CX3CR1+ monocytes modulate learning and learning-dependent dendritic spine remodeling via TNF- α
Nature Medicine 23, 714 (2017).
doi:10.1038/nm.4340
Authors: Juan Mauricio Garré, Hernandez Moura Silva, Juan J Lafaille & Guang Yang (Source: Nature Medicine)
Source: Nature Medicine - May 15, 2017 Category: General Medicine Authors: Juan Mauricio Garr é Hernandez Moura Silva Juan J Lafaille Guang Yang Tags: Article Source Type: research
Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia
Nature Medicine 23, 692 (2017).
doi:10.1038/nm.4336
Authors: Alice Giustacchini, Supat Thongjuea, Nikolaos Barkas, Petter S Woll, Benjamin J Povinelli, Christopher A G Booth, Paul Sopp, Ruggiero Norfo, Alba Rodriguez-Meira, Neil Ashley, Lauren Jamieson, Paresh Vyas, Kristina Anderson, Åsa Segerstolpe, Hong Qian, Ulla Olsson-Strömberg, Satu Mustjoki, Rickard Sandberg, Sten Eirik W Jacobsen & Adam J Mead (Source: Nature Medicine)
Source: Nature Medicine - May 15, 2017 Category: General Medicine Authors: Alice Giustacchini Supat Thongjuea Nikolaos Barkas Petter S Woll Benjamin J Povinelli Christopher A G Booth Paul Sopp Ruggiero Norfo Alba Rodriguez-Meira Neil Ashley Lauren Jamieson Paresh Vyas Kristina Anderson Å sa Segerstolpe Hong Qian Ulla Olsson-Str Tags: Article Source Type: research
Metformin ameliorates core deficits in a mouse model of fragile X syndrome
Nature Medicine 23, 674 (2017).
doi:10.1038/nm.4335
Authors: Ilse Gantois, Arkady Khoutorsky, Jelena Popic, Argel Aguilar-Valles, Erika Freemantle, Ruifeng Cao, Vijendra Sharma, Tine Pooters, Anmol Nagpal, Agnieszka Skalecka, Vinh T Truong, Shane Wiebe, Isabelle A Groves, Seyed Mehdi Jafarnejad, Clément Chapat, Elizabeth A McCullagh, Karine Gamache, Karim Nader, Jean-Claude Lacaille, Christos G Gkogkas & Nahum Sonenberg
Fragile X syndrome (FXS) is the leading monogenic cause of autism spectrum disorders (ASD). Trinucleotide repeat expansions in FMR1 abolish FMRP expression, leading to hyperactivation of ER...
Source: Nature Medicine - May 15, 2017 Category: General Medicine Authors: Ilse Gantois Arkady Khoutorsky Jelena Popic Argel Aguilar-Valles Erika Freemantle Ruifeng Cao Vijendra Sharma Tine Pooters Anmol Nagpal Agnieszka Skalecka Vinh T Truong Shane Wiebe Isabelle A Groves Seyed Mehdi Jafarnejad Cl é ment Chapat Elizabeth A McC Tags: Brief Communication Source Type: research
A chronic low dose of Δ 9-tetrahydrocannabinol (THC) restores cognitive function in old mice
Nature Medicine 23, 782 (2017).
doi:10.1038/nm.4311
Authors: Andras Bilkei-Gorzo, Onder Albayram, Astrid Draffehn, Kerstin Michel, Anastasia Piyanova, Hannah Oppenheimer, Mona Dvir-Ginzberg, Ildiko Rácz, Thomas Ulas, Sophie Imbeault, Itai Bab, Joachim L Schultze & Andreas Zimmer
The balance between detrimental, pro-aging, often stochastic processes and counteracting homeostatic mechanisms largely determines the progression of aging. There is substantial evidence suggesting that the endocannabinoid system (ECS) is part of the latter system because it modulates the physiological processes underlying aging. T...
