Direct analysis of Peucedanum palustre samples by desorption atmospheric pressure photoionization-mass spectrometry
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Teijo Yrjönen, Heikki Vuorela, Tiina J. Kauppila Desorption atmospheric pressure photoionization (DAPPI) is an ambient mass spectrometry (MS) technique that can be used for the analysis of polar and nonpolar compounds directly from surfaces. Here, the feasibility of DAPPI-MS in the screening of plant metabolites from dried Peucedanum palustre leaves and umbels was studied. DAPPI-MS requires no prior sample preparation or chromatographic separation, and the analysis can therefore be performed directly from the untreated plant material. P. ...
Source: Phytochemistry Letters - May 3, 2017 Category: Chemistry Source Type: research

Novel labdane diterpenoids from the aerial parts of Leonurus japonicus
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Yao Peng, Chuan Zheng, Ya-Nan Wang, Ou Dai Three new labdane diterpenoids, leojapones A–C (1–3), along with a new artifactual analogue (4) and four known terpenoids, were isolated from the EtOAc extract of the aerial parts of Leonurus japonicus Houtt. Their structures were elucidated by spectroscopic analyses and physicochemical evidences. The effects of new compounds against the abnormal increase in platelet aggregation induced by adenosine diphosphate were examined. But instead of inhibiting the abnormal platelet aggregation, com...
Source: Phytochemistry Letters - May 3, 2017 Category: Chemistry Source Type: research

Three new compounds from the roots of Juglans mandshurica Maxim.
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Jing Li, Ping-Sheng Xu, Zhen-Xing Zou, Hui Zou, Hong-Ping Long, Lei-Hong Tan, Rui-Huan Liu, Yi-Kun Wang, Kang-Ping Xu, Gui-Shan Tan A new biflavone glycoside juglbiflavone A (1) along with two new lupane-type triterpenes (2-3) were identified from the roots of Juglans mandshurica Maxim. Their structures and absolute configurations were elucidated by extensive spectroscopic methods including 1D/2D NMR, HRESIMS and CD. Compound 1 is the first example of biflavone glycoside consisted of a flavanol unit and a flavone unit from this genus, which al...
Source: Phytochemistry Letters - May 3, 2017 Category: Chemistry Source Type: research

New cytotoxic compounds from Myristica fatua Houtt leaves against MCF-7 cell lines
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Sofa Fajriah, Akhmad Darmawan, Megawati, Sumi Hudiyono, Soleh Kosela, Muhammad Hanafi Two novel compounds, (7S, 8R, 8′S, 7′S) 7,7′-bis(3-hydroxy-5-methoxyphenyl)-8,8′-dimethylbuthane-7,7′-diol, and 3”-hydroxydemethyldactyloidin were isolated from the leaves of Myristica fatua Houtt, and their structures were determined using spectroscopic techniques, including 2D NMR. Both compounds showed in vitro cytotoxic activity against the breast cancer cell line MCF-7, with IC50 of 26.19 and 8.33μM, respectively. G...
Source: Phytochemistry Letters - May 3, 2017 Category: Chemistry Source Type: research

Isoflavonoids and norneolignan from Caragana changduensis
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Lina Guo, Xuedong Yang, Xiaodong Sun, Xun Wu Two new isoflavonoids, named 6,7,2′-trihydroxy-4′-methoxyisoflavone (1), 7,3′-dimethoxy-5′-hydroxyisoflavone (2), one new norneolignan, named (8S)-2,4-dihydroxy-8-hydroxymethyl-4′-methoxydeoxybenzoin (3); together with six known compounds, methyl 4-hydroxylbenzoate (4), ethyl 4-hydroxybenzoate (5), piceatannol (6), cararosin A (7), 2,4-dihydroxybenzoate (8), and 6,7,4′-trihydroxyisoflavone (9) were isolated from the red heartwood in the rhizomes of Caragana changd...
Source: Phytochemistry Letters - May 3, 2017 Category: Chemistry Source Type: research

Absolute configuration of resveratrol oligomer glucosides isolated from the leaves of Upuna borneensis
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Tetsuro Ito, Hiromi Ito, Munekazu Iinuma A comprehensive investigation of the chemical constituents of the leaves of Upuna borneensis (Dipterocarpaceae) was performed. Three new glucosides of resveratrol oligomers having a pentameric aglycone [upunoside E (1)] and dimeric aglycones [upunosides F (3) and G (4)], as well as 14 resveratrol derivatives (2, 5–17), were isolated. The absolute configurations of the new compounds were elucidated by spectroscopic analysis, including two-dimensional NMR and CD spectra. Graphical abstract (Source: ...
Source: Phytochemistry Letters - May 3, 2017 Category: Chemistry Source Type: research

