Chemical constituents of the stems of Neolitsea kedahensis Gamble
Publication date: August 2018 Source:Phytochemistry Letters, Volume 26 Author(s): Nor Akmalazura Jani, Hasnah Mohd Sirat, Farediah Ahmad, Salam Ahmed Abed, Nurul Iman Aminudin Two new β-carboline alkaloids, daibucarbolines D (1) and E (2) and one new sesquiterpene dilactone, pseudovillosine (3), together with five known compounds, taraxerone, taraxerol, pseudoneoliacine, daibucarboline A and linderaggrine A were isolated from the stems of Neolitsea kedahensis (Lauraceae). The structures were confirmed through extensive spectroscopic analysis, while the relative configuration of compound (3) was determined by a single...
Source: Phytochemistry Letters - May 18, 2018 Category: Chemistry Source Type: research

Sesquiterpenoids from Ainsliaea yunnanensis and their cytotoxic activities
Publication date: August 2018 Source:Phytochemistry Letters, Volume 26 Author(s): Xin Fang, Ren-Tao Zeng, Zhi-Guo Zhuo, Yun-Heng Shen, Wei-Dong Zhang Three new sesquiterpenoids, named yunnanolides J-K and yunnanol A (1-3), together with ten known sesquiterpenoids (4-13), have been isolated from the dried whole plants of Ainsliaea yunnanensis Franch. The chemical structures of compounds 1-3 were elucidated by NMR and HRESIMS analysis. All the compounds were tested for in vitro cytotoxicity against three human tumor cell lines (95D, MDA-MB-231, and HepG2). Compound 13 showed moderate cytotoxicity against human cancer cell l...
Source: Phytochemistry Letters - May 18, 2018 Category: Chemistry Source Type: research

Three new iridolactone derivatives from the whole plant of Brillantaisia owariensis P. Beauv
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Perrin Lanversin Foning Tebou, David Ngnokam, Dominique Harakat, Laurence Voutquenne-Nazabadioko Owariensisone B-D, three new lactone iridoids, identified as lactone of α-(3-acetoxymethyl-2-hydromethylcyclopent-3-en-yl) ethanoic acid (1), lactone of α-(4-β-acetoxy-3-β-acetoxymethyl-2-hydromethyl-3-hydroxycyclopentyl) ethanoic acid (2) and lactone of α-(4-β-acetoxy-3-α-acetoxymethyl-2-hydromethyl-3-hydroxycyclopentyl) ethanoic acid (3) were isolated from the n-hexane extract of the whole plant of Brillanta...
Source: Phytochemistry Letters - April 15, 2018 Category: Chemistry Source Type: research

Endocyclic double bond isomers and by-products from rebaudioside A and stevioside formed under acid conditions
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Wilmer H. Perera, Maite L. Docampo, Frank T. Wiggers, Charles D. Hufford, Frank R. Fronczek, Bharathi Avula, Ikhlas A. Khan, James D. McChesney The hydrolysis reaction of rebaudioside A and stevioside was studied under mild and strong acidic conditions at different temperatures and times. Exposure of rebaudioside A to vigorous acid conditions yielded three different aglycone cores which were purified by silica gel chromatography: compound 1 (isosteviol), 2 (steviol) and 3 (endocyclic isomer of steviol). Four new glucoside degradation products ...
Source: Phytochemistry Letters - April 14, 2018 Category: Chemistry Source Type: research

Acylated flavone 8-C-glucosides from the flowers of Trollius chinensis
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Jin-Xia Wei, Dan-Yi Li, Zhan-Lin Li Ten new flavone 8-C-glucosides, trollichinensides A–J, with the substitution of various acyls at C-2″, C-3″, or C-6″ of the glucose moiety, together with thirteen known ones were isolated from the flowers of Trollius chinensis. Spectroscopic analyses including NMR and HRESIMS resulted in the establishment of the structures of these constituents and electronic circular dichroism (ECD) experiment was employed for the determination of the absolute configuration of the glucose residue in ...
Source: Phytochemistry Letters - April 14, 2018 Category: Chemistry Source Type: research

Four new diterpenoid alkaloids with anti-inflammatory activities from Aconitum taronense Fletcher et Lauener
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Tianpeng Yin, Xiaofang Hu, Ruifeng Mei, Yan Shu, Dong Gan, Le Cai, Zhongtao Ding Four new C19-diterpenoid alkaloids, named taronenines A-D (1-4), have been isolated from the roots of Aconitum taronense Fletcher et Lauener (Ranunculaceae), which has long been used as a folk medicine to treat rheumatism and arthritis in China. Their structures were established on the basis of extensive spectroscopic analyses. The isolated compounds were evaluated for their potential anti-inflammatory effects using LPS-stimulated RAW 264.7 macrophages. Compounds ...
Source: Phytochemistry Letters - April 13, 2018 Category: Chemistry Source Type: research

