Bayesian analysis of genetic association across tree-structured routine healthcare data in the UK Biobank
Nature Genetics 49, 1311 (2017).
doi:10.1038/ng.3926
Authors: Adrian Cortes, Calliope A Dendrou, Allan Motyer, Luke Jostins, Damjan Vukcevic, Alexander Dilthey, Peter Donnelly, Stephen Leslie, Lars Fugger & Gil McVean (Source: Nature Genetics)
Source: Nature Genetics - July 31, 2017 Category: Genetics & Stem Cells Authors: Adrian Cortes Calliope A Dendrou Allan Motyer Luke Jostins Damjan Vukcevic Alexander Dilthey Peter Donnelly Stephen Leslie Lars Fugger Gil McVean Tags: Analysis Source Type: research
Corrigendum: Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis
Nature Genetics 49, 1286 (2017).
doi:10.1038/ng0817-1286b
Author: Unnur Styrkarsdottir, Hannes Helgason, Asgeir Sigurdsson, Gudmundur L Norddahl, Arna B Agustsdottir, Louise N Reynard, Amanda Villalvilla, Gisli H Halldorsson, Aslaug Jonasdottir, Audur Magnusdottir, Asmundur Oddson, Gerald Sulem, Florian Zink, Gardar Sveinbjornsson, Agnar Helgason, Hrefna S Johannsdottir, Anna Helgadottir, Hreinn Stefansson, Solveig Gretarsdottir, Thorunn Rafnar, Ina S Almdahl, Anne Brækhus, Tormod Fladby, Geir Selbæk, Farhad Hosseinpanah, Fereidoun Azizi, Jung Min Koh, Nelson L S Tang, Maryams Danesphour, Jose I Mayordomo...
Source: Nature Genetics - July 27, 2017 Category: Genetics & Stem Cells Authors: Unnur Styrkarsdottir Hannes Helgason Asgeir Sigurdsson Gudmundur L Norddahl Arna B Agustsdottir Louise N Reynard Amanda Villalvilla Gisli H Halldorsson Aslaug Jonasdottir Audur Magnusdottir Asmundur Oddson Gerald Sulem Florian Zink Gardar Sveinbjornsson A Tags: Corrigendum Source Type: research
Corrigendum: Protein-structure-guided discovery of functional mutations across 19 cancer types
Nature Genetics 49, 1286 (2017).
doi:10.1038/ng0817-1286a
Author: Beifang Niu, Adam D Scott, Sohini Sengupta, Matthew H Bailey, Prag Batra, Jie Ning, Matthew A Wyczalkowski, Wen-Wei Liang, Qunyuan Zhang, Michael D McLellan, Sam Q Sun, Piyush Tripathi, Carolyn Lou, Kai Ye, R Jay Mashl, John Wallis, Michael C Wendl, Feng Chen & Li Ding (Source: Nature Genetics)
Source: Nature Genetics - July 27, 2017 Category: Genetics & Stem Cells Authors: Beifang Niu Adam D Scott Sohini Sengupta Matthew H Bailey Prag Batra Jie Ning Matthew A Wyczalkowski Wen-Wei Liang Qunyuan Zhang Michael D McLellan Sam Q Sun Piyush Tripathi Carolyn Lou Kai Ye R Jay Mashl John Wallis Michael C Wendl Feng Chen Li Ding Tags: Corrigendum Source Type: research
Erratum: Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation
Nature Genetics 49, 1286 (2017).
doi:10.1038/ng0817-1286c
Authors: Ingrid E Christophersen, Michiel Rienstra, Carolina Roselli, Xiaoyan Yin, Bastiaan Geelhoed, John Barnard, Honghuang Lin, Dan E Arking, Albert V Smith, Christine M Albert, Mark Chaffin, Nathan R Tucker, Molong Li, Derek Klarin, Nathan A Bihlmeyer, Siew-Kee Low, Peter E Weeke, Martina Müller-Nurasyid, J Gustav Smith, Jennifer A Brody, Maartje N Niemeijer, Marcus Dörr, Stella Trompet, Jennifer Huffman, Stefan Gustafsson, Claudia Schurmann, Marcus E Kleber, Leo-Pekka Lyytikäinen, Ilkka Seppälä, Rainer Malik, Andrea R V R Horimo...
