Cooperative targeting of melanoma heterogeneity with an AXL antibody-drug conjugate and BRAF/MEK inhibitors
Nature Medicine 24, 203 (2018).
doi:10.1038/nm.4472
Authors: Julia Boshuizen, Louise A Koopman, Oscar Krijgsman, Aida Shahrabi, Elke Gresnigt– van den Heuvel, Maarten A Ligtenberg, David W Vredevoogd, Kristel Kemper, Thomas Kuilman, Ji-Ying Song, Nora Pencheva, Jens Thing Mortensen, Marnix Geukes Foppen, Elisa A Rozeman, Christian U Blank, Maarten L Janmaat, David Satijn, Esther C W Breij, Daniel S Peeper & Paul W H I Parren (Source: Nature Medicine)
Source: Nature Medicine - January 15, 2018 Category: General Medicine Authors: Julia Boshuizen Louise A Koopman Oscar Krijgsman Aida Shahrabi Elke Gresnigt – van den Heuvel Maarten A Ligtenberg David W Vredevoogd Kristel Kemper Thomas Kuilman Ji-Ying Song Nora Pencheva Jens Thing Mortensen Marnix Geukes Foppen Elisa A Rozeman Chr Tags: Article Source Type: research
Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models
Nature Medicine 24, 194 (2018).
doi:10.1038/nm.4464
Authors: Michael L Schulte, Allie Fu, Ping Zhao, Jun Li, Ling Geng, Shannon T Smith, Jumpei Kondo, Robert J Coffey, Marc O Johnson, Jeffrey C Rathmell, Joe T Sharick, Melissa C Skala, Jarrod A Smith, Jordan Berlin, M Kay Washington, Michael L Nickels & H Charles Manning (Source: Nature Medicine)
Source: Nature Medicine - January 15, 2018 Category: General Medicine Authors: Michael L Schulte Allie Fu Ping Zhao Jun Li Ling Geng Shannon T Smith Jumpei Kondo Robert J Coffey Marc O Johnson Jeffrey C Rathmell Joe T Sharick Melissa C Skala Jarrod A Smith Jordan Berlin M Kay Washington Michael L Nickels H Charles Manning Tags: Article Source Type: research
A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment
Nature Medicine 24, 186 (2018).
doi:10.1038/nm.4474
Authors: Marc L Hyer, Michael A Milhollen, Jeff Ciavarri, Paul Fleming, Tary Traore, Darshan Sappal, Jessica Huck, Judy Shi, James Gavin, Jim Brownell, Yu Yang, Bradley Stringer, Robert Griffin, Frank Bruzzese, Teresa Soucy, Jennifer Duffy, Claudia Rabino, Jessica Riceberg, Kara Hoar, Anya Lublinsky, Saurabh Menon, Michael Sintchak, Nancy Bump, Sai M Pulukuri, Steve Langston, Stephen Tirrell, Mike Kuranda, Petter Veiby, John Newcomb, Ping Li, Jing Tao Wu, Josh Powe, Lawrence R Dick, Paul Greenspan, Katherine Galvin, Mark Manfredi, Chris Claiborne, Benjamin S Amido...
Source: Nature Medicine - January 15, 2018 Category: General Medicine Authors: Marc L Hyer Michael A Milhollen Jeff Ciavarri Paul Fleming Tary Traore Darshan Sappal Jessica Huck Judy Shi James Gavin Jim Brownell Yu Yang Bradley Stringer Robert Griffin Frank Bruzzese Teresa Soucy Jennifer Duffy Claudia Rabino Jessica Riceberg Kara Ho Tags: Article Source Type: research
Positively selected enhancer elements endow osteosarcoma cells with metastatic competence
Nature Medicine 24, 176 (2018).
doi:10.1038/nm.4475
Authors: James J Morrow, Ian Bayles, Alister P W Funnell, Tyler E Miller, Alina Saiakhova, Michael M Lizardo, Cynthia F Bartels, Maaike Y Kapteijn, Stevephen Hung, Arnulfo Mendoza, Gursimran Dhillon, Daniel R Chee, Jay T Myers, Frederick Allen, Marco Gambarotti, Alberto Righi, Analisa DiFeo, Brian P Rubin, Alex Y Huang, Paul S Meltzer, Lee J Helman, Piero Picci, Henri H Versteeg, John A Stamatoyannopoulos, Chand Khanna & Peter C Scacheri (Source: Nature Medicine)
Source: Nature Medicine - January 15, 2018 Category: General Medicine Authors: James J Morrow Ian Bayles Alister P W Funnell Tyler E Miller Alina Saiakhova Michael M Lizardo Cynthia F Bartels Maaike Y Kapteijn Stevephen Hung Arnulfo Mendoza Gursimran Dhillon Daniel R Chee Jay T Myers Frederick Allen Marco Gambarotti Alberto Righi An Tags: Article Source Type: research
Prevention of tuberculosis in rhesus macaques by a cytomegalovirus-based vaccine
Nature Medicine 24, 130 (2018).