Two new diterpenoids from Aleuritopteris argentea
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Jian-chen Li, Xian-rui Yuan, Yong-li Liu, Ye Li, Ning-ning Cui, Li-li Li, Jing Ha Two new compounds were extracted and separated from the whole plant of Aleuritopteris argentea. The structures and absolute configurations of two compounds were characterized by UV, FT-IR, NMR, MS, and single-crystal X-ray diffraction. Compound 1 was determined to be 2, 17-diol (2β, 4α)-15,16-ene-beyerane diterpenoid and compound 2 to be 2,18-diol (2β, 4α)-16-ene-ent-kaurane diterpenoid, named aleuritopsis A and aleuritopsis B respectively. ...
Source: Phytochemistry Letters - May 3, 2017 Category: Chemistry Source Type: research

Bioactive mexicanolide-type limonoids from the fruits of Trichilia connaroides
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): A-Hong Chen, Qing Wen, Yan-Lei Ma, Zhi-Hua Jiang, Qing-Long Liu, Jin-Ying Tang, Wei Xu, Yan-Ping Liu, Yan-Hui Fu Two new mexicanolide-type limonoids, trichiconnarones A (1) and B (2), along with six known analogues (3–8), were isolated from the fruits of Trichilia connaroides. The structures of 1 and 2 were elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons their data with those reported in the literatures. All new compounds were evaluated for their anti-inflammatory activities via examin...
Source: Phytochemistry Letters - May 3, 2017 Category: Chemistry Source Type: research

In vitro enzyme inhibitory properties, antioxidant activities, and phytochemical profile of Potentilla thuringiaca
Publication date: Available online 11 March 2017 Source:Phytochemistry Letters Author(s): Daniel M. Grochowski, Sengul Uysal, Abdurrahman Aktumsek, Sebastian Granica, Gokhan Zengin, Ramazan Ceylan, Marcello Locatelli, Michał Tomczyk The genus Potentilla is interesting for the pharmaceutical field due to its valuable medicinal properties, which have been observed in complementary and alternative medicine. In recent years, studies conducted to estimate the biological activity of several of the Potentilla species have shown a wide spectrum of therapeutic properties. In particular, in the present paper, different extracts ob...
Source: Phytochemistry Letters - March 11, 2017 Category: Chemistry Source Type: research

Drimane-type sesquiterpenoids from cultures of the fungus Xylaria polymorpha
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Ning Ning Yang, Fan Dong Kong, Qing Yun Ma, Sheng Zhuo Huang, Du Qiang Luo, Li Man Zhou, Hao Fu Dai, Zhi Fang Yu, You Xing Zhao Three new drimane-type sesquiterpenoids named xylariaines A–C (1–3), together with one known analogue (4), were isolated from the ethyl acetate extract of cultures of the fungus Xylaria polymorpha (Pers.: Fr.) Grer. Their structures were elucidated unambiguously by NMR and single-crystal X-ray diffraction analysis. Compounds 1 and 2 exhibited weak anti-acetylcholinesterase activities at a concentration of ...
Source: Phytochemistry Letters - March 11, 2017 Category: Chemistry Source Type: research

Two new γ-lactones from the cultures of basidiomycete Lenzites betulinus
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Chun-Nan Wen, He-Ping Chen, Zhen-Zhu Zhao, Dong-Bao Hu, Zheng-Hui Li, Tao Feng, Ji-Kai Liu Betulactones A (1) and B (2) were isolated from the cultures of basidiomycete Lenzites betulinus. Betulactone A (1) was a novel highly oxygenated rigid spiro-γ-lactone with the 5/5/6 ring system rarely found in fungal sources while betulactone B (2) was a highly degraded sterol. These structures were elucidated by extensive spectroscopic methods and computational ECD analysis. Compounds 1 and 2 were evaluated for their inhibitory activity of protei...
Source: Phytochemistry Letters - March 10, 2017 Category: Chemistry Source Type: research

Lignan glycosides from the Rhizomes of Smilax trinervula and their Biological activities
Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Jicheng Shu, Fang Liang, Genhua Zhu, Xing Liu, Jiangli Yu, Huilian Huang Phytochemical investigation of the rhizomes of Smilax trinervula led to isolation and structure elucidation of eight lignan glycosides, including five new lignans, namely, (7S, 8R, 8′R)-4, 4′, 9-trihydroxy-3, 3′, 5, 5′-tetramethoxy-7, 9′-epoxylignan-7′-one 4′-O-β-d-glucopyranoside (1), (7S, 8R, 8′R)-4, 4′, 9-trihydroxy-3, 3′, 5, 5′-tetramethoxy-7, 9′-epoxylignan-7′-one 4-O-β-d- glucopy...
Source: Phytochemistry Letters - March 9, 2017 Category: Chemistry Source Type: research

Optimization of extraction method for LC –MS based determination of phenolic acid profiles in different Impatiens species
Publication date: Available online 6 March 2017 Source:Phytochemistry Letters Author(s): Katarzyna Szewczyk, Marta Olech The main aim of presented study was the comparison of various extraction methods for the quantitative and qualitative analysis (LC-ESI–MS/MS) of phenolic acids present in extracts obtained from leaves, flowers, and roots of Impatiens glandulifera. The accelerated solvent extraction (ASE) at three temperature ranges (80°C, 100°C, and 120°C), ultrasound assisted extraction (USAE) at 60°C, and traditional extraction in Soxhlet apparatus were used. Taking into account the extraction yi...
Source: Phytochemistry Letters - March 7, 2017 Category: Chemistry Source Type: research

