Prenylflavone derivatives from the seeds of Psoralea corylifolia exhibited PPAR-γ agonist activity
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Shunan Ma, Youwu Huang, Yuanyuan Zhao, Guoxin Du, Li Feng, Cheng Huang, Yiming Li, Fujiang Guo Three new prenylflavones 2(R,S)-4′-hydroxy-6,7-[2-(1-methoxy-1-methylethyl)-furano]-flavanone (1), 4′,7-dihydroxy-3′,5′-diprenyl-isoflavone (2) and 3,4′,7-trihydroxy-2-methoxy-3′-geranyl-isoflavanone (3), as well as 19 known ones were isolated and identified from the seeds of Psoralea corylifolia. In total, 22 prenylated molecules, including flavanones, isoflavones and chalcones analogues, were screened on...
Source: Phytochemistry Letters - May 8, 2016 Category: Chemistry Source Type: research

Six new cassane diterpenoids from the seeds of Caesalpinia sappan
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Zhen-Tao Deng, Jia Su, Lin-Fen Ding, Wen-Chao Tu, Hui Yang, Li-Yan Peng, Qin-Shi Zhao, Liu-Dong Song, Xing-De Wu Six new cassane diterpenoids (1–6) and 15 known compounds were isolated and identified from the seeds of Caesalpinia sappan. The structures of the new compounds were determined based on the spectroscopic methods, including 1D and 2D NMR techniques. Compound 1 is a rare cassane diterpenoid featuring a nitrogen containing bridge between C-19 and C-20. Compounds 1 and 2 exhibited moderate cytotoxicity against HCT116, AG...
Source: Phytochemistry Letters - May 8, 2016 Category: Chemistry Source Type: research

Dianthus erinaceus var. erinaceus: Extraction, isolation, characterization and antimicrobial activity investigation of novel saponins
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Kiymet Mutlu, Nazli Boke Sarikahya, Ihsan Yasa, Suheyla Kirmizigul A phytochemical analysis of Dianthus erinaceus Boiss. var. erinaceus (Caryophyllaceae) has led to the isolation of two novel triterpenoid saponins, containing an oleane type skeleton, named dianosides K and L (1, 2), along with six known triterpenoid saponins (3–8). On the basis of chemical and spectrometric data, the structures of the new compounds were elucidated as 3-O-[β-d-glucopyranosyl (1→3)]–[β-d-glucopyranosyl (1→6)]-β-d-glucopy...
Source: Phytochemistry Letters - May 8, 2016 Category: Chemistry Source Type: research

Four new coumarins from the leaves of Calophyllum inophyllum
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Zhan-lin Li, Yuan Li, Ning-bo Qin, Da-hong Li, Zhi-guo Liu, Qian Liu, Hui-ming Hua Four new coumarins, namely (−)-12-methoxyinophyllum A, (+)-12-methoxyinophyllum H-1, (-)-12-methoxyinophyllum H-2, and inophyllum J, along with two known compounds, 12-ethoxyinophyllum D and isoinophynone were isolated from the leaves of Calophyllum inophyllum. Their structures were elucidated by spectroscopic analyses, and complete assignments of 1H and 13C NMR spectroscopic data were achieved by 1D and 2D NMR experiments. Graphical abstract (Sour...
Source: Phytochemistry Letters - May 7, 2016 Category: Chemistry Source Type: research

Microbial metabolism of prenylated apigenin derivatives by Mucor hiemalis
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Yina Xiao, Ik-Soo Lee 6-Prenylapigenin (1) and 8-prenylapegenin (2) were semi-synthesized from apigenin by nuclear prenylation. Morusin (3) was isolated from the root bark of Morus alba L. The microbial transformation studies of these three bioactive prenylated apigenin derivatives were performed using eighteen cell cultures in order to select microorganisms capable of transforming them. It was identified that Mucor hiemalis (KCTC 26779) showed the ability to metabolize the parent compounds (1–3) into three new (4–6) and one kno...
Source: Phytochemistry Letters - May 7, 2016 Category: Chemistry Source Type: research

Beilschglabrines A and B: Two new bioactive phenanthrene alkaloids from the stem bark of Beilschmiedia glabra
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Wan Mohd Nuzul Hakimi Wan Salleh, Farediah Ahmad, Heng Yen Khong, Razauden Mohamed Zulkifli, Jih-Jung Chen, Lutfun Nahar, Jean Duplex Wansi, Satyajit Dey Sarker Two new phenanthrene alkaloids, beilschglabrines A (1) and B (2) were isolated from the stem bark of Beilschmiedia glabra, together with lupeol, taraxerol, and 24-methylenelanosta-7,9-diene-3β-15α-diol. The structures of the isolated compounds were elucidated by extensive spectroscopic data analysis and comparison with respective literature data. The compounds were ...
Source: Phytochemistry Letters - May 1, 2016 Category: Chemistry Source Type: research