Five new triterpenoids from Syzygium samarangense (Bl.) Merr. et Perry
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Yi-Kao Hu, Li Wang, Yuan-Yuan Li, Meng-Jia Li, Wen Xu, Yan Zhao, Feng Li, Yong Zhao Four undescribed ursane triterpenoids, sysamarins A–D, along with an undescribed oleanane triterpenoid, sysamarin E, were isolated from the ethyl acetate extract of the leaves of Syzygium samarangense. Their structures were elucidated on the basis of extensive spectroscopic analysis including HR-ESI–MS, 1D- and 2D-NMR techniques, and comparison with the data reported in the literatures. This is the first example of ursane and oleanane triterpenoids ...
Source: Phytochemistry Letters - April 13, 2018 Category: Chemistry Source Type: research

An unprecedented spiro [furan-2,1 ’-indene]-3-one derivative and other nematicidal and antimicrobial metabolites from Sanghuangporus sp. (Hymenochaetaceae, Basidiomycota) collected in Kenya
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Clara Chepkirui, Tian Cheng, Josphat Matasyoh, Cony Decock, Marc Stadler Bioassay guided fractionation of extracts derived from submerged cultures of a Sanghuangporus sp. (i.e., the genus that was until recently referred to as the “Inonotus linteus complex” of medicinal mushrooms) originating from Kenya led to the isolation of a new spiro [furan-2,1’-indine]-3-one derivative, for which we propose the trivial name phelligridin L (1) together with the known compounds 3,14′-bihispidinyl (2), hispidin (3), ionylideneacetic ...
Source: Phytochemistry Letters - April 12, 2018 Category: Chemistry Source Type: research

Alkenylphenols from Piper dilatatum and P. diospyrifolium
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Nídia C. Yoshida, Aline M. Benedetti, Ruilan A. dos Santos, Clécio S. Ramos, Ronan Batista, Lydia F. Yamaguchi, Massuo J. Kato As part of our continuing phytochemical survey on Piper species, three previously undescribed alkenylphenols were isolated and characterized, including 4-[(3′E)-tetradec-3′-en-1-yl] phenol (1) and 4-[(2′E,4′E)-heptadeca-2′,4′-dien-1-yl] phenol (3) from P. diospyrifolium and 4-[(3′E)-hexadec-3′-en-1-yl] phenol (2) from P. dilatatum. The structures of the comp...
Source: Phytochemistry Letters - April 12, 2018 Category: Chemistry Source Type: research

Bioactive aromatic metabolites from the sea urchin-derived actinomycete Streptomyces spectabilis strain HDa1
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Zhi Kai Guo, Rong Wang, Fu Xiao Chen, Tian Mi Liu, Ming Qiu Yang An actinomycete strain HDa1, capable of producing new acetylcholinesterase (AchE) inhibitors, was isolated from the gut of sea urchin Anthocidaris crassispina and identified as Streptomyces spectabilis by morphology and 16S rRNA gene sequence. Chemical investigation of the fermentation broth of Streptomyces spectabilis HDa1 by bioactivity-guided fractionation led to the isolation of 3,4-dimethoxy-1-naphthamide (1), p-O-(3,3-dimethylallyl)-benzamide (2), cyclo-(L-Val-l-Pro) (3), c...
Source: Phytochemistry Letters - April 12, 2018 Category: Chemistry Source Type: research

Aspidsaponins A –D, Four new steroidal saponins from the rhizomes of Aspidistra elatior Blume and their cytotoxicity
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Sheng-Qi Zuo, Ying-Nan Liu, Yang Yang, Zhi-Qiang Guo, Cheng-Xiong Liu, Zhi-Yong Guo, Hai-Bo He, Xuan Tu, Kun Zou Four new furostanol saponins, named aspidsaponins A–D (2–5), together with one known steroidal saponin (1) were isolated from the rhizomes of Aspidistra elatior Blume. Their structures were determined on the basis of chemical methods and spectral data. Compounds 1 and 2, 4 and 5 were two pairs of diastereoisomeric furostanol saponins, and 3-5 were rarely steroidal glycosides of the C4-linked sugar and possessed highly ox...
Source: Phytochemistry Letters - April 12, 2018 Category: Chemistry Source Type: research

Three new eudesmane sesquiterpenoids and a new dimer from the aerial part of Salvia plebeia R. Br.
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Lie-Feng Ma, Hong Xu, Ji-Dong Wang, Xiang-Min Tong, Zha-Jun Zhan, You-Min Ying, Jian-Wei Wang, Hui Zhang, Wei-Guang Shan Four new compounds, including three eudesmane sesquiterpenoids (1–3) and a dimeric sesquiterpenoid lactone (4), were isolated from the aerial part of Salvia plebeia R. Br., together with two known eudesmanolides (5–6). Their structures were elucidated by extensive spectroscopic analysis including 1D and 2D NMR, HR-ESI–MS spectra. Antiproliferative activities of isolates against six human myeloid leukemia ce...
Source: Phytochemistry Letters - April 11, 2018 Category: Chemistry Source Type: research