Two new alkaloid metabolites produced by endophytic fungus Stagonosporopsis oculihominis isolated from Dendrobium huoshanense
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Yang Yu, Bing-ji Ma, Jin-song Liu, Jing-yi Yue, He-ping Chen, Yi-min Liang, Zhong-yu Zhou, Guo-kai Wang, Gang Wang Two new alkaloids (1–2), together with six known compounds (3–8), were isolated from cultures of the endophytic fungus Stagonosporopsis oculihominis. Their structures were elucidated through extensive spectroscopic methods including 2D NMR and HRMS analyses. The absolute configurations of 1 was determined by the comparison of experimental and theoretical electronic circular dichroism spectra. The new compounds were in...
Source: Phytochemistry Letters - February 27, 2017 Category: Chemistry Source Type: research

Comparative metabolomic study between African and Amazonian Symphonia globulifera by tandem LC –HRMS
This study highlights the relatively restrict phytochemical knowledge of Symphonia globulifera, a species with potent therapeutic metabolites and thus, allow faster phytochemical mapping for further isolation. Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - February 24, 2017 Category: Chemistry Source Type: research

Two new pyrrole derivatives isolated from Salacia amplifolia Merr
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Fengyan Yao, Yanhong Chen, Yitan Zou, Quanzhi Ye, Shanshan Lv, Wansheng Chen, Lingxiao Liang, Lianna Sun Two new pyrrole derivatives Salaciamole (1), Salaciaglycoside A (2), long with one known compound 1H-pyrrole-3-carboxylic acid (3) were isolated from the roots of Salacia amplifolia Merr (Hippocrateaceae). The structures of the new compounds were deduced from their comprehensive spectroscopic analysis including IR, HR-EI-MS, 1H NMR, 13C NMR, DEPT, COSY, HMBC and HMQC. And the structure of the known compound was identified by comparison of ...
Source: Phytochemistry Letters - February 21, 2017 Category: Chemistry Source Type: research

Two Stemona alkaloids from Stemona sessilifolia (Miq.) Miq.
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Jian-Li Dong, Zhong-Duo Yang, Shuang-Yan Zhou, Hai-Tao Yu, Xiao-Jun Yao, Hong-Yan Xue, Zong-Mei Shu Two new alkaloids, named dehydrostenine A (1) and B (2), were isolated from the roots of Stemona sessilifolia (Miq.) Miq. Their structures were elucidated by comprehensive NMR spectroscopy and X-ray single-crystal diffraction experiment. Anti-acetylcholinesterase activities of compounds 1 and 2 were also tested, but did not show significant activity. Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - February 20, 2017 Category: Chemistry Source Type: research

Plebeins A-F, sesquiterpenoids and diterpenoids from Salvia plebeian
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Cheng-Gang Zhang, Min-Rong Jin, Gui-Xin Chou, Qing-Shan Yang Plebein A (1), a sesquiterpenoid with a novel skeleton and another sesquiterpenoid, plebein B (2), and four new diterpenoids plebeins C-F (4–7), along with six known compounds were isolated from the whole plant of Salvia plebeia R. Br. The absolute configuration of 2 was established by an X-ray crystallographic study. In addition, compounds 4, 6 and 9 showed anti-proliferative activity against CaCo2 and MCF-7 cell lines, with IC50 values ranging from 9.65μM to 45.96μM. G...
Source: Phytochemistry Letters - February 17, 2017 Category: Chemistry Source Type: research

Synthesis and anti-inflammatory activities of 1-O-acetylbritannilactone analogues
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Xiao-Peng Wei, Yu-Fen Chen, Hong Zhu, Xiao-Ran Wu, Yang Yu, De-Xin Kong, Hong-Quan Duan, Mei-Hua Jin, Nan Qin Natural product 1-O-acetylbritannilactone (ABL) is a major sesquiterpene in Inula Britannica and Inula Japonica. To investigate the chemistry properties of ABL, 12 analogues were synthesized. Compound 1, a new 6-deoxybrintanilactone with a methylene at C-14 position, was characterized by 1D, 2D NMR and HR-MS spectrum. The studies of anti-inflammatory activities showed that compounds 1 and 4 exhibited significant inhibitory effects on ...
Source: Phytochemistry Letters - February 15, 2017 Category: Chemistry Source Type: research

Antiviral activity of Faramea bahiensis leaves on dengue virus type-2 and characterization of a new antiviral flavanone glycoside
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Adriana C. Nascimento, Ligia M.M. Valente, Mário Gomes, Rodolfo S. Barboza, Thiago Wolff, Rômulo L.S. Neris, Camila M. Figueiredo, Iranaia Assunção-Miranda Dengue virus infection is a neglected disease prevalent in most tropical and subtropical areas. Currently there is no any antiviral drug indicated for the routine treatment of dengue patients. As part of our ongoing search for potential anti-dengue virus agents we have investigated the methanol extract of Faramea bahiensis (Rubiaceae) leaves. This species is ende...
Source: Phytochemistry Letters - February 15, 2017 Category: Chemistry Source Type: research