Sullivantosides A-F: Pregnane glycosides from Asclepias sullivantii L.
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Juan J. Araya, Kelly Kindscher, Barbara N. Timmermann Phytochemical investigation of the above-ground biomass of Asclepias sullivantii L. (Asclepiadaceae) afforded six new pregnane glycosides, named sullivantosides A-F (1–6). The structures of 1–6 were elucidated through a variety of spectroscopic and spectrometric techniques (1D and 2D NMR; HRESIMS). To the best of our knowledge, this work represents the first phytochemical study of this species. Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - April 29, 2016 Category: Chemistry Source Type: research

Three new 3-methyl-2-arylbenzofurans from the fermentation products of an endophytic fungus Phomopsis sp. and their anti-TMV activity
Publication date: Available online 26 April 2016 Source:Phytochemistry Letters Author(s): Gang Du, Zhong-Cheng Wang, Wei-Yao Hu, Ke-Liang Yan, Xin-Lin Wang, Hong-Mei Yang, Hai-Ying Yang, Yu-Hong Gao, Qiang Liu, Qiu-Fen Hu Three new arylbenzofurans, 7-methoxy-2-(4-methoxyphenyl)-3-methyl-5-(3-prenyl)-benzofuran (1), 2-(4-methoxyphenyl)-3-methyl-5-(3-prenyl)-benzofuran-7-ol (2), 2-(4-hydroxy-3,5-dimethoxyphenyl)-3-methyl-5-(3-prenyl)benzofuran-7-ol (3), along with four known arylbenzofurans (4–7) were isolated from the fermentation products of an endophytic Phomopsis sp. Their structures were elucidated by ...
Source: Phytochemistry Letters - April 27, 2016 Category: Chemistry Source Type: research

Five new steroidal glycosides from the roots of Cynanchum stauntonii
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Kaiming Wang, Ang Li, Ruiling Zhang, Siying Li, Fang Zhang, Lei Zhao, Zhongxi Zhao, Shanzhong Li, Jianhua Cai, Jimin Cao Five new steroidal glycosides, named as stauntosides D1 (1), D2 (2), D3 (3), I1 (4), and I2 (5), were isolated from the 95% ethanol extract of the roots of Cynanchum stauntonii. Their structures were elucidated by extensive spectroscopic analyses, including 1D, 2D NMR, and HRESI–MS, and qualitative chemical methods. All compounds were tested for cytotoxicity against five human tumor cell lines (HCT-8, Bel-74...
Source: Phytochemistry Letters - April 27, 2016 Category: Chemistry Source Type: research

Two new glycosides isolated from Polygala sibirica L. var. megalopha Fr.
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Ling-Yun Zhou, Jun-Min Wang, Yan-Jie Huang, Xiao-Hong Yu, Bin Lu, Yan Hua Two new glycosides were isolated from the medicinal plant Polygala sibirica L. var. megalopha Fr. The compounds were identified as 2,6-dimethoxy-benzophenone-4-O-β-d-apiofuranosyl-(1→2)-β-d-glucopyranoside (1) and (6R, 7E, 9R)-9,13-dihydroxy-4,7-megastigmadien-3-one-9-O-[β-D-apiofurano-syl(1→6)-β-d-glucopyranoside (2) using 1D and 2D-NMR spectral data, as well as MALDI-TOF/TOF-MS data. Compounds 1 and 2 were evaluated for their inhibi...
Source: Phytochemistry Letters - April 27, 2016 Category: Chemistry Source Type: research

Dammarane-type saponins from Ziziphus jujube and their inhibitory effects against TNF-α release in LPS-induced RAW 246.7 macrophages
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Qiang Fu, Hai-Mei Yuan, Jiang Chen, Jian-You Shi Four new dammarane-type saponins jujubosides F–J, together with six known compounds were isolated from the seeds of Ziziphus jujube. Their structures were elucidated on the basis of chemical and spectroscopic evidences. Compounds 1–10 showed moderate inhibitory effects against pro-inflammatory cytokine TNF-α release in LPS-induced RAW 246.7 macrophages. Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - April 22, 2016 Category: Chemistry Source Type: research

Cucurbitane-type triterpenoids from the aerial parts of Momordica charantia L.
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Ying Jiang, Xing-Rong Peng, Mu-Yuan Yu, Luo-Sheng Wan, Guo-Lei Zhu, Gao-Ting Zhao, Lin Zhou, Ming-Hua Qiu, Jian Liu Six new cucurbitane-type triterpenoids (1–6), together with two known analogues (7 and 8) were isolated from the aerial parts of Momordica charantia L. The structures of new compounds were identified as cucurbita-6,24-dien-3β,23-diol-19,5β-olide (1), (19R)-5β,19-epoxy-19-methoxycucurbita-6,24-dien-3β,23-diol (2), (19S)-5β,19-epoxy-19-methoxycucurbita-6,24-dien-3β,23-diol (3), (19R)-5&...
Source: Phytochemistry Letters - April 20, 2016 Category: Chemistry Source Type: research