Source: Nature Medicine - May 8, 2017 Category: General Medicine Authors: Andras Bilkei-Gorzo Onder Albayram Astrid Draffehn Kerstin Michel Anastasia Piyanova Hannah Oppenheimer Mona Dvir-Ginzberg Ildiko R á cz Thomas Ulas Sophie Imbeault Itai Bab Joachim L Schultze Andreas Zimmer Tags: Letter Source Type: research
Decreased alertness due to sleep loss increases pain sensitivity in mice
Nature Medicine 23, 768 (2017).
doi:10.1038/nm.4329
Authors: Chloe Alexandre, Alban Latremoliere, Ashley Ferreira, Giulia Miracca, Mihoko Yamamoto, Thomas E Scammell & Clifford J Woolf
Extended daytime and nighttime activities are major contributors to the growing sleep deficiency epidemic, as is the high prevalence of sleep disorders like insomnia. The consequences of chronic insufficient sleep for health remain uncertain. Sleep quality and duration predict presence of pain the next day in healthy subjects, suggesting that sleep disturbances alone may worsen pain, and experimental sleep deprivation in humans s...
Source: Nature Medicine - May 8, 2017 Category: General Medicine Authors: Chloe Alexandre Alban Latremoliere Ashley Ferreira Giulia Miracca Mihoko Yamamoto Thomas E Scammell Clifford J Woolf Tags: Letter Source Type: research
Tmbim1 is a multivesicular body regulator that protects against non-alcoholic fatty liver disease in mice and monkeys by targeting the lysosomal degradation of Tlr4
Nature Medicine 23, 742 (2017).
doi:10.1038/nm.4334
Authors: Guang-Nian Zhao, Peng Zhang, Jun Gong, Xiao-Jing Zhang, Pi-Xiao Wang, Miao Yin, Zhou Jiang, Li-Jun Shen, Yan-Xiao Ji, Jingjing Tong, Yutao Wang, Qiao-Fang Wei, Yong Wang, Xue-Yong Zhu, Xin Zhang, Jing Fang, Qingguo Xie, Zhi-Gang She, Zhihua Wang, Zan Huang & Hongliang Li (Source: Nature Medicine)
Source: Nature Medicine - May 8, 2017 Category: General Medicine Authors: Guang-Nian Zhao Peng Zhang Jun Gong Xiao-Jing Zhang Pi-Xiao Wang Miao Yin Zhou Jiang Li-Jun Shen Yan-Xiao Ji Jingjing Tong Yutao Wang Qiao-Fang Wei Yong Wang Xue-Yong Zhu Xin Zhang Jing Fang Qingguo Xie Zhi-Gang She Zhihua Wang Zan Huang Hongliang Li Tags: Article Source Type: research
Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients
Nature Medicine 23, 703 (2017).
doi:10.1038/nm.4333
Authors: Ahmet Zehir, Ryma Benayed, Ronak H Shah, Aijazuddin Syed, Sumit Middha, Hyunjae R Kim, Preethi Srinivasan, Jianjiong Gao, Debyani Chakravarty, Sean M Devlin, Matthew D Hellmann, David A Barron, Alison M Schram, Meera Hameed, Snjezana Dogan, Dara S Ross, Jaclyn F Hechtman, Deborah F DeLair, JinJuan Yao, Diana L Mandelker, Donavan T Cheng, Raghu Chandramohan, Abhinita S Mohanty, Ryan N Ptashkin, Gowtham Jayakumaran, Meera Prasad, Mustafa H Syed, Anoop Balakrishnan Rema, Zhen Y Liu, Khedoudja Nafa, Laetitia Borsu, Justyna Sadowska, Jacklyn Casanova, Ruben Ba...