Caulerpenyne from Caulerpa taxifolia: A comparative study between CPC and classical chromatographic techniques
Publication date: Available online 13 February 2017 Source:Phytochemistry Letters Author(s): Estelle Sfecci, Céline Le Quemener, Thierry Lacour, Lionel Massi, Philippe Amade, Grégoire Audo, Mohamed Mehiri Caulerpenyne (Cyn) is a cytotoxic compound firstly isolated in 1978 from Caulerpa prolifera. This metabolite, constituted by a highly reactive diacetoxybutadiene moiety, exhibited a wide range of biological properties with mainly antibacterial properties and antitumoral activities. Few structure–activity relationships (SAR) are available to design more potent bioactive derivatives by pharmacomodulatio...
Source: Phytochemistry Letters - February 13, 2017 Category: Chemistry Source Type: research

C-glycosylflavone with rotational isomers from Vaccaria hispanica (Miller) Rauschert seeds
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Guohong Zhou, Hongwei Wu, Ting Wang, Rixin Guo, Jing Xu, Qiong Zhang, Liying Tang, Zhuju Wang Five C-glycosylflavone were isolated from Vaccaria hispanica (Miller) Rauschert seeds. Their NMR spectra showed separate signals because of the existence of rotational isomers, which is an unusual phenomenon. The spectroscopic data revealed that compounds 1–5 were identified as apigenin 6-C-[α-l-arabinopyranosyl-(1′′′→2′′)-β-d-glucopyranosyl]-7-O-β-d-glucopyranoside (1), apigenin 6-C-[α-l...
Source: Phytochemistry Letters - February 13, 2017 Category: Chemistry Source Type: research

Two new C11-terpenes with an octahydrobenzofuran skeleton isolated from the leaves of Ficus nota
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Felmer S. Latayada, Mylene M. Uy, Yui Akihara, Emi Ohta, Shinji Ohta Two new C11-terpenes with an octahydrobenzofuran skeleton, designated ficusnotadiol (1) and ficusnotanone (2), have been isolated from the plant Ficus nota. Their structures were elucidated on the basis of spectroscopic data. The absolute structure of 1 was determined by X-ray crystallographic analysis. The isolated compounds were evaluated for their antibacterial activity against Bacillus subtilis. Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - February 12, 2017 Category: Chemistry Source Type: research

New insight into the flavonoid composition of Chenopodium botrys
Publication date: Available online 11 February 2017 Source:Phytochemistry Letters Author(s): D. Bojilov, S. Dagnon, I. Ivanov Due to their beneficial medicinal effects, in recent years there has been an increasing interest in the research of flavonoids in plant sources. In the conducted research the flavonoid composition of Chenopodium botrys was defined by applying an approach which included different extraction procedures and methods of detection. Primary extraction of polyphenols with two different solvents, HPLC-PDA fingerprint profiling and an Orbitrap UHPLC-MS/MS detection were used. The fingerprint profile of polyp...
Source: Phytochemistry Letters - February 11, 2017 Category: Chemistry Source Type: research

Two new guaiane sesquiterpenes from Datura metel L. with anti-inflammatory activity
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Nguyen Thi Mai, Nguyen Thi Cuc, Hoang Le Tuan Anh, Nguyen Xuan Nhiem, Bui Huu Tai, Pham Hai Yen, Tran Hong Quang, Chau Van Minh, Kwan Woo Kim, Youn-Chul Kim, Hyuncheol Oh, Phan Van Kiem Chemical investigation of an acidic methanol extract of the whole plants of Datura metel resulted in the isolation of two new guainane sesquiterpenes, 1β,5α,7β-guaiane-4β,10α,11-triol (1) and 1α,5α,7α-11-guaiene-2α,3β,4α,10α,13-pentaol (2), along with eight known compounds: pterodontriol B (3)...
Source: Phytochemistry Letters - February 11, 2017 Category: Chemistry Source Type: research

HPLC-DAD analysis of arbutin produced from hydroquinone in a biotransformation process in Origanum majorana L. shoot culture
Publication date: Available online 10 February 2017 Source:Phytochemistry Letters Author(s): Ewa Skrzypczak-Pietraszek, Inga Kwiecień, Agnieszka Gołdyn, Jacek Pietraszek The hydroquinone glucoside arbutin is a plant derived compound medically applied due to its uroantiseptic activity. It also has skin whitening properties and thus is widely used in dermatology and cosmetology. Origanum majorana L. (Lamiaceae) is known to produce arbutin, however the content of the compound in cultivated plants is very variable and low. Since plant cell and tissue cultures are capable to perform specific biotransformation reactions inclu...
Source: Phytochemistry Letters - February 10, 2017 Category: Chemistry Source Type: research