Chemical structures and antimutagenic effects of unusual oximes from the peels of Citrus limon
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Takahiro Matsumoto, Maoko Koike, Chika Arai, Takahiro Kitagawa, Eriko Inoue, Daisuke Imahori, Tetsushi WatanabeGraphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - April 11, 2018 Category: Chemistry Source Type: research

Anthrone derivatives from the terrestrial actinomycete, Actinomadura sp. BCC47066
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Nantiya Bunbamrung, Khomsan Supong, Chakapong Intaraudom, Aibrohim Dramae, Patchanee Auncharoen, Pattama Pittayakhajonwut Eight new anthrone derivatives, which are (+)-oxanthromicins E (1), F (4), and G (5), (±)-hemi-oxanthromicin D (2), azanthromicin A (7), adxanthromicin A2 (10), 3-methoxy oxanthromicin (11), and (±)-oxanthromicin G (13), along with eight previously described compounds (6, 8, 9, 12, 14–17) have been isolated from the terrestrial actinomycete, Actinomodura sp. BCC47066. The chemical structures have been de...
Source: Phytochemistry Letters - April 11, 2018 Category: Chemistry Source Type: research

Bioactive aporphine alkaloids from Fissistigma tungfangense
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Qi Zhou, Yan-Hui Fu, Yu-Qin Zhang, Shou-Yuan Wu, Xiao-Ping Song, Wei Xu, Guang-Ying Chen Three new aporphine alkaloids, fissitungfines C–E (1–3), together with five known analogues (4–8) were isolated from the stems of Fissistigma tungfangense. Their structures were elucidated by extensive spectroscopic methods Among them, fissitungfines C (1) and D (2) are two unusual aporphine alkaloids with a carboxyl group as a substituent at N-6. All isolated compounds were evaluated for their anti-rheumatoid arthritis activities via exa...
Source: Phytochemistry Letters - April 11, 2018 Category: Chemistry Source Type: research

Polyoxygenated ergosteroids from the macrofungus Omphalia lapidescens and the structure-cytotoxicity relationship in a human gastric cancer cell line
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Yue Wang, Ou Dai, Cheng Peng, Hai-Guo Su, Lu-Lin Miao, Lu-Si Liu, Liang Xiong Seventeen polyoxygenated Δ22-ergosteroids (1–17), including two new compounds (1 and 15), were isolated from the ethyl acetate soluble fraction of a 95% ethanol extract of Omphalia lapidescens Schroet. According to the oxidation degree and the oxidation positions of A and B rings, the isolates could be divided into three subtypes: 3,5,6-trioxygenated Δ7-ergosteroids (1–9), 3,5,6,7-tetraoxygenated ergosteroids (10–14), and conjugated &Del...
Source: Phytochemistry Letters - April 11, 2018 Category: Chemistry Source Type: research

New aromatic lactone derivatives with inhibitory activities on nitric oxide production from Homalium stenophyllum
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Shou-Yuan Wu, Yan-Hui Fu, Qi Zhou, Meng Bai, Guang-Ying Chen, Si-Yu Zhao, Xiao-Ping Song, Chang-Ri Han Two new aromatic lactone derivatives, homastenones A (1) and B (2), together with six known compounds (3–8), were isolated from the stems of Homalium stenophyllum. Their structures were established on the basis of extensive spectroscopic analyses. Among them, homastenones A (1) and B (2) are two novel aromatic lactone derivatives containing 12 carbon atoms on the carbon skeleton, and the known compounds (3–8) were isolated from th...
Source: Phytochemistry Letters - April 11, 2018 Category: Chemistry Source Type: research

Fingerprinting metabolomics in tropical mistletoes: A case study with facultative aluminum-accumulating species
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Marcelo Claro de Souza, Annylory Lima Rosa, Charlotte Poschenrieder, Roser Tolrà, Fernando Batista Da Costa Aluminum (Al) toxicity is a hot topic due to the high sensitivity of cultivated plants. Despite the large investment in the last century in understanding the mechanisms used by sensitive and Al-excluding species to avoid Al uptake from soil, little attention has been devoted to understanding the mechanisms used by native Al-accumulating species to deal with Al-toxicity. Passovia ovata (Pohl ex DC.) Kuijt and Struthanthus polyanthu...
Source: Phytochemistry Letters - April 10, 2018 Category: Chemistry Source Type: research