Corrigendum to “Flavonoids and bis-coumarin from the tubers of Apios taiwanianus” [Phytochem. Lett. 15 (2016) 164–167]
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Chwan-Fwu Lin, Yen-Wenn Liu, Yueh-Hsiung Kuo, Chien-Chang Shen, Wen-Fei Chiou, Chien-Chih Chen (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - April 15, 2016 Category: Chemistry Source Type: research

Two new hydroxylated ent-kauranoic acids from Pteris semipinnata
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Maosong Qiu, Bao Yang, Di Cao, Jinping Zhu, Jing Jin, Yunyun Chen, Lian Zhou, Xia Luo, Zhongxiang Zhao Two new hydroxylated ent-kauranoic acids, pterisolic acid G (1) and pterisolic acid H (3), together with five known ent-kaurane-type diterpenoids (2 and 4–7) were isolated from the whole plant of Pteris semipinnata L. The structures of compounds 1–3 were elucidated on the basis of HR-MS, 1D and 2D NMR analysis, and the absolute configuration of compounds 1 and 2 were determined by the results of single crystal X-ray diff...
Source: Phytochemistry Letters - April 15, 2016 Category: Chemistry Source Type: research

Olamannosides D and E: Further kaempferol triglycosides from Olax mannii leaves
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Festus B.C Okoye, Kenneth G. Ngwoke, Abdessamad Debbab, Patience O. Osadebe, Peter Proksch Further chemical investigation of the butanol fraction of Olax mannii Oliv. (Olacaceae) methanol leaf extract led to the isolation of two new kaempferol triglycosides namely: kaempferol 3-O-[α-l-rhamnopyranosyl (1→2) α-l-arabinofuranoside]-7-O-α-l-rhamnopyranoside, (1) and kaempferol 3-O-[α-l-apiofuranosyl (1→2) β-D- galactopyranoside]-7-O-α-l-rhamnopyranoside (2). The structures of the isolated compound...
Source: Phytochemistry Letters - April 13, 2016 Category: Chemistry Source Type: research

Chemical constituents from Ainsliaea acerifolia as potential anti-obesity agents
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Taewan Kim, Cheorun Jo, Hyun-Seok Kim, Youn-Moon Park, Yong-Xiang Wu, Jae-Hyeon Cho, Tae Hoon Kim Bioassay-guided isolation of an ethanolic extract of the aerial parts from Ainsliaea acerifolia using pancreatic lipase inhibitory assay led to the isolation of a new guaianolide-type sesquiterpene lactone (1), a new dicaffeoylquinic acid derivative (4), as well as eight known secondary metabolites. Structures of the two new compounds were elucidated on the basis of spectroscopic methods. All isolated compounds were evaluated for their inh...
Source: Phytochemistry Letters - April 13, 2016 Category: Chemistry Source Type: research

Tagenols A and B: New lipoxygenase inhibitor flavonols from Tagetes minuta
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Gamal A. Mohamed Phytochemical investigation of the methanolic extract of Tagetes minuta L. (Asteraceae) aerial parts afforded two new flavonol derivatives: tagenol A (quercetagetin-8-hydroxy-3,6,4′-trimethy ether) (1) and tagenol B (quercetagetin-8-hydroxy-3-methoxy-6-O-β-d-glucopyranoside) (4), together with three known flavonoids: quercetin-3,6-dimethyl ether (2), quercetin-3-methyl ether (3), and axillarin-7-O-β-d-glucopyranoside (5). Their structures were identified by UV, IR, 1D (1H and 13C), 2D (1H–1H COSY, HSQC,...
Source: Phytochemistry Letters - April 13, 2016 Category: Chemistry Source Type: research

Antioxidant aromatic butenolides from an insect-associated Aspergillus iizukae
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Lin-Jiao Li, Tian-Xiao Li, Ling-Yi Kong, Ming-Hua Yang Four new aromatic butenolides named aspernolides H-K (1–4), along with three known compounds (5–7), were isolated from the metabolites of Aspergillus iizukae, which resided in the guts of cricket species Gryllus testaceus. The structures were elucidated by extensive spectroscopic analysis, modified Mosher methods and Mo2(OAc)4-induced electronic circular dichroism (ECD) experiments. Their antioxidant activities were evaluated through ABTS and DPPH radical scavenging assays...
Source: Phytochemistry Letters - April 8, 2016 Category: Chemistry Source Type: research

Cytotoxicity of chemical constituents from the roots of Knema globularia
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Uraiwan Sriphana, Chavi Yenjai, Mayrin Koatthada Two new diaryloctanes, kneglobularic acid A (1) and kneglobularic acid B (2), as well as a new acetophenone derivative, kneglobularone A (3), together with four known compounds (4–7) were isolated from the hexane extract of the roots of Knema globularia. Structures of all compounds were determined by IR, MS, 1D and 2D NMR spectroscopic methods. The crude extracts and all isolates were evaluated for cytotoxicity, and kneglobularone A (3) exhibited moderate cytotoxicity against the NCI-H...
Source: Phytochemistry Letters - April 6, 2016 Category: Chemistry Source Type: research

