Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis
Nature Genetics 49, 801 (2017).
doi:10.1038/ng.3816
Authors: Unnur Styrkarsdottir, Hannes Helgason, Asgeir Sigurdsson, Gudmundur L Norddahl, Arna B Agustsdottir, Louise N Reynard, Amanda Villalvilla, Gisli H Halldorsson, Aslaug Jonasdottir, Audur Magnusdottir, Asmundur Oddson, Gerald Sulem, Florian Zink, Gardar Sveinbjornsson, Agnar Helgason, Hrefna S Johannsdottir, Anna Helgadottir, Hreinn Stefansson, Solveig Gretarsdottir, Thorunn Rafnar, Ina S Almdahl, Anne Brækhus, Tormod Fladby, Geir Selbæk, Farhad Hosseinpanah, Fereidoun Azizi, Jung Min Koh, Nelson L S Tang, Maryam S Daneshpour, Jose I Mayordomo, Co...
Source: Nature Genetics - March 20, 2017 Category: Genetics & Stem Cells Authors: Unnur Styrkarsdottir Hannes Helgason Asgeir Sigurdsson Gudmundur L Norddahl Arna B Agustsdottir Louise N Reynard Amanda Villalvilla Gisli H Halldorsson Aslaug Jonasdottir Audur Magnusdottir Asmundur Oddson Gerald Sulem Florian Zink Gardar Sveinbjornsson A Tags: Letter Source Type: research
Natural variation at the soybean J locus improves adaptation to the tropics and enhances yield
Nature Genetics 49, 773 (2017).
doi:10.1038/ng.3819
Authors: Sijia Lu, Xiaohui Zhao, Yilong Hu, Shulin Liu, Haiyang Nan, Xiaoming Li, Chao Fang, Dong Cao, Xinyi Shi, Lingping Kong, Tong Su, Fengge Zhang, Shichen Li, Zheng Wang, Xiaohui Yuan, Elroy R Cober, James L Weller, Baohui Liu, Xingliang Hou, Zhixi Tian & Fanjiang Kong (Source: Nature Genetics)
Source: Nature Genetics - March 20, 2017 Category: Genetics & Stem Cells Authors: Sijia Lu Xiaohui Zhao Yilong Hu Shulin Liu Haiyang Nan Xiaoming Li Chao Fang Dong Cao Xinyi Shi Lingping Kong Tong Su Fengge Zhang Shichen Li Zheng Wang Xiaohui Yuan Elroy R Cober James L Weller Baohui Liu Xingliang Hou Zhixi Tian Fanjiang Kong Tags: Article Source Type: research
A single-copy Sleeping Beauty transposon mutagenesis screen identifies new PTEN-cooperating tumor suppressor genes
Nature Genetics 49, 730 (2017).
doi:10.1038/ng.3817
Authors: Jorge de la Rosa, Julia Weber, Mathias Josef Friedrich, Yilong Li, Lena Rad, Hannes Ponstingl, Qi Liang, Sandra Bernaldo de Quirós, Imran Noorani, Emmanouil Metzakopian, Alexander Strong, Meng Amy Li, Aurora Astudillo, María Teresa Fernández-García, María Soledad Fernández-García, Gary J Hoffman, Rocío Fuente, George S Vassiliou, Roland Rad, Carlos López-Otín, Allan Bradley & Juan Cadiñanos (Source: Nature Genetics)
Source: Nature Genetics - March 20, 2017 Category: Genetics & Stem Cells Authors: Jorge de la Rosa Julia Weber Mathias Josef Friedrich Yilong Li Lena Rad Hannes Ponstingl Qi Liang Sandra Bernaldo de Quir ó s Imran Noorani Emmanouil Metzakopian Alexander Strong Meng Amy Li Aurora Astudillo Mar í a Teresa Fern á ndez-Garc í a Mar í Tags: Article Source Type: research
Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors
Nature Genetics 49, 708 (2017).
