounds were e...
Source: Phytochemistry Letters - May 11, 2019 Category: Chemistry Source Type: research

En route to anti-glioblastoma active pomolic acid
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Oliver Kraft, Jana Wiemann, Ahmed Al-Harrasi, René CsukAbstractTormentic acid (3) can be easily photo-reduced by Saito’s procedure and is an ideal starting material for the straightforward synthesis of pomolic acid (1).Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - May 5, 2019 Category: Chemistry Source Type: research

Furanoeremophilanes from Euryops arabicus alleviate metabolic syndrome-associated exaggerated vasoconstriction via direct vasodilatation
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Hossam M. Abdallah, Ali M. El-Halawany, Hany M. El-BassossyGraphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - May 4, 2019 Category: Chemistry Source Type: research

Five new diterpenoids from the barks of Cinnamomum cassia (L.) J. Presl
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Van Cong Pham, Thi Thuy An Nguyen, Thi Oanh Vu, Thao Quyen Cao, Byung Sun Min, Jeong Ah KimAbstractHere, we report the isolation of five new diterpenoids including four lactone-type diterpenes (3, 5-7) and a hemiketal-type diterpene (12) in addition to 10 known compounds from the bark of Cinnamomum cassia (L.) J. Presl. Molecular structures were elucidated by various spectroscopic methods including 1- and 2-dimensional NMR, high-resolution MS, and circular dichroism. No cytotoxic activity was observed for any of the isolated compounds (1-15) a...
Source: Phytochemistry Letters - May 4, 2019 Category: Chemistry Source Type: research

One new sesquiterpene and one new iridoid derivative from Valeriana amurensis
Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Yang-Guo Xie, Xin-Cai Zhao, Syed Shams ul Hassan, Xiao-Yong Zhen, Ishaq Muhammad, Shi-kai Yan, Xing Yuan, Hui-liang Li, Hui-zi JinAbstractOne new sesquiterpene 1S, 3S, 4S, 7S 3,4-dihydroxy-bisabolol (1), one new iridoid amurensin A (2) and 10 known compounds were isolated from the whole plants of Valeriana amurensis. Their structures were established on the basis of extensive spectroscopic analysis and the absolute stereochemistry of compound 1 was assigned by X-ray diffraction analysis with Cu-Kα irradiation. All of compounds were evalu...
Source: Phytochemistry Letters - May 4, 2019 Category: Chemistry Source Type: research