Non-destructive chemical analysis of a Garcinia mangostana L. (Mangosteen) herbarium voucher specimen
We present herein a non-destructive method to analyze the metabolites of herbarium voucher specimens with the droplet-liquid microjunction-surface sampling probe (droplet probe) coupled to ultra-performance liquid chromatography and high-resolution mass spectrometry. As proof of concept, a herbarium voucher specimen of Garcinia mangostana (mangosteen) was utilized due to the well-characterized xanthones biosynthesized by this plant, which are of interest as potential anticancer agents. Also, the juice of the fruits of this plant is used widely in the United States and in other countries as a botanical dietary supplement. M...
Source: Phytochemistry Letters - October 27, 2018 Category: Chemistry Source Type: research

Four new flavonoids with DGAT inhibitory activity from Psoralea corylifolia
Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): Hao-Ze Li, Xiao Meng, Yi-Yu Jiang, Xin Lin, Da-Xi Xiong, Dong Wang, Hyun-Sun Lee, Long CuiAbstractFour new compounds, 3′'-methoxy-bavacoumestan C (1), 6,7-furanbavachinone B (2), 3,4- furanbavachalcone A (3) and 4,5- furanbavachalcone A (4), together with seven known flavonoids were isolated from the Psoralea corylifolia. Their structures were determined by extensive spectroscopic and physicochemical analyses. All the compounds (1–11) were evaluated for in vitro inhibitory activity against DGAT. Among them, compounds 1, 6, 7, 10 ...
Source: Phytochemistry Letters - October 27, 2018 Category: Chemistry Source Type: research

Indole and flavonoid from the herbs of Kalimeris shimadai
Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): Nan Zhang, Wen-Fang Jin, Yun-Peng Sun, Gang Wang, Yang Yu, Zhong-Yu Zhou, Guo-Kai Wang, Jin-Song LiuAbstractA new indole, kalshiliod A (1), a new flavonoid glycoside, isorhamnetin-3-O-β-D- glucuronide-6′′-ethyl ester (2), and ten known compounds (3–12) were isolated from the herbs of Kalimeris shimadai. The compounds’ structures were elucidated through comprehensive spectroscopic techniques. All of the compounds were isolated from K. shimadai for the first time. Furthermore, the new compounds’ cytotoxicitie...
Source: Phytochemistry Letters - October 27, 2018 Category: Chemistry Source Type: research

Bioactive isoquinoline alkaloids from Glaucium arabicum
Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): Ahmed Elbermawi, Amal Sallam, Hazem A. Ghabbour, Mahmoud F. Elsebai, Mohamed F. Lahloub, Hassan-Elrady A. SaadAbstractPhytochemical investigation of the aerial parts of Glaucium arabicum Fresen. (Papaveraceae) led to the isolation of two previously undescribed isoquinoline alkaloids araglaucine A, and araglaucine B, together with seven known ones 1-[(3`,4`-dimethoxy-2`-methylcarboxy)benzoyl]-6,7-methylenedioxy isoquinoline (araglaucine C), (7R,14S)-trans-N-methylcanadinium nitrate, (R,S)-trans-N-methylstylopine, 14-hydroxy-N-methyl canadine,...
Source: Phytochemistry Letters - October 27, 2018 Category: Chemistry Source Type: research

New iridoid glycosides from Viburnum punctatum
Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): Yuan Gao, Wan-Qiu Yang, Ku Yang, Xian-Jun Jiang, Xiang-Mei Li, Fei WangAbstractThree hitherto unknown valeriana-type iridoid glycosides (1−3) were isolated from Viburnum punctatum, and their structures were elucidated by extensive spectroscopic analysis. The new compounds, designated as viburpunosides A − C (1−3), are characterized by having a mono- or triacylated α-l-rhamnopyranosyl-(1→2)-β-d-glucopyranosyl moiety linked to C-11. This is the second report of an iridoid attached to a disacchari...
Source: Phytochemistry Letters - October 27, 2018 Category: Chemistry Source Type: research

Spiro-isoxazolines from the flowers of Xanthoceras sorbifolia
Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): Zhan-Lin Li, Dan-Dan Zhao, Dan-Yi LiAbstractFour tyrosine-derived spiro-isoxazoline analogues, including two new ones (3–4), were isolated from the flowers of Xanthoceras sorbifolia Bunge. The planar structures and the conformations were established by the analyses of the 1D and 2D NMR spectroscopic data, and the absolute configuration of compound 4 was determined via ECD calculation by time-dependent density functional theory (TDDFT). The biosynthetic pathway involving oxidative cyclization of the aldoxime precursor and the substrate-...
Source: Phytochemistry Letters - October 27, 2018 Category: Chemistry Source Type: research

