Two new guaiane sesquiterpenes from Datura metel L. with anti-inflammatory activity
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Nguyen Thi Mai, Nguyen Thi Cuc, Hoang Le Tuan Anh, Nguyen Xuan Nhiem, Bui Huu Tai, Pham Hai Yen, Tran Hong Quang, Chau Van Minh, Kwan Woo Kim, Youn-Chul Kim, Hyuncheol Oh, Phan Van Kiem Chemical investigation of an acidic methanol extract of the whole plants of Datura metel resulted in the isolation of two new guainane sesquiterpenes, 1β,5α,7β-guaiane-4β,10α,11-triol (1) and 1α,5α,7α-11-guaiene-2α,3β,4α,10α,13-pentaol (2), along with eight known compounds: pterodontriol B (3)...
Source: Phytochemistry Letters - February 11, 2017 Category: Chemistry Source Type: research

HPLC-DAD analysis of arbutin produced from hydroquinone in a biotransformation process in Origanum majorana L. shoot culture
Publication date: Available online 10 February 2017 Source:Phytochemistry Letters Author(s): Ewa Skrzypczak-Pietraszek, Inga Kwiecień, Agnieszka Gołdyn, Jacek Pietraszek The hydroquinone glucoside arbutin is a plant derived compound medically applied due to its uroantiseptic activity. It also has skin whitening properties and thus is widely used in dermatology and cosmetology. Origanum majorana L. (Lamiaceae) is known to produce arbutin, however the content of the compound in cultivated plants is very variable and low. Since plant cell and tissue cultures are capable to perform specific biotransformation reactions inclu...
Source: Phytochemistry Letters - February 10, 2017 Category: Chemistry Source Type: research

Three new flavonoids from Millettia pachyloba
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Zhi Na, Qing-Fei Fan, Qi-Shi Song, Hua-Bin Hu Two new prenylated isoflavones, pachyloisoflavone A (1), pachyloisoflavone B (2), and a new pterocarpan, pachylobin A (3), together with ten known flavonoids (4–13), were isolated from the vine stems and leaves of Millettia pachyloba. The structures of new compounds were elucidated on the basis of extensive spectroscopic data interpretation, including 1D, 2D NMR and HREIMS. The absolute configuration of 2 was established by the comparison of experimental and calculated electronic circular di...
Source: Phytochemistry Letters - February 10, 2017 Category: Chemistry Source Type: research

New prenylated dihydrochalcones from the leaves of Artocarpus elasticus
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Mareena Daus, Prakit Chaithada, Souwalak Phongpaichit, Ramida Watanapokasin, Anthony R. Carroll, Wilawan Mahabusarakam The leaves of Artocarpus elasticus collected in Thailand were investigated for chemical constituents. Four new prenylated dihydrochalcones named elastichalcones C, D, E, F (1, 3, 5, 6) together with elastichalcone B (2) and artocarpanone (4) were isolated. Their structures were determined from analysis of spectroscopic data. Elastichalcone C (1) exhibited good antibacterial activity and cytotoxicity. Graphical abstract (Sourc...
Source: Phytochemistry Letters - February 10, 2017 Category: Chemistry Source Type: research

Optimisation of preparative HPLC separation of four isomeric kaempferol diglycosides from Prunus spinosa L. by application of the response surface methodology
Publication date: Available online 5 February 2017 Source:Phytochemistry Letters Author(s): Aleksandra Owczarek, Anna Magiera, Magdalena Matczak, Dorota Gabriela Piotrowska, Monika Anna Olszewska, Anna Marchelak A fast and efficient preparative HPLC-PDA method was developed for the separation and isolation of four rare isomeric kaempferol diglycosides from leaves of Prunus spinosa L. The separation procedure of the enriched diglycoside fraction of the 70% (v/v) aqueous methanolic leaf extract was first optimised on analytical XBridge C18 column (100mm×4.6mm i.d., 5μm) and central composite design combined with re...
Source: Phytochemistry Letters - February 6, 2017 Category: Chemistry Source Type: research

CASMI 2016: A manual approach for dereplication of natural products using tandem mass spectrometry
Publication date: Available online 4 February 2017 Source:Phytochemistry Letters Author(s): Dejan Nikolić The Critical Assessment of Small Molecule Identification (CASMI) contest is an initiative designed as an unbiased test of manual and automated strategies for the identification of small molecules from raw mass spectrometric data. In this contest, the participants are provided a set of high resolution MS and MS/MS data and asked to identify the unknown structure. CASMI 2016 is the fourth round of this contest in which the author participated in Category 1: Best Identification of Natural Products using a manual approac...
Source: Phytochemistry Letters - February 4, 2017 Category: Chemistry Source Type: research