Source: Nature Genetics - July 27, 2017 Category: Genetics & Stem Cells Authors: Ingrid E Christophersen Michiel Rienstra Carolina Roselli Xiaoyan Yin Bastiaan Geelhoed John Barnard Honghuang Lin Dan E Arking Albert V Smith Christine M Albert Mark Chaffin Nathan R Tucker Molong Li Derek Klarin Nathan A Bihlmeyer Siew-Kee Low Peter E W Tags: Erratum Source Type: research
The osteoarthritis and height GDF5 locus yields its secrets
This study provides evidence of positive selection for short stature at GDF5 in modern humans, as well as in archaic Neandertals and Denisovans. (Source: Nature Genetics)
Source: Nature Genetics - July 27, 2017 Category: Genetics & Stem Cells Authors: Guillaume Lettre Tags: News and Views Source Type: research
Hacking DNA copy number for circuit engineering
Nature Genetics 49, 1164 (2017).
doi:10.1038/ng.3923
Authors: Feilun Wu & Lingchong You
DNA copy number represents an essential parameter in the dynamics of synthetic gene circuits but typically is not explicitly considered. A new study demonstrates how dynamic control of DNA copy number can serve as an effective strategy to program robust oscillations in gene expression circuits. (Source: Nature Genetics)
Source: Nature Genetics - July 27, 2017 Category: Genetics & Stem Cells Authors: Feilun Wu Lingchong You Tags: News and Views Source Type: research
Monogenic immune disorders and severe atopic disease
Nature Genetics 49, 1162 (2017).
doi:10.1038/ng.3925
Authors: Catherine M Biggs, Henry Y Lu & Stuart E Turvey
Severe allergic disease is common, and few monogenic causes of atopy have been described. A new study that convincingly links severe atopic dermatitis to heterozygous CARD11 mutations with dominant-interfering activity serves as a timely reminder that clinicians should consider the possibility of an underlying monogenic immune disorder when caring for patients suffering from severe allergic disease. (Source: Nature Genetics)
Source: Nature Genetics - July 27, 2017 Category: Genetics & Stem Cells Authors: Catherine M Biggs Henry Y Lu Stuart E Turvey Tags: News and Views Source Type: research
Necessary complexity
Nature Genetics 49, 1161 (2017).
doi:10.1038/ng.3932
This month's research articles span the range of scales of gene-regulatory mechanisms, from a deceptively simple gene therapy vector, via synthetic gene expression circuits, to extremely intricate epigenetic switches. We encourage investigation of synthetic circuits exploring the functions of the 3D genome. (Source: Nature Genetics)
Source: Nature Genetics - July 27, 2017 Category: Genetics & Stem Cells Tags: Editorial Source Type: research
Heterogeneity of neuroblastoma cell identity defined by transcriptional circuitries
Nature Genetics 49, 1408 (2017).
doi:10.1038/ng.3921
Authors: Valentina Boeva, Caroline Louis-Brennetot, Agathe Peltier, Simon Durand, Cécile Pierre-Eugène, Virginie Raynal, Heather C Etchevers, Sophie Thomas, Alban Lermine, Estelle Daudigeos-Dubus, Birgit Geoerger, Martin F Orth, Thomas G P Grünewald, Elise Diaz, Bertrand Ducos, Didier Surdez, Angel M Carcaboso, Irina Medvedeva, Thomas Deller, Valérie Combaret, Eve Lapouble, Gaelle Pierron, Sandrine Grossetête-Lalami, Sylvain Baulande, Gudrun Schleiermacher, Emmanuel Barillot, Hermann Rohrer, Olivier Delattre & Isabelle Janoueix-Lerose...