Three new 2,4′-epoxy-8,5′/8,3′-neolignans from Penthorum chinense
Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): Fei Liu, Ya-Cong He, Huan Zhu, Li Guo, Cheng Peng, Liang XiongAbstractThree new neolignans (1−3), including one 2,4′-epoxy-8,5′-neolignan and two 2,4′-epoxy-8,3′-neolignan glycosides, were isolated from the EtOAc-soluble portion of the water decoction of Penthorum chinense Pursh. Their structures and absolute configurations were elucidated by comprehensive analysis of spectroscopic data and electronic circular dichroism (ECD) calculations. Notably, the unusual 2,4′-epoxy-8,3′-neolignan glycosides are...
Source: Phytochemistry Letters - October 27, 2018 Category: Chemistry Source Type: research

Modulation of polyketide biosynthetic pathway of the endophytic fungus, Anteaglonium sp. FL0768, by copper (II) and anacardic acid
Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): Jair Mafezoli, Ya-ming Xu, Felipe Hilário, Brandon Freidhof, Patricia Espinosa-Artiles, Lourdes C. dos Santos, Maria C.F. de Oliveira, A.A. Leslie GunatilakaAbstractIn an attempt to explore the biosynthetic potential of endosymbiotic fungi, the secondary metabolite profiles of the endophytic fungus, Anteaglonium sp. FL0768, cultured under a variety of conditions were investigated. In potato dextrose broth (PDB) medium, Anteaglonium sp. FL0768 produced the heptaketides, herbaridine A (1), herbarin (2), 1-hydroxydehydroherbarin (3), sco...
Source: Phytochemistry Letters - October 27, 2018 Category: Chemistry Source Type: research

Two new steroidal glycosides from Anemarrhena asphodeloides rhizome, and their cytotoxic activity in vitro
Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): Pham Van Khang, Ngo Duc Hieu, Nguyen Thi Hien Lan, Sida Shen, Lei MaAbstractTwo new steroidal glycosides 1 and 2 have been isolated from the n-butanol extract portion of Anemarrhena asphodeloides Bunge (A.asphodeloides), a widely used plant as Traditional Chinese Medicine. Their structures have been confirmed through a variety of analytic approaches including 1D and 2D-NMR spectroscopic techniques as well as mass spectrometry data. Moreover, cytotoxic activity evaluation demonstrated that compound 2 exhibited micromole level cytotoxic effect...
Source: Phytochemistry Letters - October 27, 2018 Category: Chemistry Source Type: research

Phytochemical characterization of the Chinese endemic species Stemona mairei and five other Stemona species
Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): Gao Chen, Lothar Brecker, Katharina Maria Sandler, Xiang-Hai Cai, Sumet Kongkiatpaiboon, Karin Valant-Vetschera, Johann SchinnerlAbstractComparative HPLC-PDA analyses of methanolic root extracts of the almost unstudied Chinese endemic species Stemona mairei, collected from nine locations throughout its natural habitat in northern Yunnan, led to the identification of the pyrrolo[1,2-α]azepine-type alkaloid protostemonine (1) as the main alkaloid and 3,4-dehydro-δ-tocopherol (9) as the main tocopherol derivative. Analysis of the fi...
Source: Phytochemistry Letters - October 27, 2018 Category: Chemistry Source Type: research

Triterpene saponins of the root bark of Olax obtusifolia De Wild
Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): David Pertuit, Anne-Claire Mitaine-Offer, Tomofumi Miyamoto, Chiaki Tanaka, Clément Delaude, Marie-Aleth Lacaille-DuboisAbstractFour undescribed triterpenoid saponins together with five known and oleanolic acid were isolated from root bark of Olax obtusifolia De Wild. Their structures were elucidated by spectroscopic methods including 1D and 2D NMR experiments, in combination with mass spectrometry as 3-O-α-l-rhamnopyranosyl-(1→4)-α-l-rhamnopyranosyl-(1→3)-β-d-glucuronopyranosyloleanolic acid, 3-O-α-l-...
Source: Phytochemistry Letters - October 27, 2018 Category: Chemistry Source Type: research

