Billroth II or Roux-en-Y reconstruction for gastrojejunostomy after pancreaticoduodenectomy. Randomized controlled trial (PAUDA TRIAL)
Objectives Objectives: The primary aim of this randomized controlled trial (RCT) comparing Billroth II (BII) vs. Roux-en-Y (RY) after pancreaticoduodenectomy (PD) was to test the hypothesis that RY is associated with a lower incidence rate of delayed gastric emptying (DGE) Secondary endpoints were the evaluation of postoperative complications. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Juli Busquets, Silvia Martin, Llu ís Secanella, Núria Peláez, Emilio Ramos, Juan Fabregat Tags: Session 4. Surgical issues of pancreatic tumor resection - free papers Source Type: research
Laparoscopic versus open pancreatoduodenectomy (LEOPARD-2): A multicenter patient-blinded, randomized controlled trial
Objectives Laparoscopic pancreatoduodenectomy (LPD) may improve postoperative recovery but concerns exist regarding increased pancreatic fistula rates and, in low-volume centers, increased mortality . In the Netherlands, LPD was introduced within the LAELAPS-2 training program (114 LPDs, 3.5% 90-day mortality), followed by a randomized controlled trial (RCT). (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Jony van Hilst, Thijs de Rooij, Koop Bosscha, David Brinkman, Susan van Dieren, Marcel Dijkgraaf, Michael Gerhards, Ignace de Hingh, Tom Karsten, Daan Lips, Misha Luyer, Olivier Busch, Sebastiaan Festen, Marc Besselink Tags: Session 4. Surgical issues of pancreatic tumor resection - free papers Source Type: research
Type 2 diabetes mellitus and pancreatic cancer risk. An independent etiological relation?
Objectives Type 2 diabetes mellitus (T2DM) has been consistently associated with an increased risk of pancreatic ductal adenocarcinoma (PDAC), but there are still some knowledge gaps about this association. For instance, T2DM seems to have a differing impact on PDAC risk depending on the duration of T2DM, which points to the existence of two T2DM subtypes in PDAC aetiology: new-onset T2DM and long-standing T2DM (LSD). The influence of diabetes-related medication on this association is also poorly understood. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Esther Molina-Montes, Paulina G ómez-Rubio, Núria Malats, PanGenEU Study investigators Tags: Session 5. Pancreatic Cancer: predispositions and diagnostic advances - free papers Source Type: research
Exposure to cadmium is a risk factor for pancreatic cancer development: three lines of evidence
Objectives Exposure to cadmium (Cd), one of the most abundant occupational and environmental pollutants, has been hypothesized to one putative cause of pancreatic cancer (PC). Hence, the aim of this work was to provide the evidence of Cd role in PC by conducting human observational, experimental and in vitro studies. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Aleksandra Buha, Vesna Matovic, Milena Andjelkovic, David Wallace, Amie Schweitzer, Novica Boricic, Stefan Kmezic, Dejan Radenkovic, Vladimir Djordjevic Tags: Session 5. Pancreatic Cancer: predispositions and diagnostic advances - free papers Source Type: research
Novel pancreatic cancer susceptibility loci discovered through genome-wide association studies
Objectives Genome-wide association studies (GWAS) have identified several regions convincingly or suggestively associated with pancreatic cancer risk. However, estimates of heritability suggest that a large number of loci remain to be discovered. To identify additional susceptibility loci, the PANcreatic Disease ReseArch (PANDoRA) consortium participated in additional GWAS, in collaboration with USA-based consortia, namely PanScan3 and PanC4. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Federico Canzian, Daniele Campa, Ofure Obazee, Cosmeri Rizzato, Maria Gazouli, Giulia Martina Cavestro, Aldo Scarpa, Stefania Moz, Raffaele Pezzilli, Andrea Mambrini, Ugo Boggi, Gabriele Capurso, Livia Archibugi, Franco Bambi, Angelo Andriulli, Pavel Souc Tags: Session 5. Pancreatic Cancer: predispositions and diagnostic advances - free papers Source Type: research
Novel metabolic targeted LC-MS/MS assay to differentiate pancreatic cancer from chronic pancreatitis in plasma
Objectives Pancreatic ductal adenocarcinoma (PDAC) is characterized by a poor prognosis with overall 5-year survival rates of less than 6%. In resectable pancreatic cancer cases, the 5-year survival rates increase to 18-24%. Therefore, an early diagnosis is key of a potentially curative treatment, and screening of patients at risk is desirable. Chronic pancreatitis (CP) patients have a 26-fold increased risk for the development of pancreatic cancer. Conventional diagnostic methods such as transabdominal ultrasound and CA19-9 testing suffer from insufficient clinical performance. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Julia Mayerle, Holger Kalthoff, Beate Kamlage, Gordian Adam, Nicole Christiansen, Philipp Schatz, Tim Fahlbusch, Bianca Bethan, Silke Schulze Pellengahr, Solveigh Krusekopf, Ansgar Chromik, Fritz Klein, Marcus Bahra, Marius Distler, Christian Pilarsky, Ro Tags: Session 5. Pancreatic Cancer: predispositions and diagnostic advances - free papers Source Type: research
Comparative analysis of Circulating Tumour Cells detection and circulating tumor DNA in liquid biopsy for the diagnosis of early stage pancreatic adenocarcinoma
Objectives Pancreatic ductal adenocarcinoma (PDAC) survival can reach 20% when surgery is possible. If patients present locally advance disease, it is crucial to quickly establish resectability .However, when the cancer is suspected, chemoradiotherapies are often delayed because the mandatory histologic proof is difficult to make with non-informative biopsies. Searching for tumour elements in body fluids might provide valuable diagnosis assistance. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Etienne Buscail, Charline Caumont, Catherine Alix-Panabie ̀res, Pascaline Quincy, Marion Marty, Jean-Phillipe Merlio, Aurelie Bedel, François Moreau-Gaudry, Veronique Vendrely, Christophe Laurent, Laurence Chiche, Sandrine Dabernat Tags: Session 5. Pancreatic Cancer: predispositions and diagnostic advances - free papers Source Type: research