Biotransformation of capsaicin by Penicillium janthinellum AS 3.510
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Xiu-Lan Xin, Yan Wang, Guang-Jun Fan, Liang Chen, Cheng-Peng Sun Biocatalysis of capsaicin (1) was performed by Penicillium janthinellum AS 3.510. Nine metabolites including four new compounds were afforded, and their structures were elucidated as (8S)-trans-8-hydroxy-8-hydroxymethyl-N-vanillyl-6-nonenamide (2), 6-hydroxy-8-methyl-N-vanillyl-7-nonenamide (3), trans-8-methoxy-8-methyl-N-vanillyl-6-nonenamide (4), 6-methoxy-8-methyl-N-vanillyl-7-nonenamide (5), dihydrocapsaicin (6), ω-1-hydroxydihydrocapsaicin (7), ω-1-hydroxycapsai...
Source: Phytochemistry Letters - February 3, 2017 Category: Chemistry Source Type: research

Characterization of Hypericum perforatum L. (St. John ’s wort) macerates prepared with different fatty oils upon processing and storage
Publication date: Available online 16 January 2017 Source:Phytochemistry Letters Author(s): Miriam Heinrich, Veronika Vikuk, Rolf Daniels, Florian C. Stintzing, Dietmar R. Kammerer Hypericum perforatum L. (St. John’s wort, SJW) is a traditional medicinal plant with a long history of pharmaceutical application. Today, besides formulations based on hydro-alcoholic extracts, lipophilic SJW preparations are widely used in phytomedicine e.g. for the symptomatic treatment of minor inflammations of the skin and subcutaneous tissue disorders. In the present study, SJW extracts were obtained with twelve different fatty oils ...
Source: Phytochemistry Letters - January 17, 2017 Category: Chemistry Source Type: research

Antitrypanosomatid activity of flavonoid glycosides isolated from Delphinium gracile, D. staphisagria, Consolida oliveriana and from Aconitum napellus subsp. Lusitanicum
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Clotilde Marín, Jesús G. Díaz, David Irure Maiques, Inmaculada Ramírez-Macías, María José Rosales, Ramón Guitierrez-Sánchez, Rocio Cañas, Manuel Sánchez-Moreno This work describes the isolation and structure elucidation of two new acylated quercetin tetraglycosides (compounds 1 and 2) from Delphinium gracile and their antiparasitic study with other twelve compounds from D. gracile (compounds 3–8), D. staphisagria (compound 9), Consolida oliveriana (compounds 10...
Source: Phytochemistry Letters - January 17, 2017 Category: Chemistry Source Type: research

Successes and pitfalls in automated dereplication strategy using liquid chromatography coupled to mass spectrometry data: A CASMI 2016 experience
Publication date: Available online 15 January 2017 Source:Phytochemistry Letters Author(s): Samuel Bertrand, Yann Guitton, Catherine Roullier Automated annotation of data, originating from liquid chromatography coupled to high-resolution mass spectrometry profiles (LC–HRMS), remains a highly challenging task. Therefore, the Critical Assessment of Small Molecule Identification (CASMI) Contest (http://casmi-contest.org/) represents a unique opportunity to blindly evaluate annotation workflows. The 2016 CASMI contest consisted of 16 LC–HRMS/MS profiles with 18 detected peaks to annotate. Those peaks corresponded ...
Source: Phytochemistry Letters - January 15, 2017 Category: Chemistry Source Type: research

Acridone alkaloids from Vepris verdoorniana (Excell & amp; Mendon ça) Mziray (Rutaceae)
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Albert Fouda Atangana, Flavien Aristide Alfred Toze, Moses K. Langat, Emmanuel Ngeufa Happi, Luc Leonard Meva’a Mbaze, Dulcie A. Mulholland, Alain François Kamdem Waffo, Norbert Sewald, Jean Duplex Wansi Two new acridone alkaloids, verdoocridone A (1) and B (4), together with fifteen known compounds were isolated from methanol extracts of the roots and leaves of Vepris verdoorniana. The structures of all compounds were determined by comprehensive spectroscopic analyses (1D and 2D NMR, EI- and ESI–MS). The 13C NMR values of ...
Source: Phytochemistry Letters - January 12, 2017 Category: Chemistry Source Type: research

Two new benzoyl glucuronosyl glycerols from the leaves of Garcinia buchananii Baker
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Timo D. Stark, Sofie Lösch, Onesmo B. Balemba, Thomas Hofmann Two new benzoyl glucuronosyl glycerols, (2R)-1-O-4-hydroxy-benzoyl-3-O-α-d-glucuronosyl glycerol (1) and (2S)-1-O-4-hydroxy-3-methoxy-benzoyl-3-O-α-d-glucuronosyl glycerol (2), together with helicioside (3), quercetin-6-C-β-d-glucopyranoside (4), apigenin-8-C-β-d-glucopyranosyl-2″-O-L-rhamnopyranoside (5), vitexin (6), (2R,3R)-aromadendrin-6-C-β- d-glucopyranoside and (2R,3R)-taxifolin-6-C-β- d-glucopyranoside were isolated and purified fr...
Source: Phytochemistry Letters - January 12, 2017 Category: Chemistry Source Type: research

