The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue
Nature Medicine 23, 631 (2017).
doi:10.1038/nm.4297
Authors: Matthew D Lynes, Luiz O Leiria, Morten Lundh, Alexander Bartelt, Farnaz Shamsi, Tian Lian Huang, Hirokazu Takahashi, Michael F Hirshman, Christian Schlein, Alexandra Lee, Lisa A Baer, Francis J May, Fei Gao, Niven R Narain, Emily Y Chen, Michael A Kiebish, Aaron M Cypess, Matthias Blüher, Laurie J Goodyear, Gökhan S Hotamisligil, Kristin I Stanford & Yu-Hua Tseng
Brown adipose tissue (BAT) and beige adipose tissue combust fuels for heat production in adult humans, and so constitute an appealing target for the treatment of metabolic disorders...
Source: Nature Medicine - March 27, 2017 Category: Journals (General) Authors: Matthew D Lynes Luiz O Leiria Morten Lundh Alexander Bartelt Farnaz Shamsi Tian Lian Huang Hirokazu Takahashi Michael F Hirshman Christian Schlein Alexandra Lee Lisa A Baer Francis J May Fei Gao Niven R Narain Emily Y Chen Michael A Kiebish Aaron M Cypess Tags: Letter Source Type: research
VISTA is an inhibitory immune checkpoint that is increased after ipilimumab therapy in patients with prostate cancer
Nature Medicine 23, 551 (2017).
doi:10.1038/nm.4308
Authors: Jianjun Gao, John F Ward, Curtis A Pettaway, Lewis Z Shi, Sumit K Subudhi, Luis M Vence, Hao Zhao, Jianfeng Chen, Hong Chen, Eleni Efstathiou, Patricia Troncoso, James P Allison, Christopher J Logothetis, Ignacio I Wistuba, Manuel A Sepulveda, Jingjing Sun, Jennifer Wargo, Jorge Blando & Padmanee Sharma
To date, anti-CTLA-4 (ipilimumab) or anti-PD-1 (nivolumab) monotherapy has not been demonstrated to be of substantial clinical benefit in patients with prostate cancer. To identify additional immune-inhibitory pathways in the prostate-tumor microenviro...
Source: Nature Medicine - March 27, 2017 Category: Journals (General) Authors: Jianjun Gao John F Ward Curtis A Pettaway Lewis Z Shi Sumit K Subudhi Luis M Vence Hao Zhao Jianfeng Chen Hong Chen Eleni Efstathiou Patricia Troncoso James P Allison Christopher J Logothetis Ignacio I Wistuba Manuel A Sepulveda Jingjing Sun Jennifer Warg Tags: Brief Communication Source Type: research
Targeting c-FOS and DUSP1 abrogates intrinsic resistance to tyrosine-kinase inhibitor therapy in BCR-ABL-induced leukemia
Nature Medicine 23, 472 (2017).
doi:10.1038/nm.4310
Authors: Meenu Kesarwani, Zachary Kincaid, Ahmed Gomaa, Erika Huber, Sara Rohrabaugh, Zain Siddiqui, Muhammad F Bouso, Tahir Latif, Ming Xu, Kakajan Komurov, James C Mulloy, Jose A Cancelas, H Leighton Grimes & Mohammad Azam (Source: Nature Medicine)
Source: Nature Medicine - March 20, 2017 Category: Journals (General) Authors: Meenu Kesarwani Zachary Kincaid Ahmed Gomaa Erika Huber Sara Rohrabaugh Zain Siddiqui Muhammad F Bouso Tahir Latif Ming Xu Kakajan Komurov James C Mulloy Jose A Cancelas H Leighton Grimes Mohammad Azam Tags: Article Source Type: research
HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures
Nature Medicine 23, 517 (2017).
doi:10.1038/nm.4292
Authors: Helen Davies, Dominik Glodzik, Sandro Morganella, Lucy R Yates, Johan Staaf, Xueqing Zou, Manasa Ramakrishna, Sancha Martin, Sandrine Boyault, Anieta M Sieuwerts, Peter T Simpson, Tari A King, Keiran Raine, Jorunn E Eyfjord, Gu Kong, Åke Borg, Ewan Birney, Hendrik G Stunnenberg, Marc J van de Vijver, Anne-Lise Børresen-Dale, John W M Martens, Paul N Span, Sunil R Lakhani, Anne Vincent-Salomon, Christos Sotiriou, Andrew Tutt, Alastair M Thompson, Steven Van Laere, Andrea L Richardson, Alain Viari, Peter J Campbell, Michael R Stratton & Serena...
Source: Nature Medicine - March 13, 2017 Category: Journals (General) Authors: Helen Davies Dominik Glodzik Sandro Morganella Lucy R Yates Johan Staaf Xueqing Zou Manasa Ramakrishna Sancha Martin Sandrine Boyault Anieta M Sieuwerts Peter T Simpson Tari A King Keiran Raine Jorunn E Eyfjord Gu Kong Åke Borg Ewan Birney Hendrik G Stun Tags: Analysis Source Type: research
Gpr124 is essential for blood –brain barrier integrity in central nervous system disease
Nature Medicine 23, 450 (2017).
doi:10.1038/nm.4309
Authors: Junlei Chang, Michael R Mancuso, Carolina Maier, Xibin Liang, Kanako Yuki, Lu Yang, Jeffrey W Kwong, Jing Wang, Varsha Rao, Mario Vallon, Cynthia Kosinski, J J Haijing Zhang, Amanda T Mah, Lijun Xu, Le Li, Sharareh Gholamin, Teresa F Reyes, Rui Li, Frank Kuhnert, Xiaoyuan Han, Jenny Yuan, Shin-Heng Chiou, Ari D Brettman, Lauren Daly, David C Corney, Samuel H Cheshier, Linda D Shortliffe, Xiwei Wu, Michael Snyder, Pak Chan, Rona G Giffard, Howard Y Chang, Katrin Andreasson & Calvin J Kuo (Source: Nature Medicine)
Source: Nature Medicine - March 13, 2017 Category: Journals (General) Authors: Junlei Chang Michael R Mancuso Carolina Maier Xibin Liang Kanako Yuki Lu Yang Jeffrey W Kwong Jing Wang Varsha Rao Mario Vallon Cynthia Kosinski J J Haijing Zhang Amanda T Mah Lijun Xu Le Li Sharareh Gholamin Teresa F Reyes Rui Li Frank Kuhnert Xiaoyuan H Tags: Article Source Type: research