Three new flavonoids from Millettia pachyloba
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Zhi Na, Qing-Fei Fan, Qi-Shi Song, Hua-Bin Hu Two new prenylated isoflavones, pachyloisoflavone A (1), pachyloisoflavone B (2), and a new pterocarpan, pachylobin A (3), together with ten known flavonoids (4–13), were isolated from the vine stems and leaves of Millettia pachyloba. The structures of new compounds were elucidated on the basis of extensive spectroscopic data interpretation, including 1D, 2D NMR and HREIMS. The absolute configuration of 2 was established by the comparison of experimental and calculated electronic circular di...
Source: Phytochemistry Letters - February 10, 2017 Category: Chemistry Source Type: research

New prenylated dihydrochalcones from the leaves of Artocarpus elasticus
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Mareena Daus, Prakit Chaithada, Souwalak Phongpaichit, Ramida Watanapokasin, Anthony R. Carroll, Wilawan Mahabusarakam The leaves of Artocarpus elasticus collected in Thailand were investigated for chemical constituents. Four new prenylated dihydrochalcones named elastichalcones C, D, E, F (1, 3, 5, 6) together with elastichalcone B (2) and artocarpanone (4) were isolated. Their structures were determined from analysis of spectroscopic data. Elastichalcone C (1) exhibited good antibacterial activity and cytotoxicity. Graphical abstract (Sourc...
Source: Phytochemistry Letters - February 10, 2017 Category: Chemistry Source Type: research

Optimisation of preparative HPLC separation of four isomeric kaempferol diglycosides from Prunus spinosa L. by application of the response surface methodology
Publication date: Available online 5 February 2017 Source:Phytochemistry Letters Author(s): Aleksandra Owczarek, Anna Magiera, Magdalena Matczak, Dorota Gabriela Piotrowska, Monika Anna Olszewska, Anna Marchelak A fast and efficient preparative HPLC-PDA method was developed for the separation and isolation of four rare isomeric kaempferol diglycosides from leaves of Prunus spinosa L. The separation procedure of the enriched diglycoside fraction of the 70% (v/v) aqueous methanolic leaf extract was first optimised on analytical XBridge C18 column (100mm×4.6mm i.d., 5μm) and central composite design combined with re...
Source: Phytochemistry Letters - February 6, 2017 Category: Chemistry Source Type: research

CASMI 2016: A manual approach for dereplication of natural products using tandem mass spectrometry
Publication date: Available online 4 February 2017 Source:Phytochemistry Letters Author(s): Dejan Nikolić The Critical Assessment of Small Molecule Identification (CASMI) contest is an initiative designed as an unbiased test of manual and automated strategies for the identification of small molecules from raw mass spectrometric data. In this contest, the participants are provided a set of high resolution MS and MS/MS data and asked to identify the unknown structure. CASMI 2016 is the fourth round of this contest in which the author participated in Category 1: Best Identification of Natural Products using a manual approac...
Source: Phytochemistry Letters - February 4, 2017 Category: Chemistry Source Type: research

Biotransformation of capsaicin by Penicillium janthinellum AS 3.510
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Xiu-Lan Xin, Yan Wang, Guang-Jun Fan, Liang Chen, Cheng-Peng Sun Biocatalysis of capsaicin (1) was performed by Penicillium janthinellum AS 3.510. Nine metabolites including four new compounds were afforded, and their structures were elucidated as (8S)-trans-8-hydroxy-8-hydroxymethyl-N-vanillyl-6-nonenamide (2), 6-hydroxy-8-methyl-N-vanillyl-7-nonenamide (3), trans-8-methoxy-8-methyl-N-vanillyl-6-nonenamide (4), 6-methoxy-8-methyl-N-vanillyl-7-nonenamide (5), dihydrocapsaicin (6), ω-1-hydroxydihydrocapsaicin (7), ω-1-hydroxycapsai...
Source: Phytochemistry Letters - February 3, 2017 Category: Chemistry Source Type: research

Characterization of Hypericum perforatum L. (St. John ’s wort) macerates prepared with different fatty oils upon processing and storage
Publication date: Available online 16 January 2017 Source:Phytochemistry Letters Author(s): Miriam Heinrich, Veronika Vikuk, Rolf Daniels, Florian C. Stintzing, Dietmar R. Kammerer Hypericum perforatum L. (St. John’s wort, SJW) is a traditional medicinal plant with a long history of pharmaceutical application. Today, besides formulations based on hydro-alcoholic extracts, lipophilic SJW preparations are widely used in phytomedicine e.g. for the symptomatic treatment of minor inflammations of the skin and subcutaneous tissue disorders. In the present study, SJW extracts were obtained with twelve different fatty oils ...
Source: Phytochemistry Letters - January 17, 2017 Category: Chemistry Source Type: research