Illigerones A and B, two new long-chain secobutanolides from Illigera henryi W. W. Sm.
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Xue-Jiao Li, Jian-Wei Dong, Le Cai, Jia-Peng Wang, Nen-Xiang Yu, Zhong-Tao Ding Two new long-chain secobutanolides, illigerones A (1) and B (2), together with five known compounds, actinodaphnine (3), cryptodorine (4), β-sitosterol (5), daucosterol (6), and stigmasterol (7) were isolated from Illigera henryi W. W. Sm. The structures of 1 and 2 were identified by HRESIMS, EIMS, 1D/2D NMR, and electronic circular dichroism (ECD) spectra. Compound 1 exhibited the moderate cytotoxic activities against five tumour cells. This is the first rep...
Source: Phytochemistry Letters - January 12, 2017 Category: Chemistry Source Type: research

Three new monoterpene glycosides from Sibiraea laevigata (L.) Maxim
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Jian-Qiang Zhao, Yan-Ming Wang, Qi-Lan Wang, Yun Shao, Yan-Ping Shi, Li-Juan Mei, Yan-Duo Tao Three new compounds, 3,7-dimethy-7-methoxy-3-octene-5-one-1-O-β-d-glucopyranoside (1), 3,7-dimethy-7-methoxy-3(Z)-octene-5-one-1-O-β-d-glucopyranoside (2) and 3,7-dimethy-3-hydroxy-6-octene-5-one-1-O-β-d-glucopyranoside (3), together with fourteen known compounds (4–17) were isolated from the leaves and shoots of S. laevigata. The structures of the new compounds were elucidated on the basis of extensive spectroscopic analysis, in...
Source: Phytochemistry Letters - January 9, 2017 Category: Chemistry Source Type: research

New tetraacetylated iridoid glycosides from Sambucus ebulus L. leaves
Publication date: Available online 7 January 2017 Source:Phytochemistry Letters Author(s): Kalina Alipieva, Svetlana Simova, Georgi Zahmanov, Shuaizhen Zhou, Jean-Luc Wolfender, Milen I. Georgiev Two new minor “Valeriana type” iridoid glycosides (1) and (2) along with 3 known flavonol glycosides [quercetin-3-O-β-glucopyranosyl-7-O-α-rhamnopyranoside (3), quercetin-3-O-β-glucopyranoside (4) and isorhamnetin-3-O-β-glucopyranoside (5)] were isolated from Sambucus ebulus L. leaves. Their structures were unambiguously elucidated by means of 1D- and 2D-NMR, and UPLC-TOF MS. Compound 2 is a rare ...
Source: Phytochemistry Letters - January 8, 2017 Category: Chemistry Source Type: research

Three new flavonoid glycosides from the aerial parts of Graptophyllum grandulosum Turril (Acanthaceae)
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Cyrille Ngoufack Tagousop, David Ngnokam, Dominique Harakat, Laurence Voutquenne-Nazabadioko Grandulosides A-C, three new flavonoid glycosides, were isolated from the aerial parts of Graptophyllum grandulosum Turill and identified as chrysoeriol-7-O-β-d-apiofuranosyl-(1→2)-β-d-xylopyranoside (1), chrysoeriol-7-O-[4′′′-O-acetyl-β-d-apiofuranosyl-(1→2)]-β-d-xylopyranoside (2) and 7-O-α-l-rhamnopyranosyl-(1→6)-β-d-(4′′-Sodium hydrogeno sulfate) glucopyranoside (3). Four ...
Source: Phytochemistry Letters - January 6, 2017 Category: Chemistry Source Type: research

Pyrrolo-isoquinoline and glycosylated pyrrolidine alkaloids from Nigella glandulifera and their anti-PTP1B activity
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Qi-Bin Chen, Xue-Lei Xin, Haji Akber Aisa Two new alkaloids, nigellisoquinomine (1) with a novel pyrrolo-isoquinoline skeleton, and nigellapyrrolidine (2) possessing a rare glycosylated pyrrolidine moiety, together with two known alkaloids, agrocybenine (3) and 4,6,6-trimethyl-3,4-epoxypiperidin-2-one (4), were isolated from the seeds of Nigella glandulifera Freyn. Their structures were identified by extensive NMR and HR-ESIMS analysis. Compound 1 exhibited potent protein tyrosine phosphatase 1B (PTP1B) inhibitory activity with an IC50 value ...
Source: Phytochemistry Letters - January 5, 2017 Category: Chemistry Source Type: research

Isolation, structural characterization and neuraminidase inhibitory activities of polyphenolic constituents from Flos caryophylli
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Zining He, Wenwen Lian, Jiawei Liu, Runsheng Zheng, Hui Xu, Guanhua Du, Ailin Liu Neuraminidase (NA) is one of the key surface proteins of the influenza virus, which is an important target for anti-influenza therapy. In the present study, bioassay-guided fractionation led to isolation of two new compounds, rhamnetin-3-O-β-d-glucuronide-6″-methyl ester (1) and rhamnazin-3-O-β-d-glucuronide-6″-methyl ester (2), along with seventeen known compounds (3-19), from the MeOH extract of Flos Caryophylli using in vitro NA inhibiti...
Source: Phytochemistry Letters - January 3, 2017 Category: Chemistry Source Type: research