Fusidic acid ring B hydroxylation by Cunninghamella elegans
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Abdel-Rahim S. Ibrahim, Amany E. Ragab Fusidic acid (1) biotransformation using the fungus Cunninghamella elegans NRRL 1392 was studied. Two hydroxylated derivatives of fusidic acid (2, 3) were isolated, and their structures were fully elucidated using various spectroscopic techniques including 1D, 2D NMR and HRESI-FTMS. Cunninghamella elegans NRRL 1392 mediated the hydroxylation of ring B to yield 7-β-hydroxy (compound 2) and 6-β-hydroxyfusidic acid (compound 3). The antimicrobial activity of compounds 2 and 3 was evaluated against ...
Source: Phytochemistry Letters - April 10, 2018 Category: Chemistry Source Type: research

New iridoids from the flowers of Plumeria rubra “Acutifolia”
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Yu-Ying Xia, Chao-Zhan Lin, Xian-Jin Lu, Fang-Le Liu, Ai-ZHi Wu, Lei Zhang, Chen-Chen Zhu Four new iridoids, 1α-protoplumericin B-C (1-2), 13-O-caffeoyl-15-demethy-plumieride (3), 15-demethy-plumieride p-E-coumarate (4), together with six known iridoids (5-10) were isolated from the flowers of Plumeria rubra “Acutifolia”. Their structures and relative configurations were established by extensive spectroscopic methods, including IR, HRESIMS, HSQC, HMBC, 1H-1H COSY and NOESY analysis. All compounds were evaluated for cytotoxic ...
Source: Phytochemistry Letters - April 10, 2018 Category: Chemistry Source Type: research

The chemical constituents from twigs of Lindera glauca (Siebold & amp; Zucc.) Blume and their antiviral activities
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): SeonJu Park, Jae-Hyoung Song, Nguyen Xuan Nhiem, Hyun-Jeong Ko, Seung Hyun Kim Four new compounds (1–3 and 5), along with 17 known compounds, were isolated from the twigs of Lindera glauca (Siebold & Zucc.) Blume. The absolute configuration of compound 4 was determined for the first time in the present study. The structures of compounds were determined on the basis of extensive spectroscopic methods, including 1D and 2D NMR and CD spectroscopic data. All isolated compounds were tested for their antiviral activities against HRV1B-...
Source: Phytochemistry Letters - April 8, 2018 Category: Chemistry Source Type: research

Hydantoin and thioamide analogues from Lepidium meyenii
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): XiaoXue Tian, XingRong Peng, MuYuan Yu, YanJie Huang, Xia Wang, Lin Zhou, Minghua Qiu Four new compounds, including two hydantoin derivatives, macahydantoins C and D (1, 2), one urea derivative, macaurea A (3) and one thioamide analogue, macathioamide A (4), were isolated from the tube of Lepidium meyenii (Maca). Their chemical structures were determined by analyzing spectroscopic data, especially 1D and 2D NMR spectra, and comparing their specific rotation with data reported in literature. All of the isolates were obtained from plants for the...
Source: Phytochemistry Letters - March 27, 2018 Category: Chemistry Source Type: research

Acetophenone derivatives from the root bark of Cynanchum wilfordii as potential neuroprotective agents
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Hao-Wen Jiang, Jing Lin, Gui-Min Wang, Jing-Jing Zhang, Shan-Shan Gu, Lei Cao, Yan Chen, Ling Wang, He Jiao, Wei-Liang Zhu, Hai-Yan Zhang, Wei-Min Zhao, Jin-Long Li Seven new acetophenone derivatives, three couples of enantiomers (±)-cynwilforones D − F (1 − 3) together with cynwilforone G (4), were isolated form the root bark of Cynanchum wilfordii (Maxim.) Hemsl. Their structures were deduced based on spectroscopic analysis and X-ray crystallography. Each racemate was separated into individual enantiomers, and ele...
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research

Zeapyranolactone − A novel strigolactone from maize
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Tatsiana V. Charnikhova, Katharina Gaus, Alexandre Lumbroso, Mark Sanders, Jean-Paul Vincken, Alain De Mesmaeker, Carolien P. Ruyter-Spira, Claudio Screpanti, Harro J. Bouwmeester The structure of a new strigolactone present in the root exudate and root extract of maize hybrid cv NK Falkone plants was elucidated and characterized as zeapyranolactone: Methyl .(E)-3-((4-methyl-5-oxo-2,5-dihydrofuran-2-yl)oxy)-2-(4,4,5-trimethyl-2-oxo-2,3,4,6,7,7a-hexahydrocyclopenta[b]pyran-7-yl)acrylate. Unlike any other strigolactone published so far, it cont...
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research

