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5-aminoisoquinolinone attenuates social behavior deficits and immune abnormalities in the BTBR T+ Itpr3tf/J mouse model for autism
In this study, we investigated the effect of 5-AIQ on sociability tests, self-grooming, marble burying, and locomotor activities in BTBR T+ Itpr3tf/J (BTBR) mice, which serve as an ASD animal model. We further investigated the possible molecular mechanism of 5-AIQ administration on CXCR4-, CXCR6-, IFN-γ-, IL-22-, NOS2-, STAT1-, T-bet-, and RORγT-producing CD3+ T cells isolated from the spleens of treated mice. We also explored its effects on mRNA expression in brain tissue. Our results showed that in BTBR mice, 5-AIQ treatment significantly prevented self-grooming and marble burying behaviors and enhanced social interact...
Source: Pharmacology Biochemistry and Behavior - January 24, 2020 Category: Biochemistry Source Type: research

Antiamnesic effects of tofisopam against scopolamine-induced cognitive impairments in rats
In this study, we investigated the potential therapeutic effects of tofisopam, a 2,3-benzodiazepine derivative anxiolytic, on cognitive deficits in rats with scopolamine-induced amnesia. Cognitive performance of the rats was investigated by using the Morris water maze and passive avoidance tests. Changes in motor activity were assessed by using the activity cage and Rota-rod tests and then morphological changes in the hippocampus were assessed via immunohistochemical stainings. The results indicated that scopolamine impaired learning and memory parameters in rats. Worsened cognitive performance, neuronal loss, and decrease...
Source: Pharmacology Biochemistry and Behavior - January 23, 2020 Category: Biochemistry Source Type: research

Electrophysiological biomarkers of antidepressant response to ketamine in treatment-resistant depression: Gamma power and long-term potentiation
This study reviews electrophysiological studies of ketamine's effects in individuals with depression as well as healthy controls, with a focus on two putative markers of synaptic potentiation: gamma oscillations and long-term potentiation. The review focuses on: 1) measures of gamma oscillations and power and their relationship to both acute, psychotomimetic drug effects as well as delayed antidepressant response in mood disorders; 2) changes in long-term potentiation as a promising measure of synaptic potentiation following ketamine administration; and 3) recent efforts to model antidepressant response to ketamine using n...
Source: Pharmacology Biochemistry and Behavior - January 18, 2020 Category: Biochemistry Source Type: research

Serotonin 5-HT1A and 5-HT1B receptors co-mediate the RU 24629-induced locomotor activity of male and female preweanling rats
Publication date: Available online 17 January 2020Source: Pharmacology Biochemistry and BehaviorAuthor(s): Sanders A. McDougall, Jasmine A.M. Robinson, Esperanza Larios Ramirez, Henry A. DiazAbstractThe serotonin (5-HT) 1A/1B agonist RU 24969 robustly increases the locomotor activity of adult male rats and mice; however, studies using selective antagonists alternately report that 5-HT1A, 5-HT1B, or both receptor types mediate RU 24969's locomotor activating effects. The purpose of the present study was to extend these past findings by administering a selective 5-HT1 agonist and/or antagonists to male and female preweanling...
Source: Pharmacology Biochemistry and Behavior - January 18, 2020 Category: Biochemistry Source Type: research

mGlu2/3 receptor antagonism: A mechanism to induce rapid antidepressant effects without ketamine-associated side-effects
Publication date: Available online 16 January 2020Source: Pharmacology Biochemistry and BehaviorAuthor(s): Jeffrey M. WitkinAbstractThe consensus that ketamine can produce rapid-onset antidepressant effects in patients combined with the recent approval of S(+)-ketamine (Esketamine) as an antidepressant, has fueled the search for other compounds that might recapitulate the remarkable therapeutic benefits of ketamine. At the same time, discovery efforts have been additionally directed toward minimization of the tolerability, side-effect, and safety issues associated with ketamine. The history of thought on the viability of m...
Source: Pharmacology Biochemistry and Behavior - January 17, 2020 Category: Biochemistry Source Type: research

Behavioral responses of mGluR3-KO mice to the lipopolysaccharide-induced innate inflammatory reaction
Publication date: Available online 15 January 2020Source: Pharmacology Biochemistry and BehaviorAuthor(s): Lainiola Mira, Linden Anni-Maija, Aitta-aho TeemuAbstractAcute lipopolysaccharide (LPS) administration induces innate inflammatory signalling and produces sickness reaction characterized by reduced drinking, eating and reduced locomotor exploration, as well as emotional changes indicating increased helplessness/despair. LPS administration has been used to model behavioral and emotional responses to inflammatory reactions. Our aim was to find out whether the lack of metabotropic glutamate receptor 3 (mGluR3) in the kno...
Source: Pharmacology Biochemistry and Behavior - January 15, 2020 Category: Biochemistry Source Type: research

Memory deterioration based on the tobacco smoke exposure and methylazoxymethanol acetate administration vs. aripiprazole, olanzapine and enrichment environment conditions
Publication date: Available online 15 January 2020Source: Pharmacology Biochemistry and BehaviorAuthor(s): Ratajczak Piotr, Kus Krzysztof, Murawiecka Patrycja, Słodzińska Iwona, Zaprutko Tomasz, Kopciuch Dorota, Paczkowska Anna, Nowakowska ElżbietaAbstractEnrichment environment conditions, as well as tobacco smoke exposure, may affect cognitive function (e.g. spatial memory) in an animal model of schizophrenia and schizophrenic patients.The aim of this study was to find whether spatial memory function impairment is found in methylazoxymethanol acetate treated rats (an animal model of schizophrenia) and whether aripipraz...
Source: Pharmacology Biochemistry and Behavior - January 15, 2020 Category: Biochemistry Source Type: research