New cytotoxic dimeric and trimeric coumarins from Chimonanthus salicifolius
This study represents the first report of tricoumarin, CC linked dicoumarins and coumarinolignoids from Calycanthaceae. Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - April 6, 2016 Category: Chemistry Source Type: research

New triterpene and new flavone glucoside from Rhynchospora corymbosa (Cyperaceae) with their antimicrobial, tyrosinase and butyrylcholinesterase inhibitory activities
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Annie Laure Ngankeu Pagning, Jean-de-Dieu Tamokou, Mehreen Lateef, Léon Azefack Tapondjou, Jules-Roger Kuiate, David Ngnokam, Muhammad Shaiq Ali The CH2Cl2-MeOH (1:1) extract of the whole plant of Rhynchospora corymbosa (L.) Britton, led to the isolation of two new secondary metabolites 1, 2 (1 and 2a) together with nine known compounds 3–11. The flavone named tricin (11) was partially modified by esterification reaction to three semi-synthetic derivatives 11a–11c). Their structures were elucidated on the basis of sp...
Source: Phytochemistry Letters - April 6, 2016 Category: Chemistry Source Type: research

Prenylated indole alkaloids from the stem bark of Hexalobus monopetalus
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Evelyn Afua Mireku, Merlin L.K. Mensah, Abraham Yeboah Mensah Seven new prenylated indole alkaloids (1–7) together with two known compounds (8–9) were isolated from the stem bark of Hexalobus monopetalus. Their structures were established on the basis of comprehensive spectroscopic analysis, including HR-MS, 1D and 2D NMR and by comparison of their spectral data with those reported in literature. The new compounds were tested for antimicrobial activity against selected pathogenic bacteria and fungi but showed no activity. The m...
Source: Phytochemistry Letters - April 3, 2016 Category: Chemistry Source Type: research

Toxin levels in different variety of potatoes: Alarming contents of α-chaconine
This study measures the content of the two toxic alkaloids in 15 different varieties of potatoes considered important for a commercial use; measurements were taken immediately following the collection and after 20 days. The data show that after 20 days the α-solanine content decreases (with the exception of only four varieties), whereas the α-chaconine content increases to alarming levels. Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - April 3, 2016 Category: Chemistry Source Type: research

Five new N-acetyldopamine dimers from Periostracum Cicadae
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Lu Yang, Guo Yu Li, Hang Yu Wang, Ke Zhang, Yun Zhu, Wenbin Zhao, Heng Wang, Jin Hui Wang Periostracum Cicadae, the cast-off shell of the cicada Cryptotympana pustulata Fabricius, is used in traditional Chinese medicine for its diaphoretic, anticonvulsive, sedative, antipyretic, and antiallergic effects. Five new N -acetyldopamine dimers were isolated from Periostracum Cicadae, and their structures were elucidated as (2R,3S)-2-(3′,4′-dihydroxyphenyl)-3-acetylamino-7-(N-acetyl-2′′-aminoethyl)-1,4-benzodioxane 3&...
Source: Phytochemistry Letters - April 2, 2016 Category: Chemistry Source Type: research

Three cytotoxic Annonaceous acetogenins from the seeds of Annona squamosa
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Yun-Jie Miao, Ye-Ye Shi, Xiao-Fang Xu, Yong Chen, Jian-Wei Chen, Xiang Li Three new Annonaceous acetogenins, squamocin-IV (1), squamocin-V (2) and squamoxinone-E (3), together with seven other known Annonaceous acetogenins (4–10) were isolated from the seeds of Annona squamosa. The structures of all of the isolates were established and characterized through spectral and chemical methods. The new Annonaceous acetogenins 1–3 were evaluated for their cytotoxicity against the Hep-G2, SMMC-7721, BEL-7402, BGC-803 and H460 human c...
Source: Phytochemistry Letters - March 27, 2016 Category: Chemistry Source Type: research

Isolation and identification of oxygenated lanostane-type triterpenoids from the fungus Ganoderma lucidum
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Xi-Run Zhao, Bao-Jing Zhang, Sa Deng, Hou-Li Zhang, Shan-Shan Huang, Xiao-Kui Huo, Chao Wang, Fang Liu, Xiao-Chi Ma Ganoderma lucidum is widely used throughout the world as a form of traditional medicine. Phytochemical investigation of the chloroform (CHCl3) extract of the fruiting body of G. lucidum resulted in the isolation of four lanostane-type triterpenoids. Based on various spectroscopic data, the isolated triterpenoids were identified as highly oxygenated lanostane-type triterpenoids, including four new compounds (1–4). ...
Source: Phytochemistry Letters - March 27, 2016 Category: Chemistry Source Type: research