doi:10.1038/ng.3818
Authors: Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan, Kok Hao Chen, Jolene Jie Lin Goh, Say Li Kong, Clarinda Chua, Lim Kiat Hon, Wah Siew Tan, Mark Wong, Paul Jongjoon Choi, Lawrence J K Wee, Axel M Hillmer, Iain Beehuat Tan, Paul Robson & Shyam Prabhakar (Source: Nature Genetics)
Source: Nature Genetics - March 20, 2017 Category: Genetics & Stem Cells Authors: Huipeng Li Elise T Courtois Debarka Sengupta Yuliana Tan Kok Hao Chen Jolene Jie Lin Goh Say Li Kong Clarinda Chua Lim Kiat Hon Wah Siew Tan Mark Wong Paul Jongjoon Choi Lawrence J K Wee Axel M Hillmer Iain Beehuat Tan Paul Robson Shyam Prabhakar Tags: Article Source Type: research
Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis
Nature Genetics 49, 801 (2017).
doi:10.1038/ng.3816
Authors: Unnur Styrkarsdottir, Hannes Helgason, Asgeir Sigurdsson, Gudmundur L Norddahl, Arna B Agustsdottir, Louise N Reynard, Amanda Villalvilla, Gisli H Halldorsson, Aslaug Jonasdottir, Audur Magnusdottir, Asmundur Oddson, Gerald Sulem, Florian Zink, Gardar Sveinbjornsson, Agnar Helgason, Hrefna S Johannsdottir, Anna Helgadottir, Hreinn Stefansson, Solveig Gretarsdottir, Thorunn Rafnar, Ina S Almdahl, Anne Brækhus, Tormod Fladby, Geir Selbæk, Farhad Hosseinpanah, Fereidoun Azizi, Jung Min Koh, Nelson L S Tang, Maryam S Daneshpour, Jose I Mayordomo, Co...
Source: Nature Genetics - March 20, 2017 Category: Genetics & Stem Cells Authors: Unnur Styrkarsdottir Hannes Helgason Asgeir Sigurdsson Gudmundur L Norddahl Arna B Agustsdottir Louise N Reynard Amanda Villalvilla Gisli H Halldorsson Aslaug Jonasdottir Audur Magnusdottir Asmundur Oddson Gerald Sulem Florian Zink Gardar Sveinbjornsson A Tags: Letter Source Type: research
Natural variation at the soybean J locus improves adaptation to the tropics and enhances yield
Nature Genetics 49, 773 (2017).
doi:10.1038/ng.3819
Authors: Sijia Lu, Xiaohui Zhao, Yilong Hu, Shulin Liu, Haiyang Nan, Xiaoming Li, Chao Fang, Dong Cao, Xinyi Shi, Lingping Kong, Tong Su, Fengge Zhang, Shichen Li, Zheng Wang, Xiaohui Yuan, Elroy R Cober, James L Weller, Baohui Liu, Xingliang Hou, Zhixi Tian & Fanjiang Kong (Source: Nature Genetics)
Source: Nature Genetics - March 20, 2017 Category: Genetics & Stem Cells Authors: Sijia Lu Xiaohui Zhao Yilong Hu Shulin Liu Haiyang Nan Xiaoming Li Chao Fang Dong Cao Xinyi Shi Lingping Kong Tong Su Fengge Zhang Shichen Li Zheng Wang Xiaohui Yuan Elroy R Cober James L Weller Baohui Liu Xingliang Hou Zhixi Tian Fanjiang Kong Tags: Article Source Type: research
A single-copy Sleeping Beauty transposon mutagenesis screen identifies new PTEN-cooperating tumor suppressor genes
Nature Genetics 49, 730 (2017).
doi:10.1038/ng.3817
Authors: Jorge de la Rosa, Julia Weber, Mathias Josef Friedrich, Yilong Li, Lena Rad, Hannes Ponstingl, Qi Liang, Sandra Bernaldo de Quirós, Imran Noorani, Emmanouil Metzakopian, Alexander Strong, Meng Amy Li, Aurora Astudillo, María Teresa Fernández-García, María Soledad Fernández-García, Gary J Hoffman, Rocío Fuente, George S Vassiliou, Roland Rad, Carlos López-Otín, Allan Bradley & Juan Cadiñanos (Source: Nature Genetics)
Source: Nature Genetics - March 20, 2017 Category: Genetics & Stem Cells Authors: Jorge de la Rosa Julia Weber Mathias Josef Friedrich Yilong Li Lena Rad Hannes Ponstingl Qi Liang Sandra Bernaldo de Quir ós Imran Noorani Emmanouil Metzakopian Alexander Strong Meng Amy Li Aurora Astudillo Mar ía Teresa Fernández-García Mar ía Soled Tags: Article Source Type: research
Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors
Nature Genetics 49, 708 (2017).
