Reactive astrocytes potentiate tumor aggressiveness in a murine glioma resection and recurrence model
Conclusions
This study demonstrates a unique syngeneic model of glioma resection and recurrence in immune-competent mice. Furthermore, this model provided insights into the pattern of postsurgical tumor recurrence and changes in the peritumoral microenvironment, as well as the impact of injured astrocytes on glioma growth and invasion. A better understanding of the postsurgical tumor microenvironment will allow development of targeted anticancer agents that improve surgery-mediated effects on tumor biology. (Source: Neuro-Oncology)
Source: Neuro-Oncology - November 8, 2016 Category: Cancer & Oncology Authors: Okolie, O., Bago, J. R., Schmid, R. S., Irvin, D. M., Bash, R. E., Miller, C. R., Hingtgen, S. D. Tags: Basic and Translational Investigation Source Type: research
Limited role for transforming growth factor-{beta} pathway activation-mediated escape from VEGF inhibition in murine glioma models
Conclusions
Our study highlights the biological heterogeneity of murine glioma models and illustrates that cotargeting of the VEGF and TGF-β pathways might lead to improved tumor control only in subsets of glioblastoma. (Source: Neuro-Oncology)
Source: Neuro-Oncology - November 8, 2016 Category: Cancer & Oncology Authors: Mangani, D., Weller, M., Seyed Sadr, E., Willscher, E., Seystahl, K., Reifenberger, G., Tabatabai, G., Binder, H., Schneider, H. Tags: Basic and Translational Investigation Source Type: research
Stereotactic modulation of blood-brain barrier permeability to enhance drug delivery
Drug delivery in the CNS is limited by endothelial tight junctions forming the impermeable blood-brain barrier. The development of new treatment paradigms has previously been hampered by the restrictiveness of the blood-brain barrier to systemically administered therapeutics. With recent advances in stereotactic localization and noninvasive imaging, we have honed the ability to modulate, ablate, and rewire millimetric brain structures to precisely permeate the impregnable barrier. The wide range of focused radiations offers endless possibilities to disrupt endothelial permeability with different patterns and intensity foll...
Source: Neuro-Oncology - November 8, 2016 Category: Cancer & Oncology Authors: Appelboom, G., Detappe, A., LoPresti, M., Kunjachan, S., Mitrasinovic, S., Goldman, S., Chang, S. D., Tillement, O. Tags: Review Source Type: research
Highlights from the Literature
(Source: Neuro-Oncology)
Source: Neuro-Oncology - November 8, 2016 Category: Cancer & Oncology Authors: Schiff, D., Lawler, S., Chamberlain, M., Wright, K., Bhat, K. Tags: Highlights Source Type: research
Lesion momentum as explanation for preoperative neurocognitive function in patients with malignant glioma
(Source: Neuro-Oncology)
Source: Neuro-Oncology - November 8, 2016 Category: Cancer & Oncology Authors: Klein, M. Tags: Editorial Source Type: research
Molecular profiling optimizes the treatment of low-grade glioma
(Source: Neuro-Oncology)
Source: Neuro-Oncology - November 8, 2016 Category: Cancer & Oncology Authors: Schiff, D. Tags: Editorial Source Type: research
Corrigendum
(Source: Neuro-Oncology)
Source: Neuro-Oncology - November 8, 2016 Category: Cancer & Oncology Tags: Corrigendum Source Type: research
Contents_Page
(Source: Neuro-Oncology)
Source: Neuro-Oncology - November 8, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Subscriptions
(Source: Neuro-Oncology)
Source: Neuro-Oncology - November 8, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Editorial_Board
(Source: Neuro-Oncology)
Source: Neuro-Oncology - November 8, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Cover
(Source: Neuro-Oncology)
Source: Neuro-Oncology - November 8, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Author index
(Source: Neuro-Oncology)
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Tags: Author Index Source Type: research
Tmod-39. a novel ex vivo tumor slice culture system as a tool for basic and clinical research
Many cytotoxic and targeted therapies show promising activity in cultured cells but most fail to show equivalent efficacy in patients, indicating that the predictive power of cell culture models is limited. While patient derived xenograft (PDX) models are more faithful models of human cancer, they are very expensive and time consuming to generate and maintain, rendering them impractical models for most studies. To bridge the gap between in vitro cell culture and in vivo animal models, we developed a tumor slice culture system from PDX models and patient tumors. While other studies have described the use of tumor tissue sli...
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Gopalan, A., Wood, S., Yamamoto, K., Keck, J., Airhart, S., Shopland, L., Rueter, J., Yun, K. Tags: TUMOR MODELS Source Type: research
Tmod-38. development of an in vitro glioblastoma cancer stem cell bank
The Preston A. Wells Jr. Glioma Cell Line Bank began collecting tissue from UF glioma neurosurgical operations in 2014 and has established an organized repository of immortalized glioma cell lines that have been collected and maintained in a manner useful for a wide range of studies. Copies of patient’s consent to donate their tissue is obtained and clinical data from each case is logged into a secured computer database. Tissue is placed in culture as soon as it is received and the line is founded using the serum-free neurosphere method. Once a line is established, it is expanded and 100 vials are cryopreserved ...
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Reynolds, B., Vedam-mai, V., Deleyrolle, L. Tags: TUMOR MODELS Source Type: research
Tmod-37. characterization of a unique bmic population in human brain metastases
Brain Metastases (BM) are the most common neoplasm to affect the adult central nervous system, occurring at a rate 10 times greater than that of primary brain cancers. Despite the prevalence and severe lethality of BM, the current available in vivo models of metastasis neither fully recapitulate the clinical progression of BM nor allow for proper examination of metastatic cells. Not every cell within a primary tumour possess the ability to survive metastasis, and studies typical investigate large macro-metastases formed by cells that have already exited the metastatic cycle. We hypothesize that within primary tumours exist...
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Singh, M., Venugopal, C., Tokar, T., McFarlane, N., Bakhshinyan, D., Murty, N., Hassell, J., Jurisica, I., Singh, S. Tags: TUMOR MODELS Source Type: research
