Actionable perturbations in the DNA damage response establish synergistic therapeutic routes in ATM deficient pancreatic cancer
Objectives Pancreatic ductal adenocarcinoma (PDAC) is the 4th leading cause of cancer-associated death in the Western World. PDAC bears a high accumulation of oncogenic mutations. Recent sequencing studies found Ataxia-Telangiectasia Mutated (ATM) frequently mutated in PDAC. Our lab previously showed that the loss of ATM accelerates EMT and promotes genomic instability (Russell, Nature communication, 2013; Perkhofer, 2017, Cancer Research). In line with the altered genomic integrity of ATM-mutated PDAC established genotype specific strategies like PARP- and ATR- inhibition. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Johann Gout, Lukas Perkhofer, Frank Arnold, Thomas Seufferlein, Pierre-Oliver Frappart, Alexander Kleger Tags: 9. Experimental pancreatic cancer I Source Type: research
Outcomes of pancreatoduodenectomy in the German DGAV StuDoQ|Pancreas registry – A cross-validation study with the Dutch pancreatic cancer audit
Objectives Multicenter registries facilitate quality and outcome assessment in pancreatic surgery. The Dutch Pancreatic Cancer Audit (DPCA) is externally cross-validated previously and participation is mandatory. The aim of this study was to compare outcome of pancreatoduodenectomy in the recently established German DGAV StuDoQ|Pancreas registry to the DPCA as a means of external data validation. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Tara Mackay, Ulrich Wellner, Lennart van Rijssen, Thomas Stoop, Olivier Busch, Bas Groot Koerkamp, Dirk Bausch, Ekaterina Petrova, Marc Besselink, Tobias Keck, Dutch Pancreatic Cancer Group, DGAV StuDoQ|Pancreas Tags: 10. Pancreatic surgery I Source Type: research
Preoperative fecal elastase-1 (FE-1) correlates with pancreatic fistula after major pancreatic resections
Objectives Post-operative pancreatic fistula (POPF) is the major determinant of outcome after pancreatic resections. Validated predictors of POPF are usually assessed intraoperatively. The aim of the study is to evaluate the role of fecal elastase-1 (FE-1) as a predictor of POPF in the preoperative setting. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Tommaso Giuliani, Stefano Andrianello, Cecilia Bortolato, Giovanni Marchegiani, Giulia De Marchi, Antonio Amodio, Luca Frulloni, Giuseppe Malleo, Roberto Salvia, Claudio Bassi Tags: 10. Pancreatic surgery I Source Type: research
How do different surgical reconstruction techniques affect the postoperative course of patients with pancreas head resections? - A systematic review with meta-analysis
Objectives Several surgical reconstruction techniques have been introduced to reduce the high rates of postoperative mortality and morbidity after pancreaticoduodenectomy/PD. These techniques include 1) the Child reconstruction defined as pancreatojejunostomy/PJ followed by hepaticojejunostomy/HJ and the gastrojejunostomy/GJ ( “the standard/s-Child”), 2) the s-Child reconstruction with an additional Braun enteroenterostomy (“BE-Child"), or 3) Isolated-Roux-En-Y-pancreaticojejunostomy (“Iso-Roux-En-Y”), in which the pancreas anastomosis is reconstructed in a separate loop after the GJ. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Stephan Schorn, Ekin Ihsan Demir, Thomas Vogel, Daniel Reim, Rebekka Schirren, Dirk Wilhelm, Gueralp Onur Ceyhan, Helmut Friess Tags: 10. Pancreatic surgery I Source Type: research
Preoperative biliary stenting in patients with obstructive jaundice caused by the tumors of the pancreatoduodenal's area
Objectives The procedure of excision of the head of the pancreas with the duodenum (the Whipple ’s pancreatoduodenectomy) is an operation with a high risk of postoperative complications. Many patients with the tumors of pancreatoduodenal area develop obstructive jaundice as first symptom. It can be an additional risk factor of postoperative complications. Biliary stenting is on purpose to im prove the general condition of the patient before the surgical treatment, and thus reduce the number of perioperative morbidity and mortality. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Magdalena Derejska, Marek Durlik Tags: 10. Pancreatic surgery I Source Type: research
Chyle leak after pancreatic surgery: validation of the International study group of pancreatic surgery classification
This study aims to evaluate the differences in the clinical and economic burden of CL applying the new definition. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Matteo De Pastena, Salvatore Paiella, Selene Bogoni, Fabio Casciani, Stefano Andrianello, Roberto Salvia, Claudio Bassi Tags: 10. Pancreatic surgery I Source Type: research
Long term results of pancreatic surgery: structural changes of the pancreas
Objectives To evaluate long term results of surgical treatment of patients with complicated chronic pancreatitis (CP) by studying the structural features (properties) of the pancreas. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Vadym Ratchyk, Denis Orlovskyi Tags: 10. Pancreatic surgery I Source Type: research