Corrigendum to “Nitrophenyl dihydropyridine-derivatives from Seriphidium oliverianum” [Phytochem. Lett. 21 (September) (2017) 226–229]
Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): Liaquat Ali, Muhammad Imran Tousif, Naheed Riaz, Mamona Nazir, Hidayat Hussain, Ahmed Al-Harrasi, Nusrat Shafiq, Abdul Jabbar, Rasool Bakhsh Tareen, Muhammad Saleem (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - October 27, 2018 Category: Chemistry Source Type: research

Inside Front Cover (Editorial Board)
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - September 22, 2018 Category: Chemistry Source Type: research

Contents (graphical abstracts and research highlights)
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - September 22, 2018 Category: Chemistry Source Type: research

Briaviolides O and P, new briaranes from a cultured octocoral Briareum violaceum
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Jing-Hao Xu, Yu-Chia Chang, Guo-Qiang Li, Zhi-Hong Wen, Yang-Chang Wu, Ping-Jyun SungAbstractChemical investigation of the EtOAc-soluble fraction from the MeOH/DCM extract of a cultured octocoral Briareum violaceum afforded two new briarane diterpenoids, briaviolides O (1) and P (2). The structures of briaranes 1 and 2 were elucidated on the basis of spectroscopic analysis, and 1 was shown to inhibit the accumulation of pro-inflammatory iNOS protein in LPS-stimulated RAW264.7 macrophage cells.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - September 22, 2018 Category: Chemistry Source Type: research

Carboline alkaloids and isocoumarins from the wasp pathogenic fungus Ophiocordyceps sphecocephala BCC 2661
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Jittra Kornsakulkarn, Siriporn Saepua, Sukitaya Veeranondha, Pranee Rachtawee, Masahiko Isaka, Chawanee ThongpanchangAbstractTen β-carboline alkaloids, including five new and two new naturally occurring compounds, sphecolines A–G (1–7), together wit2h four known isocoumarins were isolated from a wasp-pathogenic fungus Ophiocordyceps sphecocephala BCC 2661. Structures of these compounds were determined by NMR spectroscopic and MS spectrometric analyses. Sphecolines A (1) and C (3) exhibited cytotoxic activity against human sma...
Source: Phytochemistry Letters - September 22, 2018 Category: Chemistry Source Type: research

Two new stilbenoids from the whole herb of Sphaerophysa salsula
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Li Jin Jiao, Wei Dong Wang, Yan Duo Tao, Yun Shao, Li Juan Mei, Zeng Gen Liu, Qi Lan Wang, Jun DangAbstractTwo new compounds, gnetuhainins Fa (1) and cassigarols Ea (2), were isolated from the whole herb of Sphaerophysa salsula along with eight known compounds (3-10). The compounds (4) were isolated for the first time from this species. Their structures were elucidated by ESI-MS, UV, IR, 1D NMR and 2D NMR data.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - September 22, 2018 Category: Chemistry Source Type: research

Structurally diverse glycoconjugated volatile compounds from Oxytropis falcata Bunge
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Shanshan Wang, Xiaojing Zhang, Sheng Que, Hong Liang, Pengfei Tu, Qingying ZhangAbstractA phytochemical investigation on the whole plant of Oxytropis falcata Bunge yielded 16 glycoconjugated compounds with structurally diverse volatile aglycones but similar sugars. Of these, five were previously undescribed compounds with different volatile aglycones but same glucuronic acid (1 → 2) glucosyl moiety, including three octanol glucuronic acid (1 → 2) glucosides (1–3), one acyclic monoterpenoid glucuronic acid (1 →...
Source: Phytochemistry Letters - September 22, 2018 Category: Chemistry Source Type: research

Diarylheptanoids from the root of Curcuma aromatica and their antioxidative effects
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Shengjuan Dong, Xiaodong Luo, Yaping Liu, Mi Zhang, Baocai Li, Weifeng DaiAbstractFour rare diarylheptanoids containing tetrahydropyran moieties (1–4) and five known diarylheptanoids (6–10) were isolated from the n-BuOH fraction of 75% ethanol extract from the root of Curcuma aromatica, along with a new phenol (5). Their planar and stereochemical structures were established using HRESIMS and spectroscopic methods, including ECD data. All compounds (1–10) exhibited antioxidant effects on the model of H2O2-induced damage in PC...
Source: Phytochemistry Letters - September 22, 2018 Category: Chemistry Source Type: research