doi:10.1038/ng.3818
Authors: Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan, Kok Hao Chen, Jolene Jie Lin Goh, Say Li Kong, Clarinda Chua, Lim Kiat Hon, Wah Siew Tan, Mark Wong, Paul Jongjoon Choi, Lawrence J K Wee, Axel M Hillmer, Iain Beehuat Tan, Paul Robson & Shyam Prabhakar (Source: Nature Genetics)
Source: Nature Genetics - March 20, 2017 Category: Genetics & Stem Cells Authors: Huipeng Li Elise T Courtois Debarka Sengupta Yuliana Tan Kok Hao Chen Jolene Jie Lin Goh Say Li Kong Clarinda Chua Lim Kiat Hon Wah Siew Tan Mark Wong Paul Jongjoon Choi Lawrence J K Wee Axel M Hillmer Iain Beehuat Tan Paul Robson Shyam Prabhakar Tags: Article Source Type: research
Fast, scalable prediction of deleterious noncoding variants from functional and population genomic data
Nature Genetics 49, 618 (2017).
doi:10.1038/ng.3810
Authors: Yi-Fei Huang, Brad Gulko & Adam Siepel (Source: Nature Genetics)
Source: Nature Genetics - March 13, 2017 Category: Genetics & Stem Cells Authors: Yi-Fei Huang Brad Gulko Adam Siepel Tags: Technical Report Source Type: research
Germline mutations in ABL1 cause an autosomal dominant syndrome characterized by congenital heart defects and skeletal malformations
Nature Genetics 49, 613 (2017).
doi:10.1038/ng.3815
Authors: Xia Wang, Wu-Lin Charng, Chun-An Chen, Jill A Rosenfeld, Aisha Al Shamsi, Lihadh Al-Gazali, Marianne McGuire, Nicholas Ah Mew, Georgianne L Arnold, Chunjing Qu, Yan Ding, Donna M Muzny, Richard A Gibbs, Christine M Eng, Magdalena Walkiewicz, Fan Xia, Sharon E Plon, James R Lupski, Christian P Schaaf & Yaping Yang
ABL1 is a proto-oncogene well known as part of the fusion gene BCR-ABL1 in the Philadelphia chromosome of leukemia cancer cells. Inherited germline ABL1 changes have not been associated with genetic disorders. Here we report ABL1 germline var...
Source: Nature Genetics - March 13, 2017 Category: Genetics & Stem Cells Authors: Xia Wang Wu-Lin Charng Chun-An Chen Jill A Rosenfeld Aisha Al Shamsi Lihadh Al-Gazali Marianne McGuire Nicholas Ah Mew Georgianne L Arnold Chunjing Qu Yan Ding Donna M Muzny Richard A Gibbs Christine M Eng Magdalena Walkiewicz Fan Xia Sharon E Plon James Tags: Letter Source Type: research
Disruption of the ATXN1 –CIC complex causes a spectrum of neurobehavioral phenotypes in mice and humans
Nature Genetics 49, 527 (2017).
doi:10.1038/ng.3808
Authors: Hsiang-Chih Lu, Qiumin Tan, Maxime W C Rousseaux, Wei Wang, Ji-Yoen Kim, Ronald Richman, Ying-Wooi Wan, Szu-Ying Yeh, Jay M Patel, Xiuyun Liu, Tao Lin, Yoontae Lee, John D Fryer, Jing Han, Maria Chahrour, Richard H Finnell, Yunping Lei, Maria E Zurita-Jimenez, Priyanka Ahimaz, Kwame Anyane-Yeboa, Lionel Van Maldergem, Daphne Lehalle, Nolwenn Jean-Marcais, Anne-Laure Mosca-Boidron, Julien Thevenon, Margot A Cousin, Della E Bro, Brendan C Lanpher, Eric W Klee, Nora Alexander, Matthew N Bainbridge, Harry T Orr, Roy V Sillitoe, M Cecilia Ljungberg, Zhandong L...