Four new phorbol diesters from Croton tiglium and their cytotoxic activities
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Xiao-Long Zhang, Ashfaq-Ahmad Khan, Lun Wang, Kai Yu, Fu Li, Ming-Kui Wang Phytochemical investigation of the seeds of Croton tiglium resulted in the isolation and structure elucidation of four new 4-deoxy-4β-phorbol diesters (1–4) named as 12-O-tiglylphorbol-4-deoxy-4β-phorbol-13-acetate (1), 12-O-tiglylphorbol-4-deoxy-4β-phorbol-13-hexadecanoate (2), 13-O-acetylphorbol-4-deoxy-4β-phorbol-20-oleate (3) and 13-O-acetylphorbol-4-deoxy-4β-phorbol-20-linoleate (4), respectively. The structures of the new comp...
Source: Phytochemistry Letters - March 26, 2016 Category: Chemistry Source Type: research

New norlignans and flavonoids of Dysosma versipellis
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Yue Zheng, Yang-Guo Xie, Yu Zhang, Tao Li, Hui-Liang Li, Shi-Kai Yan, Hui-Zi Jin, Wei-Dong Zhang Two new norlignans, dysosmanorlignans A and B (1–2); six new flavonoids, dysosmaflavones A–F (3–8); and 30 known compounds (9–38) were isolated from the roots of Dysosma versipellis. Their structures were determined by detailed analysis of MS and NMR spectroscopic data. Dysosmaflavones E and F both exhibited mild antibacterial activities against Streptococcus agalactiae, Pseudomonas aeruginosa, and Bacillus subtilis...
Source: Phytochemistry Letters - March 26, 2016 Category: Chemistry Source Type: research

Herbivore-induced volatile organic compounds emitted by maize: Electrophysiological responses in Spodoptera frugiperda females
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Delia M. Pinto-Zevallos, Priscila Strapasson, Paulo H.G. Zarbin Herbivory induces the emission of volatile organic compounds (VOCs) which are involved in the attraction of predators and parasitoids. In spite of the large number of studies that have addressed the electrophysiological and behavioral responses of natural enemies to herbivore-induced VOCs, whether herbivores perceive these compounds remains largely unknown. By coupling chemical and electrophysiological (Gas Chromatography–Mass Spectrometry GC–MS and Gas Chromatogra...
Source: Phytochemistry Letters - March 25, 2016 Category: Chemistry Source Type: research

Volatile constituents and antimicrobial activities of nine South African liverwort species
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Johan Linde, Sandra Combrinck, Sandy Van Vuuren, Jacques Van Rooy, Agnieszka Ludwiczuk, Ntebogeng Mokgalaka The volatile constituents of nine liverworts species (Asterella marginata, Dumortiera hirsuta, Fossombronia swaziensis, Marchantia pappeana, Marchantia polymorpha subsp. ruderalis, Pallavicinia lyellii, Plagiochasma rupestre, Riccia albolimbata and Symphyogyna podophylla) from South Africa were determined by gas chromatography. Where possible the volatile constituents identified were compared to those reported for the same species...
Source: Phytochemistry Letters - March 24, 2016 Category: Chemistry Source Type: research

Bioactive azaphilones from the fungus Penicillium multicolor CM01
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Chulida Hemtasin, Somdej Kanokmedhakul, Panawan Moosophon, Kasem Soytong, Kwanjai Kanokmedhakul Two new azaphilones, dechloroisochromophilone II (1) and epi-isochromophilone III (2), a new natural product, 5-hydroxy-4-methoxy-5,6-dihydro-2H-pyran-2-one (3), together with eleven known compounds, 4–14 were isolated from the fungus, Penicillium multicolor CM01. Their structures were elucidated by spectroscopic methods. Compounds 2, 8, 10 and 11 exhibited antimalarial activity against Plasmodium falciparum (IC50 2.1–7.8μg/mL),...
Source: Phytochemistry Letters - March 20, 2016 Category: Chemistry Source Type: research

Novel cassane diterpenes from the seeds of Caesalpinia decapetala and their antiproliferative activity
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Guo-Xu Ma, Ping Chen, Zhong-Hao Sun, Nai-Liang Zhu, Peng-Fei Li, Jun-Shan Yang, De-Li Chen, Hua Wei Two new cassane diterpenes, caesaldecapes A-B (1–2), were isolated from the seeds of Caesalpinia decapetala. Their structures were elucidated by extensive spectroscopic methods, including NMR, MS, and HRESIMS. Compounds 1–2 are novel examples of rearranged cassane diterpenes obtained from C. decapetala. The two compounds were evaluated for their antiproliferative activity in vitro against four human cancer cell lines, and co...
Source: Phytochemistry Letters - March 18, 2016 Category: Chemistry Source Type: research