Three new isobenzofurans from Lavandula angustifolia and their bioactivities
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Min Zhou, Huan-Huan Xing, Hang-Ying Ma, Lin Zhou, Yan Yang, Gan-Peng Li, Wei-Yao Hu, Qiang Liu, Xue-Mei Li, Qiu-Fen Hu Three new isobenzofurans, lavandulactones A–C (1–3), together with three known ones (4–6), were isolated from the whole herb of Lavandula angustifolia. Their structures were established on the basis of detailed spectroscopic analysis (1D- and 2D-NMR, HRESIMS, UV, and IR) and comparison with data reported in the literature. New isolates were evaluated for their anti-tobacco mosaic virus (TMV) activities and c...
Source: Phytochemistry Letters - January 3, 2017 Category: Chemistry Source Type: research

Selected latest applications of molecular spectroscopy in natural product analysis
Publication date: Available online 30 December 2016 Source:Phytochemistry Letters Author(s): Christian W. Huck The field of molecular vibrational spectroscopy applied to natural products is advancing extremely fast. Traditionally applied separation techniques (LC-, μ-LC–MS, GC, CE-MS) offer the advantages of high selectivity/sensitivity, but their application for routine quality control is limited due to long analyses times. Therefore, molecular spectroscopy in combination with multivariate analysis (MVA) enjoys excellent reputation, because of the fast and non-invasive measurement enabling the analysis of severa...
Source: Phytochemistry Letters - December 31, 2016 Category: Chemistry Source Type: research

Non-statistical isotope fractionation as a novel “retro-biosynthetic” approach to understanding alkaloid metabolic pathways
Publication date: Available online 30 December 2016 Source:Phytochemistry Letters Author(s): Richard J. Robins, Katarzyna M. Romek, Gérald S. Remaud, Piotr Paneth During the biosynthesis of natural products, isotope fractionation occurs due to the selectivity of enzymes for the heavier or lighter isotopomers. As only some of the positions in the molecule are implicated in a given reaction mechanism, position-specific fractionation occurs. Thus, the position-specific 13C/12C ratios in these compounds can be related to their known precursors and to the known isotope effects of enzymes involved in their biosynthesis, ...
Source: Phytochemistry Letters - December 31, 2016 Category: Chemistry Source Type: research

The influence of cytokinins on proliferation and polyphenol accumulation in shoot cultures of Scutellaria altissima L.
Publication date: Available online 30 December 2016 Source:Phytochemistry Letters Author(s): Izabela Grzegorczyk-Karolak, Łukasz Kuźma, Halina Wysokińska S. altissima shoots were cultivated on MS (Murashige and Skoog) solid medium supplemented with IAA (indole-3-acetic acid, 0.57μM) and various concentrations of cytokinin: zeatin, kinetin, BAP (6-benzylaminopurine) (1, 2, 4, 8μM) or TDZ (thidiazuron) (0.2, 0.5, 1μM). The effects on shoot proliferation and their accumulation of pharmacologically valuable phenolic compounds (baicalin, wogonoside, luteolin, luteolin-7-O-glucoside, verbascoside) were evaluated. Ul...
Source: Phytochemistry Letters - December 31, 2016 Category: Chemistry Source Type: research

Acetophenone glycosides from the roots of Euphorbia fischeriana and their inhibitory effects against Mycobacterium smegmatis
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Shan-Shan Huang, Ping Li, Bao-Jing Zhang, Sa Deng, Hou-Li Zhang, Cheng-Peng Sun, Xiao-Kui Huo, Xiang-Ge Tian, Xiao-Chi Ma, Chao Wang An extract of the Euphorbia fischerian root, used in the preparation of “Jieheling tablets” in China, exhibited bioactivity toward lymphoid tuberculosis and pulmonary tuberculosis. The present investigation identified three new acetophenone glycosides (1-3), and five known acetophenones (4-8). Materials were purified via chromatography and identified through spectroscopic analysis. Additionally, the ...
Source: Phytochemistry Letters - December 31, 2016 Category: Chemistry Source Type: research

The joint action in the bioactivity studies of Antarctic lichen Umbilicaria antarctica: Synergic-biodirected isolation in a preliminary holistic ecological study
Publication date: Available online 28 December 2016 Source:Phytochemistry Letters Author(s): Jose L.G. Galindo, Benito F. García, Ascensión Torres, Juan C.G. Galindo, Joanne G. Romagni, Francisco A. Macías Antarctica is one of the world’s most inaccessible regions. This area is also unique in that it has a terrestrial biota dominated by non-vascular plants, of which lichens and mosses are typically the dominant life-forms. A phytochemical study of Antarctic lichen (Umbilicaria antarctica) collected from maritime Antarctica has been carried out. The hexane, acetone and butanol extracts have been ...
Source: Phytochemistry Letters - December 29, 2016 Category: Chemistry Source Type: research

Phytochemical variations of Rhodiola rosea L. wild-grown in Bulgaria
In this study, we report on the application of NMR-based metabolomics (1D and 2D) combined with multivariate data analysis and an HPLC method development for quantitative determination of the metabolic differences in R. rosea rhizomes, roots and aerial parts from its natural habitat in Bulgaria. In the rhizomes the content of salidroside, rosarin, rosavin and rosin was 2.67%, 0.37%, 1.97% and 0.04%, respectively, while their respective amounts in the roots were 0.31%, 0.06%, 0.39% and 0.01%. Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - December 29, 2016 Category: Chemistry Source Type: research

