Experimenting with blockchain: Can one technology boost both data integrity and patients' pocketbooks?
Nature Medicine 24, 378 (2018).
doi:10.1038/nm0418-378
Author: Katharine Gammon (Source: Nature Medicine)
Source: Nature Medicine - April 10, 2018 Category: General Medicine Authors: Katharine Gammon Tags: News Source Type: research
A tale of two diseases: Aging HIV patients inspire a closer look at Alzheimer's disease
Nature Medicine 24, 376 (2018).
doi:10.1038/nm0418-376
Author: Shraddha Chakradhar (Source: Nature Medicine)
Source: Nature Medicine - April 10, 2018 Category: General Medicine Authors: Shraddha Chakradhar Tags: News Source Type: research
A checkup for the flu vaccine
Nature Medicine 24, 375 (2018).
doi:10.1038/nm.4535
Influenza causes almost 650,000 deaths worldwide each year, yet a long-lasting, protective vaccine remains elusive. Global investment—both scientific and financial—in a universal flu vaccine is overdue. (Source: Nature Medicine)
Source: Nature Medicine - April 10, 2018 Category: General Medicine Tags: Editorial Source Type: research
Targeting hepatic glutaminase activity to ameliorate hyperglycemia
Nature Medicine 24, 518 (2018).
doi:10.1038/nm.4514
Authors: Russell A Miller, Yuji Shi, Wenyun Lu, David A Pirman, Aditi Jatkar, Matthew Blatnik, Hong Wu, César Cárdenas, Min Wan, J Kevin Foskett, Junyoung O Park, Yiyi Zhang, William L Holland, Joshua D Rabinowitz & Morris J Birnbaum
Glucagon levels increase under homeostatic, fasting conditions, promoting the release of glucose from the liver by accelerating the breakdown of glycogen (also known as glycogenolysis). Glucagon also enhances gluconeogenic flux, including from an increase in the hepatic consumption of amino acids. In type 2 diabetes, dys...
Source: Nature Medicine - March 26, 2018 Category: General Medicine Authors: Russell A Miller Yuji Shi Wenyun Lu David A Pirman Aditi Jatkar Matthew Blatnik Hong Wu C é sar C á rdenas Min Wan J Kevin Foskett Junyoung O Park Yiyi Zhang William L Holland Joshua D Rabinowitz Morris J Birnbaum Tags: Letter Source Type: research
Combinatorial inhibition of PTPN12-regulated receptors leads to a broadly effective therapeutic strategy in triple-negative breast cancer
Nature Medicine 24, 505 (2018).
doi:10.1038/nm.4507
Authors: Amritha Nair, Hsiang-Ching Chung, Tingting Sun, Siddhartha Tyagi, Lacey E Dobrolecki, Rocio Dominguez-Vidana, Sarah J Kurley, Mayra Orellana, Alexander Renwick, David M Henke, Panagiotis Katsonis, Earlene Schmitt, Doug W Chan, Hui Li, Sufeng Mao, Ivana Petrovic, Chad J Creighton, Carolina Gutierrez, Julien Dubrulle, Fabio Stossi, Jeffrey W Tyner, Olivier Lichtarge, Charles Y Lin, Bing Zhang, Kenneth L Scott, Susan G Hilsenbeck, Jinpeng Sun, Xiao Yu, C Kent Osborne, Rachel Schiff, James G Christensen, David J Shields, Mothaffar F Rimawi, Matthew J Ellis, C...
Source: Nature Medicine - March 26, 2018 Category: General Medicine Authors: Amritha Nair Hsiang-Ching Chung Tingting Sun Siddhartha Tyagi Lacey E Dobrolecki Rocio Dominguez-Vidana Sarah J Kurley Mayra Orellana Alexander Renwick David M Henke Panagiotis Katsonis Earlene Schmitt Doug W Chan Hui Li Sufeng Mao Ivana Petrovic Chad J C Tags: Letter Source Type: research
A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite
Nature Medicine 24, 408 (2018).
doi:10.1038/nm.4512
Authors: Neville K Kisalu, Azza H Idris, Connor Weidle, Yevel Flores-Garcia, Barbara J Flynn, Brandon K Sack, Sean Murphy, Arne Schön, Ernesto Freire, Joseph R Francica, Alex B Miller, Jason Gregory, Sandra March, Hua-Xin Liao, Barton F Haynes, Kevin Wiehe, Ashley M Trama, Kevin O Saunders, Morgan A Gladden, Anthony Monroe, Mattia Bonsignori, Masaru Kanekiyo, Adam K Wheatley, Adrian B McDermott, S Katie Farney, Gwo-Yu Chuang, Baoshan Zhang, Natasha Kc, Sumana Chakravarty, Peter D Kwong, Photini Sinnis, Sangeeta N Bhatia, Stefan H I Kappe, B Kim Lee Sim, Steph...
Source: Nature Medicine - March 19, 2018 Category: General Medicine Authors: Neville K Kisalu Azza H Idris Connor Weidle Yevel Flores-Garcia Barbara J Flynn Brandon K Sack Sean Murphy Arne Sch ö n Ernesto Freire Joseph R Francica Alex B Miller Jason Gregory Sandra March Hua-Xin Liao Barton F Haynes Kevin Wiehe Ashley M Trama Kevi Tags: Article Source Type: research
A public antibody lineage that potently inhibits malaria infection through dual binding to the circumsporozoite protein
Nature Medicine 24, 401 (2018).