doi:10.1038/nm.4473
Authors: Scott G Hansen, Daniel E Zak, Guangwu Xu, Julia C Ford, Emily E Marshall, Daniel Malouli, Roxanne M Gilbride, Colette M Hughes, Abigail B Ventura, Emily Ainslie, Kurt T Randall, Andrea N Selseth, Parker Rundstrom, Lauren Herlache, Matthew S Lewis, Haesun Park, Shannon L Planer, John M Turner, Miranda Fischer, Christina Armstrong, Robert C Zweig, Joseph Valvo, Jackie M Braun, Smitha Shankar, Lenette Lu, Andrew W Sylwester, Alfred W Legasse, Martin Messerle, Michael A Jarvis, Lynn M Amon, Alan Aderem, Galit Alter, Dominick J Laddy, Michele Stone, Aurelio Bo...
Source: Nature Medicine - January 15, 2018 Category: General Medicine Authors: Scott G Hansen Daniel E Zak Guangwu Xu Julia C Ford Emily E Marshall Daniel Malouli Roxanne M Gilbride Colette M Hughes Abigail B Ventura Emily Ainslie Kurt T Randall Andrea N Selseth Parker Rundstrom Lauren Herlache Matthew S Lewis Haesun Park Shannon L Tags: Article Source Type: research
The role of vaccines in preventing bacterial antimicrobial resistance
Nature Medicine 24, 10 (2018).
doi:10.1038/nm.4465
Authors: Kathrin U Jansen, Charles Knirsch & Annaliesa S Anderson (Source: Nature Medicine)
Source: Nature Medicine - January 9, 2018 Category: General Medicine Authors: Kathrin U Jansen Charles Knirsch Annaliesa S Anderson Tags: Review Source Type: research
Genomics in childhood acute myeloid leukemia comes of age
Nature Medicine 24, 7 (2018).
doi:10.1038/nm.4469
Authors: Andrew M Brunner & Timothy A Graubert
A Children's Oncology Group study of nearly 1,000 pediatric acute myeloid leukemia (AML) cases reveals marked differences between the genomic landscapes of pediatric and adult AML and offers directions for future work. (Source: Nature Medicine)
Source: Nature Medicine - January 9, 2018 Category: General Medicine Authors: Andrew M Brunner Timothy A Graubert Tags: News and Views Source Type: research
Lipid metabolic reprogramming in hepatic ischemia – reperfusion injury
Nature Medicine 24, 6 (2018).
doi:10.1038/nm.4468
Author: Satdarshan P Monga
In a recent study of hepatic ischemia–reperfusion injury (IRI), Zhang et al. use tandem 'omics' approaches in mice, pigs, and nonhuman primates to identify lipid metabolic reprogramming as a key determinant of IRI, thus providing novel mechanistic and therapeutic insights. (Source: Nature Medicine)
Source: Nature Medicine - January 9, 2018 Category: General Medicine Authors: Satdarshan P Monga Tags: News and Views Source Type: research
Correction
Nature Medicine 24, 5 (2018).
doi:10.1038/nm0118-5 (Source: Nature Medicine)
Source: Nature Medicine - January 9, 2018 Category: General Medicine Tags: Correction Source Type: research
Puzzling over privilege: How the immune system protects — and fails — the testes
Nature Medicine 24, 2 (2018).
doi:10.1038/nm0118-2
Author: Shraddha Chakradhar (Source: Nature Medicine)
Source: Nature Medicine - January 9, 2018 Category: General Medicine Authors: Shraddha Chakradhar Tags: News Source Type: research
Thinking big in mental health
Nature Medicine 24, 1 (2018).
doi:10.1038/nm.4471
Mental illnesses impose a grave disease burden worldwide, yet progress in managing and treating them has largely stalled. Harnessing the power of big data may break the current impasse and open new avenues for better diagnosis, treatment and prevention of these devastating illnesses. (Source: Nature Medicine)
Source: Nature Medicine - January 9, 2018 Category: General Medicine Tags: Editorial Source Type: research
Suppression of luteinizing hormone enhances HSC recovery after hematopoietic injury
Nature Medicine 24, 239 (2018).