Synthesis and cytotoxic effects of (E)-3-(2,3-dimethoxyphenyl)-1-(5-methylfuran-2-yl) prop-2-en-1-one in MDA-MB231 and MCF-7 breast cancer cell lines
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Muhammad Nadeem Akhtar, Landa Zeenelabdin Ali Salim, Swee Keong Yeap, Nadiah Abu, Seema Zareen, Kong Mun Lo, Addila abu Bakar, Noorjahan Banu Alitheen A chalcone derivative, (E)-3-(2,3-dimethoxyphenyl)-1-(5-methylfuran-2-yl)-prop-2-en-1-one (DMMF) was synthesized and evaluated against various cancerous cell lines including colon adenocarcinoma (HT-29), myloplasticleukemia (HL60), breast cancer (MCF-7 and MDA-MB231), normal hepatic cell (WRL-68) and normal breast cell (MCF-10A). The structure of DMMF was determined by EI-MS, 1H NMR and single ...
Source: Phytochemistry Letters - December 29, 2016 Category: Chemistry Source Type: research

Bioactive flavonoid glycosides from Whole Plants of Iris japonica
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Guo-Ru Shi, Xin Wang, Yan-Fei Liu, Chun-Lei Zhang, Gang Ni, Ruo-Yun Chen, De-Quan Yu Phytochemical investigation of the ethanol extract of whole plants of Iris japonica led to the isolation of three new and eight known analogues of flavonoid glycosides. The newly isolated structures were determined by spectroscopic and chemical methods as tectorigenin-7-O-β-d-glucopyranosyl (1→3)-O-β-d-glucopyranoside (1), tectorigenin-7-O-β-d-deoxyallopyranoside (2), and tectorigenin-7-O-β-d-quinovopyranoside (3). In addition, all of...
Source: Phytochemistry Letters - December 28, 2016 Category: Chemistry Source Type: research

Early developmental onset of alkaloid biosynthesis in Mexican poppy (Argemone mexicana L) Papaveraceae
Publication date: Available online 26 December 2016 Source:Phytochemistry Letters Author(s): Jorge F. Xool-Tamayo, Miriam Monforte-González, Jorge Rubio-Piña, Gumersindo Mirón-López, Felipe Vázquez-Flota The distribution of berberine and sanguinarine, two benzylisoquinolinic alkaloids, was analysed at early developmental phases in Argemone mexicana, including hypocotyls, cotyledonary seedlings and plantlets (displaying the first pair of true meristematic leaflets). Transcripts corresponding to genes involved in the synthesis of each of these alkaloids were also analysed. Even though most...
Source: Phytochemistry Letters - December 27, 2016 Category: Chemistry Source Type: research

An ELISA method to identify the phytotoxic Pseudomonas syringae pv. actinidiae exopolysaccharides: A tool for rapid immunochemical detection of kiwifruit bacterial canker
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Alessio Cimmino, Marco Iannaccone, Milena Petriccione, Marco Masi, Marco Evidente, Rosanna Capparelli, Marco Scortichini, Antonio Evidente The phytotoxic exopolysaccharides produced by Pseudomonas syringae pv. actinidiae, the causal agent of bacterial canker of kiwifruit, were isolated and partially identified. Their phytotoxic activity was evaluated on host and non-host plants and their role in the complex mechanisms of host-pathogen interaction was also discussed. The phytotoxic exopolysaccharides, which are natural antigens, were used to a...
Source: Phytochemistry Letters - December 27, 2016 Category: Chemistry Source Type: research

Cytotoxic and anti-oxidant biphenyl derivatives from the leaves and twigs of Garcinia multiflora
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Dong-Song Tian, Wei Gu, Li-Ping Wang, Lie-Jun Huang, Qing Rao, Tao Huang, Yan-Hui Fu, Jian-Xin Zhang, Chun-Mao Yuan, Xiao-Jiang Hao Three new biphenyl derivatives (1–3), together with five known compounds, were isolated from the leaves and twigs of Garcinia multiflora. Their structures were determined by extensive spectroscopic techniques including NMR spectroscopy and mass spectrometry. All eight isolates showed weak cytotoxicity on five human tumor cell lines. In addition, the three biphenyl derivatives showed moderate anti-oxidant ac...
Source: Phytochemistry Letters - December 27, 2016 Category: Chemistry Source Type: research

Medicago sativa as a source of secondary metabolites for agriculture and pharmaceutical industry
Publication date: Available online 24 December 2016 Source:Phytochemistry Letters Author(s): Katarzyna Rafińska, Paweł Pomastowski, Olga Wrona, Ryszard Górecki, Bogusław Buszewski Medicago sativa L. (lucerne or alfalfa) is a species which is generally regarded as a cheap source of valuable protein not only for animal fodder but also for nourishment provided in the poorest and developing countries. Moreover, this plant has a long tradition of use in folk medicine. Numerous studies indicate that besides protein, M. sativa synthesizes a variety of secondary metabolites. Among secondary metabolite classes produced b...
Source: Phytochemistry Letters - December 25, 2016 Category: Chemistry Source Type: research