Quantitative CT based radiomics as predictor of local resectability of pancreatic adenocarcinoma
Objectives The only cure for pancreatic cancer is surgery. However, some 20% of patients are unexpectedly unresectable due to liver or peritoneal metastases or locally advanced disease which was not predicted by the routinely performed contrast-enhanced CT scan. This means those patients had an unnecessary operation with its associated morbidity and mortality, which also reduces the quality of life and increases health care costs. This raises the question whether image based analysis techniques could help to predict resectability. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Joost Van der Putten, Sveta Zinger, Peter de With, Mathias Prokop, John Hermans Tags: Session 5. Pancreatic Cancer: predispositions and diagnostic advances - free papers Source Type: research
Intensity of symptoms and outcomes of acute pancreatitis, a preliminary analysis of the PROMISE study
Objectives Acute pancreatitis (AP) is a frequent disease. While 2 out of 3 patients have an uneventful course of disease, one third of them have local and/or systemic complications, which are associated to increased hospital stay, morbidity and mortality. Our aim was to study the relationship between symptoms perceived by patients and complications in patients with AP. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Claudia S ánchez-Marin, Serge Chooklin, Violeta Mauriz, Rafael Mejuto, M. Lourdes Ruiz-Rebollo, Beatriz Burgueño-Gómez, M. Eugenia Lauret, Marta Katalin, Peter Hegyi, Silvia Espina-Cadena, Vanesa Bernal, Eduardo Bajador, Guillermo García-Rayado, Judit Tags: 1. Acute Pancreatitis I Source Type: research
Impact of obesity on the prognosis of an acute pancreatitis
Objectives Obesity is well-known risk factor of acute pancreatitis (AP). Negative impact of obesity on severity and prognosis of AP has not been used practically for better prediction and AP management optimization. The aim of the study was to analyze influence of individual fat parameters on severity of AP. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Olexiy Dronov, Inna Kovalska, Kristina Zadorozhna, Andriy Gorlach, Maryna Zemskova Tags: 1. Acute Pancreatitis I Source Type: research
Determinants of length of hospital stay in mild acute pancreatitis
Objectives Acute pancreatitis is one of the most frequent causes of hospitalization related to gastrointestinal pathology. Therefore, it constitutes an important area of hospital spending, directly related to the length of hospital stay. In most cases it has a mild course, without local or systemic complications and with self-limited pain. Our target was to analyze factors related to hospital stay in patients with mild acute pancreatitis (MAP). (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Soraya L ópez, Federico Bolado, Carlos Prieto, Leire Aburruza, Héctor Julián Canaval, Ana Isabel Hernando, María Asunción Marcaide, Enrique De Madaria Tags: 1. Acute Pancreatitis I Source Type: research
Сomplications of severe acute pancreatitis according to the results of pathomorphological researches
Objectives To identify the rate, character and peculiarities of structural changes in organs and tissues in case of unfavorable outcomes resulted from a severe acute pancreatitis and work out the ways to reduce mortality on this basis. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Aleh Kudelich Tags: 1. Acute Pancreatitis I Source Type: research
Diagnosis of intestinal failure and its impact on prognosis in patients with acute necrotizing pancreatitis
Objectives Acute necrotizing pancreatitis (ANP) is potentially lethal inflammatory process. Recent researches established that presence of multiorgan failure together with pancreatic infection are major determinants of its mortality. But significance of different organs failure, especially intestinal dysfunction in course of acute necrotizing pancreatitis is still remaining unclear. Objective of our study was to determine frequency and significance of intestinal failure on severity and mortality of ANP. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Olha Kuzminska, Igor Khomiak, Oleksandr Rotar, Vasyl Rotar, Andrii Khomiak Tags: 1. Acute Pancreatitis I Source Type: research
Descriptive analysis of patient outcomes following plasmapheresis for hypertriglyceridemia-induced acute pancreatitis
Objectives Therapeutic plasmapheresis is one of the treatment modalities for lowering triglycerides in acute pancreatitis secondary to hypertriglyceridemia. However, hypertriglyceridemia in the setting of acute pancreatitis is considered a weak indication for treatment given limited robust outcome data. In review of the literature, three case series have been reported over the last decade from single centers in Spain and the United States, with a total of 34 patients. We review the outcomes of plasmapheresis treatment for acute pancreatitis caused by hypertriglyceridemia in hospitalized patients. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Alexander Heckman, Keith Sacco, Abba Zubair, Michele Lewis Tags: 1. Acute Pancreatitis I Source Type: research
Contamination's risk factors of severe necrotizing pancreatitis
Objectives To research the infection's risk factors of necrotic pancreatitis witch are leading to death and determine ways to reduce mortality. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Ivan Yelskyy Tags: 1. Acute Pancreatitis I Source Type: research