Chemical constituents from the rhizomes of Gastrodia elata f. glauca and their potential neuroprotective effects
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Zhi-Wei Wang, Yun Li, Da-Hui Liu, Yan Mu, Hong-Jing Dong, Hong-Lei Zhou, Xiao Wang A phytochemical study on the rhizomes of Gastrodia elata f. glauca resulted in the isolation of three new parishin derivatives and one new adenosine derivative, together with six known compounds. Their structures were elucidated mainly by spectroscopic analysis and compared to published data. All these isolates were evaluated for their neuroprotective effects against 6-hydroxydopamine-induced cell death, and new compound 4 showed potent activity with an EC50 va...
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research

Bicyclo[3.2.1]octanoid neolignans from Indonesian red betle leaves (Piper crocatum Ruiz & amp; Pav.)
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Dayar Arbain, Nofrizal, Nova Syafni, Friardi Ismed, Sammer Yousuf, M. Iqbal Choudhary Two new bicyclo[3.2.1]octanoid neolignans of guianin-type named as (1′R,2′R,3′S,7S,8R)-Δ5′,8′-2′-acetoxy-3,4,5,3′,5′-pentamethoxy-4′-oxo-8.1′,7.3′-neolignan (crocatin A, 1) and (1′R,2′R,3′S,7S,8R)-Δ5′,8′-2′-hydroxy-3,4,5,3′,5′-pentamethoxy-4′-oxo-8.1′,7.3′-neolignan (crocatin B, 2), along with known compounds pachypo...
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research

Simple synthesis and anti-inflammatory activities of Spanrstolonin B derivatives
In this study, ten derivatives (A1–A6, B1–B2, and C1–C2) were synthesized by the structural modification of compounds 1 and 2, of which nine derivatives are new compounds. The n-octanol/water partition coefficients (K ow) of these derivatives were determined by high performance liquid chromatography method, and their anti-inflammatory activities were evaluated of inhibiting the secretion of TNF-α and IL-6 in LPS- or Pam3csk4- induced RAW264.7 cells. Preliminary structure-activity relationship study revealed that methylated, acetylated and butyrylated derivatives (A1–A6) exhibited weaker activi...
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research

Bioactive dibenzofurans from the rattans of Bauhinia championii (Benth.) Benth.
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Li-Ping Hua, Yu-Qin Zhang, Miao Ye, Wen Xu, Xiao-Ying Wang, Yan-Hui Fu, Wei Xu Two new dibenzofurans, bauhichamines A (1) and B (2), along with six known compounds (3-8), were isolated from the rattans of Bauhinia championii (Benth.) Benth. (Fabaceae). The structures of 1 and 2 were elucidated by extensive spectroscopic methods and the known compounds were identified by comparison of their data with those reported in the literatures. All new compounds were evaluated for their anti-rheumatoid arthritis activities via examining their anti-proli...
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research

Novel biflavonoids from Cephalotaxus oliveri Mast.
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Dai Ren, Fan-Cheng Meng, Hui Liu, Tong Xiao, Jin-Jian Lu, Li-Gen Lin, Xiu-Ping Chen, Qing-Wen Zhang Three new biflavonoids, umcephabiflovin A (1), umcephabiflovin B (2), and S-taiwanhomoflavone-B (3), together with seven known flavonoids (4–10) and seven known alkaloids (11–17), were isolated from the twigs of Cephalotaxus oliveri Mast. The flavonoids were found to inhibit α-glucosidase activity. Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research

Three new nortriterpenoids from the rattan stems of Schisandra chinensis
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Bing-You Yang, Zhang-Lin Chen, Yan Liu, Hai-Xue Kuang Three new nortriterpenoids, schindilactones L and M (1–2) and wuweizidilactone S (3), along with five known nortriterpenoids, schindilactone G (4), wuweizidilactone A (5), wuweizidilactone L (6), wuweizidilactone C (7) and pre-schisanartanin (8), were isolated from the rattan stems of Schisandra chinensis. The structure of the new compounds were elucidated by spectroscopic methods, including one and two-dimensional NMR as well as high-resolution mass spectrometry. All of the compound...
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research

Cytotoxic and antimicrobial labdane and clerodane diterpenoids from Kaempferia elegans and Kaempferia pulchra
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Pornsuda Chawengrum, Jutatip Boonsombat, Prasat Kittakoop, Chulabhorn Mahidol, Somsak Ruchirawat, Sanit Thongnest Three previously undescribed diterpenoids, propadanes A-C (1-3), together with seventeen known compounds (4-20), were isolated from the rhizomes of Kaempferia elegans and Kaempferia pulchra. The structures of the isolated compounds were elucidated through extensive analysis of spectroscopic data. The absolute configuration (12R) of propadane A (1) was established by CD analysis. (−)-Kolavelool (15) and (−)-2β-hydr...
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research