Chronic oral treatment with risperidone impairs recognition memory and alters brain-derived neurotrophic factor and related signaling molecules in rats
Publication date: Available online 13 January 2020Source: Pharmacology Biochemistry and BehaviorAuthor(s): Indrani Poddar, Patrick M. Callahan, Caterina M. Hernandez, Anilkumar Pillai, Xiangkun Yang, Michael G. Bartlett, Alvin V. TerryAbstractAntipsychotic drugs (APDs) are essential for the treatment of schizophrenia and other neuropsychiatric illnesses such as bipolar disease. However, they are also extensively prescribed off-label for many other conditions, a practice that is controversial given their potential for long-term side effects. There is clinical and preclinical evidence that chronic treatment with some APDs ma...
Source: Pharmacology Biochemistry and Behavior - January 14, 2020 Category: Biochemistry Source Type: research

Lisdexamfetamine suppresses instrumental and consummatory behaviors supported by foods with varying degrees of palatability: Exploration of a binge-like eating model
In conclusion, lisdexamfetamine affected both food intake and food-reinforced operant behavior, with larger effects seen in the group exposed to chocolate. (Source: Pharmacology Biochemistry and Behavior)
Source: Pharmacology Biochemistry and Behavior - January 11, 2020 Category: Biochemistry Source Type: research

Editorial Board
Publication date: January 2020Source: Pharmacology Biochemistry and Behavior, Volume 188Author(s): (Source: Pharmacology Biochemistry and Behavior)
Source: Pharmacology Biochemistry and Behavior - January 3, 2020 Category: Biochemistry Source Type: research

Duloxetine reverses the symptoms of overactive bladder co-existing with depression via the central pathways
Publication date: Available online 31 December 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Andrzej Wróbel, Anna Serefko, Andrzej Woźniak, Jacek Kociszewski, Aleksandra Szopa, Radosław Wiśniewski, Ewa PoleszakAbstractThough the association between overactive bladder (OAB) and depression was noticed years ago, the pharmaceutical market does not offer one universal drug that would cure both conditions at the same time. The main goal of our present experiments was to determine whether a 14-day administration of solifenacin (0.03 mg/kg/day), mirabegron (1 mg/kg/day), or duloxetine (1 mg/kg/day) would ...
Source: Pharmacology Biochemistry and Behavior - January 1, 2020 Category: Biochemistry Source Type: research

In vivo evaluation of the CB1 allosteric modulator LDK1258 reveals CB1-receptor independent behavioral effects
Publication date: Available online 30 December 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Mohammed Mustafa, Giulia Donvito, Lauren Moncayo, Amelia Swafford, Justin Poklis, Ralph Grauer, Teresa Olszewska, Debra A. Kendall, Dai Lu, Aron H. LichtmanAbstractIn the present study, we examined whether LDK1258, which produces strong CB1 receptor allosteric effects in in vitro assays, would elicit in vivo effects consistent with allosteric activity. In initial studies, LDK1258 reduced food consumption and elicited delayed antinociceptive effects in the chronic constrictive injury of the sciatic nerve (CCI) model o...
Source: Pharmacology Biochemistry and Behavior - December 30, 2019 Category: Biochemistry Source Type: research

Aripiprazole prevents stress-induced anxiety and social impairment, but impairs antipredatory behavior in zebrafish
Publication date: Available online 29 December 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Heloísa Helena de Alcantara Barcellos, Aline Pompermaier, Suelen Mendonça Soares, Victoria Costa Maffi, Marina Fernandes, Gessi Koakoski, Karina Kirsten, Bernardo Baldisserotto, Leonardo José Gil BarcellosAbstractEnvironmental pollution caused by antipsychotic residues is a relevant ecological problem. Studies revealed that residues of these drugs are present in a wide range of different ecosystems and can have adverse effects on non-target organisms even in low environmental concentrations. Among these antipsycho...
Source: Pharmacology Biochemistry and Behavior - December 29, 2019 Category: Biochemistry Source Type: research

Phencyclidine-induced cognitive deficits in mice are ameliorated by subsequent repeated intermittent administration of (R)-ketamine, but not (S)-ketamine: Role of BDNF-TrkB signaling
Publication date: Available online 19 December 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Yunfei Tan, Yuko Fujita, Youge Qu, Lijia Chang, Yaoyu Pu, Siming Wang, Xingming Wang, Kenji HashimotoAbstractThe N-methyl-d-aspartate receptor (NMDAR) antagonists including phencyclidine (PCP) and ketamine produce cognitive deficits in rodents and humans. We previously reported that (R)-ketamine produced the beneficial effects compared to (S)-ketamine in several animal models including depression. Here we compared the effects of two enantiomers of ketamine on cognitive deficits in mice after repeated administration o...
Source: Pharmacology Biochemistry and Behavior - December 20, 2019 Category: Biochemistry Source Type: research

Efficacy of infliximab in treatment-resistant depression: A systematic review and meta-analysis
ConclusionInfliximab was not efficient in reducing depressive symptoms according to the HAM-D, only when the patients already had increased inflammatory genes, including TNF and C-reactive protein (CRP). (Source: Pharmacology Biochemistry and Behavior)
Source: Pharmacology Biochemistry and Behavior - December 15, 2019 Category: Biochemistry Source Type: research