Three new sesquiterpene lactones from Carpesium abrotanoides
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Qiao-Ling Hu, Pei-Qian Wu, Ying-Hong Liu, Feng-Ming Qi, Chun-Xue Yu, Ye Zhao, Yi-Fan Yu, Dong-Qing Fei, Zhan-Xin ZhangAbstractThree new sesquiterpene lactones, 5α-hydroxy-4α,15-epoxy-11αH-eudesman-12,8β-olide (1), carabrol-4-O-palmitate (2) and carabrol-4-O-linoleate (3), along with five known ones, were isolated from the whole plant of Carpesium abrotanoides. The structures of new compounds were determined by extensive spectroscopic analysis, and compound 1 was also elucidated by X-ray single-crystal diffraction analys...
Source: Phytochemistry Letters - September 22, 2018 Category: Chemistry Source Type: research

Six new dihydro-β-agarofuran sesquiterpenes from the stems and leaves of Monimopetalum chinense and their antimicrobial activities
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Xingzeng Zhao, Shu Xu, Min Yin, Xiangyun Wang, Qizhi Wang, Yu Shan, Yu Chen, Fei Liu, Shenghu Guo, Xu FengAbstractSix new dihydro-β-agarofuran sesquiterpenes (1-6) were isolated from Monimopetalum chinense Rehd., and their structures were elucidated based on spectroscopic data analyses. Absolute configurations of representative compounds (1 and 3) were also determined by using quantum mechanic CD calculations. In addition, the antimicrobial activities of 1-6 against plant-pathogenic fungi and bacteria were evaluated by in vitro growth in...
Source: Phytochemistry Letters - September 22, 2018 Category: Chemistry Source Type: research

Identification of anti-inflammatory active peptide from black soybean treated by high hydrostatic pressure after germination
This study was conducted to isolate and identify the anti-inflammatory active peptide in black soybean treated by high hydrostatic pressure after germination. The anti-inflammatory activity was examined using RAW 264.7 macrophages. Black soybean was germinated for 4 days and subjected to 150 MPa for 24 h, followed by preparation of protein extracts. The extracts were sequentially filtered using membranes with a molecular weight cutoff of 30, 10, and 3 kDa. A strong inhibitory effect was observed with the 3–10 kDa fraction. The active peptide from this fraction was purified by gel permeation column chromatogra...
Source: Phytochemistry Letters - September 22, 2018 Category: Chemistry Source Type: research

Two new oleanane-type saponins from Elaeocarpus hainanensis Oliv. growing in Vietnam
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Dao Thu Nga, Pham Quang Duong, Quang Le Dang, Nguyen Huu Tung, Vu Dinh HoangAbstractTwo new oleanane-type saponins, 1α-hydroxy-olean-12-en-3-O-β-D-xylopyranoside (1) and 1α-hydroxy-olean-12-en-3-O-α-L-arabinopyranoside (2), along with six known compounds (3-8), were isolated from the leaves and twigs of Elaeocarpus hainanensis Oliv. Their structures were determined based on chemical and spectroscopic analyses. This is the first report on oleanane-type triterpenoids in the genus Elaeocarpus.Graphical abstract (Source: Ph...
Source: Phytochemistry Letters - September 22, 2018 Category: Chemistry Source Type: research

C19-diterpenoid alkaloids from Aconitum hemsleyanum var. circinatum
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Jin-bu Xu, Shuai Huang, Xian-li ZhouAbstractSix new C19-diterpenoid alkaloids, circinatines A–F (1–6), along with eight known compounds, were isolated from the roots of Aconitum hemsleyanum var. circinatum. Their structures were elucidated by extensive spectroscopic methods including NMR, IR, HR-ESI-MS and X-ray experiments. All compounds were evaluated for their cytotoxic activity against MCF-7, A549, HCT-116 and 786-0 human cancer cell lines.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - September 22, 2018 Category: Chemistry Source Type: research

Anti-inflammatory terpenoid derivatives from the twigs of Syringa oblata var. dilatata
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Kyoung Jin Park, Lalita Subedi, Sun Yeou Kim, Kang Ro LeeAbstractAs a part of our ongoing search for bioactive constituents from Korean medicinal sources, chemical investigations of Syringa oblata var. dilatata twigs were carried out, leading to the isolation and characterization of two new terpenoid derivatives (1-2) and five known compounds (3-7). The chemical structures of the compounds 1 and 2 were determined by extensive NMR data (1H and 13C NMR, 1H-1H COSY, HSQC, HMBC, and NOESY), HRMS, and chemical methods. These compounds (1-7) were e...
Source: Phytochemistry Letters - September 22, 2018 Category: Chemistry Source Type: research

