Nephrology Dialysis Transplantation This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Four seasons for reflecting: Winter. Touch
(Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - December 7, 2016 Category: Urology & Nephrology Authors: Piccoli, G. B., Giuva, D., Ruff, D., Genovese, P., Apicella, M., Kuprina, N., Finnel, S. Tags: HUMANITIES IN NEPHROLOGY Source Type: research

Sustained remission in lupus nephritis: still a hard road ahead
End-stage renal disease caused by lupus nephritis (LN) is an avoidable outcome yet there is considerable uncertainty and variability among nephrologists in their approaches to this disorder. This review discusses recent evidence relevant to the management of LN including recent consensus statements. Long-term results are encouraging compared with 30 years ago, but despite the use of the best available current therapies and achieving high levels of early clinical responses, the kidney often sustains long-term damage and nephritis relapses affect over 50%. Major hurdles to management include the complexity of the clinical pr...
Source: Nephrology Dialysis Transplantation - December 7, 2016 Category: Urology & Nephrology Authors: Quintana, L. F., Jayne, D. Tags: REVIEWS - CLINICAL SCIENCE AND OUTCOME RESEARCH IN NEPHROLOGY Source Type: research

The application of multi-omics and systems biology to identify therapeutic targets in chronic kidney disease
This article reviews relevant concepts in omics data integration using systems biology, a mathematical modelling method that globally describes a biological system on the basis of its modules and the functional connections that govern their behaviour. The review describes key databases and bioinformatics tools, as well as the challenges and limitations of the current state of the art, along with practical application to CKD therapeutic target discovery. Moreover, it describes how systems biology and visualization tools can be used to generate clinically relevant molecular models with the capability to identify specific dis...
Source: Nephrology Dialysis Transplantation - December 7, 2016 Category: Urology & Nephrology Authors: Cisek, K., Krochmal, M., Klein, J., Mischak, H. Tags: REVIEWS - CLINICAL SCIENCE AND OUTCOME RESEARCH IN NEPHROLOGY Source Type: research

Should belatacept be the centrepiece of renal transplantation?
Belatacept was developed to minimize cardiovascular risk and nephrotoxicity associated with calcineurin inhibitor (CNI)–based immunosuppression. Recently, 7-year data from the Belatacept Evaluation of Nephroprotection and Efficacy as First-line Immunosuppression Trial (BENEFIT), a phase III study comparing belatacept with cyclosporine, have been published. While during the first year of belatacept the risk of acute rejection episodes was elevated, this seemingly had marginal consequences for long-term graft survival and function as well as patient survival. For patients at a low-immunological risk, this drug seems to...
Source: Nephrology Dialysis Transplantation - December 7, 2016 Category: Urology & Nephrology Authors: Huber, M., Kemmner, S., Renders, L., Heemann, U. Tags: REVIEWS - BASIC SCIENCE AND TRANSLATIONAL NEPHROLOGY Source Type: research

Hedgehog Gli signalling in kidney fibrosis
Kidney fibrosis is the common final pathway of virtually all progressive injury to the kidney and a promising therapeutic target in chronic kidney disease (CKD). The Hedgehog pathway has been reported to be critical in kidney development, and recent evidence suggests a role in kidney injury and fibrosis. This review provides an overview of recent data suggesting an important role of Gli transcriptional activators in kidney injury and repair. We have reported that the hedgehog transcriptional activator Gli1 specifically marks perivascular mesenchymal stem cells, which are an important source of kidney myofibroblasts. Geneti...
Source: Nephrology Dialysis Transplantation - December 7, 2016 Category: Urology & Nephrology Authors: Kramann, R. Tags: REVIEWS - BASIC SCIENCE AND TRANSLATIONAL NEPHROLOGY Source Type: research