Thaixylogranins A –H: eight new limonoids from the Thai mangrove, Xylocarpus granatum
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Minghua Liao, Patchara Pedpradab, Jun Wu Eight new limonoids named thaixylogranins A–H (1–8), including seven mexicanolides (1–3 and 5–8), were isolated from the seeds of a Thai mangrove, Xylocarpus granatum. The structures of these limonoids were established on the basis of HRESIMS and NMR spectroscopic data. Compounds 1–4 possess an 8α, 30α-epoxy ring, whereas compounds 5−8 have a C8C30 bond. Compounds 1–8 exhibited weak cytotoxicities against the MDA-MB-231 cell with IC50 values of 49.4...
Source: Phytochemistry Letters - December 24, 2016 Category: Chemistry Source Type: research

A window on cyclitols: Characterization and analytics of inositols
Publication date: Available online 22 December 2016 Source:Phytochemistry Letters Author(s): Hossam Al-Suod, Magdalena Ligor, Ileana-Andreea Rațiu, Katarzyna Rafińska, Ryszard Górecki, Bogusław Buszewski Cyclitols are cycloalkanes with one hydroxyl group on each of three or more ring atoms, also called cycloalkane polyols or sugar alcohol which attract attention since they have numerous pharmaceutical properties and are widespread in the plants. Inositols are important cyclitols, which constitute a group of naturally occurring polyhydric alcohols and some isomers of this group can be commonly found in most plant...
Source: Phytochemistry Letters - December 23, 2016 Category: Chemistry Source Type: research

New metabolites with cytotoxic and antiproliferative activities isolated from Bonellia macrocarpa
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Sara E. Vila-Luna, Rosa E. Moo-Puc, Luis W. Torres-Tapia, Sergio R. Peraza-Sánchez Five compounds were isolated from Bonellia macrocarpa roots: 1,3,5,6-tetramethoxy-8-methylnaphthalene (1), 3,5-dihydroxy-1,2,2-trimethyl-benzocyclobutane (2), 3-methoxy-5-octylphenol (3), 3-methoxy-2-methyl-5-pentylphenol (4), and protoprimulagenin A (5), being 1–3 new. Compound 5 showed the best effect, exhibiting cytotoxic activity on three of the cancer cell lines (HeLa, SiHa, and MCF-7) and antiproliferative activity against two cell lines (SiH...
Source: Phytochemistry Letters - December 22, 2016 Category: Chemistry Source Type: research

Variation in polyphenolic profile and in vitro antioxidant activity of eastern teaberry (Gaultheria procumbens L.) leaves following foliar development
Publication date: Available online 20 December 2016 Source:Phytochemistry Letters Author(s): Piotr Michel, Aleksandra Owczarek, Martyna Kosno, Daniel Gontarek, Magdalena Matczak, Monika A. Olszewska Seasonal dynamics in the polyphenolic composition, antioxidant activity, and their relationships during plant development were evaluated for eastern teaberry (Gaultheria procumbens L.) leaves, a traditional herbal medicine of North American natives. With the complementary UHPLC-PDA-ESI-MS 3 , HPLC-PDA-fingerprint, Folin-Ciocalteau, and n-butanol/HCl assays of methanol-water (75:25, v/v) extracts, the dried leaf samples harvest...
Source: Phytochemistry Letters - December 21, 2016 Category: Chemistry Source Type: research

Floral scent: Regulation and role of MYB transcription factors
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Mummadireddy Ramya, Oh Keun Kwon, Hye Ryun An, Pil Man Park, Yun Su Baek, Pue Hee Park Floral scent plays a vital role in reproduction, including attracting pollinators to ensure that fertilization occurs in several plants. In addition, floral scents are widely applied in perfumes, flavors, cosmetics and medicinal substances. Floral scents mediate ecological interactions and have a primary function of attracting visitors and pollinators. Due to the importance of floral scents in plant biology, basic research on flora scent through breeding te...
Source: Phytochemistry Letters - December 17, 2016 Category: Chemistry Source Type: research

Selective oxidation-reduction and esterification of asiatic acid by Pestalotiopsis microspora and anti-HCV activity
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Zhao-Hui Gao, Ran-Ran Gao, Xin-Ran Dong, Zhong-Mei Zou, Qi Wang, De-Min Zhou, Di-An Sun Microbial transformation of asiatic acid (AA) by an endophytic fungus, Pestalotiopsis microspora, yielded six metabolites: 2-oxo-3β,15α,23-trihydroxyurs-12-ene-28-oic acid (1); 2-oxo-3β,15α,22α,23-tetrahydroxyurs-12-ene-28-oic acid (2); 2-oxo-3β,15α,23,30-tetrahydroxyurs-12-ene-28-oic acid (3); 2α,3β,15α,23,30-pentahydroxyurs-12-ene-28-oic acid methyl ester (4); 2α,3α,15α,23-tetrahyd...
Source: Phytochemistry Letters - December 16, 2016 Category: Chemistry Source Type: research

