The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis
Nature Medicine 24, 213 (2018).
doi:10.1038/nm.4461
Authors: Yan-Xiao Ji, Zan Huang, Xia Yang, Xiaozhan Wang, Ling-Ping Zhao, Pi-Xiao Wang, Xiao-Jing Zhang, Michele Alves-Bezerra, Lin Cai, Peng Zhang, Yue-Xin Lu, Lan Bai, Mao-Mao Gao, Huan Zhao, Song Tian, Yong Wang, Zhi-Xiang Huang, Xue-Yong Zhu, Yan Zhang, Jun Gong, Zhi-Gang She, Feng Li, David E Cohen & Hongliang Li (Source: Nature Medicine)
Source: Nature Medicine - January 1, 2018 Category: General Medicine Authors: Yan-Xiao Ji Zan Huang Xia Yang Xiaozhan Wang Ling-Ping Zhao Pi-Xiao Wang Xiao-Jing Zhang Michele Alves-Bezerra Lin Cai Peng Zhang Yue-Xin Lu Lan Bai Mao-Mao Gao Huan Zhao Song Tian Yong Wang Zhi-Xiang Huang Xue-Yong Zhu Yan Zhang Jun Gong Zhi-Gang She Fen Tags: Article Source Type: research
Recurrent ECSIT mutation encoding V140A triggers hyperinflammation and promotes hemophagocytic syndrome in extranodal NK/T cell lymphoma
Nature Medicine 24, 154 (2018).
doi:10.1038/nm.4456
Authors: Haijun Wen, Huajuan Ma, Qichun Cai, Suxia Lin, Xinxing Lei, Bin He, Sijin Wu, Zifeng Wang, Yan Gao, Wensheng Liu, Weiping Liu, Qian Tao, Zijie Long, Min Yan, Dali Li, Keith W. Kelley, Yongliang Yang, Huiqiang Huang & Quentin Liu (Source: Nature Medicine)
Source: Nature Medicine - January 1, 2018 Category: General Medicine Authors: Haijun Wen Huajuan Ma Qichun Cai Suxia Lin Xinxing Lei Bin He Sijin Wu Zifeng Wang Yan Gao Wensheng Liu Weiping Liu Qian Tao Zijie Long Min Yan Dali Li Keith W. Kelley Yongliang Yang Huiqiang Huang Quentin Liu Tags: Article Source Type: research
The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions
Nature Medicine 24, 103 (2018).
doi:10.1038/nm.4439
Authors: Hamid Bolouri, Jason E Farrar, Timothy Triche, Rhonda E Ries, Emilia L Lim, Todd A Alonzo, Yussanne Ma, Richard Moore, Andrew J Mungall, Marco A Marra, Jinghui Zhang, Xiaotu Ma, Yu Liu, Yanling Liu, Jaime M Guidry Auvil, Tanja M Davidsen, Patee Gesuwan, Leandro C Hermida, Bodour Salhia, Stephen Capone, Giridharan Ramsingh, Christian Michel Zwaan, Sanne Noort, Stephen R Piccolo, E Anders Kolb, Alan S Gamis, Malcolm A Smith, Daniela S Gerhard & Soheil Meshinchi (Source: Nature Medicine)
Source: Nature Medicine - December 11, 2017 Category: General Medicine Authors: Hamid Bolouri Jason E Farrar Timothy Triche Rhonda E Ries Emilia L Lim Todd A Alonzo Yussanne Ma Richard Moore Andrew J Mungall Marco A Marra Jinghui Zhang Xiaotu Ma Yu Liu Yanling Liu Jaime M Guidry Auvil Tanja M Davidsen Patee Gesuwan Leandro C Hermida Tags: Resource Source Type: research
The deubiquitinating enzyme TNFAIP3 mediates inactivation of hepatic ASK1 and ameliorates nonalcoholic steatohepatitis
Nature Medicine 24, 84 (2018).
doi:10.1038/nm.4453
Authors: Peng Zhang, Pi-Xiao Wang, Ling-Ping Zhao, Xin Zhang, Yan-Xiao Ji, Xiao-Jing Zhang, Chun Fang, Yue-Xin Lu, Xia Yang, Mao-Mao Gao, Yan Zhang, Song Tian, Xue-Yong Zhu, Jun Gong, Xin-Liang Ma, Feng Li, Zhihua Wang, Zan Huang, Zhi-Gang She & Hongliang Li (Source: Nature Medicine)
Source: Nature Medicine - December 11, 2017 Category: General Medicine Authors: Peng Zhang Pi-Xiao Wang Ling-Ping Zhao Xin Zhang Yan-Xiao Ji Xiao-Jing Zhang Chun Fang Yue-Xin Lu Xia Yang Mao-Mao Gao Yan Zhang Song Tian Xue-Yong Zhu Jun Gong Xin-Liang Ma Feng Li Zhihua Wang Zan Huang Zhi-Gang She Hongliang Li Tags: Article Source Type: research
An ALOX12 – 12-HETE – GPR31 signaling axis is a key mediator of hepatic ischemia – reperfusion injury
Nature Medicine 24, 73 (2018).
