The undercover academic keeping tabs on ‘predatory’ publishing
Nature 555, 7697 (2018). http://www.nature.com/doifinder/10.1038/d41586-018-02921-2
Author: Dalmeet Singh Chawla
Blacklists that warn against questionable publishers are in demand. (Source: Nature)
Source: Nature - March 22, 2018 Category: Research Authors: Dalmeet Singh Chawla Tags: News Source Type: research
Deadly Lassa-fever outbreak tests Nigeria's revamped health agency
Nature 555, 7697 (2018). http://www.nature.com/doifinder/10.1038/d41586-018-03171-y
Author: Amy Maxmen
Reforms put in place after Ebola epidemic in West Africa have built Nigeria's capacity to diagnose diseases and track their spread. (Source: Nature)
Source: Nature - March 22, 2018 Category: Research Authors: Amy Maxmen Tags: News Source Type: research
Spy-poison probe, white rhino and Stephen Hawking — the week in science
Nature 555, 7697 (2018). http://www.nature.com/doifinder/10.1038/d41586-018-03266-6
Author:
The week in science: 16–22 March 2018. (Source: Nature)
Source: Nature - March 22, 2018 Category: Research Tags: Seven Days Source Type: research
Let democracy rule nuclear energy
Nature 555, 7697 (2018). http://www.nature.com/doifinder/10.1038/d41586-018-03264-8
Author: Ji-Bum Chung
In South Korea, hundreds ofwell-informed citizens voted on behalf of their country — a technique that should be used more widely, says Ji-Bum Chung. (Source: Nature)
Source: Nature - March 22, 2018 Category: Research Authors: Ji-Bum Chung Tags: Column Source Type: research
Asymmetry symposium unites economists, physicists and artists
Nature 555, 7697 (2018). doi:10.1038/d41586-018-03254-w
Author:
Transdisciplinary programme explores the pervasive presence of symmetry violations. (Source: Nature)
Source: Nature - March 22, 2018 Category: Research Tags: Editorial Source Type: research
How to get public engagement right
Nature 555, 7697 (2018). doi:10.1038/d41586-018-03388-x
Author:
Dialogue with the public requires a nuanced approach and a willingness to accept uncomfortable truths. (Source: Nature)
Source: Nature - March 22, 2018 Category: Research Tags: Editorial Source Type: research
Fourier ’s transformational thinking
Fourier’s transformational thinking
Nature 555, 7697 (2018). doi:10.1038/d41586-018-03389-w
Author:
The mathematics of Joseph Fourier, born 250 years ago this week, shows the value of intellectual boldness. (Source: Nature)
Source: Nature - March 22, 2018 Category: Research Tags: Editorial Source Type: research
Structural insights into the voltage and phospholipid activation of the mammalian TPC1 channel
-chen Bai
The organellar two-pore channel (TPC) functions as a homodimer, in which each subunit contains two homologous Shaker-like six-transmembrane (6-TM)-domain repeats. TPCs belong to the voltage-gated ion channel superfamily and are ubiquitously expressed in animals and plants. Mammalian TPC1 and TPC2 are localized at the endolysosomal membrane, and have critical roles in regulating the physiological functions of these acidic organelles. Here we present electron cryo-microscopy structures of mouse TPC1 (MmTPC1)—a voltage-dependent, phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2)-activated Na+-selective ch...
Source: Nature - March 21, 2018 Category: Research Authors: Ji She Jiangtao Guo Qingfeng Chen Weizhong Zeng Youxing Jiang Xiao-chen Bai Tags: Letter Source Type: research
Shifts in tree functional composition amplify the response of forest biomass to climate
chstein
Forests have a key role in global ecosystems, hosting much of the world’s terrestrial biodiversity and acting as a net sink for atmospheric carbon. These and other ecosystem services that are provided by forests may be sensitive to climate change as well as climate variability on shorter time scales (for example, annual to decadal). Previous studies have documented responses of forest ecosystems to climate change and climate variability, including drought-induced increases in tree mortality rates. However, relationships between forest biomass, tree species composition and climate variability have not been qu...
Source: Nature - March 21, 2018 Category: Research Authors: Tao Zhang Ülo Niinemets Justin Sheffield Jeremy W. Lichstein Tags: Letter Source Type: research
Optogenetic regulation of engineered cellular metabolism for microbial chemical production
L. Avalos
The optimization of engineered metabolic pathways requires careful control over the levels and timing of metabolic enzyme expression. Optogenetic tools are ideal for achieving such precise control, as light can be applied and removed instantly without complex media changes. Here we show that light-controlled transcription can be used to enhance the biosynthesis of valuable products in engineered Saccharomyces cerevisiae. We introduce new optogenetic circuits to shift cells from a light-induced growth phase to a darkness-induced production phase, which allows us to control fermentation with only light. Furthe...