Source: Nature Genetics - July 24, 2017 Category: Genetics & Stem Cells Authors: Valentina Boeva Caroline Louis-Brennetot Agathe Peltier Simon Durand C é cile Pierre-Eug è ne Virginie Raynal Heather C Etchevers Sophie Thomas Alban Lermine Estelle Daudigeos-Dubus Birgit Geoerger Martin F Orth Thomas G P Gr ü newald Elise Diaz Bertra Tags: Letter Source Type: research
A gene encoding maize caffeoyl-CoA O-methyltransferase confers quantitative resistance to multiple pathogens
Nature Genetics 49, 1364 (2017).
doi:10.1038/ng.3919
Authors: Qin Yang, Yijian He, Mercy Kabahuma, Timothy Chaya, Amy Kelly, Eli Borrego, Yang Bian, Farid El Kasmi, Li Yang, Paulo Teixeira, Judith Kolkman, Rebecca Nelson, Michael Kolomiets, Jeffery L Dangl, Randall Wisser, Jeffrey Caplan, Xu Li, Nick Lauter & Peter Balint-Kurti (Source: Nature Genetics)
Source: Nature Genetics - July 24, 2017 Category: Genetics & Stem Cells Authors: Qin Yang Yijian He Mercy Kabahuma Timothy Chaya Amy Kelly Eli Borrego Yang Bian Farid El Kasmi Li Yang Paulo Teixeira Judith Kolkman Rebecca Nelson Michael Kolomiets Jeffery L Dangl Randall Wisser Jeffrey Caplan Xu Li Nick Lauter Peter Balint-Kurti Tags: Article Source Type: research
PRDM15 safeguards naive pluripotency by transcriptionally regulating WNT and MAPK – ERK signaling
Nature Genetics 49, 1354 (2017).
doi:10.1038/ng.3922
Authors: Slim Mzoughi, Jingxian Zhang, Delphine Hequet, Shun Xie Teo, Haitong Fang, Qiao Rui Xing, Marco Bezzi, Michelle Kay Yi Seah, Sheena L M Ong, Eun Myoung Shin, Heike Wollmann, Esther S M Wong, Muthafar Al-Haddawi, Colin L Stewart, Vinay Tergaonkar, Yuin-Han Loh, N Ray Dunn, Daniel M Messerschmidt & Ernesto Guccione (Source: Nature Genetics)
Source: Nature Genetics - July 24, 2017 Category: Genetics & Stem Cells Authors: Slim Mzoughi Jingxian Zhang Delphine Hequet Shun Xie Teo Haitong Fang Qiao Rui Xing Marco Bezzi Michelle Kay Yi Seah Sheena L M Ong Eun Myoung Shin Heike Wollmann Esther S M Wong Muthafar Al-Haddawi Colin L Stewart Vinay Tergaonkar Yuin-Han Loh N Ray Dunn Tags: Article Source Type: research
The promise of discovering population-specific disease-associated genes in South Asia
This study highlights an underappreciated opportunity for decreasing disease burden among South Asians through discovery of and testing for recessive disease-associated genes. (Source: Nature Genetics)
Source: Nature Genetics - July 17, 2017 Category: Genetics & Stem Cells Authors: Nathan Nakatsuka Priya Moorjani Niraj Rai Biswanath Sarkar Arti Tandon Nick Patterson Gandham SriLakshmi Bhavani Katta Mohan Girisha Mohammed S Mustak Sudha Srinivasan Amit Kaushik Saadi Abdul Vahab Sujatha M Jagadeesh Kapaettu Satyamoorthy Lalji Singh Da Tags: Letter Source Type: research
Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease
Nature Genetics 49, 1392 (2017).
doi:10.1038/ng.3914
Authors: Derek Klarin, Qiuyu Martin Zhu, Connor A Emdin, Mark Chaffin, Steven Horner, Brian J McMillan, Alison Leed, Michael E Weale, Chris C A Spencer, François Aguet, Ayellet V Segrè, Kristin G Ardlie, Amit V Khera, Virendar K Kaushik, Pradeep Natarajan & Sekar Kathiresan
UK Biobank is among the world's largest repositories for phenotypic and genotypic information in individuals of European ancestry. We performed a genome-wide association study in UK Biobank testing ∼9 million DNA sequence variants for association with coronary artery diseas...