Cytotoxic phloroglucinol meroterpenoid from Eugenia umbelliflora fruits
This study describe the isolation and structure elucidation of a sesquiterpenyl phloroglucinol (eugenial E), that is described here for the first time. Eugenial E (5) was isolated from the n-hexane extract of fruits, and its structural elucidation was carried out through the combined analysis of MS, IR and 1D-(¹H, ¹³C BB and DEPT, and NOEDIFF) and 2D-(COSY, HSQC, HMBC and ROESY) NMR spectra, with conformational analysis support. Cytotoxicity was assessed using MTT analysis against human leukemic cells (k562 and Nalm-6 cells) and murine melanoma cells (B16F10 cell). The extracts showed high cytotoxicity, whil...
Source: Phytochemistry Letters - September 22, 2018 Category: Chemistry Source Type: research

Phytochemical constituents and cytotoxic activity of Physalis angulata L. growing in Vietnam
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Hoang Le Tuan Anh, Do Thi Thao, Duong Thi Dung, Phan Van Kiem, Tran Hong Quang, Pham Thi Hai Yen, Do Thanh Tuan, Pham Viet Cuong, Le Canh Viet Cuong, Tran Manh HungAbstractA comprehensive phytochemical investigation of the dichloromethane-soluble fraction of Physalis angulata led to the isolation of eight compounds (1–8) including two new withanolides named physagulin P and Q (compounds 5 and 8). Their chemical structures were established using two-dimensional nuclear magnetic resonance (spectroscopy. The cytotoxic activity of these met...
Source: Phytochemistry Letters - September 22, 2018 Category: Chemistry Source Type: research

Anti-inflammatory activity of prenyl and geranyloxy furanocoumarins from Citrus garrawayi (Rutaceae)
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Ritesh Raju, Ahilya Singh, Paul Reddell, Gerald MünchAbstractAnti-inflammatory activity guided isolation from Citrus garrawayi (Rutaceae) led to the discovery of five new garracoumarins A – E (1 - 5), and five known (6 – 10) isoprenylated furanocoumarins and the known sterol bourjotinolone A (11). Discussed herein is the anti-inflammatory structure activity relationship of the ten furanocoumarins and a detailed spectroscopic analysis leading to the structure elucidation of the new and known isoprenylated furanocoumarins.Graph...
Source: Phytochemistry Letters - September 22, 2018 Category: Chemistry Source Type: research

Synthesis, antiproliferative activity and autophagic flux inhibition of new arylsparteine derivatives
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Moustafa T. Gabr, Mohammed S. Abdel-RaziqAbstractNew series of arylsparteine derivatives were synthesized and evaluated for their cytotoxic activity against four human cancer cell lines (cervical epithelial carcinoma cells Hela, breast cancer cells MCF-7, lung cancer cells A549, and glioma cells U87 MG) and one normal fibroblast cell line. Structure-activity relationship revealed that introduction of 4-quinolinyl moiety to sparteine afforded a hybrid compound 10 with considerable antiproliferative activity against all tested cancer cell lines...
Source: Phytochemistry Letters - September 22, 2018 Category: Chemistry Source Type: research

Four new megastigmane glycosides from the leaves of Eucommia ulmoides Oliver
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Jian-Kun Yan, Xu-Liu Shi, Paul Owusu Donkor, Li-Qin Ding, Feng QiuAbstractFour new megastigmane glycosides, eucomegastigsides E1 (1), eucomegastigsides E2 (2), eucomegastigsides F1 (3), and eucomegastigsides F2 (4) were isolated from the leaves of Eucommia ulmoides Oliver. Their structures were elucidated based on extensive spectroscopic analysis and their absolute configurations were determined by comparison of experimental optical rotation (OR) to DFT calculations. In addition, compounds 1-4 were evaluated for their ACE (Angiotensin Convert...
Source: Phytochemistry Letters - September 22, 2018 Category: Chemistry Source Type: research