doi:10.1038/nm.4513
Authors: Joshua Tan, Brandon K Sack, David Oyen, Isabelle Zenklusen, Luca Piccoli, Sonia Barbieri, Mathilde Foglierini, Chiara Silacci Fregni, Jessica Marcandalli, Said Jongo, Salim Abdulla, Laurent Perez, Giampietro Corradin, Luca Varani, Federica Sallusto, Betty Kim Lee Sim, Stephen L Hoffman, Stefan H I Kappe, Claudia Daubenberger, Ian A Wilson & Antonio Lanzavecchia (Source: Nature Medicine)
Source: Nature Medicine - March 19, 2018 Category: General Medicine Authors: Joshua Tan Brandon K Sack David Oyen Isabelle Zenklusen Luca Piccoli Sonia Barbieri Mathilde Foglierini Chiara Silacci Fregni Jessica Marcandalli Said Jongo Salim Abdulla Laurent Perez Giampietro Corradin Luca Varani Federica Sallusto Betty Kim Lee Sim St Tags: Article Source Type: research
Microenvironmental control of breast cancer subtype elicited through paracrine platelet-derived growth factor-CC signaling
Nature Medicine 24, 463 (2018).
doi:10.1038/nm.4494
Authors: Pernilla Roswall, Matteo Bocci, Michael Bartoschek, Hong Li, Glen Kristiansen, Sara Jansson, Sophie Lehn, Jonas Sjölund, Steven Reid, Christer Larsson, Pontus Eriksson, Charlotte Anderberg, Eliane Cortez, Lao H Saal, Christina Orsmark-Pietras, Eugenia Cordero, Bengt Kristian Haller, Jari Häkkinen, Ingrid J G Burvenich, Elgene Lim, Akira Orimo, Mattias Höglund, Lisa Rydén, Holger Moch, Andrew M Scott, Ulf Eriksson & Kristian Pietras (Source: Nature Medicine)
Source: Nature Medicine - March 12, 2018 Category: General Medicine Authors: Pernilla Roswall Matteo Bocci Michael Bartoschek Hong Li Glen Kristiansen Sara Jansson Sophie Lehn Jonas Sj ö lund Steven Reid Christer Larsson Pontus Eriksson Charlotte Anderberg Eliane Cortez Lao H Saal Christina Orsmark-Pietras Eugenia Cordero Bengt K Tags: Article Source Type: research
Dentate granule cell recruitment of feedforward inhibition governs engram maintenance and remote memory generalization
Nature Medicine 24, 438 (2018).
doi:10.1038/nm.4491
Authors: Nannan Guo, Marta E Soden, Charlotte Herber, Michael TaeWoo Kim, Antoine Besnard, Paoyan Lin, Xiang Ma, Constance L Cepko, Larry S Zweifel & Amar Sahay (Source: Nature Medicine)
Source: Nature Medicine - March 12, 2018 Category: General Medicine Authors: Nannan Guo Marta E Soden Charlotte Herber Michael TaeWoo Kim Antoine Besnard Paoyan Lin Xiang Ma Constance L Cepko Larry S Zweifel Amar Sahay Tags: Article Source Type: research
An immunosuppressive pathway for tumor progression
Nature Medicine 24, 260 (2018).
doi:10.1038/nm.4508
Authors: Antoine Marçais & Thierry Walzer
An active immunosuppressive pathway is identified in colon cancer that confers immune evasion by the cancer and can be targeted to synergize with immunotherapies. (Source: Nature Medicine)
Source: Nature Medicine - March 6, 2018 Category: General Medicine Authors: Antoine Mar ç ais Thierry Walzer Tags: News and Views Source Type: research
A previously undetected pathology of Zika virus infection
Nature Medicine 24, 258 (2018).
doi:10.1038/nm.4510
Authors: Kimberly M Christian, Hongjun Song & Guo-li Ming
In a nonhuman primate model of Zika virus infection, structural and cellular pathology deficits that could have a long-lasting impact on neural development and neurocognitive function are detected in offspring of infected mothers. (Source: Nature Medicine)
Source: Nature Medicine - March 6, 2018 Category: General Medicine Authors: Kimberly M Christian Hongjun Song Guo-li Ming Tags: News and Views Source Type: research
A human cellular model of amyotrophic lateral sclerosis
Nature Medicine 24, 256 (2018).
doi:10.1038/nm.4509
Authors: Rebecca M Marton & Sergiu P Paşca
Stem cell–derived human motor neurons were used to investigate the cellular mechanisms underlying C9ORF72-related amyotrophic lateral sclerosis. (Source: Nature Medicine)
Source: Nature Medicine - March 6, 2018 Category: General Medicine Authors: Rebecca M Marton Sergiu P Pa ş ca Tags: News and Views Source Type: research
The intestinal microbiome influences checkpoint blockade
Nature Medicine 24, 254 (2018).
doi:10.1038/nm.4511
Authors: Cynthia L Sears & Drew M Pardoll
Studies in metastatic melanoma, non-small-cell lung carcinoma and renal cell carcinoma indicate certain bacteria within the gut microbiota enhance clinical responses to checkpoint blockade. (Source: Nature Medicine)
Source: Nature Medicine - March 6, 2018 Category: General Medicine Authors: Cynthia L Sears Drew M Pardoll Tags: News and Views Source Type: research
Gut checkpoint: A rising cancer treatment may get a boost from intestinal bacteria
Nature Medicine 24, 251 (2018).
doi:10.1038/nm0318-251
Author: Anna Azvolinsky (Source: Nature Medicine)
Source: Nature Medicine - March 6, 2018 Category: General Medicine Authors: Anna Azvolinsky Tags: News Source Type: research
Going live: How microRNAs might bring living vaccines back into the fold
Nature Medicine 24, 248 (2018).
doi:10.1038/nm0318-248
Author: Shraddha Chakradhar (Source: Nature Medicine)
Source: Nature Medicine - March 6, 2018 Category: General Medicine Authors: Shraddha Chakradhar Tags: News Source Type: research