Anticomplement cycloartane triterpene glycosides from Beesia calthaefolia (Maxim.)
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Li Hua Mu, Jin Yuan Zhao, Ping Liu Investigation of the n-BuOH extract of the whole plant of Beesia calthaefolia led to the isolation of three new cycloartane triterpenoids (1–3) and two known compounds (4, 5). Their structures were elucidated by 1D and 2D NMR, HRESIMS and optical rotation spectral data. All of the isolates were investigated for their inhibitory effects on the classical pathway of the complement system. Among them, compound 3 showed stronger inhibitory activity (IC50 148.0μM) than the positive control (rosmarinic ...
Source: Phytochemistry Letters - March 5, 2016 Category: Chemistry Source Type: research

Steroidal glycosides from the roots of Cynanchum stauntonii and their effects on the expression of iNOS and COX-2
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Chang-Zhi Lai, Jian-Xin Liu, Shu-Wen Pang, Yi Dai, Hua Zhou, Zhen-Qiang Mu, Jun Wu, Jin-Shan Tang, Liang Liu, Xin-Sheng Yao Six new steroidal glycosides, named stauntosides O-T (1–6), along with eight known compounds (7–14), were obtained from the 95% aqueous ethanol extract of the roots of Cynanchum stauntonii. Their chemical structures were elucidated by IR, HR ESI-MS/MS, 1H- and 13C NMR, 1H-1H COSY, HSQC, HSQC-TOCSY, and HMBC spectroscopic analyses, which showed interesting 13,14:14,15-disecopregnane-type or 14,15-sec...
Source: Phytochemistry Letters - March 5, 2016 Category: Chemistry Source Type: research

Seco-pregnane steroidal glycosides from the roots of Cynanchum stauntonii
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Jin-Qian Yu, Lei Zhao By analyzing the steroidal content of the roots of Cynanchum stauntonii, we isolated three new C21 steroidal glycosides named cynastauosides A-C (1–3), all of which shared the 14,15-secopregnane-type skeleton. Their structures were determined on the basis of detailed spectroscopic analysis, including 2D NMR and qualitative chemical tests. Anti-inflammatory activities of compounds 1–3 were evaluated in vitro, with 2 and 3 inhibiting nitric oxide production in C57bl/6j mouse peritoneal macrophages by 17.0% an...
Source: Phytochemistry Letters - March 5, 2016 Category: Chemistry Source Type: research

Metabolite profiling of Neptunia oleracea and correlation with antioxidant and α-glucosidase inhibitory activities using 1H NMR-based metabolomics
This study evaluated metabolite variations among N. oleracea leaf and stem subjected to air drying (AD), freeze drying (FD) and oven drying (OD) using proton nuclear magnetic resonance (1H NMR) based metabolomics. The correlation was also studied for the metabolite content with total phenolic content (TPC), DPPH free radical scavenging and α-glucosidase inhibitory activities. A total of 18 metabolites were identified from N. oleracea extracts, including 10 primary metabolites, 5 flavonoids and 3 phenolic acids using NMR. Ultra-high performance liquid chromatography tandem mass spectrometry analysis (UHPLC-MS/MS) conf...
Source: Phytochemistry Letters - March 5, 2016 Category: Chemistry Source Type: research

Biflavonoids from the bark roots of Poincianella pyramidalis (Fabaceae)
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): José Cândido S. de Oliveira, Juceni P. David, Jorge M. David Poincianella pyramidalis (Fabaceae) is an endemic tree that grows in semiarid regions of Brazil. Phytochemical investigations on the bark roots of this plant led to the isolation of four new biflavonoids named (+)-5-hydroxy-7,4′-dimethoxyflavone-3α-2′′′-hydroxy-4′′′,4′′-dimethoxydihydrochalcone (1), (+)-5,7-dihydroxy-4′-methoxyflavone-3α-2′′′-hydroxy-4′′′,4&pri...
Source: Phytochemistry Letters - March 5, 2016 Category: Chemistry Source Type: research

New sesterterpenoids and other constituents from Salvia dominica growing wild in Jordan
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Mohammed R. Hasan, Hala I. Al-Jaber, Mahmoud A. Al-Qudah, Musa H. Abu Zarga A new nor-oleanane triterpene 24-nor-4(23)-12-oleanadien-2α,3α,28-triol (1) and two new sesterterpenes salvidominicolide A (2), salvidominicolide B (3) together with fifteen known compounds were isolated from Salvia dominica L. growing wild in Jordan. The known compounds comprised six flavones, three triterpenes, one diterpene, one sesterterpene, two oxygenated monoterpenes, one sterol glucoside and one flavone glucoside. The isolated compounds were el...
Source: Phytochemistry Letters - March 2, 2016 Category: Chemistry Source Type: research

Protostane alisol derivatives from the rhizome of Alisma orientale
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Xiu-Lan Xin, Zhen-Peng Mai, Xun Wang, Liang Chen, Sa Deng, Bo Zhang Alisma orientalis is a well-known traditional Chinese medicine with diuretic, hypopietic, hypolipemic, and antiatherosclerotic activities. In the present study, we investigated triterpenoids from the rhizome of A. orientalis, identifying four new alisol derivatives, namely, Alismanol M (1), Alismanol Q (2), Alismanol O (3) and Alismanol P (4). The structures of these compounds were characterized using detailed spectroscopic analysis (UV, HRESIMS, 1D and 2D NMR data incl...
Source: Phytochemistry Letters - February 29, 2016 Category: Chemistry Source Type: research

