Similarity and Dissimilarity between Angiotensin A and Angiotensin II in Cardiovascular Functions in a Rat Model
Publication date: Available online 10 March 2020Source: PeptidesAuthor(s): Byung Mun Park, Hoang Thi Ai Phuong, Weijian Li, Suhn Hee Kim (Source: Peptides)
Source: Peptides - March 11, 2020 Category: Biochemistry Source Type: research
Glucagon-based therapy: past, present and future
Publication date: Available online 5 March 2020Source: PeptidesAuthor(s): Mohan Patil, Nitin J. Deshmukh, Mahesh Patel, Ganesh V. Sangle (Source: Peptides)
Source: Peptides - March 7, 2020 Category: Biochemistry Source Type: research
Editorial Board
Publication date: April 2020Source: Peptides, Volume 126Author(s): (Source: Peptides)
Source: Peptides - March 1, 2020 Category: Biochemistry Source Type: research
Different intracellular signalling sensitivity and cell behaviour of porcine insulin with aging
Publication date: May 2020Source: Peptides, Volume 127Author(s): Shichun Li, Bo Shi, Kexin Huang, Ying Wang (Source: Peptides)
Source: Peptides - February 27, 2020 Category: Biochemistry Source Type: research
Differential effects of leptin administration on feeding and HPT axis function in early-life overfed adult rats
Publication date: Available online 24 February 2020Source: PeptidesAuthor(s): P de Gortari, V. Alcántara-Alonso, G. Matamoros-Trejo, M.I. Amaya, E. Alvarez-Salas (Source: Peptides)
Source: Peptides - February 26, 2020 Category: Biochemistry Source Type: research
Extra-oral bitter taste receptors: new targets against obesity?
Publication date: Available online 21 February 2020Source: PeptidesAuthor(s): Qiaoling Wang, Kathrin I. Liszt, Inge DepoortereAbstractTaste perception on the tongue is essential to help us to identify nutritious or potential toxic food substances. Emerging evidence has demonstrated the expression and function of bitter taste receptors (TAS2Rs) in a wide range of extra-oral tissues. In particular, TAS2Rs in gastrointestinal enteroendocrine cells control the secretion of appetite regulating gut hormones and influence hunger and food intake. Furthermore, these effects may be reinforced by the presence of TAS2Rs on intestinal ...
Source: Peptides - February 23, 2020 Category: Biochemistry Source Type: research
The early history of GIP 1969–2000: From enterogastrone to major metabolic hormone
Publication date: Available online 17 February 2020Source: PeptidesAuthor(s): Vincent MarksAbstractThis paper describes the early history of Gastric Inhibitory Polypeptide, better referred to simply as GIP, from its isolation by purification from a crude preparation of CCK-PZ (cholecystokinin/pancreozymin) to its recognition as a key play in the pathogenesis of obesity and other metabolic disorders far removed from the enterogastrone properties by which it was originally identified. Augmentation of glucose mediated insulin release, the incretin effect, was discovered soon after GIP was first isolated and only much later wa...
Source: Peptides - February 18, 2020 Category: Biochemistry Source Type: research
Hemoglobin-derived peptides and mood regulation
Publication date: Available online 15 February 2020Source: PeptidesAuthor(s): Fengmei Wei, Long Zhao, Yuhong JingAbstractEvidence accumulated over the past decades has revealed that red blood cells and hemoglobin (Hb) in the blood play important roles in modulating moods and emotions. The number of red blood cells affects the mood. Hb is the principal content in the red blood cells besides water. Denatured Hb is hydrolyzed to produce bioactive peptides. RVD-hemopressin α (RVD-Hpα), which is a fragment of α-chain (95-103) in Hb, functions as a negative allosteric modulator of cannabinoid receptor 1 and a positive alloste...
Source: Peptides - February 17, 2020 Category: Biochemistry Source Type: research
Maternal and umbilical cord blood subfatin and spexin levels in patients with gestational diabetes mellitus
This study was designed to investigate changes in blood subfatin and spexin levels during gestational diabetes mellitus (GDM) and childbirth, and define the mechanisms of these hormones in the physiopathology of GDM. A total of 60 pregnant women, comprising 30 diagnosed with GDM and 30 with normal gestation, were included in the study. The diagnosis of GDM was made through a 75-g oral glucose tolerance test (OGTT) administered between 24 and 28 weeks of pregnancy. The amounts of subfatin, spexin, and insulin were measured in blood samples by enzyme-linked immunosorbent assays; lipid profiles, glucose, and other biochemical...