Oleanane triterpenoids from the Algerian Salvia phlomoides
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Lamia Benniou, Moses K. Langat, Dulcie A. Mulholland, Fadila Benayache, Samir Benayache Three previously unreported triterpenoids 2α,3β,11α-trihydroxyolean-18-ene 1, 3β-acetoxy,2α,11α- dihydroxyolean-18-ene 2 and 2α-acetoxy,3β,11α-dihydroxyolean-18-ene 3 were isolated from the chloroform extract of aerial parts (leaves and flowers) of Salvia phlomoides collected from the Constantine region in the east of Algeria. Structures were determined using NMR spectroscopy and HR-ESI mass spectrometry. ...
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research

Two new naphthalenones from Diospyros undulata stem bark and their cytotoxic activity
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Natcha P. Suchaichit, Nattawut Suchaichit, Kwanjai Kanokmedhakul, Kitisak Poopasit, Panawan Moosophon, Somdej Kanokmedhakul Two new naphthalenones, cis-isoshinanolone-4-acetate (1) and 3,4-dihydro-4β-hydroxy-5,6-dimethoxy-2α-methyl-1(2H)-naphthalenone (2), were isolated together with three known naphthoquinone derivatives (3-5), four dimeric naphthoquinones (6-9), two coumarins (10-11) and four triterpenoids (12-15) from the stem bark of Diospyros undulata. Their structures were characterized by intensive spectroscopic data (1D and...
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research

Zonal distribution of neutral aroma components in flue-cured tobacco leaves
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Jian-An Wang, Gai-He Yang, Chun-Xia Li To understand the regional distributions of neutral aroma components (NACs) of interest in flue-cured tobacco (Nicotiana tabacum L.), samples from a single cured leaf lamina were taken at 48 distinct points with the help of a thin transparent plastic board. We investigated 28 NACs belonging to five categories, namely aromatic amino acid cleavage substances (ACS), cembratriendid alkyl degrading products (CADP), carotenoid degradation products (CDP), chlorophyll degradation products (CDPS), and Maillard re...
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research

A new phenylpropane-pimarane heterodimer and a new ent-kaurene diterpene from the husks of Oryza sativa
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Qiang Zhang, Qiao-Lin Xu, Xiao-Mei Xia, Li-Mei Dong, Bi Luo, Wen-Bin Liu, Jian-Wen Tan A new phenylpropane-pimarane heterodimer, 2-[(E)-3-(4-hydroxy-3-methoxyphenyl) allylidene] momilactone A (1), and a new ent-kaurene diterpene, ent-3α,16α-dihydroxy-kauran-19-oic acid (2), were isolated from the rice husks of Oryza sative L., along with a known ent-kaurene diterpenoid ent-7-oxo-kaur-15-en-19-oic acid (3). Their structures were determined by spectroscopic means, including nuclear magnetic resonance (NMR) and mass spectrometry (MS)...
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research

Campnospermenone A, B and C, three new cytotoxic alkyl-hydroxycyclohexenones from Campnosperma zeylanica Thwaites leaves
This study demonstrated that novel compounds isolated from C. zeylanica seem to be mediating potent cytotoxic effects in breast cancer cells through activation of caspase 3/7. Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research

Furan fragment isomerized mexicanolide-type Limonoids from the stem barks of Khaya senegalensis
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Wen-Yan Zhang, Lu Qiu, Qin-Pei Lu, Miao-Miao Zhou, Jun Luo, Yi Li Four new mexicanolide-type limonoids with isomerized furan fragment khaysenelides G–J (1–4) were isolated from the stem barks of Khaya senegalensis. Their structures were elucidated on the basis of (1D and 2D) NMR and HRESIMS, and the normal furan rings in 1-4 were isomerized to hydroxybutenolide moieties. Bioactivities screening of new compounds indicated that 1 showed potent cytotoxicities against MDA-MB-231 and HepG2 human cancer cell lines with IC50 values of 6....
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research

Phytochemical constituents and chemosystematic significance of Pulicaria jaubertii E.Gamal-Eldin (Asteraceae)
Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Abdelsamed I. Elshamy, Tarik A. Mohamed, Mona M. Marzouk, Taha A. Hussien, Akemi Umeyama, Mohamed Elamir F. Hegazy, Thomas Efferth The chemical characterization of methylene chloride/methanol (1:1) extract of the air-dried whole medicinal plant, Pulicaria jaubertii E. Gamal-Eldin, led to isolation and identification of two new hydroquinone compounds; 2-(2-acetoxy propyl), 5-methyl hydroquinone (1) and 2-(2-hydroxy propyl), 5-methyl hydroquinone-4-O-β-D-glucopyranoside (2), four known flavonols (3-6) and 7 known dihydroflavonols (7-13). T...
Source: Phytochemistry Letters - March 21, 2018 Category: Chemistry Source Type: research