Two new labdane diterpenoids and one new β-lactam from the aerial parts of Roylea cinerea
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Reena Sharma, Sona Mohammadi-Ostad-Kalayeh, Frank Stahl, Carsten Zeilinger, Gerald Dräger, Andreas Kirschning, P.C. Ravikumar Two new labdane diterpenoids cinereanoid C (1), cinereanoid D (2), a new β-lactam, cinerealactam E (3) as well as six known flavonoid glycosides (4–9) were isolated from the aerial parts of Roylea cinerea (Lamiaceae). The structures of (1–9) were all determined by MS, IR and NMR spectroscopy. The structure of cinereanoid D (2) was further proven by single crystal X-ray diffraction. Six known flavo...
Source: Phytochemistry Letters - December 15, 2016 Category: Chemistry Source Type: research

Diarylpropanes and lignans from Horsfieldia tetratepala
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Shou-Zhen Du, Zhi-Chong Wang, Ying Liu, Rui Zhan, Ye-Gao Chen Two new diarylpropanes (1–2), four known compounds, and a new artifact, were isolated from 70% aqueous acetone extract of the twigs of Horsfieldia tetratepala. Their structures were elucidated by spectroscopic analysis. Cytotoxicity evaluation against five cancer cell lines showed that none of these compounds was cytotoxic. Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - December 15, 2016 Category: Chemistry Source Type: research

2-Carboxy-dihydrostilbene and flavan glycosides from Desmodium heterocarpon
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Poolsak Sahakitpichan, Piyawadee Chadmuk, Nitirat Chimnoi, Anucha Namsa-aid, Somsak Ruchirawat, Tripetch Kanchanapoom A new 2-carboxy-dihydrostilbene glucoside, 2-carboxy-3,5,4′-trihydroxydihydrostilbene 3-O-β-d-glucopyranoside (1) and a new flavan diglycoside, (2S)-5,7,4′-trihydroxyflavan 7-O-β-d-apiofuranosyl-(1→6)-O-β-d-glucopyranoside (3) were isolated from the aerial portion of Thai origin Desmodium heterocarpon together with five known compounds, lunularic acid 4′-O-β-d-glucopyranoside (2), vit...
Source: Phytochemistry Letters - December 15, 2016 Category: Chemistry Source Type: research

Biotransformation of 20(R)-panaxatriol by Aspergillus niger AS 3.739
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Yan Song, Jie Li, Sensen Yan, Haijun Lin, Jianlin Li, Juanjuan Wu, Xuguang Zhai, Guangtong Chen Microbial transformation of 20(R)-panaxatriol (PT) was performed by using the fungus Aspergillus niger AS 3.739. Six metabolites (1–6) including five new compounds were obtained. The chemical structures of these transformed products were elucidated based on various spectroscopic analyses, including 1D and 2D NMR and HRESI-MS. Metabolites 2–6 are new compounds. Furthermore, metabolites 2, 3, 5, and 6 exhibited significant anti-hepatic fi...
Source: Phytochemistry Letters - December 14, 2016 Category: Chemistry Source Type: research

Sesquiterpenes and triterpenoids from the rhizomes of Alisma orientalis and their pancreatic lipase inhibitory activities
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Jian Cang, Chao Wang, Xiao-Kui Huo, Xiang-Ge Tian, Cheng-Peng Sun, Sa Deng, Bao-Jing Zhang, Hou-Li Zhang, Ke-Xin Liu, Xiao-Chi Ma Five new terpenoids, including three sesquiterpenes 11-hydroxy-8-ox-alismoxide (1), 11-oxo-13-nor-alismol (2), and 1β,11-dihydroxy-β-cyperone (3), and two protostane-type triterpenoids 16β-acetoxy alisol B (4) and 16α-acetoxy alisol B (5) were isolated from the rhizomes of Alisma orientalis together with 11 known compounds. Their structures were established using 1D and 2D NMR and HRESIMS spect...
Source: Phytochemistry Letters - December 14, 2016 Category: Chemistry Source Type: research

Using MS-FINDER for identifying 19 natural products in the CASMI 2016 contest
Publication date: Available online 9 December 2016 Source:Phytochemistry Letters Author(s): Arpana Vaniya, Stephanie N. Samra, Mine Palazoglu, Hiroshi Tsugawa, Oliver Fiehn In its fourth year, the CASMI 2016 contest was organized to evaluate current chemical structure identification strategies for 19 natural products using high-resolution LC–MS and LC–MS/MS challenge datasets using automated methods with or without the combination of other tools. These natural products originate from plants, fungi, marine sponges, algae, or micro-algae. Every compound annotation workflow must start with determination of elemen...
Source: Phytochemistry Letters - December 10, 2016 Category: Chemistry Source Type: research

Phytochemical and cytotoxic investigations of pinguisanoids from liverwort Porella cordaeana
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Choon Yong Tan, Masanori Inagaki, Hee-Byung Chai, Merve Karadeniz Lambrechts, Alev Önder, Hatice Özenoğlu Kiremit, Liva Harinantenaina Rakotondraibe Four new pinguisane derivatives, namely porellacetals A-D (1–4), alongside with two known compounds, phytol (5) and stigmasterol (6), were isolated from an ether extract of Porella cordaeana, guided by cytotoxicity assays against MCF-7, a human breast cancer cell line, and HT-29, a human colorectal cancer cell line. The structures of the isolated compounds were elucidated with th...
Source: Phytochemistry Letters - December 8, 2016 Category: Chemistry Source Type: research