New lignans with neuroprotective activity from Adelostemma gracillimum
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Jun Zhang, Shengjun Guo, Kim W. Chan, Estella P.S. Tong, Guangmiao Fu, Quanzhang Mu, Fanny C.F. Ip, Nancy Y. Ip Adelostemma gracillimum is an herb used as nourishing and roborant drugs and in the treatment of convulsions in children. To date, a few molecular constituents have been isolated from the root of this herb and chemically characterized, but their biological activities have never been reported. Here, we demonstrate that the crude extract of A. gracillimum (AGE) can protect primary cortical neurons against N-methyl-d-aspartate ...
Source: Phytochemistry Letters - February 27, 2016 Category: Chemistry Source Type: research

Lycopodium alkaloids from Lycopodium obscurum L. f. strictum
Publication date: March 2016 Source:Phytochemistry Letters, Volume 15 Author(s): Li-Jun Wang, Juan Xiong, Wei Wang, Hai-Yan Zhang, Guo-Xun Yang, Jin-Feng Hu Two new Lycopodium alkaloids, strictumines A (1) and B (2), along with 18 related known compounds were isolated from the whole plant of Lycopodium obscurum L. f. strictum. The structures of the new compounds were established by spectroscopic methods and chemical transformation. This is the first report on chemical constituents of the title plant. All the isolates were evaluated for their inhibitory activity against acetylcholinesterase (AChE), and only a few we...
Source: Phytochemistry Letters - February 24, 2016 Category: Chemistry Source Type: research

Phytochemical investigation of Pseudelephantopus spiralis (Less.) Cronquist
Publication date: March 2016 Source:Phytochemistry Letters, Volume 15 Author(s): Nora del Socorro Jimenez Usuga, Nicola Malafronte, Edison Javier Osorio Durango, Alessandra Braca, Nunziatina De Tommasi Three new sesquiterpenes, 1β,4β,1α,10α-diepoxy-6-oxo-7α,8α-diacetoxygermacr-11-en-12-oic acid methyl ester named as spiraloside (1), 1α,10α-epoxy-8α,13-diacetylpiptocarphol (2), and 5β-(2-methylacryloyloxy)spicatocadinanolide A (3) along with two known compounds were isolated from Pseudelephantopus spiralis aerial part extracts. Their structures were determined ...
Source: Phytochemistry Letters - February 24, 2016 Category: Chemistry Source Type: research

Cytotoxic triterpenes with diverse skeletons from Amoora tsangii
Publication date: March 2016 Source:Phytochemistry Letters, Volume 15 Author(s): Yan-Yan Ma, Deng-Gao Zhao, Ya Li, Jian-Jun Chen, Jun Zeng, Qian-Qian Zhao, Kun Gao Two new 29-nor-cycloartane triterpenes, amooratsanols A and B (1, 2) along with nine known compounds including two 29-nor-cycloartane triterpenes (3, 9), two lupane triterpenes (4, 5), two cycloartane triterpenes (6, 10), two dammarane triterpenes (7, 8), as well as one dinorcycloartane triterpene (11) were isolated from the leaves and twigs of Amoora tsangii (Merr.) X. M. Their structures were established by spectroscopic methods (IR, HRESIMS, and NMR)...
Source: Phytochemistry Letters - February 23, 2016 Category: Chemistry Source Type: research

Unusual sesquiterpenes from Centaurea athoa DC
Publication date: March 2016 Source:Phytochemistry Letters, Volume 15 Author(s): Serdar Demir, Canan Karaalp, Erdal Bedir Three new elemane-type sesquiterpenes; athoin, 14-O-acetylathoin and methyl 14-O-acetylathoin-12-oate were isolated from the aerial parts of Centaurea athoa DC., accompanying with eight known compounds: a germacrane-type sesquiterpene; 4'-hydroxypecterolide-14-O-acetate, three phenolic compounds; p-hydroxybenzoic acid, protocatechuic acid, vanillic acid-4-O-β-d-glucopyranoside methyl ester, an acetophenon glucoside; picein, two phenylpropane glucosides; syringin and 9-O-methyl coniferin, and a...
Source: Phytochemistry Letters - February 23, 2016 Category: Chemistry Source Type: research

Two new cembranic diterpenoids from the flowers of Nicotiana tabacum L.
Publication date: March 2016 Source:Phytochemistry Letters, Volume 15 Author(s): Xiao-Feng He, Xiao-Dong Hou, Xia Ren, Kai Guo, Xiu-Zhuang Li, Zhi-Qiang Yan, Yong-Mei Du, Zhong-Feng Zhang, Bo Qin Two new cembranoids, together with fifteen known ones, were isolated from the flowers of Nicotiana tabacum L. The structures of the new compounds were established as (1βH,2E,4αOH,6αOH,7E,10αH,11αH,12βOH)-10,11-epoxy-2,7-cembradiene-4,6,12-triol (1) and (1βH,2E,4αOH,6αOH,7E,10βH,11βH,12αOH)-10,11-epoxy-2,7-cembradiene-4,6, 12-triol (2) by using spectrosco...
Source: Phytochemistry Letters - February 21, 2016 Category: Chemistry Source Type: research