Synthetic and in vitro studies to indicate that the structure of the PTP1B inhibitor isolated from Acanthopanax senticosus requires reinvestigation
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Toshiro Noshita, Ryoya Onishi, Kaori Miura, Yoshitomo Hamada, Yuki Nishino, Hidekazu Ouchi, Akihiro TaiAbstractWe herein describe the syntheses of 3,5-dimethoxy-4-{2-methoxy-4-[(1E)-3-oxoprop-1-en-1-yl]phenoxy}benzaldehyde (1) (the proposed structure for the naturally occurring protein tyrosine phosphatase 1B (PTP1B) inhibitor isolated from Acanthopanax senticosus) and its three positional isomers 3, 4, and 5. The inhibitory activities of these four compounds against PTP1B were also investigated. Comparison of the spectral data for 1, 3, 4, a...
Source: Phytochemistry Letters - September 22, 2018 Category: Chemistry Source Type: research

New biphenyls from Garcinia lancilimba
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Xue-Mei Gao, Di Cui, Shan-Shan Wang, Wen-Zhong Huang, Gan-Peng Li, Guang-Zhi Zeng, Meng-Yuan Jiang, Zhi-Yong JiangAbstractGarcilancibiphenyls A–C (1–3), three new biphenyls, were isolated from the stems of the plant Garcinia lancilimba, which belongs to the family Clusiaceae. Structures of the new compounds feature the acetoxyprenyl group on a benzene ring, and were elucidated by spectroscopic evidence. These compounds showed promising anti-rotavirus activity effects with TI values above 10.Graphical abstract (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - September 22, 2018 Category: Chemistry Source Type: research

Four new triterpene saponins from Bupleurum rigidum L.
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Mustapha Chelghoum, Dalila Smati, Anne-Claire Mitaine-Offer, Thomas Paululat, Marie-Aleth Lacaille-DuboisAbstractFour previously undescribed triterpene saponins (1-4) were isolated from the EtOH/H2O extract of the aerial parts of Bupleurum rigidum, together with a known structural analogue. Their structures were elucidated by analysis of 1D-(1H, 13C) and 2D-NMR (1H-1H COSY, TOCSY, ROESY, HSQC, HMBC) spectroscopic data and mass spectrometry (ESI- and HR-ESI-MS) and by comparison with those of related metabolites. An unusual structure was chara...
Source: Phytochemistry Letters - September 22, 2018 Category: Chemistry Source Type: research

Antimycobacterial 1,4-napthoquinone natural products from Moneses uniflora
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Haoxin Li, Allyson Bos, Stéphanie Jean, Duncan Webster, Gilles A. Robichaud, John A. Johnson, Christopher A. GrayAbstractA new 1,4-naphthoquinone derivative, 5,8-dihydro-3-hydroxychimaphilin (4) and five known compounds (1, 2 and 5–7) were isolated from an extract of the Canadian medicinal plant Moneses uniflora that significantly inhibited the growth of Mycobacterium tuberculosis H37Ra. The structure of 4 was established through analysis of NMR and MS data and the absolute configuration of the glycone of 5 was determined by chem...
Source: Phytochemistry Letters - September 22, 2018 Category: Chemistry Source Type: research

Corrigendum to “Oleocanthalic and Oleaceinic acids: New compounds from Extra Virgin Olive Oil (EVOO)” [Phytochem. Lett. 26 (2018) 190–194]
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Apostolis Angelis, Lemonia Antoniadi, Panagiotis Stathopoulos, Maria Halabalaki, Leandros A. Skaltsounis (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - September 22, 2018 Category: Chemistry Source Type: research

Announcements of the Phytochemical Society of Europe
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - September 22, 2018 Category: Chemistry Source Type: research

Resveratrol oligomer C-glucosides and anti-viral resveratrol tetramers isolated from the stem bark of Shorea uliginosa
Publication date: December 2018Source: Phytochemistry Letters, Volume 28Author(s): Tetsuro Ito, Kyoko Hayashi, Masataka Nishiguchi, Toshimitsu Hayashi, Munekazu IinumaAbstractA new resveratrol dimer C-glucoside [uliginosides D (1)] was isolated from the stem bark of Shorea uliginosa, along with 21 resveratrol derivatives (2–22). Eight of these compounds (1, 3–9) comprised the building block, 4-C-glucosylresveratrol (10). The absolute configurations of six compounds (1 and 3–7) were determined using NMR and circular dichroism. The antiviral effects of the main oligostilbenoid compounds in this plant and re...
Source: Phytochemistry Letters - August 17, 2018 Category: Chemistry Source Type: research