Source: Nature Medicine - May 8, 2017 Category: General Medicine Authors: Ahmet Zehir Ryma Benayed Ronak H Shah Aijazuddin Syed Sumit Middha Hyunjae R Kim Preethi Srinivasan Jianjiong Gao Debyani Chakravarty Sean M Devlin Matthew D Hellmann David A Barron Alison M Schram Meera Hameed Snjezana Dogan Dara S Ross Jaclyn F Hechtman Tags: Article Source Type: research
Is autoimmunity the Achilles' heel of cancer immunotherapy?
Nature Medicine 23, 540 (2017).
doi:10.1038/nm.4321
Authors: Carl H June, Jeremy T Warshauer & Jeffrey A Bluestone (Source: Nature Medicine)
Source: Nature Medicine - May 5, 2017 Category: General Medicine Authors: Carl H June Jeremy T Warshauer Jeffrey A Bluestone Tags: Perspective Source Type: research
HIV persistence in macrophages
Nature Medicine 23, 538 (2017).
doi:10.1038/nm.4337
Author: Mario Stevenson
A recent study using a humanized mouse model shows that HIV-1 can persist in macrophages during antiretroviral therapy (ART), and suggests that macrophages may represent an obstacle to efforts to cure HIV-1 infection. (Source: Nature Medicine)
Source: Nature Medicine - May 5, 2017 Category: General Medicine Authors: Mario Stevenson Tags: News and Views Source Type: research
Thymosin α 1: a single drug with multiple targets in cystic fibrosis
Nature Medicine 23, 536 (2017).
doi:10.1038/nm.4339
Authors: André M Cantin & John W Hanrahan
A new study in mice suggests that a single drug, thymosin α1, may simultaneously rectify the impaired trafficking of the cystic fibrosis transmembrane conductance regulator (CFTR) in cystic fibrosis (CF) and reduce inflammation, offering new hope for CF treatment. (Source: Nature Medicine)
Source: Nature Medicine - May 5, 2017 Category: General Medicine Authors: Andr é M Cantin John W Hanrahan Tags: News and Views Source Type: research
A role for oncostatin M in inflammatory bowel disease
Nature Medicine 23, 535 (2017).
doi:10.1038/nm.4338
Authors: Walter M Kim, Arthur Kaser & Richard S Blumberg
A new study identifies oncostatin M (OSM) as a potential biomarker and therapeutic target for anti-tumor necrosis factor (TNF)-refractory inflammatory bowel disease (IBD), and pinpoints mucosal stromal cells as key players in OSM-mediated inflammation. (Source: Nature Medicine)
Source: Nature Medicine - May 5, 2017 Category: General Medicine Authors: Walter M Kim Arthur Kaser Richard S Blumberg Tags: News and Views Source Type: research
Correction
Nature Medicine 23, 534 (2017).
doi:10.1038/nm0517-534 (Source: Nature Medicine)
Source: Nature Medicine - May 5, 2017 Category: General Medicine Tags: Correction Source Type: research
Bringing RNA into the fold: Small molecules find new targets in RNA to combat disease
Nature Medicine 23, 532 (2017).
doi:10.1038/nm0517-532
Author: Shraddha Chakradhar (Source: Nature Medicine)
Source: Nature Medicine - May 5, 2017 Category: General Medicine Authors: Shraddha Chakradhar Tags: News Source Type: research
Host with the most: Targeting host cells instead of pathogens to fight infectious disease
Nature Medicine 23, 528 (2017).
doi:10.1038/nm0517-528
Author: Amanda B. Keener (Source: Nature Medicine)
Source: Nature Medicine - May 5, 2017 Category: General Medicine Authors: Amanda B. Keener Tags: News Source Type: research
The curse of uncertainty
Nature Medicine 23, 527 (2017).
doi:10.1038/nm.4342
Proposed US budget cuts and the impending exit of the UK from the European Union have the potential to destabilize the global biomedical-research enterprise. In the meantime, the uncertainty of not knowing just how bad the effects will be will inflict its own damage. (Source: Nature Medicine)
Source: Nature Medicine - May 5, 2017 Category: General Medicine Tags: Editorial Source Type: research