Pyrrolizidine alkaloids from Cynoglossum columnae Ten. (Boraginaceae)
Publication date: March 2016 Source:Phytochemistry Letters, Volume 15 Author(s): Harilaos Damianakos, Małgorzata Jeziorek, Katarzyna Sykłowska-Baranek, Waldemar Buchwald, Agnieszka Pietrosiuk, Ioanna Chinou Seven secondary metabolites were isolated from the methanolic extracts of the roots and the aerial part of Cynoglossum columnae Ten. β-Arbutin and three pyrrolizidine alkaloids, namely 2′-epi-heliosupine N-oxide, rinderine N-oxide and 3′-O-acetylrinderine N-oxide were isolated from the aerial part of the plant. Echinatine N-oxide, rosmarinic acid and 9″-methyl lithospermate were isolated...
Source: Phytochemistry Letters - February 19, 2016 Category: Chemistry Source Type: research

Two new phragmalin-type limonoids from stems of Chukrasia tabularis
Publication date: March 2016 Source:Phytochemistry Letters, Volume 15 Author(s): Jun-Lin Peng, Jun-Wang, Fan-Dong Kong, Zi-Qi Liu, Pei Wang, Cui-Juan Gai, Bei Jiang, Wen-li Mei, Hao-fu Dai Phytochemical investigation on the stems of Chukrasia tabularis A. Juss led to the isolation of two new phragmalin-type limonoids and three known ones. The structures of the new compounds were elucidated as Chuklarisin A (1) and Chuklarisin B (2) by spectroscopic techniques (IR, HRESIMS, 1D and 2D NMR) and comparing with published data. All the compounds were evaluated for α-glucosidase inhibitory activity in vitro. Comp...
Source: Phytochemistry Letters - February 18, 2016 Category: Chemistry Source Type: research

New nor-clerodane-type furanoditerpenoids from the rhizomes of Tinospora capillipes
Publication date: March 2016 Source:Phytochemistry Letters, Volume 15 Author(s): Bin Wang, Peng-Liang Zhang, Ming-Xing Zhou, Tao Shen, Yong-Xin Zou, Hong-Xiang Lou, Xiao-Ning Wang Three new nor-clerodane-type furanoditerpenoids, tinocapillins A–C (1–3), and three known diterpenoids were isolated from the rhizomes of Tinospora capillipes. Their structures were elucidated on the basis of extensive spectroscopic analysis. The absolute configuration of compound 4 was established by single-crystal X-ray diffraction analysis using Cu Kα radiation. Compounds 1, 2, and 5 exhibited moderate inhibitory act...
Source: Phytochemistry Letters - February 12, 2016 Category: Chemistry Source Type: research

A new cycloartane-type triterpene and a new eicosanoic acid ester from fruits of Paullinia pinnata L.
Publication date: March 2016 Source:Phytochemistry Letters, Volume 15 Author(s): Maurice D. Awouafack, Takuya Ito, Pierre Tane, Takeshi Kodama, Masami Tanaka, Yoshinori Asakawa, Hiroyuki Morita A phytochemical study of the MeOH-soluble portion from the CH2Cl2/MeOH extract of the fruits of Paullinia pinnata resulted in the isolation of a new triterpenoid, cyclopinnatol (1), and a new eicosanoic acid ester, paulliniester (2), together with five known compounds including cycloart-22(E)-ene-3β,25-diol (3), cycloartenol (4), β-sitosterol (5), betulonic acid (6) and oleanonic acid (7). The structures of the ne...
Source: Phytochemistry Letters - February 12, 2016 Category: Chemistry Source Type: research

Cytotoxic polycyclic polyprenylated acylphloroglucinol derivatives and xanthones from Hypericum attenuatum
Publication date: March 2016 Source:Phytochemistry Letters, Volume 15 Author(s): Zhong-Bo Zhou, Yang-Mei Zhang, Jian-Guang Luo, Ling-Yi Kong Two new polycyclic polyprenylated acylphloroglucinols, attenuatumione G (1) and attenuatumione H (2), together with five known compounds (3–7) have been isolated from the whole plant of Hypericum attenuatum. Their structures were elucidated by spectroscopic data including HRESIMS, 1D- and 2D-NMR. In biological assays, compound 2 showed moderate cytotoxic activities against Hep-G2 (IC50 9.11μM) and MCF-7 (IC50 16.24μM), compound 4 exhibited significant cytotoxic activ...
Source: Phytochemistry Letters - February 12, 2016 Category: Chemistry Source Type: research