Antitrypanosomatid activity of flavonoid glycosides isolated from Delphinium gracile, D. staphisagria, Consolida oliveriana and from Aconitum napellus subsp. Lusitanicum
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Clotilde Marín, Jesús G. Díaz, David Irure Maiques, Inmaculada Ramírez-Macías, María José Rosales, Ramón Guitierrez-Sánchez, Rocio Cañas, Manuel Sánchez-Moreno This work describes the isolation and structure elucidation of two new acylated quercetin tetraglycosides (compounds 1 and 2) from Delphinium gracile and their antiparasitic study with other twelve compounds from D. gracile (compounds 3–8), D. staphisagria (compound 9), Consolida oliveriana (compounds 10...
Source: Phytochemistry Letters - January 17, 2017 Category: Chemistry Source Type: research

Successes and pitfalls in automated dereplication strategy using liquid chromatography coupled to mass spectrometry data: A CASMI 2016 experience
Publication date: Available online 15 January 2017 Source:Phytochemistry Letters Author(s): Samuel Bertrand, Yann Guitton, Catherine Roullier Automated annotation of data, originating from liquid chromatography coupled to high-resolution mass spectrometry profiles (LC–HRMS), remains a highly challenging task. Therefore, the Critical Assessment of Small Molecule Identification (CASMI) Contest (http://casmi-contest.org/) represents a unique opportunity to blindly evaluate annotation workflows. The 2016 CASMI contest consisted of 16 LC–HRMS/MS profiles with 18 detected peaks to annotate. Those peaks corresponded ...
Source: Phytochemistry Letters - January 15, 2017 Category: Chemistry Source Type: research

Acridone alkaloids from Vepris verdoorniana (Excell & amp; Mendon ça) Mziray (Rutaceae)
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Albert Fouda Atangana, Flavien Aristide Alfred Toze, Moses K. Langat, Emmanuel Ngeufa Happi, Luc Leonard Meva’a Mbaze, Dulcie A. Mulholland, Alain François Kamdem Waffo, Norbert Sewald, Jean Duplex Wansi Two new acridone alkaloids, verdoocridone A (1) and B (4), together with fifteen known compounds were isolated from methanol extracts of the roots and leaves of Vepris verdoorniana. The structures of all compounds were determined by comprehensive spectroscopic analyses (1D and 2D NMR, EI- and ESI–MS). The 13C NMR values of ...
Source: Phytochemistry Letters - January 12, 2017 Category: Chemistry Source Type: research

Two new benzoyl glucuronosyl glycerols from the leaves of Garcinia buchananii Baker
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Timo D. Stark, Sofie Lösch, Onesmo B. Balemba, Thomas Hofmann Two new benzoyl glucuronosyl glycerols, (2R)-1-O-4-hydroxy-benzoyl-3-O-α-d-glucuronosyl glycerol (1) and (2S)-1-O-4-hydroxy-3-methoxy-benzoyl-3-O-α-d-glucuronosyl glycerol (2), together with helicioside (3), quercetin-6-C-β-d-glucopyranoside (4), apigenin-8-C-β-d-glucopyranosyl-2″-O-L-rhamnopyranoside (5), vitexin (6), (2R,3R)-aromadendrin-6-C-β- d-glucopyranoside and (2R,3R)-taxifolin-6-C-β- d-glucopyranoside were isolated and purified fr...
Source: Phytochemistry Letters - January 12, 2017 Category: Chemistry Source Type: research

Illigerones A and B, two new long-chain secobutanolides from Illigera henryi W. W. Sm.
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Xue-Jiao Li, Jian-Wei Dong, Le Cai, Jia-Peng Wang, Nen-Xiang Yu, Zhong-Tao Ding Two new long-chain secobutanolides, illigerones A (1) and B (2), together with five known compounds, actinodaphnine (3), cryptodorine (4), β-sitosterol (5), daucosterol (6), and stigmasterol (7) were isolated from Illigera henryi W. W. Sm. The structures of 1 and 2 were identified by HRESIMS, EIMS, 1D/2D NMR, and electronic circular dichroism (ECD) spectra. Compound 1 exhibited the moderate cytotoxic activities against five tumour cells. This is the first rep...
Source: Phytochemistry Letters - January 12, 2017 Category: Chemistry Source Type: research

Three new monoterpene glycosides from Sibiraea laevigata (L.) Maxim
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Jian-Qiang Zhao, Yan-Ming Wang, Qi-Lan Wang, Yun Shao, Yan-Ping Shi, Li-Juan Mei, Yan-Duo Tao Three new compounds, 3,7-dimethy-7-methoxy-3-octene-5-one-1-O-β-d-glucopyranoside (1), 3,7-dimethy-7-methoxy-3(Z)-octene-5-one-1-O-β-d-glucopyranoside (2) and 3,7-dimethy-3-hydroxy-6-octene-5-one-1-O-β-d-glucopyranoside (3), together with fourteen known compounds (4–17) were isolated from the leaves and shoots of S. laevigata. The structures of the new compounds were elucidated on the basis of extensive spectroscopic analysis, in...
Source: Phytochemistry Letters - January 9, 2017 Category: Chemistry Source Type: research