6-Methoxy-5,6-dihydrochelerythrine suppresses PANC-1 cells by down-regulating the Ras/Raf/Mek/Erk pathway
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Si-zhi Wu, Xian-lin Wu, Guang-xiong Zhou, Li Deng, Peng Pang, Hui Tang, Hua-chong Xu, Yu-cong Shi, Xiao-yin ChenAbstractTo investigate the suppression of PANC-1 pancreatic cancer cells by 6-methoxy-5,6-dihydrochelerythrine (MDC), which is a novel natural product from Radix zanthoxyli, and its underlying mechanism. PANC-1 cells were treated with MDC. Cell proliferation, cell cycle, apoptosis and cell migration or invasion abilities were measured by MTT, flow cytometry assays and invasion assays, respectively. The expression of Ras protein and ...
Source: Phytochemistry Letters - July 20, 2018 Category: Chemistry Source Type: research

Phenols and diketopiperazines isolated from Antarctic-derived fungi, Penicillium citreonigrum SP-6
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Jia-ning Huang, Qingbo Zou, Jun Chen, Si-han Xu, Dan Luo, Feng-guo Zhang, Yuan-yuan LuAbstractOne diketopiperazine (1) and three phenols (3, 5 and 6) were isolated from static culture of Antarctic fungus, Penicillium citreonigrum SP-6, as well as their structures were determined by NMR and CD spectroscopic methods. Additionally, two known compounds, cyclo-(L-Trp-L-Phe) (2) and (-)-(3S, 10R)-dichlorodiaportal (4), were isolated and identified. Antitumor biological studies demonstrated that compounds 1 and 3 showed weak inhibitions against HCT1...
Source: Phytochemistry Letters - July 20, 2018 Category: Chemistry Source Type: research

Triterpenoid cinnamate, acetate and palmitate from Hoya kerrii leaves
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Sudarat Kruakaew, Suriphon Singha, Chonticha Seeka, Wantana Mongkolvisut, Somyote SutthivaiyakitAbstractTwo new triterpenoid cinnamates, namely, 3β-O-D-friedours-11α,12α-epoxy-14-enyl cinnamate and 3β-O-29-nor-20-oxolupanyl cinnamate, as well as thirteen known compounds were isolated from hexanes extract of the leaves of Hoya kerrii. The structural elucidation of the compounds was performed using spectroscopic methods. Among several isolated triterpenoid cinnamates, lupeol cinnamate is known to possess strong anti-inflam...
Source: Phytochemistry Letters - July 20, 2018 Category: Chemistry Source Type: research

Transformation of ginsenoside Rh4 and its aglycone from the total saponins of stems and leaves of Panax ginseng by Aspergillus tubingensis
This study focused on achieving ginsenoside Rh4 and its aglycone by microbial transformation of the total saponins of stems and leaves of P. ginseng (TSSLG). A total of 78 fungal strains isolated from the rhizosphere soil of P. ginseng, and one of them, Aspergillus tubingensis, was found to be capable of biotransformation of TSSLG to ginsenoside Rh4 and its aglycone with high efficiency, especially the content of ginsenoside Rh4 aglycone was enhanced 100 folds over than that in the original TSSLG. Compared with ginsenoside Rg3 (named ShenYi capsule as antitumor drug in China), ginsenoside Rh4 aglycone exhibited stronger an...
Source: Phytochemistry Letters - July 20, 2018 Category: Chemistry Source Type: research

Chemical constituents of the fungus Stereum rugosum ATCC64657
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Jun-Mei Yan, Qing-Lan Wu, Pei-Ji Zhao, Ke-Qin Zhang, Guo-Hong LiAbstractThe chemical constituents of the fungus Stereum rugosum ATCC64657 were studied. Two new sesquiterpenes, namely, sterostreins S (1) and W (2), as well as 10 known compounds, were isolated from the EtOAc extract of the fungal culture broth. The structures of the compounds were elucidated by HRMS, and 1D, 2D-NMR spectroscopy analysis. This is the first report on the chemical constituents of the fungus Stereum rugosum.Graphical abstractTwo new sesquiterpenes, sterostrein S (1...
Source: Phytochemistry Letters - July 19, 2018 Category: Chemistry Source Type: research

Bioactive sativene sesquiterpenoids from cultures of the endophytic fungus Bipolaris eleusines
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Zheng-Hui Li, Hong-Lian Ai, Man-Si Yang, Juan He, Tao FengAbstractTwo previously undescribed sativene-type sesquiterpenoids, bipolenins G and H (1 and 2), together with two known analogues (3 and 4), were obtained from cultures of the endophytic fungus Bipolaris eleusines. The structures of new compounds were elucidated on the basis of extensive spectroscopic analyses. All compounds showed no activity against three human cancer cell lines. Compounds 1 and 4 exhibited certain anti-NO production activities with IC50 values of 23.8 and 17.5&thin...
Source: Phytochemistry Letters - July 18, 2018 Category: Chemistry Source Type: research

