DNA methylation analysis of cancer-related genes from cell-free DNA of patients with cancer
Publication date: July 2017Source: Personalized Medicine Universe, Volume 6Author(s): Yukie Saeki, Minako Abe, Fumika Kono, Akane Nakazato, Yoshimori Ishihara, Hiroyuki AbeAbstractDNA methylation is a very important mechanism for regulating gene expression in normal development and cell differentiation. However, DNA methylation, when acting on the promoter region of a tumor suppressor gene, suppresses transcription and is one of the major epigenetic modifications involved in the development and progression of many cancers (Wajed et al., 2001; Morris and Chan 2015). In our laboratory, we have carried out methylation analys...
Source: Personalized Medicine Universe - July 6, 2018 Category: Drugs & Pharmacology Source Type: research
Chlorogenic acid modulates hypoxia response of Hep3B cells
Publication date: July 2017Source: Personalized Medicine Universe, Volume 6Author(s): Ferbian Milas Siswanto, Ami Oguro, Susumu ImaokaAbstractCoffee is the most widely consumed beverage around the world, and it contains many compounds that have beneficial effects on human health. Chlorogenic acid (CGA), the most abundant polyphenol in coffee, has been reported to inhibit cancer cell growth and has a beneficial effect on ameliorating aging-related diseases. We found that CGA decreased HIF-1α levels in human hepatoma cell line Hep3B under hypoxic conditions (O2 = 1%) in a dose-dependent manner, thereby decreasing the expr...
Source: Personalized Medicine Universe - July 6, 2018 Category: Drugs & Pharmacology Source Type: research
Efficacy and safety of a compound supplement containing glucosamine, chondroitin, and five bioactive ingredients in volunteers with knee joint pain
ConclusionThese findings suggest that the compound supplementation of functional food ingredients has potential as an adjunctive and safe therapy for knee OA. (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - July 6, 2018 Category: Drugs & Pharmacology Source Type: research
Oral administration of freeze-dried powders of honey bee larvae inhibits the development of atopic dermatitis-like skin lesions in NC/Nga mice
ConclusionsOur results indicate that oral administration of the freeze-dried honey bee larvae powder could provide an adjunctive therapy for the management of AD. (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - July 6, 2018 Category: Drugs & Pharmacology Source Type: research
A case of advanced ovarian cancer effectively treated with a combination of multi-peptide dendritic cell immunotherapy, surgery, and chemotherapy
Publication date: July 2017Source: Personalized Medicine Universe, Volume 6Author(s): Amane Sasada, Minako Abe, Hiroyuki Abe (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - July 6, 2018 Category: Drugs & Pharmacology Source Type: research
Detection of aberrant DNA methylation of tumor suppressor genes in circulating tumor cells from a pancreatic cancer patient
Publication date: July 2017Source: Personalized Medicine Universe, Volume 6Author(s): Hiroaki Kawasaki, Hiroyuki Abe (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - July 6, 2018 Category: Drugs & Pharmacology Source Type: research
Gap in perception regarding recovery between patients and nurses in recovery-stage rehabilitation ward
Publication date: July 2017Source: Personalized Medicine Universe, Volume 6Author(s): Masumi Kumada, Miki Matsunami (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - July 6, 2018 Category: Drugs & Pharmacology Source Type: research
Clinical study of the efficacy of a yeast containing S-adenosyl methionine on knee osteoarthritis
Publication date: July 2017Source: Personalized Medicine Universe, Volume 6Author(s): Yukio Mitsui, Maki Satou, Shinichi Shimizu, Hiroshi Mitsui, Hirohiko Matsumoto (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - July 6, 2018 Category: Drugs & Pharmacology Source Type: research
On molecularly personalized medicine clinical trials
Publication date: July 2017Source: Personalized Medicine Universe, Volume 6Author(s): Reza Sanaye, Babak Daneshfard (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - July 6, 2018 Category: Drugs & Pharmacology Source Type: research
Personalized medicine for connective tissue disease: Historical and future perspectives
Publication date: July 2018Source: Personalized Medicine Universe, Volume 7Author(s): Masataka KuwanaAbstractConnective tissue disease (CTD), previously termed collagen disease, is a group of disorders, characterized by rheumatic symptoms, autoimmunity, and degeneration of the pathohistology of the extracellular matrix. Better classification and disease subsetting, as well as introduction of immunosuppressants and molecular-targeting drugs, have much improved patients' quality of life and prognosis. The treat-to-target strategy in combination with emphasis on early diagnosis and intervention is now advocated for many CTDs....