doi:10.1038/nm.4451
Authors: Xiao-Jing Zhang, Xu Cheng, Zhen-Zhen Yan, Jing Fang, Xiaozhan Wang, Weijun Wang, Zhen-Yu Liu, Li-Jun Shen, Peng Zhang, Pi-Xiao Wang, Rufang Liao, Yan-Xiao Ji, Jun-Yong Wang, Song Tian, Xue-Yong Zhu, Yan Zhang, Rui-Feng Tian, Lin Wang, Xin-Liang Ma, Zan Huang, Zhi-Gang She & Hongliang Li (Source: Nature Medicine)
Source: Nature Medicine - December 11, 2017 Category: General Medicine Authors: Xiao-Jing Zhang Xu Cheng Zhen-Zhen Yan Jing Fang Xiaozhan Wang Weijun Wang Zhen-Yu Liu Li-Jun Shen Peng Zhang Pi-Xiao Wang Rufang Liao Yan-Xiao Ji Jun-Yong Wang Song Tian Xue-Yong Zhu Yan Zhang Rui-Feng Tian Lin Wang Xin-Liang Ma Zan Huang Zhi-Gang She Ho Tags: Article Source Type: research
A proteolytic fragment of histone deacetylase 4 protects the heart from failure by regulating the hexosamine biosynthetic pathway
Nature Medicine 24, 62 (2018).
doi:10.1038/nm.4452
Authors: Lorenz H Lehmann, Zegeye H Jebessa, Michael M Kreusser, Axel Horsch, Tao He, Mariya Kronlage, Matthias Dewenter, Viviana Sramek, Ulrike Oehl, Jutta Krebs-Haupenthal, Albert H von der Lieth, Andrea Schmidt, Qiang Sun, Julia Ritterhoff, Daniel Finke, Mirko Völkers, Andreas Jungmann, Sven W Sauer, Christian Thiel, Alexander Nickel, Michael Kohlhaas, Michaela Schäfer, Carsten Sticht, Christoph Maack, Norbert Gretz, Michael Wagner, Ali El-Armouche, Lars S Maier, Juan E Camacho Londoño, Benjamin Meder, Marc Freichel, Hermann-Josef Gröne, Patr...
Source: Nature Medicine - December 11, 2017 Category: General Medicine Authors: Lorenz H Lehmann Zegeye H Jebessa Michael M Kreusser Axel Horsch Tao He Mariya Kronlage Matthias Dewenter Viviana Sramek Ulrike Oehl Jutta Krebs-Haupenthal Albert H von der Lieth Andrea Schmidt Qiang Sun Julia Ritterhoff Daniel Finke Mirko V ö lkers Andr Tags: Article Source Type: research
Corrigendum: ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis
Nature Medicine 23, 1499 (2017).
doi:10.1038/nm1217-1499b
Authors: David Lagares, Parisa Ghassemi-Kakroodi, Caroline Tremblay, Alba Santos, Clemens K Probst, Alicia Franklin, Daniela M Santos, Paula Grasberger, Neil Ahluwalia, Sydney B Montesi, Barry S Shea, Katharine E Black, Rachel Knipe, Meryem Blati, Murray Baron, Brian Wu, Hassan Fahmi, Rajiv Gandhi, Annie Pardo, Moisés Selman, Jiangping Wu, Jean-Pierre Pelletier, Johanne Martel-Pelletier, Andrew M Tager & Mohit Kapoor (Source: Nature Medicine)
Source: Nature Medicine - December 7, 2017 Category: General Medicine Authors: David Lagares Parisa Ghassemi-Kakroodi Caroline Tremblay Alba Santos Clemens K Probst Alicia Franklin Daniela M Santos Paula Grasberger Neil Ahluwalia Sydney B Montesi Barry S Shea Katharine E Black Rachel Knipe Meryem Blati Murray Baron Brian Wu Hassan F Tags: Corrigendum Source Type: research
Corrigendum: Persisting positron emission tomography lesion activity and Mycobacterium tuberculosis mRNA after tuberculosis cure
Nature Medicine 23, 1499 (2017).
doi:10.1038/nm1217-1499a
Authors: Stephanus T Malherbe, Shubhada Shenai, Katharina Ronacher, Andre G Loxton, Gregory Dolganov, Magdalena Kriel, Tran Van, Ray Y Chen, James Warwick, Laura E Via, Taeksun Song, Myungsun Lee, Gary Schoolnik, Gerard Tromp, David Alland, Clifton E Barry, Jill Winter & Gerhard Walzl (Source: Nature Medicine)
Source: Nature Medicine - December 7, 2017 Category: General Medicine Authors: Stephanus T Malherbe Shubhada Shenai Katharina Ronacher Andre G Loxton Gregory Dolganov Magdalena Kriel Tran Van Ray Y Chen James Warwick Laura E Via Taeksun Song Myungsun Lee Gary Schoolnik Gerard Tromp David Alland Clifton E Barry Jill Winter Gerhard Wa Tags: Corrigendum Source Type: research
Fattening the role of Ca2+ cycling in adaptive thermogenesis
Nature Medicine 23, 1403 (2017).