New tetraacetylated iridoid glycosides from Sambucus ebulus L. leaves
Publication date: Available online 7 January 2017 Source:Phytochemistry Letters Author(s): Kalina Alipieva, Svetlana Simova, Georgi Zahmanov, Shuaizhen Zhou, Jean-Luc Wolfender, Milen I. Georgiev Two new minor “Valeriana type” iridoid glycosides (1) and (2) along with 3 known flavonol glycosides [quercetin-3-O-β-glucopyranosyl-7-O-α-rhamnopyranoside (3), quercetin-3-O-β-glucopyranoside (4) and isorhamnetin-3-O-β-glucopyranoside (5)] were isolated from Sambucus ebulus L. leaves. Their structures were unambiguously elucidated by means of 1D- and 2D-NMR, and UPLC-TOF MS. Compound 2 is a rare ...
Source: Phytochemistry Letters - January 8, 2017 Category: Chemistry Source Type: research

Three new flavonoid glycosides from the aerial parts of Graptophyllum grandulosum Turril (Acanthaceae)
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Cyrille Ngoufack Tagousop, David Ngnokam, Dominique Harakat, Laurence Voutquenne-Nazabadioko Grandulosides A-C, three new flavonoid glycosides, were isolated from the aerial parts of Graptophyllum grandulosum Turill and identified as chrysoeriol-7-O-β-d-apiofuranosyl-(1→2)-β-d-xylopyranoside (1), chrysoeriol-7-O-[4′′′-O-acetyl-β-d-apiofuranosyl-(1→2)]-β-d-xylopyranoside (2) and 7-O-α-l-rhamnopyranosyl-(1→6)-β-d-(4′′-Sodium hydrogeno sulfate) glucopyranoside (3). Four ...
Source: Phytochemistry Letters - January 6, 2017 Category: Chemistry Source Type: research

Pyrrolo-isoquinoline and glycosylated pyrrolidine alkaloids from Nigella glandulifera and their anti-PTP1B activity
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Qi-Bin Chen, Xue-Lei Xin, Haji Akber Aisa Two new alkaloids, nigellisoquinomine (1) with a novel pyrrolo-isoquinoline skeleton, and nigellapyrrolidine (2) possessing a rare glycosylated pyrrolidine moiety, together with two known alkaloids, agrocybenine (3) and 4,6,6-trimethyl-3,4-epoxypiperidin-2-one (4), were isolated from the seeds of Nigella glandulifera Freyn. Their structures were identified by extensive NMR and HR-ESIMS analysis. Compound 1 exhibited potent protein tyrosine phosphatase 1B (PTP1B) inhibitory activity with an IC50 value ...
Source: Phytochemistry Letters - January 5, 2017 Category: Chemistry Source Type: research

Isolation, structural characterization and neuraminidase inhibitory activities of polyphenolic constituents from Flos caryophylli
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Zining He, Wenwen Lian, Jiawei Liu, Runsheng Zheng, Hui Xu, Guanhua Du, Ailin Liu Neuraminidase (NA) is one of the key surface proteins of the influenza virus, which is an important target for anti-influenza therapy. In the present study, bioassay-guided fractionation led to isolation of two new compounds, rhamnetin-3-O-β-d-glucuronide-6″-methyl ester (1) and rhamnazin-3-O-β-d-glucuronide-6″-methyl ester (2), along with seventeen known compounds (3-19), from the MeOH extract of Flos Caryophylli using in vitro NA inhibiti...
Source: Phytochemistry Letters - January 3, 2017 Category: Chemistry Source Type: research

Three new isobenzofurans from Lavandula angustifolia and their bioactivities
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Min Zhou, Huan-Huan Xing, Hang-Ying Ma, Lin Zhou, Yan Yang, Gan-Peng Li, Wei-Yao Hu, Qiang Liu, Xue-Mei Li, Qiu-Fen Hu Three new isobenzofurans, lavandulactones A–C (1–3), together with three known ones (4–6), were isolated from the whole herb of Lavandula angustifolia. Their structures were established on the basis of detailed spectroscopic analysis (1D- and 2D-NMR, HRESIMS, UV, and IR) and comparison with data reported in the literature. New isolates were evaluated for their anti-tobacco mosaic virus (TMV) activities and c...
Source: Phytochemistry Letters - January 3, 2017 Category: Chemistry Source Type: research

Selected latest applications of molecular spectroscopy in natural product analysis
Publication date: Available online 30 December 2016 Source:Phytochemistry Letters Author(s): Christian W. Huck The field of molecular vibrational spectroscopy applied to natural products is advancing extremely fast. Traditionally applied separation techniques (LC-, μ-LC–MS, GC, CE-MS) offer the advantages of high selectivity/sensitivity, but their application for routine quality control is limited due to long analyses times. Therefore, molecular spectroscopy in combination with multivariate analysis (MVA) enjoys excellent reputation, because of the fast and non-invasive measurement enabling the analysis of severa...
Source: Phytochemistry Letters - December 31, 2016 Category: Chemistry Source Type: research