Source: Personalized Medicine Universe - July 6, 2018 Category: Drugs & Pharmacology Source Type: research
Cloning and expansion of antigen-specific T cells using iPS cell technology: Possible use of regenerated T cells in personalized medicine
Publication date: July 2018Source: Personalized Medicine Universe, Volume 7Author(s): Hiroshi Kawamoto, Kyoko Masuda, Seiji NaganoAbstractRecent advances in adoptive immunotherapy using cytotoxic T lymphocytes (CTLs) have demonstrated that CTLs are effective in killing tumor cells in vivo for some tumor types. However, a critical issue that CTLs collected from patients are easily exhausted during expansion culture is yet to be addressed. Therefore, we have been developing a strategy that utilizes induced pluripotent stem cell (iPSC) technology, based on the idea that iPSCs produced from antigen-specific CTLs would regener...
Source: Personalized Medicine Universe - July 6, 2018 Category: Drugs & Pharmacology Source Type: research
Significance of humanized mouse models for evaluating humoral immune response against cancer vaccines
Publication date: July 2018Source: Personalized Medicine Universe, Volume 7Author(s): Yoshie Kametani, Asuka Miyamoto, Toshiro Seki, Ryoji Ito, Sonoko Habu, Yutaka TokudaAbstractBecause accumulation of mutations produces unique neoantigen patterns in cancer cells, it has been hypothesized that these patterns are recognized by the patients' immune system. Therefore, the development of cancer vaccines has been challenging owing to the possibility of an anti-cancer effect induced by the immune system against such neoantigens. However, it is difficult to develop effective vaccines because of the variety of mutations induced in...
Source: Personalized Medicine Universe - July 6, 2018 Category: Drugs & Pharmacology Source Type: research
Association of MTHF 677TT with adverse drug reactions and RFC G80A with non-response and adverse drug reactions in methotrexate therapy
Publication date: July 2018Source: Personalized Medicine Universe, Volume 7Author(s): Manahel Mahmood AlSabbaghAbstractBeing an anti-metabolite and anti-inflammatory agent, Methotrexate, a folate analogue, is indicated for a wide spectrum of diseases including moderate to severe chronic inflammatory disorders like psoriasis and rheumatoid arthritis and malignant diseases such as childhood acute lymphoblastic leukaemia and choriocarcinoma. The outcome of Methotrexate treatment varies. Though up to 50% of patients with inflammatory disorders show a favourable response; one third discontinues Methotrexate due to adverse drug ...
Source: Personalized Medicine Universe - July 6, 2018 Category: Drugs & Pharmacology Source Type: research
Assessing antitumor and T cell immune responses by cytokine assay in cancer patients treated with immunotherapy – A pilot study
We examined the usefulness of this method as a biomarker to assess the therapeutic effectiveness of immune cell therapy by statistical analysis and by plotting a cancer immunogram correlating patient data with clinical outcomes. (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - July 6, 2018 Category: Drugs & Pharmacology Source Type: research
Predictive factors for the development of bronchial asthma by the age of 3
Publication date: July 2018Source: Personalized Medicine Universe, Volume 7Author(s): Naomi Kondo, Eiko Matsui, Takahide Teramoto, Manami Kuwabara, Tomiko Nagata, Yayoi Furuta, Masayo Sanada, Ikuko Aoki, Masumi KumadaAbstractThe relationship between several factors at 1.5 years of age and the development of bronchial asthma by 3 years of age was investigated. The factors that were found to be related to the development of bronchial asthma were identified and listed as predictive factors for the development of bronchial asthma by the age of 3. As a result, a parent or a sibling with bronchial asthma, a history of wheezing w...
Source: Personalized Medicine Universe - July 6, 2018 Category: Drugs & Pharmacology Source Type: research