Source: Nature - March 21, 2018 Category: Research Authors: Evan M. Zhao Yanfei Zhang Justin Mehl Helen Park Makoto A. Lalwani Jared E. Toettcher Jos é L. Avalos Tags: Letter Source Type: research
The protein histidine phosphatase LHPP is a tumour suppressor
eim, Tony Hunter & Michael N. Hall
Histidine phosphorylation, the so-called hidden phosphoproteome, is a poorly characterized post-translational modification of proteins. Here we describe a role of histidine phosphorylation in tumorigenesis. Proteomic analysis of 12 tumours from an mTOR-driven hepatocellular carcinoma mouse model revealed that NME1 and NME2, the only known mammalian histidine kinases, were upregulated. Conversely, expression of the putative histidine phosphatase LHPP was downregulated specifically in the tumours. We demonstrate that LHPP is indeed a protein histidine phosphatase. Consistent with t...
Source: Nature - March 21, 2018 Category: Research Authors: Sravanth K. Hindupur Marco Colombi Stephen R. Fuhs Matthias S. Matter Yakir Guri Kevin Adam Marion Cornu Salvatore Piscuoglio Charlotte K. Y. Ng Charles Betz Dritan Liko Luca Quagliata Suzette Moes Paul Jenoe Luigi M. Terracciano Markus H. Heim Tony Hunte Tags: Letter Source Type: research
Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin
resistance
Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin
resistance
Nature 555, 7698 (2018). doi:10.1038/nature26138
Authors: Devram S. Ghorpade, Lale Ozcan, Ze Zheng, Sarah M. Nicoloro, Yuefei Shen, Emily Chen, Matthias Blüher, Michael P. Czech & Ira Tabas
Obesity-induced metabolic disease involves functional integration among several
organs via circulating factors, but little is known about crosstalk between liver
and visceral adipose tissue (VAT). In obesity, VAT becomes populated
with inflammatory adipose tissue macrophages (ATMs). In ob...
Source: Nature - March 21, 2018 Category: Research Authors: Devram S. Ghorpade Lale Ozcan Ze Zheng Sarah M. Nicoloro Yuefei Shen Emily Chen Matthias Bl üher Michael P. Czech Ira Tabas Tags: Letter Source Type: research
Moving magnetoencephalography towards real-world applications with a wearable system
thew J. Brookes
Imaging human brain function with techniques such as magnetoencephalography typically requires a subject to perform tasks while their head remains still within a restrictive scanner. This artificial environment makes the technique inaccessible to many people, and limits the experimental questions that can be addressed. For example, it has been difficult to apply neuroimaging to investigation of the neural substrates of cognitive development in babies and children, or to study processes in adults that require unconstrained head movement (such as spatial navigation). Here we describe a magnetoencephalogr...
Source: Nature - March 21, 2018 Category: Research Authors: Elena Boto Niall Holmes James Leggett Gillian Roberts Vishal Shah Sofie S. Meyer Leonardo Duque Mu ñoz Karen J. Mullinger Tim M. Tierney Sven Bestmann Gareth R. Barnes Richard Bowtell Matthew J. Brookes Tags: Letter Source Type: research
Reconstructing the genetic history of late Neanderthals
jko Kućan, Pavao Rudan, Liubov V. Golovanova, Vladimir B. Doronichev, Cosimo Posth, Johannes Krause, Petra Korlević, Sarah Nagel, Birgit Nickel, Montgomery Slatkin, Nick Patterson, David Reich, Kay Prüfer, Matthias Meyer, Svante Pääbo & Janet Kelso
Although it has previously been shown that Neanderthals contributed DNA to modern humans, not much is known about the genetic diversity of Neanderthals or the relationship between late Neanderthal populations at the time at which their last interactions with early modern humans occurred and before they eventually disappeared. Our ability to retrieve DNA from a larg...
Source: Nature - March 21, 2018 Category: Research Authors: Mateja Hajdinjak Qiaomei Fu Alexander H übner Martin Petr Fabrizio Mafessoni Steffi Grote Pontus Skoglund Vagheesh Narasimham H élène Rougier Isabelle Crevecoeur Patrick Semal Marie Soressi Sahra Talamo Jean-Jacques Hublin Ivan Gu šić Željko Kućan Tags: Letter Source Type: research
Insulin resistance in cavefish as an adaptation to a nutrient-limited environment
Nicolas Rohner
Periodic food shortages are a major challenge faced by organisms in natural habitats. Cave-dwelling animals must withstand long periods of nutrient deprivation, as—in the absence of photosynthesis—caves depend on external energy sources such as seasonal floods. Here we show that cave-adapted populations of the Mexican tetra, Astyanax mexicanus, have dysregulated blood glucose homeostasis and are insulin-resistant compared to river-adapted populations. We found that multiple cave populations carry a mutation in the insulin receptor that leads to decreased insulin binding in vitro and contributes to ...
Source: Nature - March 21, 2018 Category: Research Authors: Misty R. Riddle Ariel C. Aspiras Karin Gaudenz Robert Peu ß Jenny Y. Sung Brian Martineau Megan Peavey Andrew C. Box Julius A. Tabin Suzanne McGaugh Richard Borowsky Clifford J. Tabin Nicolas Rohner Tags: Letter Source Type: research