Two new triterpenoids from the stems of Celastrus orbiculatus Thunb
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Lun Wang, Huan Tang, Kai Chen, Lin-Lin Xue, Hao-Yu Ye, Li-Fang Ma, Zi-Yuan LiAbstractTwo new triterpenoids, named as 3β-(E)-p-caffeoylnepeticin (1) and 3β-(E)-3,4-dimethoxycinnamate-20(S)-dammarenediol II (2), along with three known compounds 3, 4 and 5 were isolated from the stems of Celastrus orbiculatus Thunb. The structures of these compounds were elucidated by spectroscopic methods including IR, 1D and 2D NMR as well as by high-resolution mass spectrometric analysis. The anti-inflammatory activities and the cytotoxic effects we...
Source: Phytochemistry Letters - July 18, 2018 Category: Chemistry Source Type: research

Hericinoids A‒C, cyathane diterpenoids from culture of mushroom Hericium erinaceus
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Lin Chen, Jian-Neng Yao, He-Ping Chen, Zhen-Zhu Zhao, Zheng-Hui Li, Tao Feng, Ji-Kai LiuAbstractThree previously undescribed cyathane-type diterpenoids, hericinoids A-C (1‒3) and three known analogues (4‒6) have been isolated from fermentation broth of Hericium erinaceus. Their structures of hericinoids A-C were determined by in-depth analyses of NMR spectra and HRESIMS. The absolute configurations of compounds 1 and 2 were determined by the ROESY spectra along with the DP4+ calculations based on quantum chemistry. Compounds 1–5 wer...
Source: Phytochemistry Letters - July 18, 2018 Category: Chemistry Source Type: research

Sulfurated diketopiperazines from an algicolous isolate of Trichoderma virens
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Zhen-Zhen Shi, Feng-Ping Miao, Sheng-Tao Fang, Xiu-Li Yin, Nai-Yun JiAbstractTwo new naturally occurring sulfurated diketopiperazines, dehydroxymethylbis(dethio)bis(methylthio)gliotoxin (1) and (3S,6R)-6-(para-hydroxybenzyl)-1,4-dimethyl-3,6-bis(methylthio)piperazine-2,5-dione (2), along with three known analogues (3–5) were isolated from the culture extract of Trichoderma virens Y13-3, obtained from the surface of the marine red alga Gracilaria vermiculophylla. The structures and relative configurations of 1 and 2 were determined by ex...
Source: Phytochemistry Letters - July 18, 2018 Category: Chemistry Source Type: research

Inside Front Cover (Editorial Board)
Publication date: August 2018Source: Phytochemistry Letters, Volume 26Author(s): (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - July 18, 2018 Category: Chemistry Source Type: research

Contents (graphical abstracts and research highlights)
Publication date: August 2018Source: Phytochemistry Letters, Volume 26Author(s): (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - July 18, 2018 Category: Chemistry Source Type: research

Announcements of the Phytochemical Society of Europe
Publication date: August 2018Source: Phytochemistry Letters, Volume 26Author(s): (Source: Phytochemistry Letters)
Source: Phytochemistry Letters - July 18, 2018 Category: Chemistry Source Type: research

Dihydro-β-​agarofuran sesquiterpenoids from the seeds of Celastrus paniculatus Willd. and their α-glucosidase inhibitory activity
Publication date: August 2018Source: Phytochemistry Letters, Volume 26Author(s): Sasikumar P., Sharathna P., Prabha B., Sunil Varughese, Anil Kumar N., Sivan V.V., Sherin D.R., Suresh E., Manojkumar T.K., Radhakrishnan K.V.AbstractThree previously undescribed dihydro-β-agarofuran sesquiterpenoids (1–3) along with eight known sesquiterpenoids (4–11) were isolated from the seeds of C. paniculatus. The structures of these compounds were determined on the basis of UV, IR, HR-MS (ESI), 1D and 2D NMR data obtained, and their absolute configurations were further confirmed by single-crystal X-ray diffraction. All ...
Source: Phytochemistry Letters - July 11, 2018 Category: Chemistry Source Type: research