Flavonol glycosides from the leaves of Boldoa purpurascens and their anti-inflammatory properties
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Yannarys Hernández Ortega, Kenn Foubert, Wim Vanden Berghe, Chandra Sekhar Chirumamilla, Luc Pieters, Dulce María González Mosquera, Sandra Apers Boldoa purpurascens is used in Latin America and the Caribbean as a potent diurectic. Phytochemical analysis has shown the presence of flavonoids and other active compounds. In the present work, three flavonol glycosides were isolated from the leaves of the plant. Their structures have been determined by mass spectrometry and by 1D and 2D NMR analysis as 6-methoxykaempferol-3-O-...
Source: Phytochemistry Letters - December 8, 2016 Category: Chemistry Source Type: research

Chemical solution is an efficient method to induce the formation of 2-(2-phenylethyl) chromone derivatives in Aquilaria sinensis
In this study, mechanical wounds, fungal elicitors and salt solution were applied to induce the formation of 2-(2-phenylethyl) chromones, which are the principal compounds in agarwood. In this research, chemical solution was the best inducer that could induce Aquilaria sinensis calli to produce the highest amount of chromones E and M at 79.20 and 41.62μgg−1, respectively. Chemical solution was then applied on three-year-old saplings by transfusion to verify its induction effect. Chromones E and M were detected in treated saplings after 15 d and then increased with increasing pruning time; their contents reached 22...
Source: Phytochemistry Letters - December 8, 2016 Category: Chemistry Source Type: research

Determination of phenolic compounds and diterpenes in roots of Salvia miltiorrhiza and Salvia przewalskii by two LC –MS tools: Multi-stage and high resolution tandem mass spectrometry with assessment of antioxidant capacity
Publication date: Available online 6 December 2016 Source:Phytochemistry Letters Author(s): Marcin Ożarowski, Anna Piasecka, Agnieszka Gryszczyńska, Aneta Sawikowska, Aurelia Pietrowiak, Bogna Opala, Przemysław Ł. Mikołajczak, Radosław Kujawski, Piotr Kachlicki, Waldemar Buchwald, Agnieszka Seremak-Mrozikiewicz Comparative phytochemical analyses of hydroalcoholic (50% EtOH) extracts from roots of S. miltiorrhiza (SM) and S. przewalskii (SP) were performed using two complementary LC–MS systems: the first system HPLC-DAD-MSn an ion trap mass spectrometer and the second system consisted high resolution MS/MS Orbi...
Source: Phytochemistry Letters - December 7, 2016 Category: Chemistry Source Type: research

Three new arylbenzofurans from Lavandula angustifolia and their bioactivities
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Shiyun Tang, Jianlian Shi, Chunbo Liu, Fengmei Zhang, Nengjun Xiang, Xin Liu, Yongkuan Chen, Junheng You, Qinpeng Shen, Mingming Miao, Zhihua Liu, Guangyu Yang Three new arylbenzofurans, 2-(7-methoxy-2-(4-methoxyphenyl)-3-methylbenzofuran-5-yl)ethanol (1), 4-(5-(2-hydroxyethyl)-7-methoxy-3-methylbenzofuran-2-yl)phenol (2), and 2-(6-methoxy-2-(4- methoxyphenyl)-3-methylbenzofuran-5-yl)ethanol (3), together with three known ones (4–6) were isolated from the whole plant of Lavandula angustifolia. Their structures were determined by means o...
Source: Phytochemistry Letters - December 7, 2016 Category: Chemistry Source Type: research

Three new labdane diterpenes from Loxocalyx urticifolius
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Min Zhao, Da-Le Guo, Lv-Yi Yuan, Yu-Cheng Gu, Lei Chen, Li-Sheng Ding, Yan Zhou Three new labdane diterpenes, namely loxocalyxin D (1), loxocalyxin E (2) and 13-epiloxocalyxin E (3), were isolated from the whole plants of Loxocalyx urticifolius Hemsl. Their structures were elucidated by extensive spectral analysis and chemical methods. The absolute configuration of loxocalyxin D (1) was confirmed by X-ray crystallographic analysis. The cytotoxic activities of the isolated labdane diterpenes were evaluated against the four human cancer cell li...
Source: Phytochemistry Letters - December 2, 2016 Category: Chemistry Source Type: research

Rhamnocitrin glycosides from Oxytropis chiliophylla
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Jun Wang, Yang Liu, Norbo Kelsang, Kewu Zeng, Hong Liang, Qingying Zhang, Pengfei Tu Repeated chromatography of the n-BuOH soluble fraction from ethanol extract of the aerial part of Oxytropis chiliophylla led to the isolation of six new rhamnocitrin glycosides, named oxychilioflavonosides A−F (1–6), together with eight known rhamnocitrin glycosides (7–14) of which six were isolated from the genus Oxytropis for the first time. The structures of these compounds were elucidated by extensive spectroscopic techniques and chemica...
Source: Phytochemistry Letters - November 30, 2016 Category: Chemistry Source Type: research