Non-statistical isotope fractionation as a novel “retro-biosynthetic” approach to understanding alkaloid metabolic pathways
Publication date: Available online 30 December 2016 Source:Phytochemistry Letters Author(s): Richard J. Robins, Katarzyna M. Romek, Gérald S. Remaud, Piotr Paneth During the biosynthesis of natural products, isotope fractionation occurs due to the selectivity of enzymes for the heavier or lighter isotopomers. As only some of the positions in the molecule are implicated in a given reaction mechanism, position-specific fractionation occurs. Thus, the position-specific 13C/12C ratios in these compounds can be related to their known precursors and to the known isotope effects of enzymes involved in their biosynthesis, ...
Source: Phytochemistry Letters - December 31, 2016 Category: Chemistry Source Type: research

The influence of cytokinins on proliferation and polyphenol accumulation in shoot cultures of Scutellaria altissima L.
Publication date: Available online 30 December 2016 Source:Phytochemistry Letters Author(s): Izabela Grzegorczyk-Karolak, Łukasz Kuźma, Halina Wysokińska S. altissima shoots were cultivated on MS (Murashige and Skoog) solid medium supplemented with IAA (indole-3-acetic acid, 0.57μM) and various concentrations of cytokinin: zeatin, kinetin, BAP (6-benzylaminopurine) (1, 2, 4, 8μM) or TDZ (thidiazuron) (0.2, 0.5, 1μM). The effects on shoot proliferation and their accumulation of pharmacologically valuable phenolic compounds (baicalin, wogonoside, luteolin, luteolin-7-O-glucoside, verbascoside) were evaluated. Ul...
Source: Phytochemistry Letters - December 31, 2016 Category: Chemistry Source Type: research

Acetophenone glycosides from the roots of Euphorbia fischeriana and their inhibitory effects against Mycobacterium smegmatis
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Shan-Shan Huang, Ping Li, Bao-Jing Zhang, Sa Deng, Hou-Li Zhang, Cheng-Peng Sun, Xiao-Kui Huo, Xiang-Ge Tian, Xiao-Chi Ma, Chao Wang An extract of the Euphorbia fischerian root, used in the preparation of “Jieheling tablets” in China, exhibited bioactivity toward lymphoid tuberculosis and pulmonary tuberculosis. The present investigation identified three new acetophenone glycosides (1-3), and five known acetophenones (4-8). Materials were purified via chromatography and identified through spectroscopic analysis. Additionally, the ...
Source: Phytochemistry Letters - December 31, 2016 Category: Chemistry Source Type: research

The joint action in the bioactivity studies of Antarctic lichen Umbilicaria antarctica: Synergic-biodirected isolation in a preliminary holistic ecological study
Publication date: Available online 28 December 2016 Source:Phytochemistry Letters Author(s): Jose L.G. Galindo, Benito F. García, Ascensión Torres, Juan C.G. Galindo, Joanne G. Romagni, Francisco A. Macías Antarctica is one of the world’s most inaccessible regions. This area is also unique in that it has a terrestrial biota dominated by non-vascular plants, of which lichens and mosses are typically the dominant life-forms. A phytochemical study of Antarctic lichen (Umbilicaria antarctica) collected from maritime Antarctica has been carried out. The hexane, acetone and butanol extracts have been ...
Source: Phytochemistry Letters - December 29, 2016 Category: Chemistry Source Type: research

Phytochemical variations of Rhodiola rosea L. wild-grown in Bulgaria
In this study, we report on the application of NMR-based metabolomics (1D and 2D) combined with multivariate data analysis and an HPLC method development for quantitative determination of the metabolic differences in R. rosea rhizomes, roots and aerial parts from its natural habitat in Bulgaria. In the rhizomes the content of salidroside, rosarin, rosavin and rosin was 2.67%, 0.37%, 1.97% and 0.04%, respectively, while their respective amounts in the roots were 0.31%, 0.06%, 0.39% and 0.01%. Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - December 29, 2016 Category: Chemistry Source Type: research

Synthesis and cytotoxic effects of (E)-3-(2,3-dimethoxyphenyl)-1-(5-methylfuran-2-yl) prop-2-en-1-one in MDA-MB231 and MCF-7 breast cancer cell lines
Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Muhammad Nadeem Akhtar, Landa Zeenelabdin Ali Salim, Swee Keong Yeap, Nadiah Abu, Seema Zareen, Kong Mun Lo, Addila abu Bakar, Noorjahan Banu Alitheen A chalcone derivative, (E)-3-(2,3-dimethoxyphenyl)-1-(5-methylfuran-2-yl)-prop-2-en-1-one (DMMF) was synthesized and evaluated against various cancerous cell lines including colon adenocarcinoma (HT-29), myloplasticleukemia (HL60), breast cancer (MCF-7 and MDA-MB231), normal hepatic cell (WRL-68) and normal breast cell (MCF-10A). The structure of DMMF was determined by EI-MS, 1H NMR and single ...
Source: Phytochemistry Letters - December 29, 2016 Category: Chemistry Source Type: research