Source: Nature Genetics - July 17, 2017 Category: Genetics & Stem Cells Authors: Derek Klarin Qiuyu Martin Zhu Connor A Emdin Mark Chaffin Steven Horner Brian J McMillan Alison Leed Michael E Weale Chris C A Spencer Fran ç ois Aguet Ayellet V Segr è Kristin G Ardlie Amit V Khera Virendar K Kaushik Pradeep Natarajan Sekar Kathiresan Tags: Letter Source Type: research
Association analyses based on false discovery rate implicate new loci for coronary artery disease
Nature Genetics 49, 1385 (2017).
doi:10.1038/ng.3913
Authors: Christopher P Nelson, Anuj Goel, Adam S Butterworth, Stavroula Kanoni, Tom R Webb, Eirini Marouli, Lingyao Zeng, Ioanna Ntalla, Florence Y Lai, Jemma C Hopewell, Olga Giannakopoulou, Tao Jiang, Stephen E Hamby, Emanuele Di Angelantonio, Themistocles L Assimes, Erwin P Bottinger, John C Chambers, Robert Clarke, Colin N A Palmer, Richard M Cubbon, Patrick Ellinor, Raili Ermel, Evangelos Evangelou, Paul W Franks, Christopher Grace, Dongfeng Gu, Aroon D Hingorani, Joanna M M Howson, Erik Ingelsson, Adnan Kastrati, Thorsten Kessler, Theodosios Kyriakou, Terho...
Source: Nature Genetics - July 17, 2017 Category: Genetics & Stem Cells Authors: Christopher P Nelson Anuj Goel Adam S Butterworth Stavroula Kanoni Tom R Webb Eirini Marouli Lingyao Zeng Ioanna Ntalla Florence Y Lai Jemma C Hopewell Olga Giannakopoulou Tao Jiang Stephen E Hamby Emanuele Di Angelantonio Themistocles L Assimes Erwin P B Tags: Letter Source Type: research
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
Nature Genetics 49, 1373 (2017).
doi:10.1038/ng.3916
Authors: Rebecca Sims, Sven J van der Lee, Adam C Naj, Céline Bellenguez, Nandini Badarinarayan, Johanna Jakobsdottir, Brian W Kunkle, Anne Boland, Rachel Raybould, Joshua C Bis, Eden R Martin, Benjamin Grenier-Boley, Stefanie Heilmann-Heimbach, Vincent Chouraki, Amanda B Kuzma, Kristel Sleegers, Maria Vronskaya, Agustin Ruiz, Robert R Graham, Robert Olaso, Per Hoffmann, Megan L Grove, Badri N Vardarajan, Mikko Hiltunen, Markus M Nöthen, Charles C White, Kara L Hamilton-Nelson, Jacques Epelbaum, Wolfgang Maier, Seung-Hoan Choi, Gary W Beecham, Céci...
Source: Nature Genetics - July 17, 2017 Category: Genetics & Stem Cells Authors: Rebecca Sims Sven J van der Lee Adam C Naj C é line Bellenguez Nandini Badarinarayan Johanna Jakobsdottir Brian W Kunkle Anne Boland Rachel Raybould Joshua C Bis Eden R Martin Benjamin Grenier-Boley Stefanie Heilmann-Heimbach Vincent Chouraki Amanda B Ku Tags: Letter Source Type: research