Can there be science without philosophy?
Over the last few decades, philosophy has gained an increasingly bad reputation among working scientists. Prominent researchers have suggested, in various forms and degrees of mockery, that philosophy has little or nothing positive to contribute to science. This essay provides a response to these allegations. We begin by examining, and ultimately questioning, an influential argument purporting to undermine the significance of a philosophical approach to science. Next, we offer some biomedical examples where philosophical speculation plays a prominent role. We conclude by arguing that, when understood in the appropriate con...
Source: Nephrology Dialysis Transplantation - December 7, 2016 Category: Urology & Nephrology Authors: Nathan, M. J., Brancaccio, D., Zoccali, C. Tags: IDEAS, CONJECTURES AND REFUTATIONS Source Type: research

Exercise limitation in chronic kidney disease: deep seas and new shores
(Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - December 7, 2016 Category: Urology & Nephrology Authors: McMahon, L. P. Tags: IN FOCUS Source Type: research

The natural history of symptomatic cardiac conduction-system disease in end-stage renal disease
(Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - December 7, 2016 Category: Urology & Nephrology Authors: Kambur, T. R., Das, M., Agarwal, R. Tags: IN FOCUS Source Type: research

Urine sCD163: a window onto glomerular inflammation
(Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - December 7, 2016 Category: Urology & Nephrology Authors: Moller, H. J., Tesar, V., Little, M. A. Tags: IN FOCUS Source Type: research

African Americans with left ventricular hypertrophy and chronic kidney disease: what should we do?
(Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - December 7, 2016 Category: Urology & Nephrology Authors: Tamez, H. Tags: IN FOCUS Source Type: research

Announcements
(Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - November 1, 2016 Category: Urology & Nephrology Tags: Announcements Source Type: research

Impact of the Banff 2013 classification on the diagnosis of suspicious versus conclusive late antibody-mediated rejection in allografts without acute dysfunction
Conclusions The Banff 2013 classification helps in making a diagnosis of late ABMR, identifying cases, decreasing the percentage of suspected ABMR and making more conclusive diagnoses. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Gimeno, J., Redondo, D., Perez-Saez, M. J., Naranjo-Hans, D., Pascual, J., Crespo, M. Tags: Renal Transplantation Source Type: research

Solute solver 'what if module for modeling urea kinetics
Conclusions The completed Web form calculator may be particularly useful in computing equivalent continuous clearances for incremental hemodialysis strategies. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Daugirdas, J. T. Tags: Intra- and Extracorporeal Treatments of Kidney Failure Source Type: research

Pregnancy in dialysis patients in the new millennium: a systematic review and meta-regression analysis correlating dialysis schedules and pregnancy outcomes
Conclusions Data on pregnancy on dialysis are heterogeneous but rapidly accumulating; the main determinant of outcomes on HD is the dialysis schedule. The differences between PD and HD should be further analysed. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Piccoli, G. B., Minelli, F., Versino, E., Cabiddu, G., Attini, R., Vigotti, F. N., Rolfo, A., Giuffrida, D., Colombi, N., Pani, A., Todros, T. Tags: Intra- and Extracorporeal Treatments of Kidney Failure Source Type: research

A novel COL4A1 frameshift mutation in familial kidney disease: the importance of the C-terminal NC1 domain of type IV collagen
Conclusions Missense mutations of COL4A1 that encode the CB3 [IV] segment of the triple helical domain (exons 24 and 25) are associated with HANAC syndrome (hereditary angiopathy, nephropathy, aneurysms and cramps). Missense mutations of COL4A1 that disrupt the NC1 domain are associated with antenatal cerebral haemorrhage and porencephaly, but not kidney disease. Our findings extend the spectrum of COL4A1 mutations linked with renal disease and demonstrate that the highly conserved C-terminal part of the NC1 domain of the α1 chain of type IV collagen is important in the integrity of glomerular basement membrane in hu...
Source: Nephrology Dialysis Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Gale, D. P., Oygar, D. D., Lin, F., Oygar, P. D., Khan, N., Connor, T. M. F., Lapsley, M., Maxwell, P. H., Neild, G. H. Tags: Chronic Kidney Disease Source Type: research