doi:10.1038/nm.4457
Authors: Daniel Gamu & A Russell Tupling
A new study shows that deleting uncoupling protein 1 activates Ca2+ cycling thermogenesis within beige fat, protecting mice against cold-induced hypothermia and dysglycemia following diet-induced obesity. (Source: Nature Medicine)
Source: Nature Medicine - December 7, 2017 Category: General Medicine Authors: Daniel Gamu A Russell Tupling Tags: News and Views Source Type: research
Targeted cellular immunotherapy for T cell malignancies
Nature Medicine 23, 1402 (2017).
doi:10.1038/nm.4458
Authors: Teresa Palomero & Adolfo Ferrando
In a recent study, Maciocia et al. develop a novel T cell receptor beta (TCRB) constant C1-chain-directed cellular immunotherapy for the treatment of T cell malignancies. (Source: Nature Medicine)
Source: Nature Medicine - December 7, 2017 Category: General Medicine Authors: Teresa Palomero Adolfo Ferrando Tags: News and Views Source Type: research
Recognition of self-DNA drives cardiac inflammation: why broken hearts fail
Nature Medicine 23, 1400 (2017).
doi:10.1038/nm.4455
Authors: Kory J Lavine & Douglas L Mann
Signals that govern immune cells in the heart remain poorly defined. A new report in mice shows that pathways involved in sensing viruses orchestrate monocyte and macrophage activation through recognition of DNA derived from dying cardiomyocytes following myocardial infarction. (Source: Nature Medicine)
Source: Nature Medicine - December 7, 2017 Category: General Medicine Authors: Kory J Lavine Douglas L Mann Tags: News and Views Source Type: research
Organoids lead the cancer attack
Nature Medicine 23, 1399 (2017).
doi:10.1038/nm.4454
Authors: Amber R Smith & Calvin J Kuo
In an article published recently in Nature Medicine, the authors generate organoid models of liver neoplasia. In doing so, they highlight both the diversity of current organoid methodologies and their application to cancer modeling and therapeutics discovery. (Source: Nature Medicine)
Source: Nature Medicine - December 7, 2017 Category: General Medicine Authors: Amber R Smith Calvin J Kuo Tags: News and Views Source Type: research
Reply to The small molecule CLP257 does not modify activity of the K+ – Cl − co-transporter KCC2 but does potentiate GABAA receptor activity
Nature Medicine 23, 1396 (2017).
doi:10.1038/nm.4449
Authors: Martin Gagnon, Marc J Bergeron, Jimena Perez-Sanchez, Isabel Plasencia-Fernández, Louis-Etienne Lorenzo, Antoine G Godin, Annie Castonguay, Robert P Bonin & Yves De Koninck (Source: Nature Medicine)
Source: Nature Medicine - December 7, 2017 Category: General Medicine Authors: Martin Gagnon Marc J Bergeron Jimena Perez-Sanchez Isabel Plasencia-Fern á ndez Louis-Etienne Lorenzo Antoine G Godin Annie Castonguay Robert P Bonin Yves De Koninck Tags: Correspondence Source Type: research
The small molecule CLP257 does not modify activity of the K+ – Cl − co-transporter KCC2 but does potentiate GABAA receptor activity
Nature Medicine 23, 1394 (2017).
doi:10.1038/nm.4442
Authors: Ross A Cardarelli, Karen Jones, Lucie I Pisella, Heike J Wobst, Lisa J McWilliams, Paul M Sharpe, Matthew P Burnham, David J Baker, Ilona Chudotvorova, Justine Guyot, Liliya Silayeva, Danielle H Morrow, Niek Dekker, Stephen Zicha, Paul A Davies, Jörg Holenz, Mark E Duggan, John Dunlop, Robert J Mather, Qi Wang, Igor Medina, Nicholas J Brandon, Tarek Z Deeb & Stephen J Moss (Source: Nature Medicine)
Source: Nature Medicine - December 7, 2017 Category: General Medicine Authors: Ross A Cardarelli Karen Jones Lucie I Pisella Heike J Wobst Lisa J McWilliams Paul M Sharpe Matthew P Burnham David J Baker Ilona Chudotvorova Justine Guyot Liliya Silayeva Danielle H Morrow Niek Dekker Stephen Zicha Paul A Davies J ö rg Holenz Mark E Du Tags: Correspondence Source Type: research
Drugs that made headlines in 2017
Nature Medicine 23, 1392 (2017).
doi:10.1038/nm1217-1392
Author: Shraddha Chakradhar
In 2017, cancer drugs once again dominated the news, with many of these medications making headlines for being the first of their kind to gain approval. Beyond cancer, drugs for inflammatory diseases also received attention, for both their successes and their failures. (Source: Nature Medicine)
Source: Nature Medicine - December 7, 2017 Category: General Medicine Authors: Shraddha Chakradhar Tags: News Source Type: research