Novel macamides from maca (Lepidium meyenii Walpers) root and their cytotoxicity
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Chen Xia, Jian Chen, Jun-Lin Deng, Yong-Qing Zhu, Wan-Yi Li, Bu Jie, Tian-Yuan Chen Maca, Lepidium meyenii Walpers (Brassicaceae), contains secondary metabolites, including macamides, which possess many bioactive properties. Two new macamides, namely, N-benzyl-9-oxo-10E,12E-octadecadienamide (3) and N-benzyl-9-oxo-10E,12Z-octadecadienamide (4), were isolated from maca root. In addition, two fatty acid derivatives, 9-oxo-10E,12E-octadecadienoic acid (1) and 9-oxo-10E,12Z-octadecadienoic acid (2), were found for the first time from maca. The str...
Source: Phytochemistry Letters - March 17, 2018 Category: Chemistry Source Type: research

Identification of compounds with cytotoxic activity from Millettia dorwardi Coll. Et. Hemsl
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Kai Chen, Huan Tang, Li Zheng, Lun Wang, Linlin Xue, Ai-hua Peng, Ming-hai Tang, Chaofeng Long, Xiaoxin Chen, Hao-yu Ye, Li-juan Chen Two new lignan derivatives and nine known compounds were isolated from the EtOAc and n-BuOH extracts of Millettia dorwardi Coll. Et. Hemsl. The structures of the compounds were determined by 1D and 2D NMR, CD and HRMS. Then, cytotoxic effects of these compounds were evaluated against five cancer cell lines (HepG2, HCT116, MCF7, Raji and KG-1). Results showed the isolated compounds have no obvious cytotoxic activ...
Source: Phytochemistry Letters - March 17, 2018 Category: Chemistry Source Type: research

Scumoniliosides A and B, two new flavanone glucuronate esters from Scutellaria moniliorrhiza Komarov with anti-inflammatory activities
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Qing-Tong Han, Kai Xiao, Kang-Lin Xiang, Gui-Sheng Li, Sheng-Jun Dai Two new flavanone glucuronate esters, named scumoniliosides A and B (1-2), along with two known flavonoid glucuronate esters, 5,4′-dihydroxyflavonoid-7-O-β-d-glycuronate methyl ester (3) and 5,4′-dihydroxyflavonoid-7-O-β-d-glycuronate butyl ester (4), were isolated from the ethanolic extract of the whole plant of Scutellaria moniliorrhiza. Their chemical structures including absolute configurations were determined by means of integrated spectroscopic tec...
Source: Phytochemistry Letters - March 16, 2018 Category: Chemistry Source Type: research

Excoecarins L and O from the mangrove plant Excoecaria agallocha L.
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Nguyen Van Thanh, Lai Hop Hieu, Phan Thi Thanh Huong, Le Thi Vien, Tran My Linh, Nguyen The Cuong, Nguyen Xuan Cuong, Nguyen Hoai Nam, Ngo Dai Quang, Chau Van Minh Two new beyerene-type diterpenoids (1 and 2), along with six known metabolites (3-8) were isolated from the twigs and leaves of the mangrove plant Excoecaria agallocha L. collected from coastal areas in Vietnam. The structures and relative configurations of new compounds were established on the basis of HR-ESI-MS, 1D and 2D NMR experiments. Two new metabolites were tested for cytoto...
Source: Phytochemistry Letters - March 16, 2018 Category: Chemistry Source Type: research

GC –MS detection of plant pigments and metabolites in Roman Julio-Claudian wall paintings
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Angelo Gismondi, Lorena Canuti, Giulia Rocco, Marcella Pisani, Alessandra Ghelli, Margherita Bonanno, Antonella Canini For the first time, plant pigments were detected in Roman frescoes. Indeed, only sporadic papers proved the application of natural hues in ancient paintings and none of them relative to Roman art. Therefore, eight differently coloured fragments of Julio-Claudian wall paintings, collected from Terme degli Stucchi Dipinti archaeological site (Rome, Italy), were subjected to GC–MS analysis, obtaining detailed chemical profi...
Source: Phytochemistry Letters - March 15, 2018 Category: Chemistry Source Type: research

The first phytochemical investigation of Rhododendron websterianum: triterpenoids and their cytotoxic activity
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Rui Zhang, Chunping Tang, Yan Li, Chang-Qiang Ke, Ge Lin, Hua Xie, Sheng Yao, Yang Ye The first phytochemical investigation of the fruits of Rhododendron websterianum resulted in the isolation of two new triterpenoids, 11-dehydroxytrisnormogrol acid (1), 11-dehydroxytrisnormogrol (2), and 21 known analogues. Their structures were determined by extensive analysis of spectroscopic and mass data, as well as by comparison with those in literature. All isolates were assayed their cytotoxic activities on human hepatoma SMMC-7721 cells and human lung...
Source: Phytochemistry Letters - March 15, 2018 Category: Chemistry Source Type: research