Source: Peptides - February 15, 2020 Category: Biochemistry Source Type: research
Review: Insulin resistance and mitochondrial dysfunction following severe burn injury
Publication date: Available online 8 February 2020Source: PeptidesAuthor(s): Jorge Berlanga-Acosta, Ileidys Iglesias-Marichal, Nadia Rodríguez-Rodríguez, Yssel Mendoza-Marí, Ariana García-Ojalvo, Maday Fernández-Mayola, Raymond J. PlayfordAbstractThe insulin signaling pathway plays a pivotal role in glucose metabolism and metabolic homeostasis. Disruption of this pathway is commonly seen in critical illness such as following severe burn injuries where homeostatic control is lost, leading to “insulin resistance” with poor blood glucose control. The aberrant signaling pathways involved in insulin resistance followin...
Source: Peptides - February 9, 2020 Category: Biochemistry Source Type: research
Protective effects of intermedin/adrenomedullin-2 in a cellular model of human pulmonary arterial hypertension
Publication date: Available online 1 February 2020Source: PeptidesAuthor(s): David Holmes, Michael Corr, Gavin Thomas, Mark Harbinson, Malcolm Campbell, Paul Spiers, David BellAbstractProliferation of pulmonary fibroblasts (PF) and distal migration of smooth muscle cells (PSM) are hallmarks of pulmonary arterial hypertension (PAH). Intermedin/adrenomedullin-2 (IMD/AM2) belongs to the Calcitonin Gene-Related Peptide (CGRP)/Adrenomedullin (AM) superfamily. These peptides act via Calcitonin-Like Receptors (CLR) combined with one of three Receptor activity-modifying proteins (RAMPs). IMD/AM2 is a potent pulmonary vasodilator i...
Source: Peptides - February 2, 2020 Category: Biochemistry Source Type: research
Editorial: GIP renaissance
Publication date: Available online 28 January 2020Source: PeptidesAuthor(s): Peter R. Flatt, J. Michael Conlon (Source: Peptides)
Source: Peptides - January 30, 2020 Category: Biochemistry Source Type: research
Beneficial actions of prothymosin alpha-mimetic hexapeptide on central post-stroke pain, reduced social activity, learning-deficit and depression following cerebral ischemia in mice
Publication date: Available online 23 January 2020Source: PeptidesAuthor(s): Keita Sasaki, Sebok Kumar Halder, Hayato Matsunaga, Hiroshi UedaAbstractProthymosin alpha (ProTα)-mimetic hexapeptide (amino acid: NEVDQE, P6Q) inhibits cerebral or retinal ischemia-induced behavioral, electrophysiological and histological damage. P6Q also abolishes cerebral hemorrhage induced by ischemia with tissue plasminogen activator (tPA). In the present study we examined the beneficial effects of P6Q on other post-stroke prognostic psychology-related symptoms, which obstruct the motivation toward physical therapy. Intravenous (i.v.) admini...
Source: Peptides - January 24, 2020 Category: Biochemistry Source Type: research
The new mechanism of Ghrelin/GHSR-1a on autophagy regulation
In conclusion, endogenous ghrelin system could be considered as a new target or treatment for metabolism disorders, cardiac diseases, neurodegenerative diseases, and tissue injuries. (Source: Peptides)
Source: Peptides - January 24, 2020 Category: Biochemistry Source Type: research
Anticancer potential of human intestinal defensin 5 against 1, 2-dimethylhydrazine dihydrochloride induced colon cancer: A therapeutic approach
Publication date: Available online 22 January 2020Source: PeptidesAuthor(s): Anshul Panjeta, Simran PreetAbstractThe escalating predicament of multidrug resistant cancer cells and associated side effects of conventional chemotherapy necessitates the exploration of alternative anticancer therapies. The present study evaluated anticancer therapeutic potential of human defensin 5 (HD-5) against colon cancer. The in vivo anticancer efficacy of HD-5 against 1,2-dimethylhydrazine (DMH) induced colon cancer was elucidated in terms of tumor biostatistics, number of aberrant crypt foci (ACF), in situ apoptosis assay,changes in morp...
Source: Peptides - January 24, 2020 Category: Biochemistry Source Type: research