doi:10.1038/nm.4470
Authors: Enrico Velardi, Jennifer J Tsai, Stefan Radtke, Kirsten Cooper, Kimon V Argyropoulos, Shieh Jae-Hung, Lauren F Young, Amina Lazrak, Odette M Smith, Sophie Lieberman, Fabiana Kreines, Yusuke Shono, Tobias Wertheimer, Robert R Jenq, Alan M Hanash, Prema Narayan, Zhenmin Lei, Malcolm A Moore, Hans-Peter Kiem, Marcel R M van den Brink & Jarrod A Dudakov
There is a substantial unmet clinical need for new strategies to protect the hematopoietic stem cell (HSC) pool and regenerate hematopoiesis after radiation injury from either cancer therapy or accidental ...
Source: Nature Medicine - January 8, 2018 Category: General Medicine Authors: Enrico Velardi Jennifer J Tsai Stefan Radtke Kirsten Cooper Kimon V Argyropoulos Shieh Jae-Hung Lauren F Young Amina Lazrak Odette M Smith Sophie Lieberman Fabiana Kreines Yusuke Shono Tobias Wertheimer Robert R Jenq Alan M Hanash Prema Narayan Zhenmin Le Tags: Letter Source Type: research
Macrophage extracellular trap formation promoted by platelet activation is a key mediator of rhabdomyolysis-induced acute kidney injury
Nature Medicine 24, 232 (2018).
doi:10.1038/nm.4462
Authors: Koshu Okubo, Miho Kurosawa, Mako Kamiya, Yasuteru Urano, Akari Suzuki, Kazuhiko Yamamoto, Koji Hase, Koichiro Homma, Junichi Sasaki, Hiroaki Miyauchi, Tatsuo Hoshino, Matsuhiko Hayashi, Tanya N Mayadas & Junichi Hirahashi
Rhabdomyolysis is a serious syndrome caused by skeletal muscle injury and the subsequent release of breakdown products from damaged muscle cells into systemic circulation. The muscle damage most often results from strenuous exercise, muscle hypoxia, medications, or drug abuse and can lead to life-threatening complications, such as ac...
Source: Nature Medicine - January 8, 2018 Category: General Medicine Authors: Koshu Okubo Miho Kurosawa Mako Kamiya Yasuteru Urano Akari Suzuki Kazuhiko Yamamoto Koji Hase Koichiro Homma Junichi Sasaki Hiroaki Miyauchi Tatsuo Hoshino Matsuhiko Hayashi Tanya N Mayadas Junichi Hirahashi Tags: Letter Source Type: research
Diverse genetic-driven immune landscapes dictate tumor progression through distinct mechanisms
Nature Medicine 24, 165 (2018).
doi:10.1038/nm.4463
Authors: Marco Bezzi, Nina Seitzer, Tomoki Ishikawa, Markus Reschke, Ming Chen, Guocan Wang, Caitlin Mitchell, Christopher Ng, Jesse Katon, Andrea Lunardi, Sabina Signoretti, John G Clohessy, Jiangwen Zhang & Pier Paolo Pandolfi (Source: Nature Medicine)
Source: Nature Medicine - January 8, 2018 Category: General Medicine Authors: Marco Bezzi Nina Seitzer Tomoki Ishikawa Markus Reschke Ming Chen Guocan Wang Caitlin Mitchell Christopher Ng Jesse Katon Andrea Lunardi Sabina Signoretti John G Clohessy Jiangwen Zhang Pier Paolo Pandolfi Tags: Article Source Type: research
High-dimensional single-cell analysis predicts response to anti-PD-1 immunotherapy
Nature Medicine 24, 144 (2018).
doi:10.1038/nm.4466
Authors: Carsten Krieg, Malgorzata Nowicka, Silvia Guglietta, Sabrina Schindler, Felix J Hartmann, Lukas M Weber, Reinhard Dummer, Mark D Robinson, Mitchell P Levesque & Burkhard Becher (Source: Nature Medicine)
Source: Nature Medicine - January 8, 2018 Category: General Medicine Authors: Carsten Krieg Malgorzata Nowicka Silvia Guglietta Sabrina Schindler Felix J Hartmann Lukas M Weber Reinhard Dummer Mark D Robinson Mitchell P Levesque Burkhard Becher Tags: Article Source Type: research