Chemical constituents of root and stem bark of Erythrina brucei
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Getahun Tadesse Gurmessa, Souvik Kusari, Hartmut Laatsch, Gomotsang Bojase, Godiraone Tatolo, Ishmael B. Masesane, Michael Spiteller, Runner R.T. Majinda Two new isoflavanones, erybrucein A and B (1, 2), together with nineteen known compounds are reported herein from the stem and root bark of the Ethiopian medicinal plant, Erythrina brucei. All known compounds, except erythraline (19), have been isolated for the first time from E. brucei. Their structures were established on the basis of extensive spectroscopic and spectrometric analyses (1D a...
Source: Phytochemistry Letters - March 15, 2018 Category: Chemistry Source Type: research

Protective effects of dammarane-type triterpenes from hydrolyzate of Gynostemma pentaphyllum against H2O2-induced injury and anti-hepatic fibrosis activities
In this study, phytochemical investigation of hydrolyzate of total G. pentaphyllum saponins led to the isolation of three previously undescribed triterpenes, Gypensapogenin R (1), Gypensapogenin S (2), and Gypensapogenin T (3). Their structures were mainly identified by 1D, 2D-NMR and HR-ESI–MS evidences. Anti-hepatic fibrosis activity was determined and the data showed that 2 and 3 exhibited more potent inhibitory effects (IC50 values 14.93 and 29.19, respectively) on the growth of t-HSC/Cl-6 cells than Silymarin (positive control), while having much weaker effect in the growth of normal cell. Additionally, all the ...
Source: Phytochemistry Letters - March 14, 2018 Category: Chemistry Source Type: research

Corrigendum to “Investigation of chemical constituents from Spiraea prunifolia var. simpliciflora and their biological activities” [Phytochem. Lett. 22 (2017), 255–260]
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Chung Sub Kim, Joonseok Oh, Won Se Suh, Sung Wan Jang, Lalita Subedi, Sun Yeou Kim, Sang Un Choi, Kang Ro Lee (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - March 14, 2018 Category: Chemistry Source Type: research

Monoterpene, benzyl and 3,4-dihydroxyphenethyl glycosides from Magnolia thailandica
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Tripetch Kanchanapoom, Poolsak Sahakitpichan, Nitirat Chimnoi, Chutima Srinroch, Wassapol Thamniyom, Somsak Ruchirawat A new monoterpene glucoside, (3S,6S)-6,7-dihydroxy-6,7-dihydrolinaloyl 6-O-β-d-glucopyranoside, along with two new aromatic glycosides, benzyl O-α-l-rhamnopyranosyl-(1 → 2)-β-d-glucopyranoside and 3,4-dihydroxyphenethyl O-α-l-rhamnopyranosyl-(1 → 2)-[α-l-rhamnopyranosyl−(1 → 3)]-β-d-glucopyranoside were isolated from Magnolia thailandica. Additionally, 29 known ...
Source: Phytochemistry Letters - March 14, 2018 Category: Chemistry Source Type: research

Pahangine A and B, two new oxetane containing neolignans from the barks of Beilschmiedia glabra Kosterm (Lauraceae)
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Syazreen Nadia Sulaiman, Azeana Zahari, Sook Yee Liew, Marc Litaudon, A.M. Issam, Habibah A. Wahab, Khalijah Awang Phytochemical investigation on the barks of Beilschmiedia glabra Kosterm led to the isolation of two new oxetane containing neolignans, Pahangine A (1) and Pahangine B (2) together with eight known compounds. The structures of isolated compounds were elucidated by extensive spectroscopic analysis including 1D and 2D NMR (1H–1H COSY, HSQC, and HMBC), DEPT-Q NMR, and by comparing with the published data. A possible biosyntheti...
Source: Phytochemistry Letters - March 14, 2018 Category: Chemistry Source Type: research

Acylated iridoid diglycosides from the cultivated endangered ornamental tree Gmelina hainanensis
Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Juan Xiong, Xi-Ying Wu, Pei-Pei Wang, Choiwan Lau, Hui Fan, Guang-Lei Ma, Yu Tang, Jia Li, Jin-Feng Hu Two new (1 and 2) and 10 known (3−12) acylated iridoid diglycosides were isolated from the twigs and leaves of the cultivated endangered ornamental plant Gmelina hainanensis. Based on spectroscopic data interpretation and chemical transformation, the new triacyl and the new diacyl iridoid diglycosides were established to be 6-O-α-L-(2″,3″-di-O-acetyl-4″-O-cis-cinnamoyl)rhamnopyranosylcatalpol (1) and 6-O-α-...
Source: Phytochemistry Letters - March 14, 2018 Category: Chemistry Source Type: research