Source: Nature Genetics - March 13, 2017 Category: Genetics & Stem Cells Authors: Hsiang-Chih Lu Qiumin Tan Maxime W C Rousseaux Wei Wang Ji-Yoen Kim Ronald Richman Ying-Wooi Wan Szu-Ying Yeh Jay M Patel Xiuyun Liu Tao Lin Yoontae Lee John D Fryer Jing Han Maria Chahrour Richard H Finnell Yunping Lei Maria E Zurita-Jimenez Priyanka Ahi Tags: Article Source Type: research
Reconstructing the genome of the most recent common ancestor of flowering plants
Nature Genetics 49, 490 (2017).
doi:10.1038/ng.3813
Authors: Florent Murat, Alix Armero, Caroline Pont, Christophe Klopp & Jérôme Salse (Source: Nature Genetics)
Source: Nature Genetics - March 13, 2017 Category: Genetics & Stem Cells Authors: Florent Murat Alix Armero Caroline Pont Christophe Klopp J érôme Salse Tags: Analysis Source Type: research
Single-molecule sequencing and chromatin conformation capture enable de novo reference assembly of the domestic goat genome
Nature Genetics 49, 643 (2017).
doi:10.1038/ng.3802
Authors: Derek M Bickhart, Benjamin D Rosen, Sergey Koren, Brian L Sayre, Alex R Hastie, Saki Chan, Joyce Lee, Ernest T Lam, Ivan Liachko, Shawn T Sullivan, Joshua N Burton, Heather J Huson, John C Nystrom, Christy M Kelley, Jana L Hutchison, Yang Zhou, Jiajie Sun, Alessandra Crisà, F Abel Ponce de León, John C Schwartz, John A Hammond, Geoffrey C Waldbieser, Steven G Schroeder, George E Liu, Maitreya J Dunham, Jay Shendure, Tad S Sonstegard, Adam M Phillippy, Curtis P Van Tassell & Timothy P L Smith (Source: Nature Genetics)
Source: Nature Genetics - March 6, 2017 Category: Genetics & Stem Cells Authors: Derek M Bickhart Benjamin D Rosen Sergey Koren Brian L Sayre Alex R Hastie Saki Chan Joyce Lee Ernest T Lam Ivan Liachko Shawn T Sullivan Joshua N Burton Heather J Huson John C Nystrom Christy M Kelley Jana L Hutchison Yang Zhou Jiajie Sun Alessandra Cris Tags: Technical Report Source Type: research
Identification of methylation haplotype blocks aids in deconvolution of heterogeneous tissue samples and tumor tissue-of-origin mapping from plasma DNA
Nature Genetics 49, 635 (2017).
doi:10.1038/ng.3805
Authors: Shicheng Guo, Dinh Diep, Nongluk Plongthongkum, Ho-Lim Fung, Kang Zhang & Kun Zhang (Source: Nature Genetics)
Source: Nature Genetics - March 6, 2017 Category: Genetics & Stem Cells Authors: Shicheng Guo Dinh Diep Nongluk Plongthongkum Ho-Lim Fung Kang Zhang Kun Zhang Tags: Technical Report Source Type: research
Spatiotemporal genomic architecture informs precision oncology in glioblastoma
Nature Genetics 49, 594 (2017).
doi:10.1038/ng.3806
Authors: Jin-Ku Lee, Jiguang Wang, Jason K Sa, Erik Ladewig, Hae-Ock Lee, In-Hee Lee, Hyun Ju Kang, Daniel S Rosenbloom, Pablo G Camara, Zhaoqi Liu, Patrick van Nieuwenhuizen, Sang Won Jung, Seung Won Choi, Junhyung Kim, Andrew Chen, Kyu-Tae Kim, Sang Shin, Yun Jee Seo, Jin-Mi Oh, Yong Jae Shin, Chul-Kee Park, Doo-Sik Kong, Ho Jun Seol, Andrew Blumberg, Jung-Il Lee, Antonio Iavarone, Woong-Yang Park, Raul Rabadan & Do-Hyun Nam
Precision medicine in cancer proposes that genomic characterization of tumors can inform personalized targeted therapies. However, this...
Source: Nature Genetics - March 6, 2017 Category: Genetics & Stem Cells Authors: Jin-Ku Lee Jiguang Wang Jason K Sa Erik Ladewig Hae-Ock Lee In-Hee Lee Hyun Ju Kang Daniel S Rosenbloom Pablo G Camara Zhaoqi Liu Patrick van Nieuwenhuizen Sang Won Jung Seung Won Choi Junhyung Kim Andrew Chen Kyu-Tae Kim Sang Shin Yun Jee Seo Jin-Mi Oh Y Tags: Letter Source Type: research