Postoperative acute pancreatitis following pancreaticoduodenectomy: a determinant of fistula driven by the intraoperative fluid management
Objectives A standardized definition of post-operative acute pancreatitis (POAP) after pancreaticoduodenectomy (PD) has been recently proposed, but specific studies are lacking. The aim of the study is to characterize and justify the definition of POAP. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Elisa Bannone, Stefano Andrianello, Giovanni Marchegiani, Gaia Masini, Giuseppe Malleo, Claudio Bassi, Roberto Salvia Tags: 10. Pancreatic surgery I Source Type: research
Spleen-preserving total pancreatectomy - initial experience
Objectives Total pancreatectomy (TP) is safe and effective procedure when performed in high-volume pancreatic centers. Spleen-preserving TP (SpTP) is infrequent surgical procedure. This is our first experience in such type of pancreatic resections. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Zakhar Kovalenko, Dmitriy Ananyew Tags: 10. Pancreatic surgery I Source Type: research
Laparoscopic versus open distal pancreatectomy for left-sided pancreatic cancer: A stage adjusted survival analysis according to the 8th edition AJCC staging
Objectives Despite increasing reports on favorable oncologic outcomes of laparoscopic surgery for left-sided pancreatic cancer compared to open surgery, there have been few reports with a focus on comparative survival outcomes according to the tumor stage. The aim of this study was to compare the oncologic outcomes of laparoscopic and open distal pancreatectomy for left-sided pancreatic cancer based on the AJCC 8th edition. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Yoo-Seok Yoon, In Gun Hyun, Ho-Seong Han, Sungho Kim, Kil Hwan Kim Tags: 10. Pancreatic surgery I Source Type: research
Skeletal muscle depletion and postoperative complication after pancreaticoduodenectomy
Objectives The sarcopenia which is skeletal muscle depletion has been reported to be associated with postoperative recurrence as well as postoperative complications. The aim of this study was to examine whether sarcopenia affects postoperative complications and cancer recurrence. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Huisong Lee, Hyeon Kook Lee, Seog Ki Min Tags: 10. Pancreatic surgery I Source Type: research
Intra-operative ultrasound to determine resectability during surgical exploration of primary non-resectable pancreatic cancer following induction chemotherapy
This study explores the use of intra-operative ultrasound (IOUS) during explorative laparotomy and compares IOUS with pre-operative CT-scans. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Marieke S. Walma, Eran van Veldhuisen, L.B. van Rijssen, Olivier R. Busch, Rutger C. Bruijnen, Otto M. van Delden, Nadia Haj Mohammad, Ignace de Hingh, Lonneke S. Yo, Hanneke W. van Laarhoven, Maarten S. van Leeuwen, C.Y. Nio, Hjalmar C. van Santvoort, Ja Tags: 10. Pancreatic surgery I Source Type: research
Total pancreatectomy in patients with «difficult» pancreatic stump
Objectives Pancreatodigestive anastomosis – Achilles'heel of Whipple procedure. Total pancreatectomy (TP) for technical reasons is a viable option according to recent reports from high-volume centers. The aim of this study was to assess short-term results of TP, which was undertaken for treatment of difficult pancreatic stump. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Zakhar Kovalenko, Dmitriy Ananyew Tags: 10. Pancreatic surgery I Source Type: research
Non-inferiority of open passive drains compared with closed suction drains in pancreatic surgery outcomes: A prospective observational study
Objectives Drain policies in pancreatic surgery are still under debate. Open passive drains (OPD) and closed-suction drains (CSD) are both currently used in clinical practice worldwide, but there are no reliable data regarding potential differences in the postoperative outcomes associated with each drain type. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Giampaolo Perri, Giovanni Marchegiani, Alessandra Pulvirenti, Elisabetta Sereni, Roberto Salvia, Claudio Bassi Tags: 10. Pancreatic surgery I Source Type: research
First experience with continuous glucose monitoring after pancreatic surgery
Objectives Pancreatogenic diabetes plays a major role in the quality of life after pancreatic surgery. The development of a new-onset diabetes mellitus after pancreatic resection is dependent on the progression of the underlying disease, the type of surgery and the extent of resection. Up to 18% of patients with pancreaticoduodenectomy and 31% of patients with distal pancreatectomy develop a new-onset diabetes mellitus postoperatively. Due to increasingly radical resections the incidence of pancreatogenic diabetes rises. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Christopher Lampert, Max Weniger, Konrad Karcz, Jens Werner, Jan D'Haese Tags: 10. Pancreatic surgery I Source Type: research
